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*  Neutrophil cytosolic factor 4
Wientjes FB, Reeves EP, Soskic V, Furthmayr H, Segal AW (Nov 2001). "The NADPH oxidase components p47(phox) and p40(phox) bind ... Leto TL, Adams AG, de Mendez I (1994). "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline- ... Vergnaud S, Paclet MH, El Benna J, Pocidalo MA, Morel F (2000). "Complementation of NADPH oxidase in p67-phox-deficient CGD ... Matute JD, Arias AA, Dinauer MC, Patiño PJ (2006). "p40phox: the last NADPH oxidase subunit". Blood Cells Mol. Dis. 35 (2): 291 ...
*  Neutrophil cytosolic factor 2
DeLeo FR, Quinn MT (1997). "Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins". J. Leukoc. ... the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase ... 1998). "Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42". ... Leto TL, Adams AG, de Mendez I (1994). "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline- ...
*  Neutrophil Oxidative Index
The NADPH oxidase enzyme is missing in CGD. From total blood, neutrophils can be purified and the NADPH oxidase activity can be ...
*  Renalase
Beaupre BA, Carmichael BR, Hoag MR, Shah DD, Moran GR (Sep 2013). "Renalase is an α-NAD(P)H oxidase/anomerase". Journal of the ... This reaction was proposed to repair aberrant NADH and NADPH forms that are not accepted as cofactors by most nicotinamide- ... Renalase, FAD-dependent amine oxidase is an enzyme that in humans is encoded by the RNLS gene. Renalase is a flavin adenine ... Analysis of the primary structure of renalase shows that it is an FAD-dependent oxidase. The X-ray crystal structure of ...
*  Neutrophil extracellular traps
The process is thought to begin with NADPH oxidase activation of protein-arginine deiminase 4 (PAD4) via reactive-oxygen ... This intracellular influx of calcium in turn activates NADPH oxidase, resulting in activation of the NETosis pathway as ...
*  Chronic granulomatous disease
This test depends upon the direct reduction of NBT to the insoluble blue compound formazan by NADPH oxidase; NADPH is oxidized ... This enzyme is termed "phagocyte NADPH oxidase" (PHOX). This enzyme oxidizes NADPH and reduces molecular oxygen to produce ... Thus, NADPH oxidase is critical for phagocyte killing of bacteria through reactive oxygen species. (Two other mechanisms are ... Defects in one of the four essential subunits of phagocyte NADPH oxidase (PHOX) can all cause CGD of varying severity, ...
*  NADPH oxidase
NADPH + 2O2 ↔ NADP+ + 2O2− + H+ NADPH oxidase is a major cause of atherosclerosis, and NADPH oxidase inhibitors may reverse ... NADPH oxidase can be inhibited by apocynin and DPI (diphenylene iodonium). Apocynin prevents the assembly of the NADPH oxidase ... NADPH oxidase generates superoxide by transferring electrons from NADPH inside the cell across the membrane and coupling these ... The NADPH oxidase (nicotinamide adenine dinucleotide phosphate-oxidase) is a membrane-bound enzyme complex that faces the ...
*  Agmatine
NADPH oxidase. Activation of the enzyme leading to H2O2 production. Agmatine sulfate injection can increase food intake with ... Demady DR, Jianmongkol S, Vuletich JL, Bender AT, Osawa Y (2001). "Agmatine enhances the NADPH oxidase activity of neuronal NO ... An alternative pathway, mainly in peripheral tissues, is by diamine oxidase-catalyzed oxidation into agmatine-aldehyde, which ...
*  Phagocyte
Shatwell, KP; AW Segal (1996). "NADPH oxidase". The International Journal of Biochemistry & Cell Biology. 28 (11): 1191-95. doi ...
*  Protein phosphorylation
Phosphorylation of the cytosolic components of NADPH oxidase, a large membrane-bound, multi-protein enzyme present in ... Babior BM (March 1999). "NADPH oxidase: an update". Blood. 93 (5): 1464-76. PMID 10029572. Lemmon, Mark A.; Schlessinger, ...
