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*  Development of analogs of thalidomide
In 1998 thalidomide was approved by the U.S. Food and Drug Administration (FDA) for use in newly diagnosed multiple myeloma (MM ... Cereblon is a 51 kDa protein localized in the cytoplasm, nucleus and peripheral membrane of cells in numerous parts of the body ... Findings also support the hypothesis that an increase in the expression of cereblon is an essential element of the anti-myeloma ... This is believed to be a main component of the mechanism in vivo by which thalidomide inhibits multiple myeloma. Additionally, ...
*  IGHE
Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene. "Human PubMed Reference:". "Entrez Gene: ... "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line". ...
*  Waldenström's macroglobulinemia
Blood tests show the level of IgM in the blood and the presence of proteins, or tumor markers, that are the key symptoms of WM ... A skeletal survey can help distinguish between WM and multiple myeloma. Anemia is typically found in 80% of patients with WM. A ... Serum protein electrophoresis results indicate evidence of a monoclonal spike but cannot establish the spike as IgM. An M ... Similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma, WM is commonly preceded by two clinically ...
*  LAMP2
Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. The protein encoded by this gene is a member of a ... Li L, Li J (May 2015). "[Lentivirus-mediated shRNA silencing of LAMP2A inhibits the proliferation of multiple myeloma cells]". ... LAMP2 lysosomal-associated membrane protein 2". Online Mendelian Inheritance in Man (OMIM) Lysosome-associated membrane protein ... LAMP2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
*  WHSC1
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a ... Chesi M, Nardini E, Lim RS, Smith KD, Kuehl WM, Bergsagel PL (Nov 1998). "The t(4;14) translocation in myeloma dysregulates ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197-205. doi: ... 2001). "A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 ...
*  Cubilin
... is a protein that in humans is encoded by the CUBN gene. Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin ... 1998). "Myeloma light chains are ligands for cubilin (gp280)". Am. J. Physiol. 275 (2 Pt 2): F246-54. PMID 9691015. Lindblom A ... 2001). "A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney". J. Biol. Chem. 276 (16): 13295- ... "Expression of CUBN in renal cancer - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-09-06. Christensen EI, Birn ...
*  JAG2
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... "Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines". Blood. 104 ( ... The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants ... Jagged-2 is a protein that in humans is encoded by the JAG2 gene. The Notch signaling pathway is an intercellular signaling ...
*  FNBP1
Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene. The protein encoded by this gene is a member ... "Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma". Cancer Immunol. Immunother ... The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil ... This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has ...
*  ROS1
The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function ... or Multiple Myeloma" at ClinicalTrials.gov Clinical trial number NCT02693535 for "TAPUR: Testing the Use of Food and Drug ... protein; it is encoded by the c-ros oncogene and was first identified in 1986. The exact role of the ROS1 protein in normal ... Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene. This proto-oncogene, highly ...
*  Siltuximab
It has undergone a phase I clinical trial in patients With B-cell non-Hodgkin's lymphoma, multiple myeloma, or Castleman's ... made from human and mouse proteins) monoclonal antibody. It binds to interleukin-6. Siltuximab has been investigated for the ... Encouraging results have been reported from a phase II trial for relapsed or refractory multiple myeloma. On April 23, 2014, ... Multiple Myeloma, or Castleman's Disease". "CNTO 328 Shows Promise For Ovarian Cancer In Small Clinical Trial, Say U.K. ...
*  SPA17
Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene. This gene encodes a protein present at the ... 2004). "Sp17 gene expression in myeloma cells is regulated by promoter methylation". Br. J. Cancer. 91 (8): 1597-603. doi: ... Lea IA, Widgren EE, O'Rand MG (2004). "Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella". Reprod. ... Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the ...
*  APRIL (protein)
At least one anti-APRIL monoclonal antibody has been announced to enter phase I clinical trials for multiple myeloma. GRCh38: ... The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand ... This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important ... TNFSF13 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human TNFSF13 genome location and ...
*  Cereblon
... is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the ... which leads to an antiproliferative effect on myeloma cells and a teratogenic effect on fetal development. Thalidomide was used ... As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide. "Thalidomide ... In the absence of cereblon, DDB1 forms a complex with DDB2 that functions as a DNA damage-binding protein. Furthermore, ...
*  Hematologic disease
Myelomas Multiple myeloma Waldenström macroglobulinemia Plasmacytoma Leukemias increased WBC Acute lymphocytic leukemia (ALL) ... rare acquired clonal disorder of red blood cell surface proteins) Direct physical damage to RBCs Microangiopathic hemolytic ... Hemophilia C Von Willebrand disease Disseminated intravascular coagulation Protein S deficiency Antiphospholipid syndrome ... Thrombocytosis Recurrent thrombosis Disseminated intravascular coagulation Disorders of clotting proteins Hemophilia Hemophilia ...
*  Genmab
Daratumumab is in clinical development for additional multiple myeloma indications and for non-Hodgkin's lymphoma. They also ... other types of man-made antibodies containing other animal proteins because the IgG antibodies produced have human proteins. ... for the treatment of heavily pretreated or double refractory multiple myeloma. ...
