Chen S, Maul RS, Kim HR, Chang DD (Jul 2000). "Characterization of the human EPLIN (Epithelial Protein Lost in Neoplasm) gene ... Maul RS, Chang DD (Feb 2000). "EPLIN, epithelial protein lost in neoplasm". Oncogene. 18 (54): 7838-41. doi:10.1038/sj.onc. ... LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene. EPLIN is a cytoskeleton- ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...
Infection (secondary obstruction) Neoplasm (secondary obstruction) Sarcoidosis (secondary obstruction). Amyloidosis. Systemic ... thus making it a preferred protein for quantification of gut protein loss in protein loosing enteropathy. Treatment for protein ... causing protein loss and protein loosing enteropathy. The widespread hypoproteinemia seen in protein loosing enteropathy may ... The diagnosis of protein losing enteropathy is made by excluding other causes of protein loss. Endoscopy can be used to ...
It is generally accepted that the BRD4-NUT protein promotes these neoplasms by maintaining their neoplastic cells in a ... The nuclear protein in testis gene (i.e. NUTM1 gene) encodes (i.e. directs the synthesis of) a 1,132-amino acid protein termed ... The BRD4-NUTM1 fusion gene is a translocation that encodes a fusion protein that has merged most of the protein coding region ... This translocation is notated as t(15;19)(q13, p13.1). BRD4 protein recognizes acetylated lysine residues on proteins and by ...
... a marker protein for neuroendocrine cells and neoplasms". Proceedings of the National Academy of Sciences of the United States ... The encoded protein has 313 amino acids with a predicted molecular weight of 33.845 kDa. The protein is a synaptic vesicle ... Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. ... The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when ...
The protein-coding DNA within the nucleus is about 1.5% of the total genomic DNA. Within this protein-coding DNA (called the ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The word neoplasm is from Ancient Greek νέος- neo 'new' and πλάσμα plasma 'formation, creation'. A neoplasm can be benign, ... The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that ...
The coding region is 2086 base pairs, and the protein sequence contains 615 amino acids. The protein encoded by c2orf81 is ... Disease states in which it is expressed include in gliomas, neoplasm, and lymphoma. Only a few mutations have been documented ... The N-terminus of the protein has evolved less quickly than the rest of the protein. "Chromosome 2: 74,414,176-74,421,591 - ... The c2orf81 protein is conserved highly in primates and other mammals, but less so in non-mammalian vertebrates. Its most ...
... in cervical carcinoma and cervical intraepithelial neoplasm". Anticancer Research. 23 (4): 3195-8. PMID 12926053. Iwasa S, Jin ... Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded ... Bae S, Park CW, Son HK, Ju HK, Paik D, Jeon CJ, Koh GY, Kim J, Kim H (September 2008). "Fibroblast activation protein alpha ... Several bioactive peptides and structural proteins were reported to be cleaved by FAP, such as neuropeptide Y (NPY), Peptide YY ...
... for neuroendocrine neoplasms". Advances in Anatomic Pathology. 10 (2): 101-6. doi:10.1097/00125480-200303000-00005. PMID ... Microtubule-associated protein 2 is a protein in humans that is encoded by the MAP2 gene. This gene encodes a protein that ... Herrmann H, Wiche G (1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 ... "The RII subunit of cAMP-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A ...
The same article also pointed out that MYB-QKI protein facilitates the growth of vessels around the glioma. AG often behaves as ... Brat DJ, Scheithauer BW, Fuller GN, Tihan T (July 2007). "Newly codified glial neoplasms of the 2007 WHO Classification of ... Yet, a series of suspected causes are under discussion, including the possible MYB-QKI protein fusion theory on AG etiology. ... The research group proved that this protein alternation could be the critical contributor to AG oncogenicity since mice showed ...
"Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms". Cancer Genetics and Cytogenetics. 162 (2 ... DOCK family proteins contribute to cell signalling by activating G proteins of the Rho family, such as Rac and Cdc42. Dock4 has ... Dedicator of cytokinesis protein 4 (Dock4), is a large (~190 kDa) protein encoded in the human by the DOCK4 gene, involved in ... The adaptor protein ELMO has been shown to bind DOCK proteins and induce a conformational change which relieves the inhibition ...
The protein is encoded in the human by the PDGFRA gene. This receptor binds to certain isoforms of platelet-derived growth ... Mutations in PDGFRA, are associated with an array of clinically significant neoplasms, notably ones of the clonal ... The molecular mass of the mature, glycosylated PDGFRα protein is approximately 170 kDA. cell surface tyrosine kinase receptor ... The fused gene encodes a FIP1L1-PDGFRA protein that causes: a) chronic eosinophilia which progresses to chronic eosinophilic ...
The protein was identified during investigations on the origin of multiple myeloma, a B-cell hematologic neoplasm. To ... The discovery of Protein M, a new protein from M. genitalium, was announced in February 2014. ... The protein is about 50 kDa in size, and composed of 556 amino acids. Smallest organisms Tully, J. G.; Taylor-Robinson, D.; ... The antibody reactivity was due to a protein never known before, and is chemically responsive to all types of human and ...
2013). "Screening for Muir-Torre syndrome using mismatch repair protein immunohisochemistry of sebaceous neoplasms". J Genet ... Along with neoplasms of the sebaceous gland, this patient developed cerebral neoplasms, characteristic of Turcot syndrome. ... Age of onset of first sebaceous neoplasm: 2 = 2 points. Personal history of Lynch related cancers: No = 0 points, Yes = 1 point ... 2014). "A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch ...
2006). "Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms". Cancer Biol. Ther ... Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene. This gene encodes a protein ... 2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and ... 2004). "Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in ...
2007). "Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms". Haematologica. 92 (2): 176- ... This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH ... Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene. ... "Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2". Yisraeli JK (2005). "VICKZ proteins: a multi- ...
... matrix protein (M), fusion protein (F), neuraminidase (NA) and large protein (L). All these proteins have variable functions ... Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... F-protein, as other paramyxoviral fusion proteins, is a trimeric class I viral membrane fusion protein. It is produced in the ... "ASGR1 protein expression summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2020-01-14. "ASGR2 protein ...
This V617F mutation render's the protein's tyrosine kinase continuously active and results in a myeloproliferative neoplasm ... The FLT3 gene codes for the cluster of differentiation antigen 135 (i.e. CD135) protein or FLT3 protein. This protein is a ... The ACSL6 gene encodes a protein, CSL6 acyl-CoA synthetase long-chain family member 6 (or ACSL6 protein). This protein is a ... BCR encodes the breakpoint cluster region protein. This protein possess Serine/threonine-specific protein kinase activity and ...
This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. NUP88 has been shown ... "Developing chick embryos express a protein which shares homology with the nuclear pore complex protein Nup88 present in human ... The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 ... Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene. The nuclear pore complex is a massive ...
"Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms". Thyroid. 15 (10): 1131-6 ... acetylation of ribosomal protein S18". Protein Science. 17 (10): 1781-90. doi:10.1110/ps.035899.108. PMC 2548364. PMID 18596200 ... "N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...
Roskoski R (2016). "Ibrutinib inhibition of Bruton protein-tyrosine kinase (BTK) in the treatment of B cell neoplasms". ... Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene. SYK ... Without Syk, the protein it makes, and genetic disruption in a panel of 55 genes thought also to be controlled by Syk, breast ... "Entrez Gene: SYK Spleen tyrosine kinase". Chan AC, Iwashima M, Turck CW, Weiss A (November 1992). "ZAP-70: a 70 kd protein- ...
"Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms". Thyroid. 15 (10): 1131-6 ... The crystal structure of human NatA bound to the protein HYPK has also been solved. Because TPR motifs mediate protein-protein ... NatA may also regulate co-translational protein folding and protein targeting to the endoplasmic reticulum, possibly through ... NMDA receptor-regulated protein 1 (NARG1), and Tbdn100 is a protein that in humans is encoded by the NAA15 gene. NARG1 is the ...
PaSCs express the intermediate filament proteins desmin and glial fibrillary acidic protein. The expression of a diverse range ... distinguished by an increase in the connective tissue that surrounds the neoplasm. Activated PaSCs in the tumour desmoplasia of ... Protein kinases such as MAPKs are primary mediators of activating signals initiated by the growth factors, angiotensin II and ... The up regulation of matri-cellular proteins such as galectin-1, and tenascin-C is present in the stromal tissues of pancreatic ...
... in the serum protein electrophoresis because there will be an excess of production of one protein. There are two large classes ... It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. It is ... AL amyloidosis These are characterized by the presence of any abnormal protein that is involved in the immune system, which are ... The β band consists of transferrin, low-density lipoproteins, and complement system proteins. The γ band is where the ...
The mammalian TET proteins were found to be orthologues of Trypanosoma brucei base J-binding protein 1 (JBP1) and JBP2. Base J ... Mutations in this gene were first identified in myeloid neoplasms with deletion or uniparental disomy at 4q24. TET2 may also be ... An explanation for protein function was provided in 2009 via computational search for enzymes that could modify 5mC. At this ... TET2 encodes a protein that catalyzes the conversion of the modified DNA base methylcytosine to 5-hydroxymethylcytosine. The ...
... proteins, and fats in food entering the duodenum from the stomach. Papillary - In oncology, papillary refers to neoplasms with ... Antibody - (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is ... Fingernails and toenails are made of a tough protective protein called alpha-keratin which is found in the hooves, hair, claws ... Cytokines - are a broad and loose category of small proteins (~5-20 kDa) that are important in cell signaling. Cytokines are ...
One small series of 6 cases showed that MDM2 protein was expressed in 5 of them (83%), and p53 protein was overexpressed in 50 ... Although it is not normally considered a fast-growing malignant neoplasm, FA can exhibit high uptake on FDG-PET scanning. ... Identification of aberrant nuclear localization of a mutated protein product of the beta-catenin gene has been proposed as a ...
Urinalysis: A test to check the color of urine and its contents, such as sugar, protein, blood, bacteria, and the level of β- ...
... is a fusion protein consisting of interleukin 3 (IL-3) fused to diphtheria toxin. The fusion protein readily kills ... Hammond D, Pemmaraju N (June 2020). "Tagraxofusp for Blastic Plasmacytoid Dendritic Cell Neoplasm". Hematology/Oncology Clinics ... it was not possible to be sure how effective the medicine was in treating blastic plasmacytoid dendritic cell neoplasm. In ... Engineered proteins, Orphan drugs, All stub articles, Antineoplastic and immunomodulating drug stubs). ...
Pathologists discovered a BCL-2 protein, commonly present in neoplasms, to exist in the tissue layers of the GOC. The protein ... The analysis of PTCH, a gene that specialises in neoplasm inhibition, was carried out to determine if any existing mutations ... a popular type of neoplasm at the salivary glands. GOC is usually misdiagnosed with other lesions developed at the glandular ...
Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene. Mutations in ... in pulmonary neuroendocrine cells and neoplasms". Pathol. Int. 46 (6): 393-8. doi:10.1111/j.1440-1827.1996.tb03629.x. PMID ... Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ... Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and ...