*Mycophenolic acid

Thus, use of mycophenolic acid leads to a relatively selective inhibition of DNA replication in T cells and B cells . ... Mycophenolic acid is 15 times more expensive than azathioprine. The exact role of mycophenolate vs azathioprine has yet to be ... Mycophenolic acid was discovered by Italian medical scientist Bartolomeo Gosio. Gosio collected a fungus from spoiled corn and ... It was rediscovered by two American scientists C.L. Alsberg and O.M. Black in 1912, and gave the name mycophenolic acid. The ...

*Mycophenolic acid acyl-glucuronide esterase

Mycophenolic acid acyl-glucuronide (AcMPAG) is an important product in the metabolism of mycophenolic acid, and ABHD10 is the ... Mycophenolic acid acyl-glucuronide esterase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular ... Mycophenolate mofetil is the prodrug of mycophenolic acid (MPA) and widely used for the prevention of acute rejection after ... Mycophenolic acid acyl-glucuronide esterase, mitochondrial, also called abhydrolase domain-containing protein 10, mitochondrial ...

*Anthony Clifford Allison

Allison, AC; Kowalski, WJ; Muller, CD; Eugui, EM (1993). "Mechanisms of action of mycophenolic acid". Annals of the New York ... Allison, AC; Eugui, EM (1993). "Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate ... "Synthesis and immunosuppressive activity of some side-chain variants of mycophenolic acid". Journal of Medicinal Chemistry. 33 ...

*Bartolomeo Gosio

It was rediscovered by two American scientists C.L. Alsberg and O.M. Black in 1912, and gave the name mycophenolic acid. The ... Allison, A. C.; Kowalski, W. J.; Muller, C. D.; Eugui, E. M. (2006). "Mechanisms of action of mycophenolic acid". Annals of the ... Bentley, Ronald (2000). "Mycophenolic Acid: A One Hundred Year Odyssey from Antibiotic to Immunosuppressant". Chemical Reviews ... He also discovered an antibacterial compound called mycophenolic acid from the mould Penicillium brevicompactum. He ...

*Pure red cell aplasia

Drugs such as mycophenolic acid or erythropoietin.[citation needed] Congenital. The term "hereditary pure red cell aplasia" has ...

*Penicillium brevicompactum

Mycophenolic acid can be isolated from P. brevicompactum. Penicillium brevicompactum on www.cybertruffle.org.uk. ...

*UGT1A10

The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. Click on genes, ... Mojarrabi B, Mackenzie PI (Oct 1997). "The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid". ...

*Fungal isolate

Ciclosporin, mycophenolic acid, mizoribine, and gliotoxin, are immunosuppressant fungal isolates. Penicillin, cephalosporins, ... fusafungine, usnic acid, fusidic acid, fumagillin, brefeldin A, verrucarin A, alamethicin, are antibiotic fungal isolates. ... Irofulven and acylfulvene are anticancer derivatives of illudin S. Clavaric acid is a reversible farnesyltransferase inhibitor ... Inonotus obliquus creates betulinic acid precursor betulin. Flammulina velutipes creates asparaginase. Plinabulin is a fungal ...

*5-Hydroxymaltol

... and mycophenolic acid, secondary metabolites from Penicillium echinulatum. H.A. Anderson, J.M. Bracewell, A.R. ...

*Penicillium echinulatum

5-Hydroxymaltol and mycophenolic acid are substances that can be found in P. echinulatum. "Penicillium echinulatum". www. ... "5-Hydroxymaltol and mycophenolic acid, secondary metabolites from Penicillium echinulatum". Transactions of the British ...

*Squamous cell skin cancer

The antimetabolites azathioprine and mycophenolic acid have an intermediate risk profile. Diagnosis is confirmed via biopsy of ...

*Penicillium pinophilum

... produces 3-O-methylfunicone and mycophenolic acid Pol, D; Laxman, R. S.; Rao, M (2012). "Purification ... Study on production of mycophenolic acid by Penicillium pinophilum using response surface metodology. 2012 IEEE 2nd Portuguese ...

*Medicinal fungi

Mycophenolic acid was discovered in Penicillium stoloniferum. Thermophilic fungi were the source of the fingolimod precursor ... fusidic acid, itaconic acid, MT81, nigrosporin B, usnic acid, verrucarin A, vermiculine and many others. Antibiotics ... Pichia is used to produce the amino acid tryptophan and the vitamin pyridoxine. Rhodotorula is used to produce the amino acid ... 11,11'-Dideoxyverticillin A, andrastin A, barceloneic acid A, and barceloneic acid B, are farnesyl transferase inhibitors that ...

