Loading...
*  MYH7
... type I fibers). This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β ... Approximately 300 myosin molecules constitute one thick filament. There are two isoforms of cardiac MHC, α and β, which display ... It is the enzymatic activity of the ATPase in the myosin head that cyclically hydrolyzes ATP, fueling the myosin power stroke. ... MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in ...
*  ACTC1
Myosin binding increases the flexibility of actin, and cross-linking studies have shown that myosin subfragment-1 binds to ... Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each ... "Non-viral cellular substrates for human immunodeficiency virus type 1 protease". FEBS Letters. 278 (2): 199-203. doi:10.1016/ ... Buckingham M, Alonso S, Barton P, Cohen A, Daubas P, Garner I, Robert B, Weydert A (Dec 1986). "Actin and myosin multigene ...
*  MYH1
Class II Myosins are hexameric proteins composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light ... "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". The American Journal of ... it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the ... Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene. This ...
*  MYL9
Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene ... Higashihara M, Watanabe M, Usuda S, Miyazaki K (2008). "Smooth muscle type isoform of 20 kDa myosin light chain is expressed in ... The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different ... "Entrez Gene: myosin". Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for ...
*  Actin, alpha 1
England, Karen; Ashford David; Kidd Daniel; Rumsby Martin (June 2002). "PKC epsilon is associated with myosin IIA and actin in ... Burgess DR, Broschat KO, Hayden JM (1987). "Tropomyosin distinguishes between the two actin-binding sites of villin and affects ... 1991). "Non-viral cellular substrates for human immunodeficiency virus type 1 protease". FEBS Lett. 278 (2): 199-203. doi: ... 85 (2): 331-7. doi:10.1111/j.1432-1033.1978.tb12243.x. PMID 648524. den Hartigh JC, van Bergen en Henegouwen PM, Verkleij AJ, ...
*  Cytokinesis
Cytokinetic furrow ingression is powered by Type II Myosin ATPase. Since Myosins are recruited to the medial region, the ... RhoA promotes myosin II activation by the kinase ROCK, which activates myosin II directly by phosphorylation of the myosin ... The force for the contractile processes is generated by movements along actin by the motor protein myosin II. Myosin II uses ... Besides actin and myosin II, the contractile ring contains the scaffolding protein anillin. Anillin binds to actin, myosin, ...
*  List of MeSH codes (D08)
... myosins MeSH D08.811.277.040.025.525.500 --- myosin type i MeSH D08.811.277.040.025.525.750 --- myosin type ii MeSH D08.811. ... myosin type iii MeSH D08.811.277.040.025.525.843 --- myosin type iv MeSH D08.811.277.040.025.525.875 --- myosin type v MeSH ... nonmuscle myosin type iia MeSH D08.811.277.040.025.525.750.500 --- nonmuscle myosin type iib MeSH D08.811.277.040.025.525. ... type ii, archaeal MeSH D08.811.399.403.741.300 --- dna topoisomerases, type ii, bacterial MeSH D08.811.399.403.741.300.500 --- ...
*  Keith Burridge
... he showed that at least two distinct types of myosin II exist in non-muscle cells and that some cells expressed both types. He ... "Purification and structural analysis of myosins from brain and other non-muscle tissues". Journal of Molecular Biology. 99 (1 ... 97 (2): 359-67. doi:10.1083/jcb.97.2.359. PMC 2112532 . PMID 6684120. Geiger, B; Volk, T; Volberg, T (1985). "Molecular ... 75 (2): 588-99. Bibcode:1978PNAS...75..588K. doi:10.1073/pnas.75.2.588. PMC 411302 . PMID 147464. Lazarides E, Burridge K; ...
*  Motor unit
These genes form one of ~18 classes of myosin genes, identified as class II which should not be confused with the type II ... S and Type I, FR and type IIa, FF and type IIb, FI and IIi. Immunohistochemical (a more recent form of fiber typing)Myosin ... Myosin Light Chain - regulatory (MLC2) The Immunohistochemical types are as follows, with the type IIa, IIb and slow ... histochemical types: Table reproduced from Gene characterization of myosins There are currently about 15 known different types ...
