Increased activity of Rho-kinase leading to enhanced myosin light chain phosphorylation has been implicated in the pathogenesis ... Smooth Muscle Hypercontractility At a cellular level, pathways that lead to enhanced myosin light chain phosphorylation promote ...

... has two primary molecular targets in humans: calmodulin and myosin light-chain kinase 2, found in skeletal and ...

... inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase, and Na+/K+-ATPase ( ...

... a member of the myosin light chain kinase protein family. SPEG is involved in the development of the muscle cell cytoskeleton, ... phylogeny of a novel family of tandem myosin light chain kinases" (PDF). Dev. Genes Evol. 214 (7): 352-9. doi:10.1007/s00427- ... "SPEG striated muscle enriched protein kinase [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 6 June 2021 ... Luo, S; Rosen, SM; Li, Q; Agrawal, PB (2021-05-27). "Striated Preferentially Expressed Protein Kinase (SPEG) in Muscle ...

... a member of the titin and Dbl families of myosin light chain kinases". Gene. 282 (1-2): 237-46. doi:10.1016/S0378-1119(01)00795 ... phylogeny of a novel family of tandem myosin light chain kinases" (PDF). Development Genes and Evolution. 214 (7): 352-9. doi: ... Moreover, the kinase domains of obscurin are enzymatically active and appear to be involved in the regulation of cell adhesion ... Obscurin appears to be necessary for the proper incorporation of myosin filaments into sarcomeres and in the assembly of A- ...

Calcium imaging Calcium in biology Calmodulin Cameleon (protein) Green fluorescent protein Myosin light-chain kinase Nakai J, ... a peptide sequence from myosin light-chain kinase. When bound to Ca2+, GCaMP fluoresces green with a peak excitation wavelength ... Since the blue light used to excite GCaMP is scattered by tissue and the emitted green light is absorbed by blood, red ... Jones JR, Simon T, Lones L, Herzog ED (September 2018). "SCN VIP Neurons Are Essential for Normal Light-Mediated Resetting of ...

Protein kinase Signal transduction G protein-coupled receptor Serine/threonine-specific protein kinase Myosin light-chain ... It should not be confused with 5'-AMP-activated protein kinase (AMP-activated protein kinase). Protein kinase A, more precisely ... out of 540 different protein kinase genes that make up the human kinome, only one other protein kinase, casein kinase 2, is ... The dimerization and docking (D/D) domain of the dimer binds to the A-kinase binding (AKB) domain of A-kinase anchor protein ( ...

Underexpressed genes in both groups included myosin light chain kinase-2, enolase-3 and 6-phosphofructo-2-kinase/fructose-2,6- ... leucine-rich repeat kinase-2, follistatin, collagen type XIX alpha-1, ceramide kinase-like, sestrin-3 and CXorf64. No genes ... The graph illustrates predicted N-glyc sites across the protein chain (x-axis represents protein length from N- to C-terminal ... ceramide kinase-like, sestrin-3 and CXorf64. In conclusion, there is differential tissue-specific gene expression in patients ...

... include Myosin light-chain kinase, Phosphatase, Ca2+/calmodulin-dependent protein kinase II, etc. Proteins, such as neurogranin ... they can be regulated through post-translational modifications by enzymes like kinases and phosphatases to affect their ... domain and a serine residue that can be used to inhibit calmodulin binding upon phosphorylation of Protein kinase C (PKC). By ...

Both of these changes inactivate myosin light-chain kinase and activate myosin light-chain phosphatase. In addition, β2 ... and decreased myosin light chain kinase activity leads to smooth muscle relaxation and bronchodilation. Findings indicate that ... cAMP decreases calcium concentrations within cells and activates protein kinase A. ...

"ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells". FEBS Letters. 451 (1): 81-4. doi:10.1016/ ... Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene. Death-associated protein kinase 3 ( ... Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates ... characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase ...

PKA then continues the cascade by promoting the phosphorylation of the myosin light chain kinase, which inhibits it and leads ... This cAMP then goes on to activate protein kinase A (PKA). ...

"Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in ... Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans ... which was inhibited by both Rho kinase and myosin light chain kinase inhibition. In a canine model of atrial fibrillation, ... Human ALC-2 is phosphorylated at its N-terminus at Serine-15 by a cardiac-specific myosin light chain kinase; ALC-2 has a ...

PKA also prevents the activation of an enzyme (myosin light-chain kinase) that is important in the contraction of smooth muscle ... An increase in cAMP results in an increase in the active form of protein kinase A (PKA), which is directly related with an ...

Protein kinase A then goes on to phosphorylate (and thus inactivate) myosin light-chain kinase, which causes smooth muscle ... Shih M, Lin F, Scott JD, Wang HY, Malbon CC (Jan 1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases ... Fan G, Shumay E, Wang H, Malbon CC (Jun 2001). "The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein ... Zamah AM, Delahunty M, Luttrell LM, Lefkowitz RJ (Aug 2002). "Protein kinase A-mediated phosphorylation of the beta 2- ...

... which inhibits myosin light chain phosphatase (MLCP), and in turn, increases myosin light chain phosphorylation by MLC kinase ... Drugs that dilate canaliculi work by inhibiting MLCK or RhoA/Rho-kinase and include diclofenac, bosentan, entacapone, ... These drugs activate the RhoA/Rho-kinase pathway, ...

Mixed lineage kinase 2 (MLK2) - MLK2 is myosin light chain kinase 2 The b2 adaptin of the AP2 complex Calcium-dependent ... 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin ... Nagao M, Hayashi H (2009). "Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease". J. ... Hippocalcin takes part in the following processes: Activation of PLD1 and PLD2 expression Inhibition of apoptosis MAP kinase ...

