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*  Polycomb Group Proteins and Cancer
PcG proteins function as multiprotein complexes. Biochemical purification and functional genetic studies have assigned the ... and Polycomb Repressive Complex 2 (PRC2). The exact composition of these complexes varies but their core components are ... All PRC1 complexes contain homologs of the Drosophila Ring protein. Ring1A and Ring1B (which are also known as Rnf1 and Rnf2, ... PRC1 complexes can be divided into at least two classes according to the presence or absence of Cbx proteins, which are ...
*  Caspase
Multiprotein complexes often form during caspase activation. Some activating multiprotein complexes includes: The death- ... This is done by the formation of a multiprotein Death Inducing Signalling Complex (DISC) that recruits and activates a pro- ... This cellular ion imbalance leads to oligomerisation of NLRP3 molecules to form a multiprotein complex called the NLRP3 ... These proteins allow caspase-1 activation by forming a multiprotein activating complex called Inflammasomes. For example, a NOD ...
*  ETS1
Their interaction results in formation of multiprotein complexes. When Ets1 interacts with other transcription factors (Runx1, ... ETS1 binds with DNA-dependent protein kinase (DNA-PK) [where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku ( ...
*  NLRP7
... via their involvement in multiprotein complexes called inflammasomes. ENSG00000167634, ENSG00000278173, ENSG00000277179, ...
*  Von Willebrand factor type C domain
A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in ... The presence of this region in a number of other complex-forming proteins points to the possible involvement of the VWFC domain ... Fraser extracellular matrix complex subunit 1 (FRAS1) Neural EGFL like 1 (NELL1) Neural EGFL like 2 (NELL2) Peroxidasin like ( ... in complex formation. BMP binding endothelial regulator (BMPER) Cysteine-rich motor neuron 1 protein (CRIM1) Extracellular ...
*  Von Willebrand factor type A domain
A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in ...
*  Anammox
Nov 2015). "The inner workings of the hydrazine synthase multiprotein complex". Nature. 527 (7578): 394-7. Bibcode:2015Natur. ... At the same time, nitrite is reduced to hydroxylamine at the cytoplasmic site of the same enzyme complex responsible for ... One mechanism hypothesizes that a membrane-bound enzyme complex converts ammonium and hydroxylamine to hydrazine first, ... ammonium and hydroxylamine are converted to hydrazine by a membrane-bound enzyme complex, hydrazine is oxidized in the ...
*  Hsp90 inhibitor
Hsp90 acts in a multiprotein complex with several co-chaperones. One of these, cochaperone p23, appears to stabilize Hsp90- ... Finally they concluded that Hsp90, and consequently signaling mediated by client proteins in the Hsp90 multiprotein complex, ... Geldanamycin and radicicol tightly bind to this pocket and prevent the release of protein from chaperone complex. Thus the ... Mitochondrial Hsp90 is involved in complex signaling pathway that prevents initiation of induced apoptosis. Gamitrinib is a ...
*  SMC1A
The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural ... Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore ... 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proc. Natl. Acad. ... 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749-62. doi: ...
*  Protein quaternary structure
Structural biology Nucleic acid quaternary structure Multiprotein complex Biomolecular complex Here quaternary means "fourth- ... Other assemblies referred to instead as multiprotein complexes also possess quaternary structure. Examples include nucleosomes ... In some cases, proteins form complexes that then assemble into even larger complexes. In such cases, one uses the nomenclature ... e.g., "dimer of dimers" or "trimer of dimers", to suggest that the complex might dissociate into smaller sub-complexes before ...
*  APBA1
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of ... "Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach". EMBO J. 21 (10): 2332-42. doi: ... It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to ... Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to ...
*  PDLIM5
LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in ... 2003). "A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels". Nat. Neurosci. 6 (5): 468-75. doi: ...
*  LIN7C
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, ... "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium ... "Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach". EMBO J. 21 (10): 2332-42. doi: ... Bohl J, Brimer N, Lyons C, Vande Pol SB (2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 ...
