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*  Amyloid beta
Aβ is also destroyed by several amyloid-degrading enzymes including neprilysin. Autosomal-dominant mutations in APP cause ... Nalivaeva NN, Belyaev ND, Zhuravin IA, Turner AJ (2012). "The Alzheimer's amyloid-degrading peptidase, neprilysin: can we ...
*  Neprilysin
... the relationship between neprilysin expression and carcinogenesis remains obscure. In cancer biomarker studies, the neprilysin ... which thus depresses the activity of neprilysin and promotes aggregation of unprocessed amyloid beta. Declining neprilysin ... Neprilysin is expressed in a wide variety of tissues and is particularly abundant in kidney. It is also a common acute ... Because neprilysin is thought to be the rate-limiting step in amyloid beta degradation, it has been considered a potential ...
*  Endopeptidase
Works best at pH 8. Neprilysin "endopeptidase". Merriam-Webster. Archived from the original on 18 January 2017. Retrieved 18 ...
*  Arni
... , angiotensin receptor-neprilysin inhibitor: Valsartan/sacubitril. ...
*  Sacubitril
In addition, neprilysin degrades a variety of peptides including bradykinin, an inflammatory mediator exerting potent ... Sacubitrilat inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, ... for the PARADIGM-HF Investigators and Committees (August 30, 2014). "Angiotensin-Neprilysin Inhibition versus Enalapril in ... a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)". The Journal of Clinical Pharmacology. 50 (4): 401-414. ...
*  Atrial natriuretic peptide
Neutral endopeptidase (NEP) also known as neprilysin is the enzyme that metabolizes natriuretic peptides. Several inhibitors of ... "Angiotensin-neprilysin inhibition versus enalapril in heart failure". The New England Journal of Medicine. 371 (11): 993-1004. ...
*  Nicastrin
Pardossi-Piquard R, Dunys J, Yu G, St George-Hyslop P, Alves da Costa C, Checler F (May 2006). "Neprilysin activity and ... Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment ...
*  Adrenomedullin
Mature AM is degraded by the aminopeptidase neprilysin. Adrenomedullin (AM) exerts its actions through combinations of the ...
*  Sacubitril/valsartan
King JB, Bress AP, Reese AD, Munger MA (2015). "Neprilysin Inhibition in Heart Failure with Reduced Ejection Fraction: A ... It consists of the neprilysin inhibitor, sacubitril and the angiotensin receptor blocker, valsartan, in a 1:1 mixture by ... Bavishi C, Messerli FH, Kadosh B, Ruilope LM, Kario K (2015). "Role of neprilysin inhibitor combinations in hypertension: ... The combination is sometimes described as an "angiotensin receptor-neprilysin inhibitor" (ARNi). It was approved under the ...
*  Milton Packer
11 September 2014). "Angiotensin-neprilysin inhibition versus enalapril in heart failure". The New England Journal of Medicine ...
*  Candoxatril
Oefner C; D'Arcy A; Hennig M; Winkler FK; Dale GE (February 2000). "Structure of human neutral endopeptidase (Neprilysin) ... Candoxatril is the orally active prodrug of candoxatrilat (UK-73967) human neutral endopeptidase (Neprilysin) as the neutral ... neprilysin family, clan MA(E)) the gluzincins a faint but significant structural relationship of the metzincins to the ...
*  Ecadotril
The peptidase M13 family believed to activate or inactivate oligopeptide (pro)-hormones such as opioid peptides, neprilysin is ... Turner AJ, Isaac RE, Coates D (March 2001). "The neprilysin (NEP) family of zinc metalloendopeptidases: Genomics and function ...
*  Drug-induced angioedema
2 Nov 2014 2. Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure (PARADIGM-HF Investigators); NEJM.org, ... and Angiotensin-Neprilysin Inhibitor LCZ969. The angioedema appears to be dose dependent as it may resolve with decreased dose ...
*  Calla (disambiguation)
Common acute lymphoblastic leukemia antigen, also known as CD10 or Neprilysin. Princess Calla from Disney's Adventures of the ...
*  PITRM1
... and neprilysin". Cellular and Molecular Life Sciences. 65 (16): 2574-85. doi:10.1007/s00018-008-8112-4. PMC 2756532 . PMID ...
*  Gemopatrilat
It inhibits both angiotensin-converting enzyme (ACE) and neutral endopeptidase (neprilysin). "International Nonproprietary ...
*  Omapatrilat
It inhibits both neprilysin (neutral endopeptidase, NEP) and angiotensin-converting enzyme (ACE). NEP inhibition results in ... and neprilysin (neutral endopeptidase), both of these enzymes are responsible for the metabolism of bradykinin which causes ...
*  John R. Hetling
2015). Reduction of amyloid-beta levels in mouse eye tissues by intravitreally delivered neprilysin. Experimental Eye Research ...
*  MMEL1
Whyteside, A. R.; Turner, A. J. (2008). "Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and ...
*  Endothelin converting enzyme 1
2007). "On the role of endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer". Breast Cancer Res. Treat ...
*  Kell antigen system
The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc ...
*  Epigenetics of neurodegenerative diseases
Repressive hypermethylation caused by amyloid-beta has been observed at the promoter of NEP, the gene for neprilysin, which is ... "The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells." Biochem ...
*  Angiotensin (1-7)
Action of the neprilysin on Angiotensin I. Action of the Prolyl endopeptidase on Angiotensin I. Action of the ACE on ... by the actions of neprilysin (NEP) and Thimet oligopeptidase (TOP) enzymes. Also, Ang II can be hydrolyzed into Ang (1-7) ...
*  NLN (gene)
... and neprilysin (EC 3.4.24.11)". Analytical Biochemistry. 292 (2): 257-65. doi:10.1006/abio.2001.5083. PMID 11355859. Rioli V, ...
*  Endopeptidase inhibitor
Some examples of endopeptidase inhibitors include the following: Neprilysin inhibitors Selective neprilysin inhibitors ... inhibitor of neprilysin and thermolysin; also inhibits ECE RB-101 - also inhibits aminopeptidase N (APN) (an exopeptidase) ... active metabolite of racecadotril UK-414,495 Non-selective neprilysin inhibitors Aladotril - also inhibits angiotensin ...