This experimental approach was also used to investigate other lymphocyte populations, including "natural killer" cells. His ... functions of T cells were invested in a single lineage or represented the specialized activities of distinct T cell subsets. ... Mobilization of natural killer cells inhibits development of collagen-induced arthritis. Proc Natl Acad Sci USA 2011;108:14584 ... Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity, 2007;26: 593 †Leavenworth JW ...
... among them being that mosquito saliva led to an increase in natural killer T cells in peripheral blood; to an overall decrease ... changes to proportions of subsets of PBMCs; changes in the prevalence of T cell subtypes across organs; and changes to ... 2005) observed a suppression of antibody-specific T cell responses mediated by mosquito saliva and dependent on mast cells and ... suggesting natural feeding of mosquitoes can have a profound, enduring, and systemic effect on the immune response. T cell ...
"NK T cells" was first used in mice to define a subset of T cells that expressed the natural killer (NK) cell-associated marker ... Natural killer T cells should neither be confused with natural killer cells nor killer T cells (cytotoxic T cells). The term " ... Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer ... semi-invariant T-cell receptor and NK cell markers. NKT cells are a subset of T cells that coexpress an αβ T-cell receptor, but ...
... whose other arm is mediated by killer T cells. Acquired immunity's two principal mediators, B cells and T cells, are subsets of ... On the other hand, innate immunity is mediated not only by phagocytes but also by a third subset of lymphocytes: natural killer ... Lida H Mattman, Cell Wall Deficient Forms: Stealth Pathogens, 3rd edn (Boca Raton FL: CRC Press, 2000), pp 286 & 289, while p ... whereas the other three zones-surrounding the zone of infection-revealed immune cells or other host cells but no bacteria. Fish ...
... natural killer (NK), B, and T cells. Dendritic cells (DC) are a group of heterogeneous cells that can be divided into different ... IRF4 and IRF8 specify and direct the differentiation of different subsets of DCs by stimulating subset-specific gene expression ... IRF8 and IRF4 are also involved in the regulation of B and T-cell development at multiple stages. IRF8 and IRF4 function ... In addition to IRF4 and IRF8, IRF1 and IRF2 are also involved in DC subset development. IRF8 has also been implicated in the ...
... increase in the number of natural killer cells and changes in T-cell and NK-cell subsets in human blood". Immunology. 59 (3): ... These cells are seen as a representation of resting cells, precursors of various cell types, or an unknown cell type. Null ... The number of null cells has increased over time in subpopulations of mononuclear cells. Mononuclear cells are blood cells that ... These cells do not have receptors like one would typically find on either mature B cells or T cells. There are common ...
... and natural killer cells and subsets of T and B cells. It mediates inflammation by regulating leukocyte adhesion and migration ... Beside TLR signalling, CD11b also negatively regulates B cell receptor (BCR) signalling, and it suppresses T cell activation ... One of them are myeloid-derived suppressor cells (MDSC) and tumour-associated macrophages (TAMs), which are myeloid cells ... doi:10.1016/j.cell.2020.02.041. PMC 9358771. PMID 32164908. DeNardo DG, Galkin A, Dupont J, Zhou L, Bendell J (August 2021). " ...
... especially on a subset classified as naturally occurring Tregs. It can also be found on activated B cells, NK (natural killer) ... Langerhans cells). IL2RA protein can be expressed in many types of neoplastic cells, such as in most B-cell neoplasms, T-cell ... Abel AM, Yang C, Thakar MS, Malarkannan S (2018-08-13). "Natural Killer Cells: Development, Maturation, and Clinical ... cells, thymocytes, and some myeloid lineage cells (e.g. macrophages, dendritic cells). IL2RA has been used as a marker to ...
... natural MeSH A11.118.637.555.567.537.500 - killer cells, lymphokine-activated MeSH A11.118.637.555.567.550 - lymphocyte subsets ... cho cells MeSH A11.251.210.505 - l cells (cell line) MeSH A11.251.210.520 - llc-pk1 cells MeSH A11.251.210.700 - 3t3 cells MeSH ... k562 cells MeSH A11.251.860.180.750 - pc12 cells MeSH A11.251.860.180.880 - u937 cells MeSH A11.284.149.165 - cell membrane ... l cells MeSH A11.329.228.900 - 3t3 cells MeSH A11.329.228.900.080 - balb 3t3 cells MeSH A11.329.228.900.550 - nih 3t3 cells ...
Alaska Cytokine-induced killer cell, a subset of natural killer T cells Crypto Ignition Key, or KSD-64, a security token ...
T cell subsets bearing invariant TCRs, such as CD1d-restricted Natural Killer T cells, gamma delta T cells exhibit several ... Naive T cells Memory T cells Helper T cells Cytotoxic T cells Natural killer T cells Innate immune system Adaptive immune ... Gamma delta T cells (γδ T cells) are T cells that have a γδ T-cell receptor (TCR) on their surface. Most T cells are αβ (alpha ... γδ T cells have clinical association with many autoimmune diseases. γδ T cells are a major T cell subset of intraepithelial ...
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases ... Baker E, Sutherland GR, Smyth MJ (Apr 1994). "The gene encoding a human natural killer cell granule serine protease, Met-ase 1 ... 2003). "The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell ... cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells". J. ...
... natural killer cells, and a subset of B cells). It is most prominently known to be recruited upon antigen binding to the T cell ... Langerhans cells and B cells) via the MHC. Upon this activation, the TCR co-receptor CD4 (expressed on T helper cells) or CD8 ( ... The final outcome of T cell activation is the transcription of several gene products which allow the T cells to differentiate, ... ZAP-70 expression in B cells is correlated with the development of chronic lymphocytic leukemia (CLL). The T cell receptor has ...
Like other 'unconventional' T cell subsets bearing invariant TCRs, such as CD1d-restricted natural killer T cells, γδ T cells ... ILCs do not express myeloid or dendritic cell markers. Natural killer cells (NK cells) are lymphocytes and a component of the ... As with B cells, each type of T cell recognizes a different antigen. Killer T cells are activated when their T-cell receptor ... This allows killer T cells to recognize the tumor cell as abnormal. NK cells also kill tumorous cells in a similar way, ...
... natural killer cells, B cells and a subset of cytotoxic T cells by interacting with sialic acid molecules in the ligands on ... CD169+ macrophages mediate signaling between the various cells and seem to promote hematopoietic stem cell retention to the ... Sialoadhesin is a cell adhesion molecule found on the surface of macrophages. It is found in especially high amounts on ... Sialoadhesin (CD169) positive macrophages, along with mesenchymal stem cells and beta-adrenergic neurons, form the ...
The Kronenberg lab focuses on understanding innate-like lymphocytes, mainly natural killer T (NKT) cells, a subset of T cells ... "LIGHT-HVEM Signaling in Innate Lymphoid Cell Subsets Protects Against Enteric Bacterial Infection". Cell Host and Microbe. 24 ( ... "Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria". Nature Immunology. 7 (9): 978-986. doi: ... "Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria". Nature Immunology. 12 (10): 966 ...
... has a very specialized role in cell recognition by natural killer cells (NK cells). HLA-E binds a restricted subset of ... This interaction has been shown to trigger expansion of NK cell subsets in antiviral responses, where adaptive NK cells that ... "Human natural killer cells: their origin, receptors and function". European Journal of Immunology. 32 (5): 1205-11. doi:10.1002 ... "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature. 391 (6669): 795-9. Bibcode:1998Natur.391..795B. doi: ...
Natural killer T cells (NKT cells - not to be confused with natural killer cells of the innate immune system) bridge the ... Gamma delta T cells (γδ T cells) represent a small subset of T cells which possess a γδ TCR rather than the αβ TCR on the cell ... Cytotoxic T cells (TC cells, CTLs, T-killer cells, killer T cells) destroy virus-infected cells and tumor cells, and are also ... A different population of T cells, the CD4+ T cells, function as "helper cells". Unlike CD8+ killer T cells, the CD4+ helper T ...
Role of natural killer cell subsets in cardiac allograft rejection. Am J Transplant. 6(3):505-13 Yu G, Xu X, Vu MD, Kilpatrick ... 17 cells. Nature 448(7152):484-7 Villard J. (2011), The role of natural killer cells in human solid organ and tissue ... NK cells can also directly target the transplanted tissue. It depends on the balance of activating and inhibitory NK cell ... Receptors of KIR (Killer-cell immunoglobulin-like receptor) family bind concrete MHC class I molecules. If the graft has these ...