*  NLRP4
... via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM] GRCh38: Ensembl ...
*  NABP1
"HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response". The Journal of Biological ... Huang J, Gong Z, Ghosal G, Chen J (August 2009). "SOSS complexes participate in the maintenance of genomic stability". ... "Streamlined analysis schema for high-throughput identification of endogenous protein complexes". Proceedings of the National ...
*  Endoplasmic reticulum
Nascent peptides reach the ER via the translocon, a membrane-embedded multiprotein complex. Proteins that are destined for ... A ribosome only binds to the RER once a specific protein-nucleic acid complex forms in the cytosol. This special complex forms ... The rough endoplasmic reticulum works in concert with the Golgi complex to target new proteins to their proper destinations. A ... and Golgi Complex". Molecular Biology of the Cell. 14 (3): 889-902. doi:10.1091/mbc.E02-08-0468. PMC 151567 . PMID 12631711. ...
*  GINS2
Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, Araki H (2003). "GINS, a novel multiprotein complex required for ... DNA replication complex GINS protein PSF2 is a protein that in humans is encoded by the GINS2 gene. GINS2 has been shown to ... "Entrez Gene: GINS2 GINS complex subunit 2 (Psf2 homolog)". Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J ...
*  EXOC7
"The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae". EMBO J. 15 (23): 6483-94. PMC ... Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. It was formerly known as Exo70. It forms ... In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the ... Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (Apr 2003). "The exocyst complex is required for targeting of Glut4 to the ...
*  ATP-sensitive potassium channel
Ardehali H, Chen Z, Ko Y, Mejía-Alvarez R, Marbán E (August 2004). "Multiprotein complex containing succinate dehydrogenase ... More recently, it was discovered that certain multiprotein complexes containing succinate dehydrogenase can provide activity ...
*  HDAC4
It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Furthermore, HDAC4 is required for TGFbeta1-induced ... "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". ... "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". The EMBO Journal. 19 (16): 4342-50 ...
*  Beta-catenin
Geng L, Burrow CR, Li HP, Wilson PD (December 2000). "Modification of the composition of polycystin-1 multiprotein complexes by ... Cell-cell adhesion complexes are essential for the formation of complex animal tissues. β-catenin is part of a protein complex ... This complex is usually called the beta-catenin destruction complex, although it is distinct from the proteosome machinery ... "Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex". Genes & ...
*  CDH1 (gene)
Geng L, Burrow CR, Li HP, Wilson PD (December 2000). "Modification of the composition of polycystin-1 multiprotein complexes by ... Hazan RB, Kang L, Roe S, Borgen PI, Rimm DL (December 1997). "Vinculin is associated with the E-cadherin adhesion complex". J. ... Huber AH, Weis WI (May 2001). "The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand ... Wijnhoven BP, Dinjens WN, Pignatelli M (2000). "E-cadherin-catenin cell-cell adhesion complex and human cancer". The British ...
*  Postsynaptic density
April 2006). "Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic ...
*  EXOC6
It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring ... Exocyst complex component 6 is a protein that in humans is encoded by the EXOC6 gene. The protein encoded by this gene is ... Exocyst complex component 6". Zhang XM, Ellis S, Sriratana A, Mitchell CA, Rowe T (October 2004). "Sec15 is an effector for the ... "The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit". Journal of Cell ...
*  Origin recognition complex
Bell SP, Stillman B (May 1992). "ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex ... First, the ORC and Cdc6 form a complex on origin DNA (marked by ARS type regions). New ORC/Cdc6 complexes then recruit Cdt1/ ... DnaA Pre Replication Complex DNA Helicase Cyclins Cyclin Dependant Kinases (CDK) Origin Recognition Complex at the US National ... In molecular biology, Origin Recognition Complex (ORC) is a multi-subunit DNA binding complex (6 subunits) that binds in all ...
*  WIPI2
They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible ...