In 1998 thalidomide was approved by the U.S. Food and Drug Administration (FDA) for use in newly diagnosed multiple myeloma (MM ... Cereblon is a 51 kDa protein localized in the cytoplasm, nucleus and peripheral membrane of cells in numerous parts of the body ... Findings also support the hypothesis that an increase in the expression of cereblon is an essential element of the anti-myeloma ... The role of angiogenesis in the support of myeloma was first discovered by Vacca in 1994. They discovered increased bone marrow ...

In lymphocytic neoplastic diseases such as multiple myeloma and lymphoma, but also other illnesses, there can be a massive ... expansion of a single B-cell clone, detectable by measuring the excessively-produced antibodies, measured in a serum protein ...

A PrEST (protein epitope signature tag) is a type of recombinantly produced human protein fragment. They are inserted into an ... are typically made by fusing the spleen cells from a mouse that has been immunized with the desired antigen with myeloma cells ... These antibodies are monospecific against the human protein. Recent research has led to the discovery that unstable hinged ...

Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene. Transforming ... close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165 ... and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at ... 2000). "D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo". EMBO J. 19 (2 ...

... such as protein kinase inhibitors or PARP inhibitors people who have had bone marrow or stem cell transplants in the last 6 ... lymphoma or myeloma who are at any stage of treatment people having immunotherapy or other continuing antibody treatments for ...

It is of great importance for the diagnosis and monitoring of certain blood related diseases such as myeloma. The method ... After application of an electric current that allows the separation of proteins according to their size, antibodies specific ... Immunofixation tends to replace protein electrophoresis because :[citation needed] it is faster (results within three hours) ; ... Immunofixation may reveal an immunoglobulin missed out by protein electrophoresis, especially at low concentrations (less than ...

... such as multiple myeloma and Waldenström's macroglobulinemia. About 10% to 15% of patients with multiple myeloma may develop ... An abnormal light chain in urine is known as Bence Jones protein. AL amyloidosis can affect a wide range of organs, and ... Daratumumab, a monoclonal antibody to CB38, a protein that is expressed on plasma cells, was approved in US and EU for AL ... The tissue is stained with red dye, and under a microscopic examination, amyloid proteins can be detected if the tissue turns ...

... where an antibody-producing B cell is fused with a myeloma (B cell cancer) cell. There are several examples of immortalised ... from testing toxicity of compounds or drugs to production of eukaryotic proteins. While immortalised cell lines often originate ... Artificial expression of key proteins required for immortality, for example telomerase which prevents degradation of chromosome ...

... has been studied for several human conditions including melanoma, multiple myeloma, gastrointestinal cancer, ... lymphocyte-specific protein tyrosine kinase (Lck), focal adhesion kinase (FAK) and fibroblast growth factor receptor 3 (FGFR3) ... enzymes responsible for the activation of many proteins by signal transduction cascades. Specifically, masitinib targets the ...

They identified a number of common features, but not blood protein abnormalities or elevation of the rate of erythrocyte ... Bloodgood invited Geschickter to work on multiple myeloma, and Geschickter invited his classmate Murray Copeland to work with ... Moehler, Thomas (2011-01-01). Multiple Myeloma. Springer. ISBN 978-3-540-85772-3. Retrieved 2013-01-02. Null, Gary; McDonald, ...

For example, immunoglobin-producing B lymphocytes can be fused with myeloma to produce an immortal line of cells called ... Certain oncogenic viruses encode for fusogens, which are proteins that encourage two cell membranes to fuse. When the viral ...

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene. The protein encoded by this gene, ... 2004). "Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF- ... 2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth ... Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci ...

... multiple myeloma, and lymphoma. The laboratory analysis of blood is frequently performed by a medical technologist or medical ... blood proteins, bone marrow, platelets, blood vessels, spleen, and the mechanism of coagulation. Such diseases might include ...

... also targets Myc Binding Protein (MYCBP). This prevents transcription of c-Myc target genes by silencing c-MYCBP. ... multiple myeloma and hepatocellular carcinoma. Mir-22 expression was associated with survival in multiple breast cancer ... microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein". Oncogene. 29 ...

Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene. SEMA4A is a member of the semaphorin family of soluble ... April 2022). "Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma". Blood. 139 ... Recently it has been identified as a novel therapeutic target in Multiple myeloma. GRCh38: Ensembl release 89: ENSG00000196189 ... and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune ...

This stops cytochrome C protein passing out through VDAC into the cytoplasm where it triggers apoptosis via a caspase protein ... In multiple myeloma, TIGAR expression is linked to the activity of MUC-1. MUC-1 is an oncoprotein that is overexpressed in ... In this state, Rb binds to a protein transcription factor E2F and prevents E2F from activating transcription of proteins ... Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA ...

... is a bispecific antibody against two targets: human CD3, a T-cell surface antigen, and human G-protein coupled ... Talquetamab, sold under the brand name Talvey, is a humanized monoclonal antibody used for the treatment of multiple myeloma. ... Talquetamab is indicated for the treatment of adults with relapsed or refractory multiple myeloma who have received prior lines ... "FDA Grants Breakthrough Therapy Designation to Talquetamab for R/R Myeloma". Targeted Oncology. 29 June 2022. Archived from the ...

