Loading...
*  POEMS syndrome
Overproduction of the myeloma protein and VEGF may underlie some, but are insufficient to explain all, of the multi-organ ... Monoclonal paraprotein: In most cases a serum myeloma protein can be detected, although this is not universal. This may ... of instances the myeloma proteins contain a λ chain that is restricted to either of two V lambda 1 subfamily members viz., ... a myeloma protein, as well as certain cytokines by the malignant plasma cells. POEMS syndrome typically begins in middle age - ...
*  Proteinuria
Protein dipstick measurements should not be confused with the amount of protein detected on a test for microalbuminuria which ... Gammopathy of Undetermined Significance Smoldering multiple myeloma Malignant plasma cell dyscrasias Multiple myeloma ... Traditionally, dipstick protein tests would be quantified by measuring the total quantity of protein in a 24-hour urine ... Since serum proteins are readily reabsorbed from urine, the presence of excess protein indicates either an insufficiency of ...
*  Nephrology
A 24-hour urine collection can be used to quantify daily protein loss (see proteinuria), urine output, creatinine clearance or ... multiple myeloma) and metabolic diseases (diabetes, cystinosis). Structural abnormalities of the kidneys are identified with ... protein in the urine (proteinuria), pus cells in the urine (pyuria) or cancer cells in the urine. ...
*  IRF4
Interferon regulatory factor 4 also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23 ... "Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma". Nat. Genet. 17 (2): 226-30. doi:10.1038/ng1097-226 ... FactorBook IRF4 IRF4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article ... "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins". J. Immunol. 166 (10): 6104 ...
*  PTPRC
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling ... CD45 and the src-kinases in myeloma cell proliferation". Leuk. Lymphoma. 44 (9): 1477-81. doi:10.3109/10428190309178767. PMID ... "Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine ... Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. ...
*  MUC1
The protein is anchored to the apical surface of many epithelia by a transmembrane domain. Beyond the transmembrane domain is a ... Li Y, Chen W, Ren J, Yu WH, Li Q, Yoshida K, Kufe D (2003). "DF3/MUC1 signaling in multiple myeloma cells is regulated by ... MUC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. ...
*  2018 in science
The new test, based on cancer-related DNA and proteins found in the blood, produced 70% positive results in the tumor-types ... that will encompass the use of CRISPR technology to modify the T cells of patients with multiple myeloma, sarcoma and melanoma ...
*  Dana-Farber Cancer Institute
Expertscape ranks its programs in aplastic anemia and multiple myeloma as best in the world. It has been also ranked the fourth ... produces dramatic benefits in non-small cell lung cancer patients who carry an abnormal version of a key protein, a potentially ... Dana-Farber is a member of the Multiple Myeloma Research Consortium. In addition to being a principal teaching affiliate of ... "Expertscape: Multiple Myeloma, February 2014". expertscape.com. February 2014. Retrieved 2014-02-18. "Best Hospitals 2012 ...
*  Network of Cancer Genes
... expression of a manually curated list of 1,571 protein-coding cancer genes. Cancer genes are genes with a driver role in the ... Glioblastoma Head and neck squamous cell carcinoma Leukemia Lymphoma Medulloblastoma Melanoma Myelodysplasia Myeloma ...
*  William A. Haseltine
The Haseltine laboratory discovered a novel transacting protein, they named the transactivator tat, and a second protein, ... Today Velcade is an important drug in the treatment of multiple myeloma. Knowledge of the importance of dendritic cells in HIV ... This protein fragment was used by Cambridge BioSciences (Later named Cambridge BioTech) to develop a rapid test for HIV ... A drug that inhibits the rev protein has been approved by the USA Food and Drug administration for treatment of HIV infection. ...
*  Molecular Partners
They are derived from natural ankyrin repeat proteins. Repeat proteins are among the most common classes of binding proteins in ... "Molecular Partners to Conduct Phase II Trial of MP0250, a Multi-DARPin Targeting VEGF and HGF, in Multiple Myeloma". January 8 ... Plückthun, A (2015). "Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy". ... soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins". Journal of Molecular Biology. ...
*  Edelfosine
... can activate the Fas/CD95 cell death receptor, can inhibit the MAPK/ERK mitogenic pathway and the Akt/protein kinase ... Edelfosine apoptosis-inducing abilities were studied with several types of cancer, among them multiple myeloma and non-small ... Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream ... 2010). "Lipid raft-targeted therapy in multiple myeloma". Oncogene. 29 (26): 3748-3757. doi:10.1038/onc.2010.131. PMID 20418917 ...
*  IFN1@
2007). "Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin ... "Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein ...
*  Cancer-associated fibroblast
CAFs produce a number of proteins that are specific to the origin of the cells However, as there are no specific protein to ... Focus on Multiple Myeloma". Cancers. 6 (3): 1363-1381. doi:10.3390/cancers6031363. Shiga, Kazuyoshi; Hara, Masayasu; Nagasaki, ... The group of proteins known as the matrix metalloproteinases are key to this process. CAF also direct the movement of ... Additionally, CAF have the ability to break down proteins in the extracellular matrix and basement membranes leading to ...
