Loading...
*  MYL9
The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different ... consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate ... Higashihara M, Watanabe M, Usuda S, Miyazaki K (2008). "Smooth muscle type isoform of 20 kDa myosin light chain is expressed in ... Myosin regulatory light polypeptide 9 is a protein that in humans is encoded by the MYL9 gene. Myosin, a structural component ...
*  Myosin light-chain kinase
... also known as MYLK or MLCK is a serine/threonine-specific protein kinase that phosphorylates a ... 2005). "Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure ... specific myosin light chain, namely, the regulatory light chain of myosin II. Four different MLCK isoforms exist: MYLK - smooth ... 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): ...
*  Prostaglandin F receptor
... calmodulin-modulated myosin light chain kinase; RAF/MEK/Mitogen-activated protein kinases; PKC/Ca2+/Calcineurin/Nuclear factor ... regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase ... phospholipase C/IP3/cell Ca2+ mobilization/diacylglycerol/protein kinase Cs; ... to activate the Rho family of GTPases signaling proteins and Gi-Gβγ G proteins to activateRaf/MEK/mitogen-activated kinase ...
*  Neuregulin 1
Downstream effectors of NRG-1/ErbB, include cardiac-specific myosin light chain kinase (cMLCK), Protein Phosphatase type 1 (PP1 ... "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812-24. ... "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571-80. doi:10.1161/CIRCRESAHA.107.161687. ... The cMLCK protein is an important regulator of sarcomere assembly through activation of the myosin regulatory light chain, as ...
*  MYLK3
Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates ... 2005). "Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure ... Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene. ... 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): ...
*  MYLK2
"Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle". Arch Biochem Biophys. 510 (2 ... Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene. This gene encodes a ... "Entrez Gene: MYLK2 myosin light chain kinase 2, skeletal muscle". Stull JT, Kamm KE, Vandenboom R (February 2011). " ... Christie JD, Ma SF, Aplenc R (2008). "Variation in the myosin light chain kinase gene is associated with development of acute ...
*  MYLK4
... light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin ... Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085. There are other known myosin light-chain kinase ... Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK2 gene. MYLK4 is a member of ... Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K (June 2001). "Myosin light chain kinase as a multifunctional ...
*  Telokin
... myosin-light-chain kinase". BRENDA. "KM values for EC 2.7.11.18 - myosin-light-chain kinase". BRENDA. Herring BP, Lyons GE, ... Telokin catalyzes the following reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. (Reaction type: ... myosin light chain] O-phosphotransferase and its recommended name is myosin-light-chain. (EC 2.7.11.18). The gene MYLK, a ... As a consequence of this, in vivo KRP might slow down the rate of myosin phosphorylation by myosin light chain kinase (MLCK) ...
*  N-alpha-acetyltransferase 10
"Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase". PLOS ONE. 4 (10): e7451. doi:10.1371 ... is bound to the ribosome and co-translationally acetylates proteins starting with small side chains such as Ser, Ala, Thr, Gly ... structural rearrangements of the substrate binding pocket Naa10 allow acetylation of N-termini with acidic side chains. ...
*  Penicillium verruculosum
"Isolation of Myosin Light Chain Kinase Inhibitors from Microorganisms: Dehydroaltenusin, Altenusin, Atrovenetinone, and ...
*  MYL2
"Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in ... Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin ... "The influence of P-light chain phosphorylation by myosin light chain kinase on the calcium sensitivity of chemically skinned ... Ventricular myosin light chain-2 (MLC-2v) refers to the ventricular cardiac muscle form of myosin light chain 2 (Myl2). MLC-2v ...
*  Vasoconstriction
... which in turn activates myosin light-chain kinase. This enzyme is responsible for phosphorylating the light chain of myosin to ... Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). Biochem. J. 389 (Pt 3): 763-74. doi: ...
*  Voltage-gated calcium channel
The activated calmodulin molecule activates myosin light-chain kinase (MLCK), which phosphorylates the myosin in thick ... containing a guanylate kinase (GK) domain and an SH3 (src homology 3) domain. The guanylate kinase domain of the β subunit ... Phosphorylated myosin is able to form crossbridges with actin thin filaments, and the smooth muscle fiber (i.e., cell) ... The intracellular β subunit (55 kDa) is an intracellular MAGUK-like protein (Membrane-Associated Guanylate Kinase) ...
*  Calmodulin
... the head of the myosin light chain must be phosphorylated. This phosphorylation is done by Myosin Light Chain (MLC) Kinase. ... dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within ... New insights into the role of myosin light chain kinase". Channels. 8 (5): 402-413. doi:10.4161/19336950.2014.950537. ISSN 1933 ... Proteopedia page for Calmodulin and its conformational change Protein kinase Ca2+/calmodulin-dependent protein kinase Stevens ...