Albumin is a protein produced by the liver which makes up roughly 50%-60% of the proteins in the blood while the other 40%-50% ... gammopathy of undetermined significance Smoldering multiple myeloma Malignant plasma cell dyscrasias Multiple myeloma ... Protein dipstick measurements should not be confused with the amount of protein detected on a test for microalbuminuria which ... Traditionally, dipstick protein tests would be quantified by measuring the total quantity of protein in a 24-hour urine ...

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a ... Chesi M, Nardini E, Lim RS, Smith KD, Kuehl WM, Bergsagel PL (Nov 1998). "The t(4;14) translocation in myeloma dysregulates ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197-205. doi: ... 2001). "A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 ...

Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. In vertebrates, the genes encoding the class ... March 2011). "Initial genome sequencing and analysis of multiple myeloma". Nature. 471 (7339): 467-472. Bibcode:2011Natur.471.. ... October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-1178. ... "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448- ...

NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. The encoded protein, ... Chu L, Su MY, Maggi LB, Lu L, Mullins C, Crosby S, Huang G, Chng WJ, Vij R, Tomasson MH (August 2012). "Multiple myeloma- ... Tang J, Kao PN, Herschman HR (June 2000). "Protein-arginine methyltransferase I, the predominant protein-arginine ... Tang J, Kao PN, Herschman HR (June 2000). "Protein-arginine methyltransferase I, the predominant protein-arginine ...

Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that ... grp94 has been shown to be a target for treatment of a plethora of diseases such as glaucoma, multiple myeloma, and metastatic ... GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Recurrent or Progressive Glioma Bloch O, Crane CA, ... Li Z, Dai J, Zheng H, Liu B, Caudill M (March 2002). "An integrated view of the roles and mechanisms of heat shock protein gp96 ...

... low C1-INH protein level, low C1q level, and decreased C1-INH protein function. Using the diagnostic approach mentioned here ... Multiple myeloma (MM) is a malignant plasma cell disorder that progresses from MGUS. MM is characterized by elevated monoclonal ... The role of C1-INH is to regulate and control the activities of the complement cascade, such that complement proteins remain in ... As shown in the figure above, the complement cascade starts with the C1q protein which binds to an antibody-antigen complex ...

Some of these proteins are linked to the exterior of the cell membrane. An example of this is the CD59 protein, which ... This procedure is now used extensively, for example by fusing B-cells with myeloma cells. The resulting "hybridoma" from this ... The most common class of this type of protein is the G protein-coupled receptor (GPCR). GPCRs are responsible for much of the ... The first of these proteins to be studied were the viral fusion proteins, which allow an enveloped virus to insert its genetic ...

A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene. It involves in the intracellular ... AKAP4 is over expressed in multiple myeloma (MM) AKAP4 has been shown to interact with: AKAP3, and PRKAR1A. GRCh38: Ensembl ... AKAP 4 protein belongs to the family of scaffold proteins and is involved in controlled mechanism of flagellar function. In ... AKAP4 is not normally expressed in mRNA and protein level in MM cell line. The A-kinase anchor proteins (AKAPs) are a group of ...

Multiple myeloma can be treated with daratumumab (Darzalex) monoclonal antibody. Studies with in vitro materials and patient ... Antibodies can then bind to these viral proteins. Next, the NK cells which have reciprocal Fcγ receptors will bind to that ... During replication of a virus, some of the viral proteins are expressed on the cell surface membrane of the infected cell. ... 2011). "Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other ...

... genes Prophage Prophase Prophylactic surgery Proplastid Propositus Prostate cancer Protease Protein Protein product Protein ... site Mutation Mutation breeding Mutation event Mutation frequency Mutation rate Mutational load Mutator mutation Muton Myeloma ... Ala Alagille syndrome Albino Alcoholism Alkylating agent Allele Allele frequency Alleles Allopolyploid Allosteric protein ... Aaron Y-chromosomal Adam YAC Y-chromosome haplogroups in populations of the world Z-DNA Zinc finger Zinc-finger protein Zygote ...

... is a protein that in humans is encoded by the CUBN gene. Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin ... 1998). "Myeloma light chains are ligands for cubilin (gp280)". Am. J. Physiol. 275 (2 Pt 2): F246-54. doi:10.1152/ajprenal. ... "Expression of CUBN in renal cancer - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-09-06. Christensen EI, Birn ... Cubilin shows a restricted mode of expression according to protein profiling and transcriptomics analyses, and is essentially ...

As of 2013[update], Sanofi was in a race with Amgen and Pfizer to win approval for a drug that inhibits PCSK9, a protein that ... "Mozobil approved for non-hodgkin's lymphoma and multiple myeloma" (Press release). Monthly Prescribing Reference. 18 December ... It used recombinant protein-based technology for Sanofi's flu vaccine along with GSK's pandemic technology and was seeking ... In July 2017, the company announced its intention to acquire Protein Sciences, a privately held Connecticut-based vaccines ...

The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function ... or Multiple Myeloma" at ClinicalTrials.gov Clinical trial number NCT02693535 for "TAPUR: Testing the Use of Food and Drug ... protein; it is encoded by the c-ros oncogene and was first identified in 1986. The exact role of the ROS1 protein in normal ... Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene. This proto-oncogene, highly ...