*  Cell culture
Although many simpler proteins can be produced using rDNA in bacterial cultures, more complex proteins that are glycosylated ( ... Drexler HG, MacLeod RA, Dirks WG (December 2001). "Cross-contamination: HS-Sultan is not a myeloma but a Burkitt lymphoma cell ... The cost of growing mammalian cell cultures is high, so research is underway to produce such complex proteins in insect cells ... Ou D, Mitchell LA, Décarie D, Tingle AJ, Nepom GT (March 1998). "Promiscuous T-cell recognition of a rubella capsid protein ...
*  Gaucher's disease
Cancer risk may be increased, particularly myeloma. This is thought to be due to accumulation of glucosylceramide and complex ... 497-amino acid-long protein that catalyses the breakdown of glucocerebroside, a cell membrane constituent of red and white ... Ayto R, Hughes DA (2013). "Gaucher disease and myeloma". Crit Rev Oncog. 18 (3): 247-68. doi:10.1615/critrevoncog.2013006061. ...
*  Steven T. Rosen
"Multiple Myeloma Research Foundation Annual Report 2006" (PDF). Multiple Myeloma Research Foundation. 2006. Retrieved 22 ... the role of proteins in cancer metabolism. One of the nucleoside analogs he has worked on is in trials for the treatment of ... the American Society of Clinical Oncology's Conquer Cancer Foundation and the Scientific Advisory Board of the Multiple Myeloma ...
*  Pevonedistat
... is a heterodimeric molecule consisting of amyloid beta precursor protein-binding protein 1 (APPBP1) and ubiquitin-like modifier ... These include pevonedistat trials against relapsed/refractory multiple myeloma or lymphoma, metastatic melanoma, and advanced ... In addition to proteasome-mediated protein degradation, activated NEDD8 is needed for at least two pathways of DNA repair, ... "Inhibition of NAE prevents activation of cullin-RING ligases (CRLs), which are critical for proteasome-mediated protein ...
*  PIM1
Other known substrates/binding partners of Pim-1 include proteins involved in transcription regulation (nuclear adaptor protein ... Keane NA, Reidy M, Natoni A, Raab MS, O'Dwyer M (July 2015). "Targeting the Pim kinases in multiple myeloma". Blood Cancer ... Heat shock protein 90kDa alpha (cytosolic), member A1, NFATC1, Nuclear mitotic apparatus protein 1, P21, SND1 and RELA. ... Modification of the protein at amino acid 67 (lysine to methionine) results in the inactivation of the kinase. Pim-1 is ...
*  Drug repositioning
... for example the introduction of thalidomide for multiple myeloma was seen by many analysts at the time as high risk and even ... on virtual screening of comprehensive libraries of approved and other human use compounds against large numbers of protein ...
*  Kinesin family member 11
Kinesin-5 is a molecular motor protein that is essential in mitosis. Kinesin-5 proteins are members of kinesin superfamily, ... of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells ... The unique assembly of Kinesin-5 proteins not only organizes the protein complex for a different cellular function ( ... Currently, there are over 70 different eukaryotic kinesin-5 proteins identified by sequence similarity. Members of this protein ...
*  Plerixafor
Up to 58% are bound to plasma proteins, the rest mostly resides in extravascular compartments. The drug is not metabolized in ... The drug is approved for patients with lymphoma and multiple myeloma. Studies in pregnant animals have shown teratogenic ... ISBN 3-85200-196-X. Wagstaff, A. J. (2009). "Plerixafor: in patients with non-Hodgkin's lymphoma or multiple myeloma". Drugs. ... "Mozobil approved for non-Hodgkin's lymphoma and multiple myeloma" (Press release). Monthly Prescribing Reference. December 18, ...
*  Cyclin D1
This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated ... Chromosomal translocation of the cyclin D1 gene locus is also observed in 15 - 20% of multiple myelomas. Cyclin D1 and the ... Cyclin-D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human ... that controls nuclear export and protein stability. The protein encoded by this gene belongs to the highly conserved cyclin ...
*  Lymphoma
Plasma cell myeloma (also known as multiple myeloma) Plasmacytoma Monoclonal immunoglobulin deposition diseases Heavy chain ... In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so ... multiple myeloma and immunoproliferative diseases. About 90% of lymphomas are non-Hodgkin lymphomas. Lymphomas and leukemias ... thick that plasmapheresis is performed to remove the protein. Watchful waiting may be appropriate for certain types. The ...
*  ADAM9
The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, ... 1996). "Cloning of a novel membrane-linked metalloproteinase from human myeloma cells". Biochem. J. 318 (2): 459-62. PMC ... Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene. This ... 2003). "Expression of ADAM-9 mRNA and protein in human breast cancer". Int. J. Cancer. 105 (6): 754-61. doi:10.1002/ijc.11161. ...
*  Myeloma protein
"Multiple Myeloma Patient Handbook". International Myeloma Foundation. "Multiple Myeloma Concise Review". International Myeloma ... typically in multiple myeloma. Other terms for such a protein are M protein, M component, M spike, spike protein, or ... A myeloma protein is an abnormal immunoglobulin fragment, such as an immunoglobulin light chain, that is produced in excess by ... This proliferation of the myeloma protein has several deleterious effects on the body, including impaired immune function, ...
*  DAZAP2
DAZ-associated protein 2 is a protein that in humans is encoded by the DAZAP2 gene. In mammals, the Y chromosome directs the ... Shi YW, Shen R, Ren W, Tang LJ, Tan DR, Hu WX (2007). "Molecular features and expression of DAZAP2 in human multiple myeloma". ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3 ...