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*  Myeloma protein
"Multiple Myeloma Patient Handbook". International Myeloma Foundation. "Multiple Myeloma Concise Review". International Myeloma ... typically in multiple myeloma. Other terms for such a protein are M protein, M component, M spike, spike protein, or ... A myeloma protein is an abnormal immunoglobulin fragment, such as an immunoglobulin light chain, that is produced in excess by ... This proliferation of the myeloma protein has several deleterious effects on the body, including impaired immune function, ...
*  IGHG1
... myeloma protein Nie), I: Purification and characterization of the protein, the L- and H-chains, the cyanogenbromide cleavage ... The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain ... Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene. "Human PubMed Reference:". "Entrez Gene: ... "Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from ...
*  Gustav Gaudernack
His research these years was focused on mouse myeloma protein λ315. He further became interested in the innate immune system, ... "Production of BALB/c Anti-Idiotypic Antibodies Against the BALB/c Myeloma Protein 315 Does Not Require an Intact Ligand-Binding ... "Ligand-Induced Redistribution and Augmentation of Surface-Bound Myeloma Protein on MOPC315 Plasmacytoma Cells". Scandinavian ... The peptides contain the various mutations that are present in the catalytic site of the Ras protein. In 1993, five patients ...
*  Immunoglobulin heavy constant alpha 1
Primary structure of a human monoclonal IgA-immunoglobulin (myeloma protein Tro). VII. Purification and characterization of the ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... Europe, Protein Data Bank in. "Ig alpha-1 chain C region in PDB entry 1ow0 ‹ PDBe ‹ EMBL-EBI". www.ebi.ac.uk. Retrieved 2016-10 ... "Results for the protein: P01876". bioinf.umbc.edu. Retrieved 2016-10-16. Kerr MA (1990). "The structure and function of human ...
*  Plasma cell dyscrasia
IgM myeloma proteins or in rare cases other myeloma proteins such as IgA, free κ light chains, or free λ light chains may ... cases in which there is evidence of myeloma protein secretion such as renal myeloma protein deposits. A Mayo Clinic study of ... Non-secretory multiple myeloma represents a class of plasma cell dyscrasias where no myeloma protein is detected in serum or ... Protein electrophoresis generally detects one of the following pattern of monoclonal myeloma protein spikes representing: a) ...
*  POEMS syndrome
Overproduction of the myeloma protein and VEGF may underlie some, but are insufficient to explain all, of the multi-organ ... Monoclonal paraprotein: In most cases a serum myeloma protein can be detected, although this is not universal. This may ... of instances the myeloma proteins contain a λ chain that is restricted to either of two V lambda 1 subfamily members viz., ... a myeloma protein, as well as certain cytokines by the malignant plasma cells. POEMS syndrome typically begins in middle age - ...
*  IGHG2
"The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein". Canadian Journal of ... Ig gamma-2 chain C region is a protein that in humans is encoded by the IGHG2 gene. "Human PubMed Reference:". "Entrez Gene: ...
*  Onconephrology
Also, cancer cells by infiltrating the kidney or myeloma proteins by precipitating with in the tubules of the kidney can cause ... Myeloma Nephrology 6. Amyloidosis Nephrology 7. Thrombotic Microangiopathy and all its causes and treatment strategies( HUS/TTP ...
*  Multiple myeloma
A monoclonal protein (Myeloma protein) in either serum or urine (except in cases of true non-secretory myeloma) Evidence of end ... The most common cause of kidney failure in multiple myeloma is due to proteins secreted by the malignant cells. Myeloma cells ... Femur with multiple myeloma lesions. Same femur before myeloma lesions for comparison Humerus with multiple myeloma lesions. ... and smoldering multiple myeloma are typically diagnosed fortuitously by detecting a myeloma protein on serum protein ...
*  List of MeSH codes (D12.776)
... bence jones protein MeSH D12.776.377.715.548.900.225 - cryoglobulins MeSH D12.776.377.715.548.900.500 - myeloma proteins MeSH ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...
*  List of MeSH codes (D12.776.124)
... bence jones protein MeSH D12.776.124.486.485.900.225 -- cryoglobulins MeSH D12.776.124.486.485.900.500 -- myeloma proteins MeSH ... bence jones protein MeSH D12.776.124.790.651.900.225 -- cryoglobulins MeSH D12.776.124.790.651.900.500 -- myeloma proteins MeSH ... complement c1 inactivator proteins MeSH D12.776.124.486.274.920.250.500 -- complement c1 inhibitor protein MeSH D12.776.124.486 ... This is a sub-part (blood proteins only) of List of MeSH codes (D12.776), itself a part of the list of the "D" codes for MeSH. ...
*  Index of biochemistry articles
... muscle protein - mutagen - mutation - myc gene - mycology - myelin basic protein - myeloma protein - myosin - N- ... protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein folding - protein isoform - ... protein P16 - protein P34cdc2 - protein precursor - protein structure prediction - protein subunit - protein synthesis - ... proto-oncogene protein C-kit - proto-oncogene proteins c-abl - proto-oncogene proteins c-bcl-2 - Proto-oncogene proteins c-fos ...
*  Plasma cell leukemia
... of monoclonal plasma cells in their bone marrow plus a malignant plasma cell-secreted circulating monoclonal myeloma protein, ... of plasma cells that cause the more serious but still premalignant disorder of smoldering multiple myeloma, overt myeloma ... Compared to multiple myeloma patients, pPCL patients also: exhibit 1) high rates of developing an hypercalcemic crisis, i.e. an ... The International Myeloma Working Group has defined the diagnostic criteria for plasma cell leukemia as the presence in blood ...
