vascular permeability; vascular smooth muscle contraction; allergy. antagonists of CYSLTR1 used in asthma as well as other ... vascular permeability; vascular smooth muscle contraction; allergy. antagonists of CYSLTR1 used in asthma as well as other ... platelet aggregation, vascular smooth muscle contraction. PGI2 analogs used to treat vascular disorders like pulmonary ... They stimulate vascular permeability in an ex vivo human vascular endothelial model system,[87] and in a small study of 32 ...
On vascular smooth muscle cells if not otherwise specified Transduction (↑ = increases. ↓ = decreases)[5] ... within vascular smooth muscle cells.[2] However, the specific mechanisms for generating an increased intracellular ... On smooth muscle cells: Activation of Gq --, ↑PLC activity --, ↑IP3 and DAG --, activation of IP3 receptor in SR --, ↑ ... Arginine vasopressin receptor 1 (V1) on smooth muscle cells Activation of Gq --, ↑PLC activity --, ↑IP3 and DAG --, activation ...
"Expression of functional delta opioid receptors in vascular smooth muscle". International Journal of Molecular Medicine. 6 (6 ...
... adrenoceptors in human vascular smooth muscle cells". American Journal of Physiology. Heart and Circulatory Physiology. 286 (1 ...
Hagiwara M, Endo T, Hidaka H (February 1984). "Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle ... and vascular cell adhesion molecule-1 (VCAM-1). In mice, vinpocetine reduced lipopolysaccharide inoculation induced ...
"Isolation of multiple types of plasminogen activator inhibitors from vascular smooth muscle cells". Thrombosis and Haemostasis ... "Serpins promote cancer cell survival and vascular co-option in brain metastasis". Cell. 156 (5): 1002-16. doi:10.1016/j.cell. ... "Imaging of Angiotropism/Vascular Co-Option in a Murine Model of Brain Melanoma: Implications for Melanoma Progression along ...
"Role of the small heat shock proteins in regulating vascular smooth muscle tone". Journal of the American College of Surgeons. ... Hsp20 phosphorylation correlates well with smooth muscle relaxation and is one significant phosphoprotein involved in the ... "Small heat shock proteins in smooth muscle". Pharmacology & Therapeutics. 119 (1): 44-54. doi:10.1016/j.pharmthera.2008.04.005 ... Hsp20 appears significant in development of the smooth muscle phenotype during development. Hsp20 also serves a significant ...
Takahashi K, Hiwada K, Kokubu T (June 1988). "Vascular smooth muscle calponin. A novel troponin T-like protein". Hypertension. ... Winder SJ, Walsh MP (June 1990). "Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation ... "Entrez Gene: ACTA1 actin, alpha 1, skeletal muscle". Bandman E (December 1992). "Contractile protein isoforms in muscle ... "Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell ...
Matsumoto T, Kobayashi T, Kamata K (August 2003). "Phosphodiesterases in the vascular system". J Smooth Muscle Res. 39 (4): 67- ... PDE1C has been shown to be a major regulator of smooth muscle proliferation, at least in human smooth muscle. Nonproliferating ... PDE1A most likely serves to regulate vascular smooth muscle concentration and has been found to be up-regulated in rat aorta in ... For example, in airway smooth muscles of humans and other species, generic PDE1 accounts for more than 50% of the hydrolytic ...
Indeed, direct stimulation of vascular smooth muscle, M3 mediates vasconstriction in pathologies wherein the vascular ... which diffuses to adjacent vascular smooth muscle cells and causes their relaxation, thereby explaining the paradoxical effect ... They are located in the smooth muscles of the blood vessels, as well as in the lungs. Because the M3 receptor is Gq-coupled and ... it typically causes contraction of smooth muscle, such as that observed during bronchoconstriction and bladder voiding.[21] ...
Statins also inhibit PPARγ in human macrophages, vascular endothelial cells, and smooth muscle cells; this action may ... "Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation ... In atherosclerosis, an underlying cause of Coronary artery disease and strokes, atheromatous plaques accumulate in the vascular ... plasma and erythrocytes of patients with Alzheimer's disease and in the plasma but not erythrocytes of patients with vascular ...
"The pharmacology of vascular smooth muscle". Pharmacological Reviews. 7 (2): 184-265, hier S. 213. PMID 13245382. S. Guimarães ... und β-adrenoceptors co-existing in vascular smooth muscle. Veins and their receptors remained favourites. Guimarães has ... S. Guimarães, I. Azevedo, W. Cardoso, M. C. Oliveira (1975). "Relation between the amount of smooth muscle of venous tissue and ... In 1982, Guimarães wrote in Trends in Pharmacological Sciences: „In vascular tissue there are two different biophases for ...
Szasz, Theodora; Tostes, Rita C. A. (2016). Vascular Smooth Muscle Function in Hypertension. Biota Publishing. ISBN ... muscles, nerves, veins and arteries; and special anatomy which is concerned with the internal parts of the body like the heart ...
Calcification forms among vascular smooth muscle cells of the surrounding muscular layer, specifically in the muscle cells ... of plaque-resident cells are vascular smooth muscle cell derived. Therefore, it is important to research the role of vascular ... Vascular smooth muscle cells play a key role in atherogenesis and were historically considered to be beneficial for plaque ... However, in addition to the fibrous cap, vascular smooth muscle cells also give rise to many of the cell types found within the ...
... vascular endothelial and smooth muscle cells; various types of epithelial cells, liver hepatocytes, neural tissue glial cells, ...
Khalil, Raouf A. (2010). Rho Kinase in Vascular Smooth Muscle. Morgan & Claypool Life Sciences. Nagumo, Hiromitsu; Sasaki, ... On a cellular level, ROCK has multiple functions, including regulation of smooth muscle cell contraction, cell migration, and ... "RhoA/ROCK Pathway Activation is Regulated by AT1 Receptor and Participates in Smooth Muscle Migration and Dedifferentiation via ... "Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells". American Journal of ...
Pericytes and smooth muscle cells encircle ECs when they are differentiating into arterial or venous arrangements. Surrounding ... Lymphatic-specific vascular endothelial growth factors VEGF-C and VEGF-D function as ligands for the vascular endothelial ... It is suggested pericytes and smooth muscle cells come from neural crest cells and the surrounding mesenchyme. ECs derived from ... The vascular system is made up of two parts: 1) Blood vasculature 2) Lymphatic vessels Both parts consist of ECs that show ...
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the ... Ignarro then speculated that nitric oxide could be the key to relaxing vascular smooth muscles. In turn, this led to his ... Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci ... Role of p42/p44 mitogen-activated protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell ...
"Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction". American ... "Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi. 49: 89-98. doi:10.1540/jsmr.49.89. PMC 5137305. PMID ... smooth muscle myosin IIA heavy-chain actin activated ATPase 3 μM[24] ... smooth muscle myosin IIB heavy-chain actin activated ATPase 3 μM[24] ...
"Chapter 7Rho Kinase in Vascular Smooth Muscle". Jacobs M, Hayakawa K, Swenson L, Bellon S, Fleming M, Taslimi P, Doran J ( ... Other functions involve smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, ... "Rho-associated kinase of chicken gizzard smooth muscle". The Journal of Biological Chemistry. 274 (6): 3744-52. doi:10.1074/jbc ... Fasudil has been used to characterize the role of ROCK1 in vascular function in clinical studies and has been approved for use ...
Robinson, B. F. (1981). "Drugs acting directly on vascular smooth muscle". British Journal of Clinical Pharmacology. 12 (Suppl ... Vallance, Patrick (1997). "Exploring vascular nitric oxide in health and disease. The Goulstonian Lecture 1996". Journal of the ...
Lynch RM, Paul RJ (March 1987). "Compartmentation of carbohydrate metabolism in vascular smooth muscle". The American Journal ... This was first discovered in red blood cells (Schrier, 1966), but has later been evidenced in renal cells,[5] smooth muscles ... of Na/K-ATPase molecules-specifically the α2 isoform in heart and arterial smooth muscle (Kd = 32 nM) -- are inhibited, not ... release from the muscle cells' sarcoplasmic reticulum. Immediately after muscle contraction, intracellular Ca²⁺ is quickly ...
... and LTE4 which promote vascular permeability, contract airways smooth muscle, and otherwise perturb these tissues and b) LTB4 ... monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration". Cardiovascular ... Fibroblasts, smooth muscle cells and endothelial cells express low levels of ALOX5.[6][7] Up-regulation of ALOX5 may occur ... micro-vascular permeability, and mucus secretion; they likewise contribute to various allergic and non-allergic reactions ...
... vascular smooth muscle, and skeletal muscle.[4] β3-adrenergic receptors are located in fat cells.[6] ... Since β2 adrenergic receptors can cause vascular smooth muscle dilation, beta blockers may cause some vasoconstriction. However ... Beta receptors are found on cells of the heart muscles, smooth muscles, airways, arteries, kidneys, and other tissues that are ... Stimulation of β2 receptors induces smooth muscle relaxation,[62] induces tremor in skeletal muscle,[63] and increases ...
"Vascular smooth muscle contractility depends on cell shape". Integrative Biology. 3 (11): 1063-70. doi:10.1039/c1ib00061f. PMID ... Walboomers, X. F.; Monaghan, W.; Curtis, A. S. G.; Jansen, J. A. (August 1999). "Attachment of fibroblasts on smooth and ...
... which reach vascular smooth muscle. The vasomotor center changes vascular smooth muscle tone. This changes local and systemic ... This reduces sympathetic tone to vascular smooth muscle. This reduces heart rate and vascular resistance. Digoxin increases ...
They mainly control smooth and vascular muscle dilation. Strength of response is dependent upon the concentration of receptors ...
cause constriction or dilation in vascular smooth muscle cells. *cause aggregation or disaggregation of platelets ... acts on mesangial cells (specialised smooth muscle cells) in the glomerulus of the kidney to increase glomerular filtration ... as well as regulating the contraction of smooth muscle tissue.[3] Conversely, thromboxanes (produced by platelet cells) are ... "Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (5): 986-1000. doi:10.1161/ATVBAHA.110.207449. PMC 3081099. PMID ...
"The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells". Biochem Biophys ... positive regulation of smooth muscle cell proliferation. • positive regulation of glial cell proliferation. • cellular response ...
It can be used to treat hypertension as it will relax vascular smooth muscle to lower blood pressure. Hyperpolarisation of ... smooth muscle cell membranes pulls their membrane potential away from the threshold, so making it more difficult to excite them ...
One of the main advantages of using PET is that it can also provide muscle activation data about deeper lying muscles such as ... Cardiology, atherosclerosis and vascular disease study: In clinical cardiology, FDG-PET can identify so-called "hibernating ... a smoothing prior leading to total variation regularization or a Laplacian distribution leading to ℓ. 1. {\displaystyle \ell _{ ... Musculoskeletal imaging: PET has been shown to be a feasible technique for studying skeletal muscles during exercises like ...
"Muscle Activation of Paraspinal Muscles in Different Types of High Heels during Standing." Journal of Physical Therapy Science ... Lastly, American Smooth shoes are closed toed, flexible soled shoes that range in heel height from 2 to 2.5 inches. An ... "Influence of High-Heeled Shoes on Venous Function in Young Women." Journal of Vascular Surgery, vol. 56, Oct 2012. ... The researchers mentioned that over time these results would increase local muscle fatigue that could lead to muscle swelling, ...
Smooth. muscle. *Calmodulin. *Vascular smooth muscle. Striated. muscle. Skeletal. muscle. Costamere/. DAPC. ... Muscle spindles are stretch receptors within the body of a muscle that primarily detect changes in the length of the muscle. ... Muscle spindles are found within the belly of muscles, between extrafusal muscle fibers.[b] The specialised fibers that ... Muscle spindle. Mammalian muscle spindle showing typical position in a muscle (left), neuronal connections in spinal cord ( ...
... such as the effects of inflammatory mediators on airway and vascular smooth muscle tone. As a rule of thumb, all these models ... Histological changes consist of epithelial necrosis and detachment, increase in the area of smooth muscle, epithelial ... is affected by increases in the dispersion of both alveolar ventilation and cardiac output because bronchial and vascular ...
a) Vascular thrombosis in three or more organs or tissues and. *b) Development of manifestations simultaneously or in less than ... Anti-smooth muscle *Anti-actin. *Anti-TPO/Antimicrosomal. Cell membrane. *Anti-ganglioside ... Classification with APS requires evidence of both one or more specific, documented clinical events (either a vascular ... are associated with thrombosis and vascular disease. The syndrome can be divided into primary (no underlying disease state) and ...
Julie Hazel Campbell is a cell biologist specializing in vascular smooth muscle. Dr. Campbell's postdoctoral experiences ... vascular smooth muscle and tissue engineering of the arteries. - Therapeutic Uses of Beta-casein a2 and dietary supplement ... Her studies consolidated her early findings on vascular smooth muscle biology. In 1991, she left her position as the Principal ... In the early 1970s, she was the first to discover that smooth muscle cells can exist in a spectrum of phenotypes that control ...
Congenital smooth muscle hamartoma. *Cystic lymphatic malformation. *Median raphe cyst. *Melanotic neuroectodermal tumor of ...
... reach underlying vascular smooth muscle cells at a concentration sufficient to activate ion channels, and initiate smooth ... its action is to hyperpolarize vascular smooth muscle cells, causing these cells to relax, thus allowing the blood vessel to ... Contact-mediated mechanisms bestow endothelial hyperpolarization that passively spreads to the smooth muscle through inter- ... "Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?". British Journal of ...
... vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. ... PDGF[1][2] is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells. In ... it is also produced by other cells including smooth muscle cells, activated macrophages, and endothelial cells[5] ... Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)[16][17] which are ...
It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also ... from the effect of snake venom on intestinal smooth muscle, which was noted to slowly contract.[citation needed] ...
positive regulation of vascular smooth muscle cell proliferation. • negative regulation of gene expression. • protein ... positive regulation of smooth muscle cell proliferation. • positive regulation of protein kinase activity. • positive ... positive regulation of leukocyte adhesion to vascular endothelial cell. • positive regulation of blood microparticle formation ... "The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk". J Physiol. 587 (23): 5559-5568. doi ...
There is a smooth muscle layer below the epithelium arranged as two ribbons of muscle that spiral in opposite directions. This ... "Journal of Cardiothoracic and Vascular Anesthesia. 17 (3): 289-98. doi:10.1016/S1053-0770(03)00046-6. PMID 12827573. Archived ... Hyaline cartilage is present in the bronchi, surrounding the smooth muscle layer. In the main bronchi, the cartilage forms C- ... As the cartilage decreases, the amount of smooth muscle increases. The mucous membrane also undergoes a transition from ...
Underlying the mucous membrane in the mouth is a thin layer of smooth muscle tissue and the loose connection to the membrane ... Vascular *Budd-Chiari syndrome. *Hepatic veno-occlusive disease. *Portal hypertension. *Nutmeg liver ... The muscular layer of the body is of smooth muscle tissue that helps the gallbladder contract, so that it can discharge its ... The suspensory muscle attaches the ascending duodenum to the diaphragm. This muscle is thought to be of help in the digestive ...
Some of the other signs are poor eyelid function, contracture of the facial muscles, a backward tilt of the head with ... These are fine movements, that can be mistaken for nystagmus, except that they are saccadic in nature, with no smooth phase. ... strength training with progressive resistive exercises and isokinetic exercises and stretching of the neck muscles.[37] While ... stiffening of the neck muscles, sleep disruption, urinary incontinence and constipation. The visual symptoms are of particular ...
Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type. Atherosclerosis ...
... which relax smooth muscle of constricted airway in asthma, or (4) mast cell stabilizers, which inhibit the degranulation of ... and increased vascular permeability, it is presumed, to allow other immune cells to gain access to tissues, but which can lead ...
The common ostrich's sternum is flat, lacking the keel to which wing muscles attach in flying birds.[17] The beak is flat and ... The feathers lack the tiny hooks that lock together the smooth external feathers of flying birds, and so are soft and fluffy ... The air then flows through the anatomical dead space of a highly vascular trachea (c. 78 cm (31 in)) and expansive bronchial ... During expiration, oxygen poor air flows to the anterior air sacs[62] and is expelled by the action of the expiratory muscles. ...
