*Multiple myeloma

"Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)-Health Professional Version". NCI. July 29, 2016. Archived ... Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally ... The plasma cells seen in multiple myeloma have several possible morphologies. Typical of plasma cells, they will usually have ... Plasma cell dyscrasia, the spectrum of plasma cell disorders which evolve from benign to malignant conditions Development of ...

*Syndecan 1

... a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms". American Journal of Clinical ... It is a useful marker for plasma cells, but only if the cells tested are already known to be derived from blood. GRCh38: ... The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for ... The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and ...

*C90

... designated C90 in a 90 cc version Ruy Lopez chess openings ECO code Multiple myeloma and malignant plasma cell neoplasms ICD-10 ...

*Plasma cell

Waldenström macroglobulinemia and plasma cell leukemia are malignant neoplasms ("cancer") of the plasma cells. Multiple myeloma ... Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete ... In humans, CD27 is a good marker for plasma cells, naive B cells are CD27-, memory B-cells are CD27+ and plasma cells are ... Germinal center B cells may differentiate into memory B cells or plasma cells. Most of these B cells will become plasmablasts ( ...

*Paraproteinemia

... but usually B-cell Non-Hodgkin lymphomas with a plasma cell component. Myeloma Plasmacytoma Lymphoplasmacytic lymphoma ... It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. It is ... Plasma cell dyscrasia Monoclonal gammopathy of undetermined significance Health Communication Network. Immunoproliferative ... sometimes considered equivalent to plasma cell dyscrasia. Causes of paraproteinemia include the following:[citation needed] ...

*Plasma cell dyscrasia

... or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. The clinical importance of understanding ... Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of ... In the most malignant form of plasma cell dyscrasias, primary plasma cell leukemia, the plasma cell population contains >1900 ... 2x109 plasma cells per liter or, alternatively, >20% of nucleated blood cells being plasma cells. More recently, the Group has ...

*List of MeSH codes (C11)

... plasma cell, orbital MeSH C11.675.659 --- orbital neoplasms MeSH C11.675.700 --- retrobulbar hemorrhage MeSH C11.710.090 --- ... iris neoplasms MeSH C11.941.375.385 --- iritis MeSH C11.941.855 --- uveal neoplasms MeSH C11.941.855.198 --- choroid neoplasms ... uveal neoplasms MeSH C11.319.494.198 --- choroid neoplasms MeSH C11.319.494.400 --- iris neoplasms MeSH C11.338.133 --- ... eyelid neoplasms MeSH C11.319.457 --- orbital neoplasms MeSH C11.319.475 --- retinal neoplasms MeSH C11.319.475.760 --- ...

*ICD-10 Chapter II: Neoplasms

Multiple myeloma and malignant plasma cell neoplasms (C90.0) Multiple myeloma (C90.1) Plasma cell leukemia (C90.2) Plasmacytoma ... Neoplasms. (C00) Malignant neoplasm of lip (C01) Malignant neoplasm of base of tongue (C02) Malignant neoplasm of other and ... Malignant neoplasm of breast (C51) Malignant neoplasm of vulva (C52) Malignant neoplasm of vagina (C53) Malignant neoplasm of ... small cell (diffuse) (C83.1) Small cleaved cell (diffuse) (C83.2) Mixed small and large cell (diffuse) (C83.3) large cell ( ...

*CD79A

The protein remains present when B-cells transform into active plasma cells, and is also present in virtually all B-cell ... neoplasms, including B-cell lymphomas, plasmacytomas, and myelomas. It is also present in abnormal lymphocytes associated with ... Because even on B-cell precursors, it can be used to stain a wider range of cells than can the alternative B-cell marker CD20, ... Loss of only one of the two functional CD79a/b ITAMs resulted in impaired B cell development but B cell functions such as the T ...

*Clear cell acanthoma

... plasma cells and neutrophils. Simple surgical excision is curative. Epidermis List of cutaneous conditions List of cutaneous ... neoplasms associated with systemic syndromes Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; ... Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos acanthoma," and "Pale cell ... squamous cell carcinoma, verruca vulgaris, psoriatic plaque, and melanoma. Clear cell acanthoma is characterized by a sharply ...