*  SPEG
... phylogeny of a novel family of tandem myosin light chain kinases". Dev. Genes Evol. 214 (7): 352-9. doi:10.1007/s00427-004-0413 ...
*  GCaMP
Fused to the new terminus is calmodulin (CaM) and the M13 domain of a myosin light chain kinase. Calmodulin is a symmetrical, ... a peptide sequence from myosin light chain kinase. The advantage of GECI's is that they can be genetically specified for ... When calcium is present, CaM undergoes a conformational change, and the hinge region is able to bind helical peptide chains on ...
*  MYLK
... encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory ... Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is ... 2005). "Distinct Temporal-Spatial Roles for Rho Kinase and Myosin Light Chain Kinase in Epithelial Purse-String Wound Closure ... "Entrez Gene: MYLK myosin, light chain kinase". Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial ...
*  Obscurin
... a member of the titin and Dbl families of myosin light chain kinases". Gene. 282 (1-2): 237-46. doi:10.1016/S0378-1119(01)00795 ... phylogeny of a novel family of tandem myosin light chain kinases". Development Genes and Evolution. 214 (7): 352-9. doi:10.1007 ... Moreover, the kinase domains of obscurin are enzymatically active and appear to be involved in the regulation of cell adhesion ... Obscurin appears to be necessary for the proper incorporation of myosin filaments into sarcomeres and in the assembly of A- ...
*  CAMK2G
"Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase ... Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene. The ... "Entrez Gene: CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma". Moyers JS, Bilan PJ, Zhu J, Kahn CR ( ... In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is ...
*  Prenylamine
... has two primary molecular target in human, Calmodulin and Myosin light-chain kinase 2 found in skeletal and cardiac ...
*  PRR32
Underexpressed genes in both groups included myosin light chain kinase-2, enolase-3 and 6-phosphofructo-2-kinase/fructose-2,6- ... leucine-rich repeat kinase-2, follistatin, collagen type XIX alpha-1, ceramide kinase-like, sestrin-3 and CXorf64. No genes ... The graph illustrates predicted N-glyc sites across the protein chain (x-axis represents protein length from N- to C-terminal ... ceramide kinase-like, sestrin-3 and CXorf64. In conclusion, there is differential tissue-specific gene expression in patients ...
*  Beta2-adrenergic agonist
... inactivate myosin light-chain kinase and activate myosin light-chain phosphatase. In addition, β2 agonists open large ... and decreased myosin light chain kinase activity leads to smooth muscle relaxation and bronchodilation. Findings indicate that ... enlarged intracellular cyclic AMP will increase the activity of cAMP-dependent protein kinase A, that inhibits the ... cAMP decreases calcium concentrations within cells and activates protein kinase A. Both of these changes, ...
*  MYL7
"Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in ... Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans ... which was inhibited by both Rho kinase and myosin light chain kinase inhibition. In a canine model of atrial fibrillation, ... Human ALC-2 is phosphorylated at its N-terminus at Serine-15 by a cardiac-specific myosin light chain kinase; interestingly, ...
*  Prostacyclin
PKA then continues the cascade by promoting the phosphorylation of the myosin light chain kinase, which inhibits it and leads ... This cAMP then goes on to activate protein kinase A (PKA). ...
*  Myosin-light-chain phosphatase
... which in turn activates myosin light-chain kinase (MLC kinase). MLC kinase phosphorylates the myosin light chain (MLC20) at the ... Myosin Myosin light-chain kinase Rhoa Rho kinase Terrak, Mohammed; Kerff, Frederic; et al. (June 17, 2004). "Structural Basis ... Thus, myosin phosphatase undoes the muscle contraction process initiated by myosin light-chain kinase. The enzyme is composed ... Myosin II, also known as conventional myosin, has two heavy chains that consist of the head and tail domains and four light ...
*  Reduced muscle mass, strength and performance in space
Giger, JM; Haddad, F; Qin, AX; Zeng, M; Baldwin, KM (April 2005). "Effect of unloading on type I myosin heavy chain gene ... Concomitantly, a decrease occurs in the activity of key protein kinase enzyme systems (constituting the PI3kinase/akt/mTOR ... corresponding to the light, medium, and heavy work respectively for each individual. For the Apollo 9 and 10 missions, a stress ... Also, transformations in the myosin heavy chain profile indicated that there was a greater level of hybrid slow/fast fibers in ...