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*  Ames test
... there are differences in metabolism between human and rat that can affect the mutagenicity of chemicals being tested. The test ... Furylfuramide in fact had previously passed animal test, but more vigorous tests after its identification in the Ames test ... The mutagenicity of a substance is proportional to the number of colonies observed. Mutagens identified via Ames test are also ... The Ames test is a widely employed method that uses bacteria to test whether a given chemical can cause mutations in the DNA of ...
*  Methyl yellow
CDC - NIOSH Pocket Guide to Chemical Hazards Chung, K. T.; Fulk, G. E.; Andrews, A. W. (1981). "Mutagenicity testing of some ...
*  Peto's paradox
Peto, R. (1977). "Epidemiology, multistage models, and short-term mutagenicity tests" (PDF). The Origins of Human Cancer. Cold ...
*  Liquid Paper
... is not teratogenic and carcinogenicity and mutagenicity testing has proven inconclusive. King, Gregory S.; Smialek, John E.; ...
*  Adsorbable organic halides
"Determination of halogenated organic compounds and mutagenicity testing of spent bleach liquors". Science of The Total ...
*  Environmental Mutagenesis and Genomics Society
It influenced research direction, regulatory procedures and mutagenicity testing within industry. In 1970 the EMS established ... particularly the development of tests for genetic toxicology, through the establishment of a register of substances tested for ... Bruce N. Ames on the Salmonella (Ames) mutagenicity assay. In 1979, the EMS began publishing its own journal, Environmental ... "Genetic Toxicology Data Bank (GENE-TOX) - Peer-reviewed genetic toxicology test data for over 3,000 chemicals". US National ...
*  Salmonella
"Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test". Mutat Res. 31 (6): ... These genetic tools also led to a simple test for carcinogens, the Ames Test. Host-pathogen interface 1984 Rajneeshee bioterror ... such as is used in the triple sugar iron test. Most isolates exist in two phases: a motile phase I and a nonmotile phase II. ... of strains to assist clinical and epidemiological investigation may be achieved by antibiotic sensitivity testing and by other ...
*  Auxotrophy
"Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test". Mutation Research/ ... Negative ames test means the possible mutagen DID not cause increase in revertants and positive ames test signifies that the ... The Salmonella Mutagenisis test (Ames test) uses multiple strains of Salmonella typhimurium that are auxotrophic to histidine ... "Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict ...
*  Fluparoxan
No mutagenic potential was identified in microbiological mutagenicity tests including a fluctuation test with S9 activation. No ...
*  Cadmium telluride
CdTe has low acute inhalation, oral, and aquatic toxicity, and is negative in the Ames mutagenicity test. Based on notification ... Current CdTe modules pass the U.S. EPA's Toxicity Characteristic Leaching Procedure (TCLP) test, designed to assess the ...
*  John W. Drake
It significantly influenced research direction, regulatory procedures and mutagenicity testing within industry within the ...
*  7-Keto-DHEA
These studies include: AMES Mutagenicity Test, Acute Oral Dose LD50 in Rats, Escalating Dose Oral Gavage in Rhesus Monkeys and ... Researchers have raised concern that supplements may trigger positive tests for performance-enhancing drugs. The World Anti- ...
*  Benzo(j)fluoranthene
Six bands of metabolites were collected and tested for mutagenicity toward S. typhimurium TA 100 with activation. The results ... Here the potential of BjF-9,10-dihydrodiol" and BkF-8,9-dihydrodiol to contribute to the mutagenicity of BjF and BkF toward S. ... Other metabolites may also contribute to the mutagenicity of BjF. This includes BjF-9,10-epoxide which is the likely precursor ... When tested separately, each of Peaks A and B of Band 3 was mutagenic (Table 1). Dihydrodiols are proximate mutagenic ...
*  Bruce Ames
He is the inventor of the Ames test, a system for easily and cheaply testing the mutagenicity of compounds. Ames, raised in New ... The Ames test on the other hand uses the bacteria Salmonella typhimurium to test for mutagens, and is considerably cheaper and ... Previous carcinogenic testing used live animals, and the procedures are expensive and time-consuming. This made animal testing ... The Ames test became widely used as an initial screen for possible carcinogens and has been used to identify potential ...