*Synergistic enhancer (antiretroviral)

It enhances AZT through depleting a dNTP analogous to HU, RV and mycophenolic acid. Mycophenolic acid Mycophenolic acid is an ... Mycophenolic acid is currently approved for used in organ transplantation as mycophenolate mofetil, trade name: CellCept. There ...

*IMP dehydrogenase

It is inhibited by Mycophenolic acid, ribavirin, and 6TGMP (6-thioguanine monophosphate). 6TGMP inhibition prevents purine ... Magasanik B, Moyed HS, Gehring LB (May 1957). "Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5'- ... IMP dehydrogenase EC 1.1.1.205 (Inosine-5'-monophosphate dehydrogenase) (Inosinic acid dehydrogenaseis) (IMPDH) an enzyme that ...

*Sarcoidosis

Mycophenolic acid has been used successfully in uveal sarcoidosis, neurosarcoidosis (especially CNS sarcoidosis; minimally ... Antimetabolites, also categorized as steroid-sparing agents, such as azathioprine, methotrexate, mycophenolic acid, and ... Ursodeoxycholic acid has been used successfully as a treatment for cases with liver involvement. Thalidomide has also been ... Due to these safety concerns it is often recommended that methotrexate is combined with folic acid in order to prevent toxicity ...

*Systemic lupus erythematosus

"FDA Alert: Mycophenolate Mofetil (marketed as CellCept) and Mycophenolic Acid (marketed as Myfortic)". May 16, 2008. Archived ...

*Danheiser benzannulation

Danheiser, R. L., Gee, S. K., Perez, J. J. "Total Synthesis of Mycophenolic Acid." J. Am. Chem. Soc. 1986, 108, 807. Lam, T. Y ... Mycophenolic acid was prepared in nine steps in an overall yield of 17-19%. In the synthesis of highly substituted indoles ... Mycophenolic acid is a Penicillium metabolite that was originally prepared via a key benzannulation step. An alkyne and a ... There he studied under E. J. Corey and completed his thesis on the total synthesis of gibberellic acid. Rick currently teaches ...

*Tumor metabolome

Mycophenolic acid inhibits of IMPDH and pyrimidine biosynthesis and is clinically used as immunosuppressant. Both agents also ... Malonyl CoA leads to fatty acid synthesis (FAS) and is involved in the elongation of fatty acids through Fatty acid synthase ( ... Fatty acid synthase (FASN), a key complex catalyzing fatty acid synthesis has been found to be linked to acquired docetaxel, ... Amino acids and fatty acids have been shown to function as fuels for tumor cells to proliferate. The carnitine ...

*Eliezer (Eli) Huberman

"The Immunosuppressor Mycophenolic Acid Kills Activated Lymphocytes by Inducing a Nonclassical Actin-Dependent Necrotic Signal ...

*IMPDH2

2010). "An inosine 5'-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid". ... 2008). "Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate ...

*UGT2B7

"Genetic polymorphisms of MRP2 and UGT2B7 and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid ... "Population Pharmacokinetics and Pharmacogenetics of Mycophenolic Acid Following Administration of Mycophenolate Mofetil in De ... using uridine diphosphate glucuronic acid. Together with UGT2B4, UGT2B7 is capable of glucosidation of hyodesoxycholic acid in ... Its function is to catalyse the conjugation of a wide variety of lipophilic aglycon substrates with glucuronic acid, ...

*Inosine-5′-monophosphate dehydrogenase

Jonsson, Charlotte A; Carlsten, Hans (2003). "Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses ... Progress in Nucleic Acid Research and Molecular Biology. Progress in Nucleic Acid Research and Molecular Biology. 61: 181-209. ... IMPDH has also been shown to bind nucleic acids, and this function can be impaired by mutations that are located in the ... monophosphate dehydrogenase binds nucleic acids in vitro and in vivo". Biochemical Journal. 379 (2): 243-251. doi:10.1042/ ...

*Middle East respiratory syndrome

Cheng KW, Cheng SC, Chen WY, Lin MH, Chuang SJ, Cheng IH, Sun CY, Chou CY (Mar 2015). "Thiopurine analogs and mycophenolic acid ... as well as other agents such as mycophenolic acid and camostat. MERS was also implicated in an outbreak in April 2014 in Saudi ...

*Byssochlamys

Species of the genus Byssochlamys can produce the mycotoxin patulin, as well as byssochlamic acid and mycophenolic acid. ...

*ATC code L04

L04AA06 Mycophenolic acid L04AA10 Sirolimus L04AA13 Leflunomide L04AA15 Alefacept L04AA18 Everolimus L04AA19 Gusperimus L04AA21 ...