It has features of a cytoplasmic signaling protein, including several domains that allow for binding to multiprotein complexes ... The AIF1 gene is located within a segment of the major histocompatibility complex class III region. It has been shown that this ... Hung AY, Sheng M (February 2002). "PDZ domains: structural modules for protein complex assembly". The Journal of Biological ... December 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". ...

HATs are part of a multiprotein complex that is recruited to chromatin when activators bind to DNA binding sites. Acetylation ... The SWI/SNF protein complex in yeast is one example of a chromatin remodeling complex that regulates the expression of many ... In eukaryotes, genomic DNA is coiled into protein-DNA complexes called chromatin. Histones, which are the most prevalent type ... The nucleosome remodeling complexes reposition nucleosomes by several mechanisms, enabling or disabling accessibility of ...

MLL1 is a multiprotein complex that regulates gene expression and chromosomal translocations involving this gene often lead to ... Pin1 also triggers the activation of the DSIF complex and NELF, which are responsible for pausing RNAP II in mammalian cells, ... K4me3 represses gene transcription and depends upon the Set1 methyltransferase complex subunit Spp1 being balanced with the ...

Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, ... "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium ... Bohl J, Brimer N, Lyons C, Vande Pol SB (Mar 2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and ... Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to ...

... analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex". ... The CacyBP/SIP complex instead, is known to be a part of stress respons, since it interacts with chaperone HSP90. GRCh38: ... It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of ...

Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97 ... Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, ... Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to ... "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. ...

... is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly". The Journal of Biological ... The elastin receptor complex includes S-Gal, neuraminidase and Cathepsin A. When elastin-derived peptides bind to the S-Gal ... The S-Gal protein is a peripheral membrane protein that functions as part of an elastin receptor complex on the surface of ... The ability of the GLB1-derived elastin binding protein and the elastin receptor complex to influence cell proliferation ...

... is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly(A) 3 ... Ccr4-Not complex plays an important role in mRNA decay and protein quality control in the cytoplasm. The human CCR4-Not complex ... The complex is present both in the nucleus where it regulates transcription and in the cytoplasm where it associates with ... Miller, Jason E.; Reese, Joseph C. (2012-03-15). "Ccr4-Not complex: the control freak of eukaryotic cells". Critical Reviews in ...

This multiprotein-mRNA complex then recruits the ribosome subunits and scans the mRNA until it reaches the start codon. ... Once eIF4F is bound to the mRNA this protein complex interacts with the poly(A) binding protein which is present within the 3′ ...

This multiprotein junctional complex has a regulatory function in passage of ions, water and solutes through the paracellular ... This cooperation provides the formation of large molecular complex at tight junctions in the endothelium. JAM4 is a component ...

Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine ... "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". ... Rountree MR, Bachman KE, Baylin SB (July 2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at ... Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (September 1999). "Mi-2 complex couples DNA methylation to ...

"Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol ... "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes Dev. 16 (24): 3130-5. doi ... Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK ... Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (May 2000). "A core SMRT corepressor complex containing ...

"Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". ... "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes & Development. 16 (24): ... Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (February 1998). "Role of the histone deacetylase complex in acute ... Deltour S, Guerardel C, Leprince D (December 1999). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a ...

Wei CJ, Francis R, Xu X, Lo CW (May 2005). "Connexin43 associated with an N-cadherin-containing multiprotein complex is ... Martin PE, Errington RJ, Evans WH (2001). "Gap junction assembly: multiple connexin fluorophores identify complex trafficking ...

Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of ... Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (September 2006). "Epilepsy-related ligand/receptor complex LGI1 ... Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL (July 2003). "Exocyst complex subunit sec8 binds to ... Sheng M, Sala C (2001). "PDZ domains and the organization of supramolecular complexes". Annu. Rev. Neurosci. 24: 1-29. doi: ...

1996). "Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in ... This protein forms a complex with MRE11 and NBS1 (also known as Xrs2 in yeast). This MRN complex (MRX complex in yeast) binds ... identification of a conserved multiprotein complex implicated in recombinational DNA repair". Mol. Cell. Biol. 16 (9): 4832-41 ... Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (2000). "BASC, a super complex of BRCA1-associated proteins involved in ...

"Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". ... Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D (September 2000). "HDAC1, a histone deacetylase, forms a complex with Hus1 and ... Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (February 1998). "Role of the histone deacetylase complex in acute ... Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK ...

"Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". ... "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". ... Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK ...

... identification of a conserved multiprotein complex implicated in recombinational DNA repair". Molecular and Cellular Biology. ... The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and ... identification of a conserved multiprotein complex implicated in recombinational DNA repair". Molecular and Cellular Biology. ... Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (April 2000). "BASC, a super complex of BRCA1-associated proteins involved ...

Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of ... As a result, CASK is unable to form complexes with other proteins leading to a cascade of events. Research has shown there is ... Butz S, Okamoto M, Südhof TC (September 1998). "A tripartite protein complex with the potential to couple synaptic vesicle ... Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (September 2004). "Nephrin forms a complex with adherens junction ...

Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97 ... Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97 ... "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)- ... "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)- ...

Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of ... Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, ... "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. ... "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. ...

"Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol ... Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK ... Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (May 2000). "A core SMRT corepressor complex containing ... Underhill C, Qutob MS, Yee SP, Torchia J (December 2000). "A novel nuclear receptor corepressor complex, N-CoR, contains ...

