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*  Pyruvate dehydrogenase lipoamide kinase isozyme 1
... is a part of a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the ... Within the complex, there are three serine residues on the E1 component that are sites for phosphorylation; this ... As PDK1 regulates the PDH complex, it has been proven to be an important regulator in certain cells, including the beta cells ... The Pyruvate Dehydrogenase (PDH) complex must be tightly regulated due to its central role in general metabolism. ...
*  Multienzyme complex
A multienzyme complex has several catalytic domains on several polypeptide chains and can therefore catalyze multiple reactions ...
*  Perry A. Frey
Kresge, Nicole; Robert D. Simoni; Robert L. Hill (21 August 2009). "Multienzyme Complexes and Hydrogen Transfer: the Work of ...
*  NEU1
"Mutations in sialidosis impair sialidase binding to the lysosomal multienzyme complex". J. Biol. Chem. 276 (20): 17286-90. doi: ... "Association of N-acetylgalactosamine-6-sulfate sulfatase with the multienzyme lysosomal complex of beta-galactosidase, ... In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter ... sialidase molecular defects in sialidosis patients suggests the structural organization of the lysosomal multienzyme complex". ...
*  Neocallimastix patriciarum
"Purification and characterization of a cellulolytic multienzyme complex produced by Neocallimastix patriciarum J11". ...
*  Inosinic acid
Enzymes taking part in IMP synthesis constitute a multienzyme complex in the cell. Evidences demonstrate that there are ... The inosinate synthesis is complex, beginning with a 5-phosphoribosyl-1-pyrophosphate (PRPP). In the first step, an amino group ...
*  Eubacterium acidaminophilum
"Purification and partial characterization of the glycine decarboxylase multienzyme complex from Eubacterium acidaminophilum". ...
*  Methylotroph
... a bacterial dehydrogenase in a multienzyme complex". FEBS Letters. 168 (2): 217-221. doi:10.1016/0014-5793(84)80249-5. ISSN ...
*  Dihydrolipoyl transacetylase
... is an enzyme component of the multienzyme pyruvate dehydrogenase complex. The pyruvate dehydrogenase complex is responsible for ... de Kok A, Hengeveld AF, Martin A, Westphal AH (Jun 1998). "The pyruvate dehydrogenase multi-enzyme complex from Gram-negative ... "Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex". Science. 255 (5051): 1544-50. Bibcode: ... Typically PDH is the result of a mutation in the X-linked gene for the E1 subunit of the pyruvate dehydrogenase complex. ...
*  Degradosome
The composition of this multienzyme may vary depending on the organism. The multiprotein complex RNA degradosome in E. Coli ... it is really difficult for RNA to scape from the complex. The RNA degradosome is a huge multi-enzyme association that is ... function and relationship in other ribonucleolytic multienzyme complexes". Biochem. Soc. Trans. 30 (2): 150-5. doi:10.1042/ ... This muli-protein complex is stimulated by a non-coding RNA, called miRNA in Eukaryotic cells and sRNA in bacteria. Small ...
*  DARS (gene)
Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of aminoacyl-tRNA synthetases. Aspartyl-tRNA synthetase ... 1999). "Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex". Proc. Natl. Acad. Sci. U.S.A. 96 ... Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts ... 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys ...
*  Exosome complex
... function and relationship in other ribonucleolytic multienzyme complexes". Biochem. Soc. Trans. 30 (2): 150-5. doi:10.1042/ ... The exosome complex (or PM/Scl complex, often just called the exosome) is a multi-protein intracellular complex capable of ... Exosome complexes are found in both eukaryotic cells and archaea, while in bacteria a simpler complex called the degradosome ... In yeast, Rrp44 is associated with all exosome complexes and has a crucial role in the activity of the yeast exosome complex. ...
*  Congregibacter litoralis
Spring, S (2014). "Function and Evolution of the Sox Multienzyme Complex in the Marine Gammaproteobacterium Congregibacter ... When grown in culture, C. litoralis KT71 has a generation time of 4.5 hours and prefers to grow on complex substrates where the ... used direct plating on complex low-nutrient media called MPM developed by Schut et al. MPM was designed to mimic seawater. ... and fatty acids as well as more complex substrates like yeast extract and trypticase peptone. Within its genome, genes, ...
*  Cytosol
Mowbray J, Moses V (June 1976). "The tentative identification in Escherichia coli of a multienzyme complex with glycolytic ... Consequently, the importance of these complexes for metabolism in general remains unclear. Some protein complexes contain a ... Srere PA (1987). "Complexes of sequential metabolic enzymes". Annu. Rev. Biochem. 56: 89-124. doi:10.1146/annurev.bi.56.070187. ... The cytosol is a complex mixture of substances dissolved in water. Although water forms the large majority of the cytosol, its ...
*  Naringinase
It is a multienzyme complex which possesses alpha-L-rhamnosidase and beta glucosidase active centers. The E.C. No.(EC 3.2.1.40 ...