*  Anti-dsDNA antibodies
Occasionally the monoclonal proteins produced by myeloma patients can be anti-dsDNA. Also, some patients with type 1 autoimmune ... There is a higher rate of apoptosis in people with SLE and various changes in genes and proteins have been implicated in the ... Serum amyloid P component is a protein that is thought to aid in the clearance of chromatin produced by apoptotic cells and ... Anti-dsDNA antibodies might also be created secondary to the production of antibodies to other proteins within the nucleosome. ...
*  M protein
... non structural protein linking the viral envelope with the virus capsid Myeloma protein, also called paraprotein, an abnormal ... M protein may refer to: M protein (Streptococcus), a virulence factor of the bacterium Streptococcus pyogenes Another name for ... a protein composing the M-line of muscle cell sarcomeres Protein M in Mycoplasma genitalium which is different from the above- ... protein in the urine or blood, often seen in multiple myeloma or monoclonal gammopathy of undetermined significance MYOM2 ( ...
*  Serum protein electrophoresis
The most common indications for a serum protein electrophoresis test are to diagnose or monitor multiple myeloma, a monoclonal ... The net charge on a protein is based on the sum charge of its amino acids, and the pH of the buffer. Proteins are applied to a ... "Serum protein electrophoresis". Medscape. Retrieved 2 October 2013. McCudden, C. (2016). "Monitoring multiple myeloma patients ... Of note, any protein migrating in the gamma region will be stained and appear on the gel, which may include protein ...
*  IL1RL1
1997). "The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells". J. ... The protein is known to interact with MyD88, IRAK1, IRAK4 and TRAF6. It appears to be essential for the normal function of T ... The ST2 protein has two isoforms and is directly implicated in the progression of cardiac disease: a soluble form (referred to ... It encodes a protein of 556 amino acids (molecular weight 63,358 Da). Both membrane bound and soluble forms are known. ...
*  Unfolded protein response
"Proteasome inhibitors disrupt the unfolded protein response in myeloma cells". Proceedings of the National Academy of Sciences ... An important example is that the proapoptotic protein CHOP (CCAAT/-enhancer-binding protein homologous protein), is upregulated ... exposed hydrophobic residues of the misfolded protein are bound by the protein glucose regulate protein 78 (Grp78), a heat ... Unsuccessful protein folding can be caused by HLA-B27, disturbing balance of important (IL-10 and TNF) signaling proteins. At ...
*  Immunoglobulin light chain
Ig light chains produced in neoplastic plasma cells, such as in multiple myeloma, are called Bence Jones proteins. Increased ... Specific rearrangement of lambda light chain of immunoglobulins can lead to loss of some protein coding genes, which does not ... that is important for binding antigen The approximate length of a light chain protein is from 211 to 217 amino acids. The ...
*  STAT5A
Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and ... induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins". Mol. Cell. ... interacts with chaperones and facilitates protein-protein interactions for transcriptional regulation DNA binding domain (aa331 ... The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth ...
*  Bence Jones protein
Bence Jones proteins are present in 2/3 of multiple myeloma cases. The proteins are immunoglobulin light chains (paraproteins) ... Detection of Bence Jones protein may be suggestive of multiple myeloma or Waldenström's macroglobulinemia. Bence Jones proteins ... A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular ... as seen in nonsecretory multiple myeloma and AL amyloidosis. The Bence Jones protein was described by the English physician ...
*  Daniel Nathans
Struck by how little was known about cancer biology, he became interested in protein synthesis in myeloma tumors, and published ... He continued working on the problem of protein synthesis as time allowed. In 1959, he decided to work on the research full time ...
*  Smouldering myeloma
... also termed myeloma protein or M protein) causes the relatively benign disease of monoclonal gammopathy of undetermined ... Smouldering myeloma, also known as smoldering myeloma, smoldering multiple myeloma, indolent myeloma or asymptomatic myeloma, ... Thus, some patients with smouldering myeloma progress to multiple myeloma and plasma cell leukemia. Smouldering myeloma, ... Smouldering myeloma Infosheet Smoldering Myeloma on International Myeloma Foundation.. ...
*  Serum free light-chain measurement
"Correlation of serum immunoglobulin free light chain quantification with urinary Bence Jones protein in light chain myeloma". ... February 2009). "International Myeloma Working Group guidelines for serum-free light-chain analysis in multiple myeloma and ... The distal tubules of the kidneys secrete large amounts of uromucoid (Tamm-Horsfall protein). This is the dominant protein in ... This is termed "cast nephropathy" or "myeloma kidney" and is typically found in patients with multiple myeloma. This can block ...
*  CUL4B
"The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins". Science. 343 (6168): 305-9. doi: ... protein is a CRL4 substrate only when directed by viral proteins §protein is a CRL4 substrate only when directed by IMiDs ... Essentially, HIV proteins such as Vpr and Vpx bind to VPRBP (a DDB1-binding substrate receptor protein) and induce the ... These proteins are not degraded by CRL4 complexes in the absence of virus. According to data from The Cancer Genome Atlas, ...
*  Melflufen
The Zn(2+) dependent ectopeptidase (also known as alanine aminopeptidase), degrades proteins and peptides with a N-terminal ... In relapsed and refractory multiple-myeloma (RRMM) patients, promising activity was seen in heavily pre-treated RRMM patients ... against multiple myeloma cells". Clinical Cancer Research. 19 (11): 3019-31. doi:10.1158/1078-0432.CCR-12-3752. PMC 4098702 . ... against multiple myeloma cells". Clinical Cancer Research. 19 (11): 3019-31. doi:10.1158/1078-0432.CCR-12-3752. PMC 4098702 . ...