*POEMS syndrome

... plasma cell dyscrasia). The signs and symptoms of most neoplasms are due to their mass effects caused by the invasion and ... 2 plasmacytoma bone lesions and/or increases in bone marrow clonal plasma cells are treated with a low-dose or high-dose ... Castillo JJ (2016). "Plasma Cell Disorders". Primary Care. 43 (4): 677-691. doi:10.1016/j.pop.2016.07.002. PMID 27866585. ... It is suggested that various other cytokines produced by the clonal plasma cells, perhaps working in concert with each other as ...

*Clone (cell biology)

For instance, two plasma cells belonging to the same clone could be derived from different memory cells (in turn with shared ... of cells is neoplasms. Many of the tumors derive from one (sufficiently) mutated cell, so they are technically a single clone ... bone marrow cells. Most other cells cannot divide indefinitely as after a few cycles of cell division the cells stop expressing ... plasma cells, and the memory and the naive cells-both of which retain their proliferative potential. Another important area ...

*Connective tissue

Cells of the immune system, such as macrophages, mast cells, plasma cells and eosinophils are found scattered in loose ... There are many types of connective tissue disorders, such as: Connective tissue neoplasms including sarcomas such as ... The cells of connective tissue include fibroblasts, adipocytes, macrophages, mast cells and leucocytes. Connective tissue can ... Fibroblasts are the cells responsible for the production of some CT. Type I collagen is present in many forms of connective ...

*Bloodwise

"Plasma cell leukaemia". Bloodwise. Retrieved 2015-12-04. "Bloodwise - T-cell acute lymphoblastic leukaemia". "Lymphoma". ... "Myeloproliferative neoplasms (MPN)". Bloodwise. Retrieved 2015-11-26. "Bloodwise - MGUS". "Bloodwise - Solitary plasmacytoma ... Large granular lymphocytic leukaemia Plasma cell leukaemia T-cell acute lymphoblastic leukaemia (T-ALL) Specific sub-sets of ... "Hairy cell leukaemia". Bloodwise. Retrieved 2015-11-26. "Chronic lymphocytic leukaemia". Bloodwise. Retrieved 2015-11-26. " ...

*IQGAP1

It is usually found in the nucleus, plasma membrane, and cytoplasm. In other words it is found throughout the cell as well as ... IQGAP1 is localized at the invasive front of the neoplasm, indicating a role in mobilization of the cells. Importantly, ... a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 ... weakening these junctions and thus decreasing cell-cell adhesion. IQGAP weakens cell adhesion by displacing a-catenin from the ...

*List of cancer types

Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm ... leukemia Cutaneous T-cell lymphoma Diffuse large B-cell lymphoma Follicular lymphoma Hairy cell leukemia Hepatosplenic T-cell ... myeloid dendritic cell leukemia AIDS-related lymphoma Anaplastic large cell lymphoma Angioimmunoblastic T-cell lymphoma B-cell ... Ovarian germ cell tumor Penile cancer Renal cell carcinoma Renal pelvis and ureter, transitional cell cancer Prostate cancer ...

*Lymphoma

Splenic marginal zone lymphoma Hairy cell leukemia Plasma cell neoplasms: Plasma cell myeloma (also known as multiple myeloma) ... Mature T cell and natural killer (NK) cell neoplasms T-cell prolymphocytic leukemia T-cell large granular lymphocyte leukemia ... Mature B cell neoplasms B-cell chronic lymphocytic leukemia/small cell lymphoma 3 to 4% of lymphomas in adults Small resting ... of lymphomas in adults Variable cell size and differentiation, 40% show plasma cell differentiation, homing of B cells to ...

*Waldenström's macroglobulinemia

... lymphoplasmacytoid cells and plasma cells. Both cell types are white blood cells. WM is characterized by having high levels of ... ISBN 0-7817-5007-5. Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and ... WM is commonly classified as a form of plasma cell dyscrasia. Similar to other plasma cell dyscrasias that, for example, lead ... One recent investigation showed that a population of cells, lacking both B-cell and plasma cell markers, has characteristics of ...