... as well as natural killer cells (NK cells) involved in innate immunity. This selective inhibition is not observed in ... Fior R (2019), "Cancer - when Cells Break the Rules and Hijack Their Own Planet", Molecular and Cell Biology of Cancer, ... conventional chemotherapy which reduces the number of all lymphocyte subsets. In addition, some chemotherapeutic agents ... Tumor cells develop various means to evade immunosurveillance of the host. The number of CD4+ CD25+ FOXP3+ regulatory T cells ( ...
... a subset of dendritic cells and of natural killer cells. Molecular characterization of CD93 revealed that this protein is ... In the context of the endothelial cells, CD93 is involved in endothelial cell-cell adhesion, cell spreading, cell migration, ... McKearn JP, Baum C, Davie JM (January 1984). "Cell surface antigens expressed by subsets of pre-B cells and B cells". Journal ... CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell-cell adhesion processes but also in host ...
Natural killer T (NKT) cells are a similar population with affinity to CD1d (the only group 2 CD1 molecule). Both groups ... two CD4+ TCRαβ+ T cell populations which differ from the otherwise variable TCR composition of previously isolated subsets, one ... Most identified T-cells that bind group 1 CD1 proteins are αβ T cells and some are γδ T cells. Both foreign and endogenous ... Langerhans cells and in some stages of thymocyte maturation. Some subsets of B cells express CD1c. These proteins are related ...
"Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells". ... "Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer". ... resulting in recovered cytolytic activity and anti-tumor effects of natural killer (NK) cells and T cells, as well as reduced ... The primary function of scavenger receptors is to regulate phagocytosis of pathogens, but they also participate in cell-cell ...
Like other 'unconventional' T cell subsets bearing invariant TCRs, such as CD1d-restricted natural killer T cells, γδ T cells ... as opposed to CD4+ and CD8+ αβ T cells and share characteristics of helper T cells, cytotoxic T cells and natural killer cells ... Cytotoxic T cells (also known as TC, killer T cell, or cytotoxic T-lymphocyte (CTL)) are a sub-group of T cells that induce the ... These include expansion of natural killer (NK) cells with so-far unexplained specificity for antigens, expansion of NK cells ...
SEMA7A acts as an activator of T cells and monocytes, while KLDR1 encodes an antigen presented on natural killer cells. IL13RA1 ... Lanier, L. L. (2015). "KLRK1 (killer cell lectin-like receptor subfamily K, member 1)". Atlas of Genetics and Cytogenetics in ... Many SNPs (single nucleotide polymorphisms) have been detected in the TMEM39B gene, of which a smaller subset cause ... By percentile rank, TMEM39B is most highly expressed with respect to other genes in BDCA4+ dendritic cells, CD19+ B-cells, and ...
... including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine ... Mehta DS, Wurster AL, Weinmann AS, Grusby MJ (February 2005). "NFATc2 and T-bet contribute to T-helper-cell-subset-specific ... In addition, IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as T follicular cells. In fact ... "IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like ...
See the Natural killer cell page for further information on NK cells in tumor surveillance. ILC1s influence the tumor ... "Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells". ... doi:10.1016/j.cell.2016.01.002. PMC 4733424. PMID 26806130. Cerwenka A, Lanier LL (October 2001). "Natural killer cells, ... April 2016). "Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity". Cell ...
"Activating and inhibitory receptors of natural killer cells". Immunology and Cell Biology. 89 (2): 216-24. doi:10.1038/icb. ... NKT cells, and even on some subsets of CD4+ T cells or myeloid cells. NKG2D expression can also be present on cancer cells and ... NKG2 also known as CD159 (Cluster of Differentiation 159) is a receptor for natural killer cells (NK cells). There are 7 NKG2 ... They are generally expressed on NK cells and a subset of CD8+ T cells, although the expression of NKG2D was also confirmed on ...
... cells with intracellular bacteria, and cancer cells displaying tumor antigens; Macrophage and natural killer cell action: ... Type 1 immunity makes use of the type 1 subset for each of these cell types. By secreting interferon gamma and TNF, TH1, TC1, ... NKp cells may then be induced to differentiate into natural killer cells by IL-15. CHILp cells may be induced to differentiate ... CD4+ TH1 cells CD8+ cytotoxic T cells (Tc1) T-Bet+ interferon gamma producing group 1 ILCs(ILC1 and Natural killer cells) CD4+ ...
Natural killer cells transfected with MCAM-1 demonstrate decreased rolling velocity and increased cell adhesion to an ... October 2008). "A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule/MUC18- ... or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage ... Schwab KE, Gargett CE (November 2007). "Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells ...