"Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II". Eur. J. ... Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to ... Geppert M, Goda Y, Stevens CF, Südhof TC (1997). "The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle ... Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered ...

... and Rho family monomeric GTP-binding proteins and protein kinase C-alpha". The Journal of Biological Chemistry. 272 (6): 3860-8 ... There are two splice variants of the protein, PLD1a and PLD1b, but they do not seem to localize any differently. Alzheimer's ... Type II Diabetes: the protein PED/PEA15 is often elevated in type II diabetic patients, thus enhancing PLD1 activity, and in ... Bae CD, Min DS, Fleming IN, Exton JH (May 1998). "Determination of interaction sites on the small G protein RhoA for ...

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 ... The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding ... Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related ... highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in ...

... (Ras homology Growth-related) (or ARGH) is a small (~21 kDa) monomeric GTP-binding protein (G protein), and is an ... Other proteins known to bind RhoG in its GTP-bound state include the microtubule-associated protein kinectin, Phospholipase D1 ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". The Journal of ... As with all small G proteins RhoG is able to signal to downstream effectors when bound to GTP (Guanosine triphosphate) and ...

... is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular ... "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. ... Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene. ... Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding ...

ROP proteins are a type of monomeric G proteins found in plants belonging to the Rho family. ROP binding to GTP or GDP ... act as binding sites during protein activity. The serine residue at amino acid 74 has been shown to be a potential protein ... Motifs G2 (switch I loop) and G3 (switch II loop) possess distinct conformations depending on GTP binding state. In addition, ... Plant proteins, All stub articles, Plant physiology stubs, Protein stubs). ...

... but are in fact monomeric, consisting of only a single unit. However, like their larger relatives, they also bind GTP and GDP ... "Regulator of G protein signalling"). Receptors stimulate GTP binding (turning the G protein on). RGS proteins stimulate GTP ... GTP-Binding Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology G protein at ... 5 Gβ proteins, and 12 Gγ proteins. G protein can refer to two distinct families of proteins. Heterotrimeric G proteins, ...

eIF-2b regenerates the GTP-bound form of eIF-2 for an additional cycle in protein synthesis initiation, i.e., its binding to ... Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the ... GTP generally binds in its place, as the cytosolic ratio of GTP is much higher than GDP at 10:1. The binding of GTP to the ... Cherfils J, Chardin P (August 1999). "GEFs: structural basis for their activation of small GTP-binding proteins". Trends in ...

Furthermore, like tubulin, monomeric FtsZ is bound to GTP and polymerizes with other FtsZ monomers with the hydrolysis of GTP ... a DNA-binding protein that specifically binds to 10 direct repeats in the parC region on the R1 plasmid. This binding occurs on ... One of these gradient-forming systems consists of MinCDE proteins (see below). MreB is a bacterial protein believed to be ... Not only have analogues for all major cytoskeletal proteins in eukaryotes been found in prokaryotes, cytoskeletal proteins with ...

... a structure conserved among ATP and GTP-binding proteins that binds to a magnesium ion and a molecule of ATP. Binding of ATP or ... An actin protein is the monomeric subunit of two types of filaments in cells: microfilaments, one of the three major components ... Other proteins bind to the ends of actin filaments, stabilizing them. These are called "capping proteins" and include CapZ and ... These proteins are called actin-binding proteins and they are involved in actin's polymerization, depolymerization, stability, ...

... an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29- ... promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is ... with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein ... Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene. During the ...

The GTP-binding protein synthesis factor family also includes the eukaryotic peptide chain release factor GTP-binding subunits ... EF-Tu is a monomeric protein with molecular weight around 43 kDa in Escherichia coli. The protein consists of three structural ... As a G-protein, it uses GTP to facilitate its function. Outside of the ribosome, EF-Tu complexed with GTP (EF-Tu • GTP) ... GTP-binding domain is conserved in both EF-1alpha/EF-Tu and also in EF-2/EF-G and thus seems typical for GTP-dependent proteins ...

