The NGF gene provides instructions for making a protein called nerve growth factor beta (NGFβ) that is important in the ... February 19, 2004). "A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception". Hum. Mol. Genet. ... The NCV shows reduced or absent sensory nerve action potentials and nerve biopsy shows total loss of myelinated fibers and ... Sphingolipids are found in myelin, which is the covering that protects nerves and promotes the efficient transmission of nerve ...

These include nerve growth factor, transforming growth factor beta (TGF-β), platelet-derived growth factor, and glycoprotein ... or cyclotide The growth factor cystine knot was first observed in the structure of nerve growth factor (NGF), solved by X-ray ... The vascular endothelial growth factor subfamily, categorized as part of the platelet-derived growth factor superfamily, ... Sherbet, G.V. (2011), "Growth Factor Families", Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer ...

"Persistent Nociception Triggered by Nerve Growth Factor (NGF) is Mediated by TRPV1 and Oxidative Mechanisms". The Journal of ... in nerve tissues of neurodegenerative diseases, and in the various tissues compromised by diabetes (see oxidative stress). Free ...

... on neurotrophic factors, specifically nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), were assessed in ... Hatanaka, Hiroshi; Nihonmatsu, Itsuko; Tsukui, Hiroko (1988). "Nerve growth factor promotes survival of cultured magnocellular ... showed decreases in nerve growth factor levels. BDNF protein has been shown to be necessary for procedural learning (form of ... in response to neurotransmitters and growth factors. This can result in subsequent protein to protein interactions and signal ...

... nerve growth factor, the RAD51-BRCA2 DNA recombination complex, and the DNA ligase shown at right. His group has written ... Å resolution crystal structure of nerve growth factor". Nature. 354 (6352): 411-414. Bibcode:1991Natur.354..411M. doi:10.1038/ ... Blundell has made contributions to the structural biology of polypeptide hormones, growth factors, receptor activation, signal ... Systems studied include DNA repair, hormones, growth factors and hormone/receptor interactions, cellular signalling, ...

Nerve growth factor (50 ng/ml) induced functional differentiation in PC12 cells has been reported. The studies have been ... intake in rats and suggest that MCP can be a possible independent and potent environmental cardiovascular risk factor. ...

In healthy nerves, nerve growth factor (NGF) is produced in very small amounts. However, upon injury, NGF mRNA expression ... leukemia inhibitory factor, insulin-like growth factor, and fibroblast growth factor. These factors together create a favorable ... "Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection" (PDF). The Journal of ... "Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts". The ...

... has been shown to interact with Low affinity nerve growth factor receptor and PKC alpha. GRCh38: Ensembl release 89: ...

"Nerve growth factor regulates the subcellular localization of the nerve growth factor-inducible protein PC4 in PC12 cells". J. ... "Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition". Cell Growth ... Tirone F, Shooter EM (1989). "Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related ... "Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related gene". Proc. Natl. Acad. Sci. U. ...

... molecular mimetics of nerve growth factor and brain‐derived neurotrophic factor: Design and pharmacological properties". ... Gudasheva, T. A.; Logvinov, I. O.; Antipova, T. A.; Seredenin, S. B. (July 2013). "Brain-derived neurotrophic factor loop 4 ... Gao, Hua (2002-06-01). "Up-regulation of Brain-Derived Neurotrophic Factor Expression by Brimonidine in Rat Retinal Ganglion ... "Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves". Proceedings of the National Academy of ...

"Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases." Cell 68 (1992): ...

"Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases". Cell. Elsevier BV ...

"Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor". Nature. 306 ( ... Studies on the development of the trigeminal nerve and ganglion led on to observations of the organisation of their ... Heffner CD, Lumsden AG, O'Leary DD (January 1990). "Target control of collateral extension and directional axon growth in the ... "The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation". Nature ...

"Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition". Cell Growth ... a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization". Proceedings of the National ... a primary response gene induced by growth factors and tumor promoters". The Journal of Biological Chemistry. 266 (22): 14511-8 ... Treatment with CXCL3 prevents the growth of medulloblastoma lesions in a Shh-type mouse model of medulloblastoma. Thus, CXCL3 ...

... insulin-like growth factor-1), demonstrating an effect on epithelial healing. Nerve Growth Factor (NGF) play a role in the ... Cornea 34 Suppl 11 (2015) S121-7 Lambiase A, Rama P, Bonini S, Caprioglio G, Aloe L. Topical treatment with nerve growth factor ... Recently, a recombinant human nerve growth factor eye drop formulation has been developed for clinical use. Cenegermin, a ... Most corneal nerve fibres are sensory in origin and are derived from the ophthalmic branch of the trigeminal nerve. Congenital ...

IL-17F also dimerizes in a fashion similar to nerve growth factor (NGF) and other neurotrophins. Recent work suggests the IL-23 ... May 2006). "Transforming growth factor-beta induces development of the T(H)17 lineage". Nature. 441 (7090): 231-4. Bibcode: ... Growth Factor Reviews. 14 (2): 155-74. doi:10.1016/S1359-6101(03)00002-9. PMID 12651226. Johansen C, Usher PA, Kjellerup RB, ... Transcription factors such as TRAF6, JNK, Erk1/2, p38, AP-1 and NF-κB have been implicated in IL-17 mediated signaling in a ...

BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a ... "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell ... Jones KR, Reichardt LF (October 1990). "Molecular cloning of a human gene that is a member of the nerve growth factor family". ... Binder DK, Scharfman HE (September 2004). "Brain-derived neurotrophic factor". Growth Factors. 22 (3): 123-31. doi:10.1080/ ...

Astrocytes also increase the production of growth factors like BDNF and NDF, therefore, enhance nerve regeneration. C-PC also ... In the mixotrophic culture, the sum of heterotrophic and autotrophic growth separately was equal to the mixotrophic growth. ... C-PC has been found to prevent cell growth. C-PC stops the formation of tumour before the S phase. DNA synthesis is not ... Guo N, Zhang X, Lu Y, Song X (March 2007). "Analysis on the factors affecting start-up intensity in the upstream sequence of ...

Morillo, S.M., Abanto, E.P., Roman, M.J., and Frade, J.M. (2012). Nerve Growth Factor-Induced Cell Cycle Reentry in Newborn ... Cell Growth Differ. 11, 625-633. Williams, G.H., and Stoeber, K. (2012). The cell cycle and cancer. 352-364. Yang, Y., Mufson, ... This is supported by experiments in which the G2/M checkpoint is removed through addition of brain-derived neurotrophic factor ... Under conditions such as DNA damage, oxidative stress, and activity withdrawal these factors have been shown to be upregulated ...

Using nerve growth factor (NGF) as a neurotrophic co-dopant could induce ideal cell responses in vivo. NGF is a water-soluble ... Seeding implants with growth factors, such as neural progenitor cells (NPCs), improves the brain-implant interface. NPCs are ... PPy has been shown to support cell adhesion and growth of a number of different cell types including primary neurons which is ... Two of the biggest determining factors that have been observed are surface roughness and surface free energy. In the case of ...

Cattaneo A (February 2010). "Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and ...

In fact, sElk1 counteracts Elk1 in neuronal differentiation and the regulation of nerve growth factor/ERK signaling. The ... in nerve growth factor-induced PC12 differentiation". J. Biol. Chem. 276 (7): 5189-96. doi:10.1074/jbc.M006678200. PMID ... Raf itself is activated by Ras, which is linked to growth factor receptors with tyrosine kinase activity via Grb2 and Sos. Grb2 ... The B domain allows Elk1 to bind to a dimer of its cofactor, serum response factor (SRF). Located adjacent to the B domain, the ...

... has been shown to interact with Ryanodine receptor 2 and Low affinity nerve growth factor receptor. GRCh38: Ensembl ... Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications ...

With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. In their active form, the ... Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily ... Tumor+Necrosis+Factor+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ...

Ohmichi M, Decker SJ, Pang L, Saltiel AR (August 1991). "Nerve growth factor binds to the 140 kd trk proto-oncogene product and ... Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T (March 2000). "Direct interaction of nerve growth factor ... "The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating ... Cbl gene CISH Epidermal growth factor receptor, Eukaryotic translation elongation factor 1 alpha 1, FLT1, GAB1, GIT1, Grb2, ...

Research in use of nerve grafts and nerve growth factors is being done to speed recovery time. A nerve injury in continuity ... axons that arrive at the recovery site along the pathway ahead of the rest of the nerve fibers. Nerve growth factors and nerve ... insulation to the nerve to allow better conduction along the axon, around the nerve fibers and secrete growth factors that play ... A nerve graft will be about 10 percent longer than the gap between the nerves, and the cross-section of the nerve end will be a ...

Culturing of pheochromocytoma cells with Nerve Growth Factor (NGF) induced differentiation and the development of neuronal ... Sapir T, Elbaum M, Reiner O (December 1997). "Reduction of microtubule catastrophe events by LIS1, platelet-activating factor ... Sapir T, Elbaum M, Reiner O (December 1997). "Reduction of microtubule catastrophe events by LIS1, platelet-activating factor ...

Nerve+Growth+Factor+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Reichardt, L. F. (2006 ... Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to ... Nerve+Growth+Factor+Receptor+p75 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Bibel, M.; Hoppe, E ... and NT-3 TrkC binds and is activated only by NT-3 The Low affinity nerve growth factor receptor commonly known as "p75", can ...

... of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor ... recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor ... recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor ... "Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling". FASEB J. ...

The continuous delivery of neurotropic growth factor (NGF) would increase the nerve regeneration in the spinal cord. However, ... Biochemical repair Neurotropic factor therapy and gene therapy Neurotropic growth factors regulate growth, survival, and ... They benefit nerve regeneration after injury to the nervous system. They are a potent initiator of sensory axon growth and are ... These factors would promote nerve repairs to the target area. Hydrogels' macroporous properties would enable attachment of ...