*  NOX4
NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. ... 2004). "A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes". J. Invest. Dermatol. 122 ... Schwarzer C, Machen TE, Illek B, Fischer H (2004). "NADPH oxidase-dependent acid production in airway epithelial cells". J. ... 2005). "Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells". Arterioscler. ...
*  NOX3
NADPH oxidase 3 is an enzyme that in humans is encoded by the NOX3 gene. NADPH oxidases, such as NOX3, are plasma membrane- ... "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers ... "Entrez Gene: NOX3 NADPH oxidase 3". Lachgar A, Sojic N, Arbault S, Bruce D, Sarasin A, Amatore C, Bizzini B, Zagury D, ... Ueyama T, Geiszt M, Leto TL (2006). "Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases". ...
*  NOX1
NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene. NOX1 is a homolog of the catalytic subunit of the ... "Entrez Gene: NOX1 NADPH oxidase 1". Lachgar A, Sojic N, Arbault S, et al. (1999). "Amplification of the inflammatory cellular ... 2004). "A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes". J. Invest. Dermatol. 122 ... Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variant". J. Biol. Chem. 279 (49): 51661-8 ...
*  Respiratory tract antimicrobial defense system
Phagocytes possess a superoxide-producing NADPH oxidase enzyme complex. Other cells in the respiratory tract also produce ... Nauseef WM (October 2004). "Assembly of the phagocyte NADPH oxidase". Histochem. Cell Biol. 122 (4): 277-91. doi:10.1007/s00418 ... superoxide and hydrogen peroxide through the activity of dual oxidase 2 proteins, also known as Duox2. The superoxide generated ...
*  RhoG
... protection from anoikis and regulation of the neutrophil NADPH oxidase. As with all small G proteins RhoG is able to signal to ... "RhoG regulates the neutrophil NADPH oxidase". Journal of Immunology. 176 (9): 5314-20. doi:10.4049/jimmunol.176.9.5314. PMID ...
*  NOXO1
2005). "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase ... NADPH oxidase organizer 1 is an enzyme that in humans is encoded by the NOXO1 gene. GRCh38: Ensembl release 89: ENSG00000196408 ... Park HS, Park D, Bae YS (2006). "Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1". Biochem. Biophys. ... 2004). "NOX3, a superoxide-generating NADPH oxidase of the inner ear". J. Biol. Chem. 279 (44): 46065-72. doi:10.1074/jbc. ...
*  NOXA1
"Entrez Gene: NOXA1 NADPH oxidase activator 1". Opitz N, Drummond GR, Selemidis S, Meurer S, Schmidt HH (Jan 2007). "The 'A's ... NADPH oxidase activator 1 is an enzyme that in humans is encoded by the NOXA1 gene. GRCh38: Ensembl release 89: ENSG00000188747 ... Valente AJ, El Jamali A, Epperson TK, Gamez MJ, Pearson DW, Clark RA (Aug 2007). "NOX1 NADPH oxidase regulation by the NOXA1 ... Bánfi B, Clark RA, Steger K, Krause KH (Feb 2003). "Two novel proteins activate superoxide generation by the NADPH oxidase NOX1 ...
*  RHO protein GDP dissociation inhibitor
The protein plays an important role in the activation of the oxygen superoxide-generating NADPH oxidase of phagocytes. This ... Segal AW (1996). "The NADPH oxidase and chronic granulomatous disease". Mol. Med. Today (Regul. Ed.). 2 (3): 129-135. doi: ... "Role of the rac1 p21-GDP-dissociation inhibitor for rho heterodimer in the activation of the superoxide-forming NADPH oxidase ...
*  NAD(P)H oxidase
Apocynin is also known to inhibit NAD(P)H oxidase by preventing the assembly of the NADPH oxidase subunits. In one study, ... Superoxide produced from NADPH oxidase is used to kill bacteria and fungi by mechanisms that are not yet fully understood. Thus ... Vascular NADPH oxidases are regulated by a variety of hormones and factors known to be important players in vascular remodeling ... NADPH oxidase is dormant in resting cells but becomes rapidly activated by several stimuli, including bacterial products and ...