*  Stuart Schreiber
... a protein complex responsible for the bulk of proteolysis in the cell, as well as proteolytic activation of certain protein ... used to treat multiple myeloma. In 1996, Schreiber and co-workers used the small molecules trapoxin and depudecin to discover ... cytoplasmic anchoring proteins, developmental signaling proteins (e.g., histacin, tubacin, haptamide, uretupamine, ... Monastrol was shown to inhibit kinesin-5, a motor protein and was used to gain new insights into the functions of kinesin-5. ...
*  CD226
... protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD226 genome location and ... and NKp46 in the natural killer cell-mediated killing of myeloma cells". Cancer Research. 67 (18): 8444-9. doi:10.1158/0008- ... is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3. CD226 is a ~65 kDa ... on T cells forms a dynamic molecular complex with protein 4.1G and human discs large". The Journal of Biological Chemistry. 279 ...
*  Cryoglobulinemia
... non-IgM smoldering multiple myeloma, or multiple myeloma. The interruption of blood flow to neurological tissues can cause ... In these mixed-protein depositions, the monoclonal or polyclonal IgM typically possesses rheumatoid factor activity and ... Monoclonal IgG or, rarely, IgA, κ light chain, or λ light chain cryoglobulins occur in cases of multiple myeloma and the pre- ... Mixtures of monoclonal or polyclonal IgM, IgG, and/or IgA along with blood complement proteins such as C4 are the cryoglobulins ...
*  CKAP2
Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene. GRCh38: Ensembl release 89: ... Thus deletions have been detected in multiple myeloma, prostate cancer, head-and-neck squamous-cell carcinoma, B-cell ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... "Entrez Gene: CKAP2 cytoskeleton associated protein 2". Alternative titles: TUMOR- AND MICROTUBLE-ASSOCIATED PROTEIN; TMAP, LB1 ...
*  HOXA9
Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. In vertebrates, the genes encoding the class ... "Initial genome sequencing and analysis of multiple myeloma". Nature. 471 (7339): 467-72. doi:10.1038/nature09837. PMC 3560292 ... "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Mol. Cell. Biol. 17 (11): 6448-58. PMC 232497 ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038/ ...
*  Hypoxanthine-guanine phosphoribosyltransferase
HPRT expression on the mRNA and protein level is induced by hypoxia inducible factor 1 (HIF1A). HIF-1 is a transcription factor ... HAT medium inhibits de novo synthesis of nucleic acids, killing myeloma cells that cannot switch over to the salvage pathway, ... myeloma cells. They are created to produce monoclonal antibodies in biotechnology. ...
*  Masitinib
It also inhibits the platelet derived growth factor receptor (PDGFR), lymphocyte-specific protein tyrosine kinase (Lck), focal ... Masitinib has been studied for several human conditions including melanoma, multiple myeloma, gastrointestinal cancer, ...
*  Obatoclax
... is an inhibitor of the Bcl-2 family of proteins. This inhibition induces apoptosis in cancer cells, preventing tumor ... Clinical Lymphoma Myeloma and Leukemia. 10 (4): 285-9. doi:10.3816/CLML.2010.n.059. PMID 20709666. Gemin X Presents New Data on ... Clinical Lymphoma Myeloma and Leukemia. 14 (6): 534-9. doi:10.1016/j.clml.2014.04.007. PMID 25052051. Clinical trial number ...
*  Russell bodies
... which is thought to be a result of insufficient protein transport within the cell. This causes the proteins to neither be ... This is one cell variation found in multiple myeloma. They are named for William Russell (1852-1940), a Scottish physician. See ... Russell bodies are thought to have originated as an SOS compartment, where abnormal proteins that are not secreted, but have ... "Multiple myeloma with numerous intranuclear Russell bodies". Haematologica. 84 (2): 179-80. PMID 10091418. synd/1962 at Who ...
*  LIG3
Nuclear DNA ligase III-alpha exists and functions in a stable complex with the DNA repair protein XRCC1. These proteins ... LIG3 is upregulated in chronic myeloid leukemia, multiple myeloma, and breast cancer. Cancers are very often deficient in ... Several genes encoding proteins that interact directly with DNA ligase III-alpha or indirectly via interactions with XRCC1 have ... XRCC1 has no enzymatic activity but instead appears to acts as a scaffold protein by interacting with a large number of ...
*  Suparnostic
Between each step the plate is rinsed with a wash buffer to dispose of any proteins that do not specifically bind to any of the ... as an independent factor predicting worse prognosis and extra-bone marrow involvement in multiple myeloma patients. British ...
*  MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene. The ... which is under investigation as a potential multiple myeloma treatment) both act in part by inhibiting synthesis of Mcl-1. MCL1 ... Bae J, Donigian JR, Hsueh AJ (February 2003). "Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of ... encodes a proapoptotic protein possessing only the BH3 domain". J. Biol. Chem. 275 (33): 25255-61. doi:10.1074/jbc.M909826199. ...