The first identified myosin, myosin II, is responsible for generating muscle contraction. Myosin II is an elongated protein ... Because myosin II is essential for muscle contraction, defects in muscular myosin predictably cause myopathies. Myosin is ... The myosin heads bind and hydrolyze ATP, which provides the energy to walk toward the plus end of an actin filament. Myosin II ... In addition to myosin II, many other myosin types are responsible for variety of movement of non-muscle cells. For example, ...
It is the enzymatic activity of the ATPase in the myosin head that cyclically hydrolyzes ATP, fueling the myosin power stroke. ... MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in ... Harris SP, Lyons RG, Bezold KL (March 2011). "In the thick of it: HCM-causing mutations in myosin binding proteins of the thick ... An accepted mechanism for this process is that ADP-bound myosin attaches to actin while thrusting tropomyosin inwards, then the ...
Hodge T, Cope M (1 October 2000). "A myosin family tree". J Cell Sci. 113 (19): 3353-4. doi:10.1242/jcs.113.19.3353. PMID ... National Science Foundation's Assembling the Tree of Life Project PhyloCode A Multiple Alignment of 139 Myosin Sequences and a ...
... myosin storage; 608358; MYH7 Myopathy, nemaline, 3; 161800; ACTA1 Myopathy, proximal, with early respiratory muscle involvement ...
Myosin fought back before Chiswick Bridge to reduce the deficit, but Actin won by around two lengths. Oxford's men's trial race ... The CUWBC president, Larkin Sayre, rowed in Myosin who lost the toss and were on the Middlesex side of the river. The race was ... As such the boats were named Actin and Myosin, the proteins which make the two muscle fibres that pull against each other in ... "CUWBC: Actin vs Myosin". The Boat Race Company Limited. 16 December 2019. Retrieved 10 January 2020. "OUBC Trial Eights Crews ...
Berg JS, Powell BC, Cheney RE (April 2001). "A millennial myosin census". Molecular Biology of the Cell. 12 (4): 780-794. doi: ... They also generate movement, with myosin hydrolyzing adenosine triphosphate (ATP) to generate muscle contraction, and also ...
Interactions between actin, myosin and an actin-binding protein from rabbit alveolar macrophages. Alveolar macrophage myosin ... Interactions of actin, myosin and a new actin-binding protein of rabbit pulmonary macrophages II. Role in cytoplasmic movement ... Interactions of actin, myosin and an actin-binding protein of rabbit pulmonary macrophages III. Effects of cytochalasin B. J ... Interactions of actin, myosin and an actin-binding protein of chronic myelogenous leukemia leukocytes. J Clin Invest. 1976; 57: ...
Myosin-If is a protein that in humans is encoded by the MYO1F gene. It is expressed mainly in the immune system and might be ... "Entrez Gene: MYO1F myosin IF". Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell ... 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl ... "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431-9. doi:10.1006/geno.1996.0488. PMID 8884266. " ...
Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene. Myosin-Ie is a long tailed myosin. It contains an N ... Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco- ... "Entrez Gene: MYO1E myosin IE". McConnell RE, Tyska MJ (July 2010). "Leveraging the membrane - cytoskeleton interface with ... El Mezgueldi M, Tang N, Rosenfeld SS, Ostap EM (June 2002). "The kinetic mechanism of Myo1e (human myosin-IC)". The Journal of ...
Myosin VIIA is protein that in humans is encoded by the MYO7A gene. Myosin VIIA is a member of the unconventional myosin ... Myosin VIIA is an unconventional myosin with the longest tail (1360 aa). The tail is expected to dimerize, resulting in a two- ... Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain ... Unconventional myosins have diverse functions in eukaryotic cells and are primarily thought to be involved in the movement or ...
Myosin VIIA has a similar structure to all other myosins, with a motor, neck and actin-binding domain, but is unique due to its ... Myosin VIIA is an unconventional member of the myosin family and is heavily expressed within ciliated epithelium such as that ... Another key component of this junction is the protein myosin VIIA and primarily its interaction with vezatin. Myosins are ... Myosin VIIA is almost always expressed with vezatin but the absence of this partnership within the testis is yet to be fully ...
Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans. Recent evidence suggests that Myosin-Vb is related ... "Entrez Gene: MYO5B myosin VB". Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P, Ponstingl H, Partsch J, ... Fan GH, Lapierre LA, Goldenring JR, Sai J, Richmond A (May 2004). "Rab11-family interacting protein 2 and myosin Vb are ... Wakabayashi Y, Dutt P, Lippincott-Schwartz J, Arias IM (Oct 2005). "Rab11a and myosin Vb are required for bile canalicular ...
Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene. MYH13 is a myosin ... Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221-30. PMC 1886840. PMID 8424456. v t e (Articles with short ... Winters LM, Briggs MM, Schachat F (November 1998). "The human extraocular muscle myosin heavy chain gene (MYH13) maps to the ... 1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. ...
He called this protein myosin. He began to investigate the chemistry of digestion while at Berlin with Virchow. In 1876, he ... Hartman, MA; Spudich, JA (1 April 2012). "The myosin superfamily at a glance". Journal of Cell Science. 125 (Pt 7): 1627-32. ...