They are also called small or monomeric guanine nucleotide-binding regulatory proteins, small or monomeric GTP-binding proteins ... bound to GTP) only for a short time before deactivating themselves by converting bound GTP to bound GDP. However, many GTPases ... G protein signaling is terminated by hydrolysis of bound GTP to bound GDP. This can occur through the intrinsic GTPase activity ... For heterotrimeric G proteins and many small GTP-binding proteins, GEF activity is stimulated by cell surface receptors in ...

The biggest non-structural difference between heterotrimeric and monomeric G protein is that heterotrimeric proteins bind to ... which activates the G-protein by exchanging the GDP on the alpha subunit to GTP. The binding of GTP to the alpha subunit ... Generally, the alpha subunit binds membrane-bound effector proteins for the downstream signaling cascade, but the beta-gamma ... G proteins (as opposed to the subclass of smaller, monomeric small GTPases) are membrane-associated G proteins that form a ...

... mushroom which has a lectin function that is specific to the sugar binding site of D-galactose. It is a monomeric protein with ... Instead, it acts as a phosphatase for nucleoside triphosphate, particularly for GTP. At lower concentrations, it is a mitogen ... Studies have shown that at low concentrations, protein kinases C (PKC) are activated in vitro and in vero cells, leading to an ... Kretz, Olivier; Creppy, Edmond Ekue; Dirheimer, Guy (January 1991). "Disposition of the toxic protein, bolesatine, in rats: its ...

Because ATP is unable to orient properly in the ATP binding pocket, AMPylation cannot occur. FICD proteins are also capable of ... The conserved fic domain is involved in the addition of phosphate-containing compounds including AMP,GTP and other nucleoside ... in which FICD in its monomeric form is responsible for AMPylation, while FICD as a dimer is responsible for de-AMPylation. FIC ... Fic proteins play a vital role in the mediation of post-translational modifications in host cell proteins that interfere with ...

This conformational change causes the alpha subunit to dissociate from the complex and become bound to GTP. This G-alpha-GTP ... Adenylyl cyclase is regulated by G proteins, which can be found in the monomeric form or the heterotrimeric form, consisting of ... γ-phosphate binding, structural stabilization, DxD motif for metal ion binding, and finally ribose binding. These adenylyl ... The cAMP produced by AC then serves as a regulatory signal via specific cAMP-binding proteins, either transcription factors, ...

... both of which contain a GTP-binding domain, while the prokaryotic SRP receptor comprises only the monomeric loosely membrane- ... shared by both proteins. The bound structure is a quasi-symmetric heterodimer termed a targeting complex. The signal ... SR-alpha binds to the SRP54 subunit of the SRP complex. The SR-beta subunit is a transmembrane GTPase that anchors the SR-alpha ... The receptor binds to SPR54/Ffh by the "NG domain", a combination of a 4-helical-bundle "N" domain (InterPro: IPR013822) and a ...

... monomeric gtp-binding proteins MeSH D08.811.277.040.330.300.400.100 - adp-ribosylation factors MeSH D08.811.277.040.330.300. ... gtp-binding protein alpha subunits MeSH D08.811.277.040.330.300.200.100.100 - gtp-binding protein alpha subunits, g12-g13 MeSH ... gtp-binding protein alpha subunits, gi-go MeSH D08.811.277.040.330.300.200.100.200.500 - gtp-binding protein alpha subunit, gi2 ... gtp-binding protein alpha subunits, gq-g11 MeSH D08.811.277.040.330.300.200.100.400 - gtp-binding protein alpha subunits, gs ...

... mitogen-activated protein kinase 14 MeSH D12.644.360.525 - monomeric gtp-binding proteins MeSH D12.644.360.525.100 - adp- ... ral gtp-binding proteins MeSH D12.644.360.525.462 - ran gtp-binding protein MeSH D12.644.360.525.475 - rap gtp-binding proteins ... rab2 gtp-binding protein MeSH D12.644.360.525.400.100 - rab3 gtp-binding proteins MeSH D12.644.360.525.400.100.100 - rab3a gtp- ... rho gtp-binding proteins MeSH D12.644.360.525.700.050 - cdc42 gtp-binding protein MeSH D12.644.360.525.700.050.500 - cdc42 gtp- ...

GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene. This gene encodes a Ras-related protein that ... 2002). "Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic β-cell". Br. J. ... "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559-68 ... The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small ...

The first step of this cycle is the binding of cargo. Importin can perform this function as a monomeric importin-β protein, but ... The NLS-Importin α-Importin β trimer dissociates after binding to Ran GTP inside the nucleus, with the two importin proteins ... which will bind to the major and/or minor binding sites on importin-α. Once the cargo protein is bound, importin-β interacts ... Importin-β returns to the cytoplasm, still bound to Ran-GTP. Once in the cytoplasm, Ran-GTP is hydrolysed by RanGAP, forming ...

... is a member of the Ras superfamily of monomeric guanine nucleotide-binding (G) proteins, and functions as a GTPase- ... GDP-bound) and active (GTP-bound) conformations. It also has the apolipophorin-III and tetratricopeptide repeat (TPR) domains. ... All of these proteins are in the guanosine nucleotide-binding protein family There are 63 orthologs of EVI5L that have been ... Protein EVI5-like protein isoform 1 SDSC Biology Workbench: SAPS [workbench.sdsc.edu EVI5L Statistical Analysis of Protein ...

In 1995, human KIF1A was first identified to be a monomeric, globular motor protein that was shown at the time to have the ... In UNC-104, the C. elegans homolog for KIF1A, the binding of adapter proteins such as, UNC-16 (JIP3), DNC-1 (DCTN-1/Glued), and ... GTP or GDP). KIF1A is known to transport Rab3-coated vesicles in the axon. Rab3 functions as a synaptic vesicle protein that ... Autoinhibited or inactive KIF1A can be activated from cargo binding directly to the motor. Often, cargo adapter proteins are ...

Crystal structures of StTdcD bound to PO4 (phosphate), AMP, ATP, Ap4 (adenosine tetraphosphate), GMP, GDP, GTP, CMP and CTP ... Molecular dynamics simulations on monomeric and dimeric forms of StTdcD revealed plausible open and closed states, and also ... Protein families, EC 2.7.2, All stub articles, EC 2.7 stubs). ... Observation of an ethylene glycol molecule bound sufficiently ... GTP>CTP≈TTP; dATP>dGTP>dCTP) and metal ions (Mg2+≈Mn2+>Co2+). Inhibition of StTdcD by tricarboxylic acid (TCA) cycle ...

Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. ... Miyakawa H, Woo SK, Dahl SC, Handler JS, Kwon HM (1999). "Tonicity-responsive enhancer binding protein, a Rel-like protein that ... the GEF domain of Brx facilitates activation of Rho-type small G proteins from its inactive GDP state to active GTP state. ... 1999). "Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to ...

Once dATP binds to ribonucleotide reductase, the overall catalytic activity of the enzyme decreases, as it signifies an ... The precursors for RNA are GTP, CTP, UTP and ATP, which is a major source of energy in group-transfer reactions. Scientists ... Following Mieschers work, was the German biochemist, Albrecht Kossel, who, in 1878, isolated the non-protein components of " ... Ribonucleotides themselves are basic monomeric building blocks for RNA. Deoxyribonucleotides, formed by reducing ...

The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α ... thereby allowing interaction with Ras and the exchange of GDP for GTP on Ras. Whereas the interaction between Grb2 and PDGFR ... Ca 2+ then binds to calmodulin, which subsequently activates a family of calmodulindependent protein kinases (CamKs). In ... PDGF-AA binds only to PDGFR-αα, while PDGF-BB is the only PDGF that can bind all three receptor combinations with high affinity ...

They serve as monomeric units of the nucleic acid polymers - deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of ... First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for ... Signaling cyclic nucleotides are formed by binding the phosphate group twice to the same sugar molecule, bridging the 5'- and 3 ... protein and cell membrane synthesis, moving the cell and cell parts (both internally and intercellularly), cell division, etc. ...

Davidson MM, Haslam RJ (1994). "Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+ ... actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin ... Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and ... "Cofilin Phosphorylation by Protein Kinase Testicular Protein Kinase 1 and Its Role in Integrin-mediated Actin Reorganization ...