*Xanthogranulomatous osteomyelitis

Neutrophils, hemorrhagic foci and numerous plasma cells are additional findings. Staphylococcus aureus was isolated in the case ... Vankalakunti M, Saikia UN, Mathew M, Kang M (2007). Xanthogranulomatous osteomyelitis of ulna mimicking a neoplasm. World J ... Cell composition and possible pathogenetic role of cell-mediated immunity.Pathol Res Pract 183:395-482.. ... T cells are represented by a mixture of CD4+ and CD8+ lymphocytes. Macrophages and lymphocytes show marked expression of HLA-DR ...

*Angioimmunoblastic T-cell lymphoma

Polyclonal plasma cells and CD21+ follicular dendritic cells are also seen. Clonal T-cell receptor gene rearrangements are ... and NK-cell neoplasms: Angioimmunoblastic T-cell lymphoma". WHO Classification of Tumours of Haematopoietic and Lymphoid ... plasma cells, and follicular dendritic cells. In addition, blast-like B-cells are occasionally seen. A classic morphological ... October 1999). "Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with ...

*Glassy cell carcinoma of the cervix

PAS staining distinctively extenuates the plasma membrane. The treatment is dependent on the stage. Advanced tumours are ... "Uterine Neoplasms". Journal of the National Comprehensive Cancer Network. 7 (5): 498-531. doi:10.6004/jnccn.2009.0035. ISSN ... Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix. ... Under the microscope, glassy cell carcinoma tumours are composed of cells with a glass-like cytoplasm, typically associated ...

*CD20

... but not on either early pro-B cells or plasma blasts and plasma cells. It is found on B-cell lymphomas, hairy cell leukemia, B- ... Because CD20 remains present on the cells of most B-cell neoplasms, and is absent on otherwise similar appearing T-cell ... CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through ... encodes a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. ...

*MicroRNA

MiRNAs influence B cell maturation, generation of pre-, marginal zone, follicular, B1, plasma and memory B cells. A study of ... Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms). Germ line mutations in DNA repair ... and cell cycle in mice lacking miRNA-1-2". Cell. 129 (2): 303-17. doi:10.1016/j.cell.2007.03.030. PMID 17397913. Thum T, ... B-cell migration/adhesion, cell-cell interactions in immune niches and the production and class-switching of immunoglobulins. ...

*Gout

... y tophi, in particular when not located in a joint, can be mistaken for basal cell carcinoma or other neoplasms. Both ... Hyperuricemia is defined as a plasma urate level greater than 420 μmol/l (7.0 mg/dl) in males and 360 μmol/l (6.0 mg/dl) in ... both the white blood cells and ESR may be elevated due to gout in the absence of infection. A white blood cell count as high as ... Gout may be secondary to sleep apnea via the release of purines from oxygen-starved cells. Treatment of apnea can lessen the ...

*Choroid plexus

CSF is formed as plasma is filtered from the blood through the epithelial cells. Choroid plexus ependymal cells actively ... These malignant neoplasms are rare. Choroid plexus translates from the Latin plexus chorioides, which mirrors Ancient Greek ... The choroid plexus is a plexus of cells that produces the cerebrospinal fluid in the ventricles of the brain. The choroid ... The epithelium of the choroid plexus is continuous with the ependymal cell layer that lines the ventricles, but unlike the ...

*Tetratricopeptide repeat protein 39B

TTC39A has been tested for association to diseases like breast neoplasms and is expected to have molecular binding function and ... TTC39B is expressed in a multitude of tissues: testis, lung, islets of langerhans, pancreas, kidney, pooled germ cell tumors, ... resulted in significantly higher plasma HDL-C levels at 4 days and 7 days. The data indicates that TTC39B as causal genes for ... Conjugation of ubiquitin monomers or polymers leads to different effects within a cell. Ubiquitination has been associated with ...