Actin, desmin, myosin, and tropomyosin". The American Journal of Pathology. 142 (1): 221-30. PMC 1886840. PMID 8424456. Tiso N ... myosin ATPase activity, and the cardiac response to stress. A decrease in β-tropomyosin in patients with heart failure was ... troponin C and troponin T-to modulated the actin and myosin interaction. In diastole, the tropomyosin-troponin complex inhibits ...
Surks HK, Riddick N, Ohtani K (2006). "M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain ... Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin ... Koga Y, Ikebe M (2005). "p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by ... Myosin phosphatase Rho-interacting protein is an enzyme that in humans is encoded by the MPRIP gene. M-RIP has been shown to ...
Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene. The protein encoded by this gene may regulate muscle- ... "Entrez Gene: MYO18B myosin XVIIIB". Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for ... a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol ...
The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. ... Myosin-Ic is a protein that in humans is encoded by the MYO1C gene. This gene encodes a member of the unconventional myosin ... "Entrez Gene: MYO1C myosin IC". Ruppert C, Godel J, Müller RT, et al. (1997). "Localization of the rat myosin I molecules myr 1 ... Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco- ...
Surks HK, Richards CT, Mendelsohn ME (2003). "Myosin phosphatase-Rho interacting protein. A new member of the myosin ... The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 ...
"Entrez Gene: MYO1B myosin IB". Ruppert C, Godel J, Müller RT, et al. (1997). "Localization of the rat myosin I molecules myr 1 ... Myosin-Ib is a protein that in humans is encoded by the MYO1B gene. GRCh38: Ensembl release 89: ENSG00000128641 - Ensembl, May ... 2006). "Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes". J. Cell Sci. ... 2003). "Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia". J. Assoc. Res. Otolaryngol. 3 (4): 375-89. doi ...
Myosin-14 is a protein that in humans is encoded by the MYH14 gene. This gene encodes a member of the myosin superfamily. ... 2004). "Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family". J. Biol. Chem. 279 ... "Entrez Gene: MYH14 myosin, heavy chain 14". Chen AH, Ni L, Fukushima K, et al. (1995). "Linkage of a gene for dominant non- ... Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221-30. PMC 1886840. PMID 8424456. Xu XR, Huang J, Xu ZG, et ...
This phosphorylation results in higher ATPase activity and the assembly of myosin II filaments. "Myosin, light chain 12B, ... Myosin, light chain 12B, regulatory is a protein that in humans is encoded by the MYL12B gene. The gene is also known as MLC-B ... The activity of nonmuscle myosin II is regulated by phosphorylation of a regulatory light chain, such as MYL12B. ...
Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin ...
Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene. GRCh38: Ensembl release 89: ENSG00000196535 - Ensembl ... "Entrez Gene: MYO18A myosin XVIIIA". Chroneos ZC, Abdolrasulnia R, Whitsett JA, et al. (1996). "Purification of a cell-surface ... 2005). "Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A". J. Biol. Chem. 280 (41): ... "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)". J Biochem. ...
This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension ... Myosin-XV is a protein that in humans is encoded by the MYO15A gene. Read-through transcript containing an upstream gene and ... "Entrez Gene: MYO15A myosin XVA". Riahi, Z; Bonnet, C; Zainine, R; Louha, M; Bouyacoub, Y; Laroussi, N; Chargui, M; Kefi, R; ... 2001). "Myosin XVA Expression in the Pituitary and in Other Neuroendocrine Tissues and Tumors". Am. J. Pathol. 159 (4): 1375-82 ...
Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene. MYO1G is a member of ... Olety B, Wälte M, Honnert U, Schillers H, Bähler M (February 2010). "Myosin 1G (Myo1G) is a haematopoietic specific myosin that ... "Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient ... MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells ( ...
General model of myosin filament structure. III. Molecular packing arrangements in myosin filaments. J Mol Biol. 1973 Jun 25;77 ... polarity in the myosin filaments of vertebrate smooth muscle, and the proposal of a general packing scheme of myosin molecules ... Probing muscle myosin motor action: X-ray (m3 and m6) interference measurements report motor domain not lever arm movement. J ... Atomic model of the human cardiac muscle myosin filament. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):318-323. "CCP13 - - ...
Myosin is primarily class II in smooth muscle. Myosin II contains two heavy chains (MHC) which constitute the head and tail ... Myosin functions as an ATPase utilizing ATP to produce a molecular conformational change of part of the myosin and produces ... The myosin light chain phosphatase is inhibited to increase the gain or sensitivity of myosin light chain kinase to calcium. ... myosin II has two heads. In smooth muscle, there is a single gene (MYH11) that codes for the heavy chains myosin II, but there ...
Use of Bis-Tris propane has also been documented in an investigation of the MgATPase activity of the myosin subfragment 1 ... Bachouchi N, Garrigos M, Morel JE (September 1986). "MgATPase activity of myosin subfragment 1. The dimer is more active than ...
Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene. MYH7B is a slow-twitch ... 2010). "Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and ... McGuigan K, Phillips PC, Postlethwait JH (2004). "Evolution of sarcomeric myosin heavy chain genes: evidence from fish". Mol. ... "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 ( ...