*  Vascular remodelling in the embryo
August, 2005). p47phox-dependent NADPH oxidase regulates flow-induced vascular remodelling. Circulation Research 97: 533 - 540 ...
*  Iron oxide
O₂ + e⁻ → O₂•⁻ The formation of the superoxide anion (O₂•⁻) is catalyzed by a transmembrane enzyme called NADPH oxidase. The ... Bedard, Karen; Krause, Karl-Heinz (2007-01-01). "The NOX Family of ROS-Generating NADPH Oxidases: Physiology and ... NADPH and FAD are bound to cytoplasmic binding sites on the enzyme. Two electrons from NADPH are transported to FAD which ... enzyme facilitates the transport of an electron across the plasma membrane from cytosolic NADPH to extracellular oxygen (O2) to ...
*  NOX5
NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a protein which in humans is encoded by the NOX5 gene. ... 2002). "A comparison of the NADPH oxidase in human sperm and white blood cells". Int. J. Androl. 25 (4): 223-9. doi:10.1046/j. ... 2001). "A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes". J. Biol. Chem. 276 (40): 37594-601. doi:10.1074/ ... Tirone F, Cox JA (2007). "NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin". FEBS Lett. 581 (6): 1202-8. ...
*  Cytochrome b-245, alpha polypeptide
NADPH) oxidase complex in phagocytes. Cytb, the redox element of the NADPH oxidase complex, is a membrane heterodimer composed ... Inoue N, Kawashima S, Kanazawa K, Yamada S, Akita H, Yokoyama M (Jan 1998). "Polymorphism of the NADH/NADPH oxidase p22 phox ... Bánfi B, Malgrange B, Knisz J, Steger K, Dubois-Dauphin M, Krause KH (Oct 2004). "NOX3, a superoxide-generating NADPH oxidase ... It is also interesting to underline that phosphorylation of Thr147 close to the PRR region of p22phox enhances NADPH oxidase ...
*  Dual oxidase 2
... or dual oxidase (DUOX). This new family of proteins, termed the NOX/DUOX family or NOX family of NADPH oxidases, consists of ... Dual oxidase 2, also known as DUOX2 or ThOX2 (for thyroid oxidase) is an enzyme which in humans is encoded by the DUOX2 gene. ... Schwarzer C, Machen TE, Illek B, Fischer H (2004). "NADPH oxidase-dependent acid production in airway epithelial cells". J. ... Rada B, Leto TL (2008). "Oxidative innate immune defenses by Nox/Duox family NADPH oxidases". Contrib Microbiol. 15: 164-87. ...
*  Reactive oxygen species
Rada B, Leto TL (2008). "Oxidative innate immune defenses by Nox/Duox family NADPH oxidases" (PDF). Contributions to ... Deffert C, Cachat J, Krause KH (Aug 2014). "Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections ... NADPH oxidase (NOX) complexes (7 distinct isoforms) in cell membranes, mitochondria, peroxisomes, and endoplasmic reticulum. ... As a result, production of NADPH is greatly enhanced, which functions as a cofactor to provide reducing power in many enzymatic ...
*  Metabolism
Nicotinamide adenine dinucleotide exists in two related forms in the cell, NADH and NADPH. The NAD+/NADH form is more important ... In humans, these include cytochrome P450 oxidases, UDP-glucuronosyltransferases, and glutathione S-transferases. This system of ... This process uses the ATP and NADPH produced by the photosynthetic reaction centres, as described above, to convert CO2 into ... An alternative route for glucose breakdown is the pentose phosphate pathway, which reduces the coenzyme NADPH and produces ...
*  CYBB
Cytochrome b-245 heavy chain also known as cytochrome b(558) subunit beta or NADPH oxidase 2 or Nox2 is a protein that in ... Leto TL, Adams AG, de Mendez I (October 1994). "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to ... Nox2 is the catalytic, membrane-bound subunit of NADPH oxidase. It is inactive until it binds to the membrane-anchored p22phox ... Sathyamoorthy M, de Mendez I, Adams AG, Leto TL (April 1997). "p40(phox) down-regulates NADPH oxidase activity through ...