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*  Lipoprotein lipase
... into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of ... Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase ... NIH/UW entry on Familial Lipoprotein Lipase Deficiency Gene therapy for lipoprotein lipase deficiency Lipoprotein lipase at the ... "Entrez Gene: LPL lipoprotein lipase". Wang H, Eckel RH (2009). "Lipoprotein lipase: from gene to obesity". Am J Physiol ...
*  Monoacylglycerol lipase
... , also known as MAG lipase, MAGL, MGL or MGLL is a protein that, in humans, is encoded by the MGLL gene ... Monoacylglycerol lipase functions together with hormone-sensitive lipase (LIPE) to hydrolyze intracellular triglyceride stores ... Monoacylglycerol lipases at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.1.1.23 This article ... Monoacylglycerol lipase is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). It converts ...
*  Starvation response
Cellular monoacylglycerol lipase (MGL), liberates the final fatty acid. The remaining glycerol enters gluconeogenesis. Fatty ... These enzymes, along with CGI-58 and adipose triglyceride lipase (ATGL), complex at the surface of lipid droplets. The ... Zechner, R, Kienesberger, PC, Haemmerle, G, Zimmermann, R and Lass, A (2009) Adipose triglyceride lipase and the lipolytic ... Wilson, DE; Zeikus, R; Chan, IF (Apr 1987). "Relationship of organ lipoprotein lipase activity and ketonuria to ...
*  URB754
to be a potent, noncompetitive inhibitor of monoacylglycerol lipase (MGL). However, recent studies have shown that URB754 ...
*  Lipid signaling
2-AG can also activate both cannabinoid receptors and is inactivated by monoacylglycerol lipase. It is present at approximately ... which is produced when phospholipase C releases diacylglycerol which is then converted to 2-AG by diacylglycerol lipase. ...
*  Endocannabinoid system
The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. ... Hashimotodani Y, Ohno-Shosaku T, Kano M (2007). "Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid ... which cleaves anandamide into arachidonic acid and ethanolamine or monoacylglycerol lipase (MAGL), and 2-AG into arachidonic ...
*  2-Oleoylglycerol
It is metabolized to oleic acid and glycerol primarily by the enzyme monoacylglycerol lipase (MAGL). In 2011, 2OG was found to ... 2-Oleoylglycerol (2OG) is a monoacylglycerol that is found in biologic tissues. Its synthesis is derived from diacylglycerol ... "Brain monoglyceride lipase participating in endocannabinoid inactivation". Proceedings of the National Academy of Sciences. 99 ...
*  Gliotransmitter
... a Response Limited by Monoacylglycerol Lipase". Journal of Neuroscience. 24 (3): 8068-8074. doi:10.1523/jneurosci.2419-04.2004 ...
*  ABHD6
Together, monoacylglycerol lipase (MAGL), ABHD12, and ABHD6 control 99% of 2-AG signalling in the brain. Fatty acid amide ... alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol ...
*  Acylglycerol lipase
Other names in common use include monoacylglycerol lipase, monoacylglycerolipase, monoglyceride lipase, monoglyceride hydrolase ... fatty acyl monoester lipase, monoacylglycerol hydrolase, monoglyceridyllipase, and monoglyceridase. This enzyme participates in ... In enzymology, an acylglycerol lipase (EC 3.1.1.23) is an enzyme that catalyzes a chemical reaction that uses water molecules ...
*  2-Arachidonoylglycerol
2-AG is hydrolyzed in vitro by monoacylglycerol lipase (MAGL), fatty acid amide hydrolase (FAAH), and the uncharacterized ... The activities of Phospholipase C (PLC) and diacylglycerol lipase (DAGL) mediate its formation. 2-AG is synthesized from ... August 2002). "Brain monoglyceride lipase participating in endocannabinoid inactivation". Proceedings of the National Academy ... and diacylglycerol lipase (DAGL). 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3nM, 2-AG induces a ...
*  ABHD12
Together, ABHD12 along with two other enzymes, monoacylglycerol lipase (MAGL) and ABHD6, control 99% of 2-AG hydrolysis in the ... Orlistat (tetrahydrolipstatin; THL) and methyl arachidonyl fluorophosphonate (MAFP), so-called "universal lipase/serine ...
*  JZL184
... is an irreversible inhibitor for monoacylglycerol lipase (MAGL), the primary enzyme responsible for degrading the ...