*  Sedoheptulose-bisphosphatase
Some studies have suggested the SBPase may be part of a large (900 kDa) multi-enzyme complex along with a number of other ... Ellis K.H; Arkona C.; Mantbuffel R.; Adler K. (June 1993). "Calvin cycle multienzyme complexes are bound to chloroplast ... "Origin and Distribution of Calvin Cycle Fructose and Sedoheptulose Bisphosphatases in Plantae and Complex Algae: A Single ... Secondary Origin of Complex Red Plastids and Subsequent Propagation via Tertiary Endosymbioses". Protist. 158 (3): 263-276. doi ...
*  OGDH
This enzyme is also part of a larger multienzyme complex that channels the intermediates in the catalysis between subunits of ... This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2- ... "Crystal structure of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex". Journal of ... "Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity". The ...
*  Nodularin
Synthesis is conducted by multienzyme complexes, such as peptide synthetases, polypetide synthases, and tailoring enzymes. The ... nodularin is processed in a complex manner to induce toxic effects. During digestion, nodularins diffuse from small intestine ...
*  Fatty acid synthase
"Specific release of the thioesterase component of the fatty acid synthetase multienzyme complex by limited trypsinization". ... Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole ... as the domains of the FAS II enzymes are largely homologous to their domain counterparts in FAS I multienzyme polypeptides. ... of yeast FAS and mammalian FAS show two distinct organization of highly conserved catalytic domains/enzymes in this multi-enzyme ...
*  Metabolon
in Russian)[2] Kurganov B.I., Lyubarev A.E. Enzymes and multienzyme complexes as controllable systems. In: Soviet Scientific ... This hypothesis was well accepted in the former USSR and further developed for the complex of glycolytic enzymes (Embden- ... in Russian) [1]. Kurganov B. I, Lyubarev A. E. Hypothetical structure of the complex of glycolytic enzymes (glycolytic ... In biochemistry, a metabolon is a temporary structural-functional complex formed between sequential enzymes of a metabolic ...
*  Pyruvate dehydrogenase (lipoamide) alpha 2
The protein encoded by the human PDHA2 gene is part of the pyruvate dehydrogenase multienzyme complex. The entire human complex ... The E1 complex specifically uses the TPP cofactor to cleave the Calpha-C(=O) bond of pyruvate, and then transfer the acetyl ... Overall the complex catalyzes five reactions, with the overall reaction being: Pyruvate + CoA + NAD+ → acetyl-CoA + CO2 There ... The pyruvate dehydrogenase complex is responsible for the oxidative decarboxylation of pyruvate, with the final product being ...
*  Dihydrolipoyllysine-residue succinyltransferase
... structure of the truncated cubic core component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex". J. ... the core of the 2-oxoglutarate dehydrogenase complex". Proc. Natl. Acad. Sci. U.S.A. 68 (6): 1135-7. doi:10.1073/pnas.68.6.1135 ...
*  Pyruvate dehydrogenase
"Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution". ... While defects have been identified in all 3 enzymes of the complex, the E1-α subunit is predominantly the culprit. Malfunction ... Pyruvate Dehydrogenase Complex Deficiency at eMedicine Recny MA, Hager LP (1982). "Reconstitution of native Escherichia coli ... Pyruvate dehydrogenase (E1) performs the first two reactions within the pyruvate dehydrogenase complex (PDC): a decarboxylation ...
*  Cellulose
Such enzymes are usually secreted as part of multienzyme complexes that may include dockerins and carbohydrate-binding modules ... In vascular plants cellulose is synthesized at the plasma membrane by rosette terminal complexes (RTCs). The RTCs are hexameric ... "Immunogold labeling of rosette terminal cellulose-synthesizing complexes in the vascular plant vigna angularis". The Plant Cell ...
*  Purinosome
The purinosome is a putative multi-enzyme complex that carries out de novo purine biosynthesis within the cell. It is ... Thus far, isolation of a multienzyme complex inclusive of all purine biosynthesis enzymes has not been achieved. Purinosome ... The enzymes of the multi-step de novo purine biosynthesis pathway have been postulated to form a multi-enzyme complex to ... "Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2". J Biol Chem. 285 (15): 11093-11099. doi:10.1074/ ...
*  Dihydrolipoamide dehydrogenase
This enzyme is required for the complete reaction of at least five different multi-enzyme complexes. Additionally, DLD is a ... In these complexes, DLD converts dihydrolipoic acid and NAD+ into lipoic acid and NADH. DLD also has diaphorase activity, being ... Hiromasa Y, Fujisawa T, Aso Y, Roche TE (2004). "Organization of the cores of the mammalian pyruvate dehydrogenase complex ... 2004). "Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by ...
*  Sheldon Schuster
The Regulation of the Pyruvate Dehydrogenase Multienzyme Complex by Calcium and Magnesium in Heart Mitochondrial Systems (Ph. D ...