... which leads to hyperpolarization and relaxation Stimulates a cGMP-dependent protein kinase that activates myosin light chain ... the enzyme that dephosphorylates myosin light chains, which leads to smooth muscle relaxation. eNOS plays a critical role in ...

... but most prominently by Rho-dependent kinase and/or by the calcium-calmodulin-dependent myosin light chain kinase, not only ... Myosin-9 also known as myosin, heavy chain 9, non-muscle or non-muscle myosin heavy chain IIa (NMMHC-IIA) is a protein which in ... two regulatory light chains (20 KDa) controlling the myosin activity, and two essential light chains (17 kDa), which stabilize ... Phosphorylation of the 20 KDa light chains on Serine 19 and Threonine 18 by a number of different kinases, ...

Myosins MAP-1C Metavinculin Moesin (the M of ERM proteins) Myosin light chain kinase MAL Mip-90 Myosin Light Chain A1 MARKS MIM ... p21-activated Kinase) Plectin p47PHOX Parvin (actopaxin) Prefoldin p53 PASK (Proline, Alanine rich Ste20 related Kinase) ... actin regulating kinase) Radixin (the R of ERM proteins) Rapsyn Rhizopodin RPL45 RTX toxin (Vibrio cholerae) RVS 167 Sac6 Sla1p ... 5-trisphosphate 3-kinase A) IQGAP Integrins Jaspisamide A Jasplakinolide Kabiramide C Kaptin Kettin Kelch protein 5- ...

... some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high ... "Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C ... a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase". Chemistry & Biology. 12 ... Kim SH, Jang YW, Hwang P, Kim HJ, Han GY, Kim CW (January 2012). "The reno-protective effect of a phosphoinositide 3-kinase ...

... calmodulin dependent protein kinase MeSH D08.811.913.696.620.682.700.125.500 - myosin-light-chain kinase MeSH D08.811.913.696. ... map kinase kinase kinase 1 MeSH D08.811.913.696.620.682.700.559.200 - map kinase kinase kinase 2 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 3 MeSH D08.811.913.696.620.682.700.559.400 - map kinase kinase kinase 4 MeSH D08.811.913.696.620.682. ... i-kappa B kinase MeSH D08.811.913.696.620.682.700.559 - map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 - ...

... protein kinase Cs, calmodulin-modulated myosin light chain kinase, Mitogen-activated protein kinases, and Calcineurin; b) G12/ ... TP receptor-independent agents that stimulate cells to activate protein kinases C or protein kinases A can also down-regulate ... protein kinase C, and Mitogen-activated protein kinase but inhibits adenyl cyclase. Following its activation of these pathways ... These receptor down regulating events are triggered by the G protein-coupled receptor kinases mobilized during TP receptor ...

Calcium binds to calmodulin which then binds and activates myosin light-chain kinase, that will enable the myosin crossbridge ...

The fall in concentration of Ca2+ ensures that the myosin light-chain kinase (MLCK) can no longer phosphorylate the myosin ... Cyclic-GMP activates protein kinase G, which causes reuptake of Ca2+ and the opening of calcium-activated potassium channels. ... mitogen-activated protein kinase, PPAR gamma, HIF1A, NRF2, ion channels, cystathionine beta synthase, and numerous other ...

... calmodulin-modulated myosin light chain kinase, RAF/MEK/Mitogen-activated protein kinases, PKC/Ca2+/Calcineurin/Nuclear factor ... A critical role for protein kinase c". The Journal of Biological Chemistry. 273 (36): 23258-66. doi:10.1074/jbc.273.36.23258. ... Lawler OA, Miggin SM, Kinsella BT (September 2001). "Protein kinase A-mediated phosphorylation of serine 357 of the mouse ... see Protein kinase C#Function). Studies suggest that stimulation of Gsβγ complexes is required for activation of the Gqβγ- and ...

The fall in concentration of Ca2+ ensures that the myosin light-chain kinase (MLCK) can no longer phosphorylate the myosin ... Cyclic-GMP activates protein kinase G, which causes reuptake of Ca2+ and the opening of calcium-activated potassium channels. ... mitochondrial electron transport chain, or (iv) non-enzymatic reactions. It is a signaling molecule, acts mainly against ... and the IP3 receptor-associated cGMP kinase substrate (IRAG). In addition, cGMP has been proposed to also cause smooth muscle ...

... myosin-light-chain kinase MeSH D12.644.360.150 - casein kinases MeSH D12.644.360.150.300 - casein kinase i MeSH D12.644.360.150 ... map kinase kinase kinase 1 MeSH D12.644.360.400.200 - map kinase kinase kinase 2 MeSH D12.644.360.400.300 - map kinase kinase ... kinase 3 MeSH D12.644.360.400.400 - map kinase kinase kinase 4 MeSH D12.644.360.400.500 - map kinase kinase kinase 5 MeSH ... map kinase kinase 1 MeSH D12.644.360.440.200 - map kinase kinase 2 MeSH D12.644.360.440.300 - map kinase kinase 3 MeSH D12.644. ...

... inhibitors of myosin light-chain kinases or Rho kinases, H-7 or ML-7, which reduce cell contractility and consequently motility ... 1993), "Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in ... Saxena, M. (1999), "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase", Nat. Cell ... cAMP can inhibit ERKs in a variety of ways, most of which involve the cAMP-dependent protein kinase (PKA) and the inhibition of ...

ROCK is a kinase that acts to phosphorylate MLCP (myosin-light-chain phosphatase), as well as the NMMII light chain, which ... "Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)". Science. 273 (5272): 245-248. Bibcode:1996Sci ... In addition, ROCK also phosphorylates and activates LIM-kinase. LIM-kinase will in turn phosphorylate and inactivate cofilin, ... Maekawa, M. (August 6, 1999). "Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase". ...