*  Molecule mining
Structure-Activity Relationship and Artificial Intelligence Systems To Improve in Silico Prediction of Ames Test Mutagenicity, ... Data Mining and Machine Learning Techniques for the Identification of Mutagenicity Inducing Substructures and Structure ...
*  GADD45A
To test a substance for mutagenicity, it is applied to these cells and fluorescence is measured. GADD45A has been shown to ... that expression of this gene is an indicator of DNA damage has been exploited to construct an in vitro test for mutagenicity, ...
*  Umu Chromotest
The high correlation between the Umu Chromotest and traditional Ames test for mutagenicity supports it as a reasonable ... The umu test, using only a single Salmonella strain, could potentially test a greater range of new chemicals with the same ... A simple colorimetric test is possible by adding a lactose analog which is degraded by β-galactosidase, producing a colored ... This test uses an operon fusion placing the lac operon (responsible for producing β-galactosidase, a protein which degrades ...
*  Spearmint
... showed potential for antifungal activity against food poisoning pathogens and had no evidence of mutagenicity in the Ames test ...
*  Glycidamide
Sugiura, K., & Goto, M. (1981). Mutagenicities of styrene oxide derivatives on bacterial test systems: relationship between ... Alkylation of DNA forms DNA adducts and can cause mutagenicity. There are often tumors observed at the site of exposure. ... Glycidamide gives a positive response in the Ames/Salmonella mutagenicity assay, which indicates that it can cause mutations in ...
*  Bill Harris (geneticist)
This was the exciting era of environmental toxicology with predictive mutagenicity and carcinogenicity testing of thousands of ... IRI Ltd were a contract research organisation providing safety testing facilities for new chemicals. They later merged with the ... and developed an ELISA based test for the environmental monitoring of Legionella pneumophila, marketed by Boots Microcheck. ...
*  Sudan I
The mutagenicity and genetic hazard has been evaluated with the Ames-test and animal experiments. Further it is more suspected ... Due to the suspicion of genotoxicity and mutagenicity of Sudan 1, a daily intake was not tolerable. The fast reaction of the ... The carcinogenicity is estimated by animal testing. The regulation of Sudan 1 in Europe started in 2003 after repeated ... Toxicology and toxicological testing of colorants. Review of Progress in Coloration and Related Topics 2005, 35 (1), 76-89 http ...
*  Mutagen
... they are therefore not used as a first screen for mutagenicity or carcinogenicity. Ames test - This is the most commonly used ... In Ames test, where the varying concentrations of the chemical are used in the test, the dose response curve obtained is nearly ... Sex-Linked Recessive Lethal Test - Males from a strain with yellow bodies are used in this test. The gene for the yellow body ... Rodents are usually used in animal test. The chemicals under test are usually administered in the food and in the drinking ...
*  Pangamic acid
Positive results from mutagenicity analysis via the Ames test of compounds commonly found in preparations labelled "pangamic ... Herbert V, Gardner A, Colman N (June 1980). "Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic ... Gelernt MD, Herbert V (1982). "Mutagenicity of diisopropylamine dichloroacetate, the "active constituent" of vitamin B15 ( ...
*  High production volume chemicals
Only 21 companies (or 3% of the 830 companies) have all SIDS tests available for their chemicals. The basic set of test data ... mutagenicity, ecotoxicity and environmental fate. Using SIDS and detailed exposure data OECD's High Production Volume Chemicals ... of TRI chemicals have had full SIDS testing, while only 7% of other chemicals have full test data". They wrote "...of the 830 ... In 2011, the EPA announced, but as of 2013 had yet to finalize, plans to require testing for 23 additional chemicals, so ...
*  List of geneticists
... created Ames test to screen chemicals for mutagenicity D. Bernard Amos (1923-2003), UK-US immunologist who studied the genetics ...
*  Aflatoxin B1
Chen, Tao; Heflich, Robert H; Moore, Martha M; Mei, Nan (2009). "Differential mutagenicity of aflatoxin B1in the liver of ... have been used to test for aflatoxin B1 contamination in foods. According to the Food and Agriculture Organization (FAO), the ...