*  Myosin
... II (also known as conventional myosin) is the myosin type responsible for producing muscle contraction in muscle cells. ... holding the two heavy chains together (imagine two snakes wrapped around each other, as in a caduceus). Thus, myosin II has two ... Myosin Isoforms MBInfo - The Myosin Powerstroke Myosin Video A video of a moving myosin motor protein. Myosins at the US ... Myosin VI is thought to transport endocytic vesicles into the cell. Myosin VII is an unconventional myosin with two FERM ...
*  MYO1F
"Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332-41. doi: ... 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl ... Myosin-If is a protein that in humans is encoded by the MYO1F gene. It is expressed mainly in the immune system and might be ... "Entrez Gene: MYO1F myosin IF". Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell ...
*  MYO1C
"Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332-41. doi: ... The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. ... Myosin-Ic is a protein that in humans is encoded by the MYO1C gene. This gene encodes a member of the unconventional myosin ... "Entrez Gene: MYO1C myosin IC". Ruppert C, Godel J, Müller RT, et al. (1997). "Localization of the rat myosin I molecules myr 1 ...
*  Actinin alpha 3
There are two types of filaments: actin (thin filaments) and myosin (thick filaments) which are arranged in parallel. A muscle ... There are two types of muscle fibers, slow twitch or muscle contraction (type I) and fast twitch (type II). Slow twitch fibers ... Actin filaments are stabilized by actin binding proteins known as actinins of which there are two main types, type 2 and type 3 ... Studies have linked the fiber twitch type with ACTN3, i.e. fast twitch fiber abundant individuals carry the non-mutant gene ...
*  Chromosome 12 (human)
... cblB type MON2: encoding protein Protein MON2 homolog MUCL1: encoding protein Mucin-like protein 1 MYO1A: myosin IA NANOG: NK-2 ... type II, gamma PIWIL1: encoding protein Piwi-like protein 1 POP5: encoding enzyme Ribonuclease P/MRP protein subunit POP5 ... activin A receptor type II-like 1f APOF: encoding protein Apolipoprotein F APOLD1: apolipoprotein L domain containing 1 ARL6IP4 ... types II and XI cornea plana 2 episodic ataxia hereditary hemorrhagic telangiectasia hypochondrogenesis ichthyosis bullosa of ...
*  Troponin C type 1
In cCTnC the two EF-hand motifs constitute two high affinity Ca2+-binding sites. that are occupied at all physiologically ... allowing actin-myosin cross-bridging and muscle contraction to proceed. Strong actin-myosin interaction can further shift the ... and a flexible linker connecting the two domains (residues 87-92). Each domain contains two EF-hands, Ca2+-binding helix-loop- ... This prevents actin-myosin cross-bridging and effectively shuts off muscle contraction. As the cytoplasmic Ca2+ concentration ...
*  Motor protein
Myosin II is an elongated protein that is formed from two heavy chains with motor heads and two light chains. Each myosin head ... many other myosin types are responsible for variety of movement of non-muscle cells. For example, myosin is involved in ... Myosin II are also vital in the process of cell division. For example, non-muscle myosin II bipolar thick filaments provide the ... Because myosin II are essential for muscle contraction, defects in muscular myosin predictably cause myopathies. Because myosin ...
*  USH2A
2002). "Mutations in myosin VIIA (MYO7A) and usherin (USH2A) in Spanish patients with Usher syndrome types I and II, ... 2001). "Spectrum of mutations in USH2A in British patients with Usher syndrome type II". Exp. Eye Res. 72 (5): 503-9. doi: ... GeneReviews/NCBI/NIH/UW entry on Usher Syndrome Type II. ... loss and a missense mutation in the Usher syndrome type II gene ... gene that encode multiple conserved functional domains and that are mutated in patients with Usher syndrome type II". Am. J. ...
*  Reduced muscle mass, strength and performance in space
... followed by Type IIA and then Type I myofibers; that expression of Type II myosin heavy chain (MHC) protein was significantly ... Atrophy of both major myofiber types, with atrophy of Type II > Type I, is somewhat different from the more selective Type I ... myosin heavy chain (MHC) isoform expression does not seem to shift from Type I MHC to Type II during short (< 18-day) ... In general, Type II myofibers seem to be more likely to atrophy than do Type I myofibers during short-term unloading, with no ...