A tetratricopeptide repeat region, a protein-protein interaction domain most often found in multiprotein complexes, is present ... and a ternary complex made of NSP3, RoXaN, and eIF4G I can be detected in rotavirus-infected cells, implicating RoXaN in ... forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3". J. Virol. 78 (8): 3851-62. doi:10.1128/JVI. ...

Another proposed mechanism for regulation of apoptosis is oligomerization, or the process of forming multi-protein complexes ... The heteromeric complexes that contain the distinct pore are electrically inactive or non-conducting, but unlike other ... Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ...

... and alpha-actinin are components of the nephrin multiprotein complex. Proc. Natl. Acad. Sci. 102:9814-19. Head, B. P., Patel, H ...

Recognition of PAMPs and DAMPs triggers the formation of multi-protein complex inflammasomes, which then activates caspases to ... In gastric cancer cells, presence of GSDMD can inhibit cyclin A2/CDK2 complexes, leading to cell cycle arrest and thus inhibit ... In addition to their formation as a complex to induce pyroptosis, inflammasomes can also be integral components of larger cell ... The process is initiated by formation of a large supramolecular complex termed the inflammasome (also known as a pyroptosome) ...

Mediator complex subunit 9 (Med9) is a protein that in humans is encoded by the MED9 gene. The multiprotein Mediator complex is ... "Entrez Gene: Mediator complex subunit 9". Retrieved 2018-02-06. v t e This article incorporates text from the United States ... The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith- ...

This multi-protein complex is stimulated by a non-coding RNA, called miRNA in Eukaryotic cells and sRNA in bacteria. Small ... The multi-protein complex also serves as a machine for processing structured RNA precursors in the course of their maturation. ... The multiprotein complex RNA degradosome in E. coli consists of 4 canonical components: RNase E: a large hydrolytic endo- ... The degradosome is a multiprotein complex present in most bacteria that is involved in the processing of ribosomal RNA and the ...

... analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex". J ... "The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies". Biochemistry. 44 (27): 9462-71. doi: ...

They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible ...

Exon junction complexes (EJCs) mark the exon-exon boundaries. EJCs are multiprotein complexes that assemble during splicing at ... "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense- ... The Ski7-exosome complex rapidly deadenylates the mRNA molecule which allows the exosome to decay the transcript in a 3' to 5' ... A surveillance complex consisting of various proteins (eRF1, eRF3, Upf1, Upf2 and Upf3) is assembled and scans the mRNA for ...

They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible ...

HATs form large multiprotein complexes that weaken the association of histones to DNA by acetylating the N-terminal histone ... In this method, an activator binds to an enhancer site and recruits a HAT complex that then acetylates nucleosomal promoter- ... Once the activator-coactivator complex binds to the enhancer, RNA polymerase II and other general transcription machinery are ... Binding of the activator-coactivator complex increases the speed of transcription by recruiting general transcription machinery ...

These channels are occupied by nuclear pore complexes (NPCs), complex multiprotein structures that mediate the transport across ... At this point, Ran-GTP will bind to the importin-protein complex, and its binding will cause the importin to lose affinity for ... The protein is released, and now the Ran-GTP/importin complex will move back out of the nucleus through the nuclear pore. A ... The presence of several million pore complexes in the oocyte nuclear membrane and the fact that they appeared to admit many ...

... work large multiprotein complexes. If the noise in proteins of such complexes are to discoordinated, it can lead to reduced ... level of production of multiprotein complexes, with potentially deleterious effects. Reduction in noise may provide an ...

The E3, which may be a multi-protein complex, is, in general, responsible for targeting ubiquitination to specific substrate ... and the SCF complex (Skp1-Cullin-F-box protein complex). SCF complexes consist of four proteins: Rbx1, Cul1, Skp1, which are ... F-box proteins contain an F-box, which binds the rest of the SCF complex, and a substrate binding domain, which gives the E3 ... E3A mdm2 Anaphase-promoting complex (APC) UBR5 (EDD1) SOCS/ BC-box/ eloBC/ CUL5/ RING LNXp80 CBX4, CBLL1 HACE1 HECTD1, HECTD2, ...

She is known for her work on multiprotein complexes involved in gene expression and development of new supports for cryo-EM. ... Her group uses in vitro reconstitution, biochemical assays and cryo-EM to understand the function of multiprotein complexes ... She performed in vitro biochemical characterisation of the activity of the anaphase-promoting complex (APC) and used cryo-EM to ... Rajendra E, Garaycoechea JI, Patel KJ, Passmore LA (2014). "Abundance of the Fanconi anaemia core complex is regulated by the ...

... studies the composition and function of organelles and multiprotein complexes found within the nucleus. This work is helping to ... as well as the protein-DNA complexes that are involved in this packaging. The controlled unravelling of DNA is an important ...

1999). "memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell ... "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes". Mol. ... "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes". Mol. ... a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. 275 (20): 14910-5. ...

... protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. ... Hurd TW, Gao L, Roh MH, Macara IG, Margolis B (2003). "Direct interaction of two polarity complexes implicated in epithelial ... "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity". Curr. ... "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 ...