It increases vessel permeability, dilates blood vessels and causes smooth muscle cells to contract. Bradykinin plays an ... "Vascular Health and Risk Management. 6: 795-802. doi:10.2147/vhrm.s4332. PMC 2941790. PMID 20859548.. ...
Congenital smooth muscle hamartoma. *Cystic lymphatic malformation. *Median raphe cyst. *Melanotic neuroectodermal tumor of ...
... induces iNOS in bovine vascular smooth muscle cells: no relationship between nitric oxide production and gamma-carboxylation ...
They are the superior longitudinal muscle, the inferior longitudinal muscle, the vertical muscle, and the transverse muscle. ... A deceptive person is said to have a forked tongue, and a smooth-talking person said to have a silver tongue. ... The sublingual route takes advantage of the highly vascular quality of the oral cavity, and allows for the speedy application ... MusclesEdit. The eight muscles of the human tongue are classified as either intrinsic or extrinsic. The four intrinsic muscles ...
... and LTE4 which promote vascular permeability, contract airways smooth muscle, and otherwise perturb these tissues and b) LTB4 ... monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration". Cardiovascular ... Fibroblasts, smooth muscle cells and endothelial cells express low levels of ALOX5.[6][7] Up-regulation of ALOX5 may occur ... micro-vascular permeability, and mucus secretion; they likewise contribute to various allergic and non-allergic reactions ...
negative regulation of vascular smooth muscle cell proliferation. Sources:Amigo / QuickGO. Orthologs. ...
Azzopardi G.; Petkov N. (2011). Detection of retinal vascular bifurcations by trainable V4-like filters, in Computer Analysis ... The mapping of vascular bifurcations is one of the basic steps in biometric identification.[45] Results of such analyses of ... "Retinal fundus images - Ground truth of vascular bifurcations and crossovers". University of Groningen. Retrieved 20 April 2018 ... In birds, the pecten is a vascular structure of complex shape that projects from the retina into the vitreous humour; it ...
Congenital smooth muscle hamartoma. *Cystic lymphatic malformation. *Median raphe cyst. *Melanotic neuroectodermal tumor of ...
The water vascular system that develops from their middle coelom or hydrocoel. Echinoderms use this system for many things ... In recent years, the sea cucumber industry in Alaska has increased due to increased demand for the skins and muscles to China.[ ... the podia can be of smooth aspect or provided with fleshy appendages (like Thelenota ananas). The podia on the dorsal surface ... In most sea cucumbers, this is the only substantial part of the skeleton, and it forms the point of attachment for muscles that ...
Smooth. muscle. *Calmodulin. *Vascular smooth muscle. Striated. muscle. Skeletal. muscle. Costamere/. DAPC. ... This muscle article is a stub. You can help Wikipedia by expanding it.. *v ... Perimysium is a sheath of connective tissue that groups muscle fibers into bundles (anywhere between 10 and 100 or more) or ... Studies of muscle physiology suggest that the perimysium plays a role in transmitting lateral contractile movements. This ...
smooth muscle:. *Leiomyoma/leiomyosarcoma. skeletal muscle:. *Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma *Sarcoma ... vascular. *see Template:Soft tissue tumors and sarcomas, Template:Vascular tumors, Template:Myeloid malignancy (for ...
By acting on vascular smooth muscle, they reduce contraction of the arteries and cause an increase in arterial diameter, a ... The class of CCBs known as dihydropyridines mainly affect arterial vascular smooth muscle and lower blood pressure by causing ... CCBs do not work on venous smooth muscle).. *By acting on cardiac muscles (myocardium), they reduce the force of contraction of ... Voltage-dependent calcium channels are responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle ...
... smooth muscle and the extracellular matrix are quantitatively the largest components of the aortic vascular wall. The ... This contribution of the neural crest to the great artery smooth muscle is unusual as most smooth muscle is derived from ... The smooth muscle of the great arteries and the population of cells that form the aorticopulmonary septum that separates the ... In fact the smooth muscle within the abdominal aorta is derived from mesoderm, and the coronary arteries, which arise just ...