*  List of MeSH codes (D12.776)
... myosin type i MeSH D12.776.210.500.600.470 - myosin type ii MeSH D12.776.210.500.600.470.249 - cardiac myosins MeSH D12.776. ... myosin type i MeSH D12.776.220.525.475.475 - myosin type ii MeSH D12.776.220.525.475.475.124 - cardiac myosins MeSH D12.776. ... myosin type iii MeSH D12.776.220.525.475.681 - myosin type iv MeSH D12.776.220.525.475.750 - myosin type v MeSH D12.776.220.525 ... Type I collagen MeSH D12.776.860.300.250.300.200 - Type II collagen MeSH D12.776.860.300.250.300.300 - Type III collagen MeSH ...
*  Smooth muscle tissue
Myosin is primarily class II in smooth muscle. Myosin II contains two heavy chains which constitute the head and tail domains. ... Different combinations of heavy and light chains allow for up to hundreds of different types of myosin structures, but it is ... myosin II has two heads. In smooth muscle, there is a single gene (MYH11) that codes for the heavy chains myosin II, but there ... Myosin II also contains 4 light chains, resulting in 2 per head, weighing 20 (MLC20) and 17 (MLC17) kDa. These bind the heavy ...
*  UCN2
"Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role ... gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the ... 2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by ... In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. GRCh38: ...
*  Corticotropin releasing hormone receptor 2
"Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF ... "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role ... CRF2 receptors are activated by two structurally similar peptides, urocortin II and urocortin III, as well as CRH. The human ... CRF2 receptors are type 2 G protein-coupled receptors for corticotropin-releasing hormone (CRH) that are resident in the plasma ...
*  MYO5A
"Human myosin V gene produces different transcripts in a cell type-specific manner". Biochemical and Biophysical Research ... "Two genes are responsible for Griscelli syndrome at the same 15q21 locus". Genomics. 63 (3): 299-306. doi:10.1006/geno. ... Rodriguez OC, Cheney RE (Mar 2002). "Human myosin-Vc is a novel class V myosin expressed in epithelial cells". Journal of Cell ... "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the ...
*  Meromyosin
... two types of meromyosin are formed: heavy meromyosin (HMM) and light meromyosin (LMM). Light meromyosin has a long, straight ... The majority of myosin activity is concentrated in HMMS-1. HMMS-1 has an Actin binding site and ATP binding site (myosin ATPase ... In Human anatomy, Myosin, of which meromyosin is a part of, along with actin constitute the basic functional unit of a muscle ... HMM consists of two subunits, Heavy Meromyosin Subunit 1 and 2 (HMMS-1 and HMMS-2). ...
*  Chromosome 3 (human)
People normally have two copies of this chromosome. Chromosome 3 spans almost 200 million base pairs (the building material of ... type V, alpha (long QT syndrome 3) SETD5: SET domain containing 5 SFMBT1: Scm-like with four mbt domains 1 SLC25A20: solute ... Myosin VIIA and Rab interacting protein NBEAL2: Neurobeachin-like 2 NKTR: NK-tumor recognition protein NPRL2: Nitrogen permease ... zinc finger MYND-type containing 10 ZNF502: encoding protein Zinc finger protein 502 ZNF621: encoding protein Zinc finger ...
*  Proto-oncogene tyrosine-protein kinase Src
Two transcript variants encoding the same protein have been found for this gene. In 1979, J. Michael Bishop and Harold E. ... The expression of these Src family members are not the same throughout all tissues and cell types. Src, Fyn and Yes are ... 3.0.CO;2-N. PMID 9014858. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (January 1987). "Human breast cancer: ... 3.0.CO;2-N. PMID 9585256. Verbeek BS, Vroom TM, Adriaansen-Slot SS, Ottenhoff-Kalff AE, Geertzema JG, Hennipman A, Rijksen G ( ...
*  Chromosome 4 (human)
Two-hundred and eleven (27.9%) of these coding sequences did not have any experimental evidence at the protein level, in 2012. ... Polycystic kidney disease Romano-Ward syndrome SADDAN Tetrahydrobiopterin deficiency Thanatophoric dysplasia Type 1 Type 2 ... Myosin light chain 5 NOA1: encoding protein Nitric oxide associated 1 NUDT6: nudix hydrolase 6 NUDT9: nudix hydrolase 9 OTUD4: ... Two-hundred and seventy one appear to be membrane proteins. Fifty-four have been classified as cancer associated proteins. The ...