*  Lipolysis
... catalyzes the hydrolysis of diacylglycerol to monoacylglycerol and monoacylglycerol lipase (MGL) catalyzes the hydrolysis of ... When lipases are phosphorylated, they access lipid droplets and through multiple steps of hydrolysis, breakdown triglycerides ... The first step and the rate-limiting step of lipolysis is carried out by adipose triglyceride lipase (ATGL). This enzyme ... Lipolysis can be regulated through cAMP's binding and activation of protein kinase A (PKA). PKA can phosphorylate lipases, ...
*  Fatty acid amide hydrolase
2015). "Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and ...
*  Endocannabinoid enhancer
Examples of different types of eCBEs include fatty acid amide hydrolase (FAAH) inhibitors, monoacylglycerol lipase (MAGL) ...
*  URB602
... in rat brain presumably by inhibiting the enzyme monoacylglycerol lipase (MAGL), which is the primary metabolic enzyme of 2-AG ... is a compound that has been found to inhibit hydrolysis of monoacyl glycerol compounds, such as 2-arachidonoylglycerol (2-AG) ...
*  List of MeSH codes (D08)
... lipoprotein lipase MeSH D08.811.277.352.100.500 --- monoacylglycerol lipases MeSH D08.811.277.352.100.550 --- naphthol as d ... lipase MeSH D08.811.277.352.100.400.745 --- pancrelipase MeSH D08.811.277.352.100.430 --- ...
*  IDFP
... while it is a potent inhibitor of two enzymes monoacylglycerol lipase (MAGL), the primary enzyme responsible for degrading the ... Casida, J. E.; Nomura, D. K.; Vose, S. C.; Fujioka, K. (2008). "Organophosphate-sensitive lipases modulate brain ...
*  JZL195
... is a potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the primary enzymes ...
*  List of investigational analgesics
... selective monoacylglycerol lipase inhibitor[35] APD-371 - CB2 receptor agonist[36] Cannabidiol (CBD) - cannabinoid receptor ...
*  MGL
... also known as Massachusetts General Laws Monoacylglycerol lipase, a human protein a multiple grenade launcher, such as the ...
*  Ram Rajasekharan
A Bifunctional Enzyme That Has Both Monoacylglycerol Acyltransferase and Lipase Activities. Plant Physiol. 160, 667−683. ... 2016 Sep; 590(18):3155-67 Yadav, P. K., and R. Rajasekharan (2016) Misregulation of a DDHD domain-containing lipase causes ... Oleosin Is a Bifunctional Enzyme That Has Both Monoacylglycerol Acyltransferase and Phospholipase Activities. J. Biol. Chem. ...
*  Triglyceride
In the intestine, following the secretion of lipases and bile, triglycerides are split into monoacylglycerol and free fatty ... The pancreatic lipase acts at the ester bond, hydrolysing the bond and "releasing" the fatty acid. In triglyceride form, lipids ... Special enzymes on the walls of blood vessels called lipoprotein lipases must break down triglycerides into free fatty acids ... the hormone glucagon signals the breakdown of the triglycerides by hormone-sensitive lipase to release free fatty acids. As the ...
*  Diacylglycerol lipase
It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol. Two separate genes encoding ... Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2- ... Diacylglycerol Lipase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.1.1.34 Molecular and Cellular ... November 2003). "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid ...
*  Lipoprotein
... then pancreatic lipase cleaves triacylglycerol molecules into two fatty acids and one 2-monoacylglycerol. Enterocytes readily ... or they can be further hydrolyzed by hepatic lipase. Hydrolysis by hepatic lipase releases glycerol and fatty acids, leaving ... Via apolipoprotein C-II, mature chylomicrons activate lipoprotein lipase (LPL), an enzyme on endothelial cells lining the blood ... Again, like chylomicrons, VLDL particles circulate and encounter lipoprotein lipase (LPL) expressed on endothelial cells. ...
*  Serine hydrolase
... endothelial lipase, and lipoprotein lipase Intracellular lipases, including hormone sensitive lipase, monoacylglycerol lipase, ... and subtilisin Extracellular lipases, including pancreatic lipase, hepatic lipase, gastric lipase, ... adipose triglyceride lipase, and diacylglycerol lipase Cholinesterases, including acetylcholinesterase and ...