... involves treatment aimed at molecular targets that have a unique expression in ... These molecular targets of this disease include GD2, ALK, and CD133. GD2 is a target of immunotherapy, and is the most fully ... A number of molecular targets have been identified for the treatment of high-risk forms of this disease. Aiming treatment in ... For this reason, molecular targets have been identified and are being developed for treatment in patients who have more ...
... refers to using agents specifically designed to selectively target molecular pathways ... Rossi A, Maione P, Palazzolo G, Sacco PC, Ferrara ML, Falanga M, Gridelli C (September 2008). "New targeted therapies and small ... Dempke WC, Suto T, Reck M (March 2010). "Targeted therapies for non-small cell lung cancer". Lung Cancer (Amsterdam, ... "The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies". ...
... Targeted drug delivery Targeted molecular therapy for neuroblastoma Targeted therapy of lung cancer Treatment ... Targeted Therapy Database (TTD) [1] from the Melanoma Molecular Map Project [2] Targeted therapy Fact sheet from the U.S. ... As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted ... The most successful targeted therapies are chemical entities that target or preferentially target a protein or enzyme that ...
Gray-Schopfer, Vanessa; Wellbrock, Claudia; Marais, Richard (2007). "Melanoma biology and new targeted therapy". Nature. 445 ( ... He was elected a member of the European Molecular Biology Organization (EMBO) in 2009, a Fellow of the Royal Society (FRS) in ... He went on to validate B-RAF as a therapeutic target. In collaboration with David Barford, he solved the crystal structure of B ... His citation on election reads: Richard Marais is Professor of Molecular Oncology at Cancer Research UK and has made important ...
Signal Transduction and Targeted Therapy. 6 (1): 205. doi:10.1038/s41392-021-00630-3. PMC 8141052. PMID 34023856. Zhuang Y, ... and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease" (PDF). Molecular ... D1-D2 receptor complex D1−H3−NMDAR receptor complex − a target to prevent neurodegeneration D1-D3 receptor complex D1-NMDAR ... Dearry A, Gingrich JA, Falardeau P, Fremeau RT, Bates MD, Caron MG (September 1990). "Molecular cloning and expression of the ...
In recent years, various molecular targeted therapies have been developed for the treatment of advanced lung cancer. Gefitinib ... "EGFR targeted therapy in non-small cell lung cancer: potential role of cetuximab". Biologics: Targets and Therapy. 3: 215-224. ... "New Progress in Targeted Lung Cancer Therapy; Researchers Report Positive Results With Drugs Matched to a Tumor's Molecular ... "FDA Approves First Targeted Therapy for Subset of Non-Small Cell Lung Cancer". FDA. 21 May 2021. RYBREVANT- amivantamab ...
"Targeted Therapy-based Combination Treatment in Rhabdomyosarcoma". Molecular Cancer Therapeutics. 17 (7): 1365-1380. doi: ... In individuals with more resistant rhabdomyosarcoma, more targeted therapies and immunotherapies in clinical trials have been ... Advancement in the use of radiation therapy includes using three-dimensional conformal radiation therapy (3D-CRT) to create a ... Arnold MA, Barr FG (2017). "Molecular diagnostics in the management of rhabdomyosarcoma". Expert Review of Molecular ...
Stone VN, Xu P (December 2017). "Targeted antimicrobial therapy in the microbiome era". Molecular Oral Microbiology. 32 (6): ... Methods in Molecular Biology. Vol. 1279. pp. 15-23. doi:10.1007/978-1-4939-2398-4_2. ISBN 978-1-4939-2397-7. PMC 4819415. PMID ... Methods in Molecular Biology. Vol. 1279. Humana Press. p. 248. doi:10.1007/978-1-4939-2398-4. ISBN 978-1-4939-2397-7. S2CID ... Methods in Molecular Biology. Vol. 2377. Humana Press. p. 434. doi:10.1007/978-1-0716-1720-5. ISBN 978-1-0716-1719-9. S2CID ...
"Cell-Specific Aptamers for Targeted Therapies". In Mayer G (ed.). Nucleic Acid and Peptide Aptamers. Methods in Molecular ... Examples of RNA aptamer molecular targets and potential targets include vascular endothelial growth factor, osteoblasts, and C- ... Karikó K (April 2019). "In vitro-Transcribed mRNA Therapeutics: Out of the Shadows and Into the Spotlight". Molecular Therapy. ... Zhu G, Chen X (September 2018). "Aptamer-based targeted therapy". Advanced Drug Delivery Reviews. 134: 65-78. doi:10.1016/j. ...
"A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins". Signal Transduction and Targeted Therapy. 5 ... Forni, Diego; Cagliani, Rachele; Clerici, Mario; Sironi, Manuela (January 2017). "Molecular Evolution of Human Coronavirus ... Frontiers in Molecular Biosciences. 7: 605236. doi:10.3389/fmolb.2020.605236. PMC 7773825. PMID 33392262. Neches, Russell Y.; ... Experiments and molecular dynamics simulations". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808 (2): 572-579. doi: ...
"A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins". Signal Transduction and Targeted Therapy. 5 ...
"A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins". Signal Transduction and Targeted Therapy. 5 ... Satija N, Lal SK (2007). "The molecular biology of SARS coronavirus". Ann N Y Acad Sci. 1102 (1): 26-38. Bibcode:2007NYASA1102 ... and the protein is targeted to the Golgi apparatus. In SARS-CoV-2, ORF7a protein has been described as an effective interferon ... Frontiers in Molecular Biosciences. 7: 605236. doi:10.3389/fmolb.2020.605236. PMC 7773825. PMID 33392262. Neches, Russell Y.; ...
Mitsuya H, Yarchoan R, Broder S (September 1990). "Molecular targets for AIDS therapy". Science. American Association for the ... It is phosphorylated in T cells and other HIV target cells into its active triphosphate form, ddCTP. This active metabolite ... Yarchoan R, Mitsuya H, Broder S (October 1988). "AIDS therapies". Scientific American. Springer Nature. 259 (4): 110-9. Bibcode ...
Mitsuya H, Yarchoan R, Broder S (1990). "Molecular targets for AIDS therapy". Science (Submitted manuscript). 249 (4976): 1533- ... Early long-term higher-dose therapy with AZT was initially associated with side effects that sometimes limited therapy, ... this type of therapy is known as HAART (Highly Active Anti Retroviral Therapy). AZT is a thymidine analogue. AZT works by ... AZT was usually dosed twice a day in combination with other antiretroviral therapies. This approach is referred to as Highly ...
ISBN 978-0-8053-9612-6. Mitsuya H, Yarchoan R, Broder S (September 1990). "Molecular targets for AIDS therapy". Science. 249 ( ... It is used in combination with other medications as part of highly active antiretroviral therapy (HAART). It is of the reverse- ... Watson JD, Hopkins NH, Roberts JW, Steitz JA, Weiner AM (1987). Molecular Biology of the Gene (4th ed.). Benjamin/Cummings. ... Yarchoan R, Mitsuya H, Broder S (October 1988). "AIDS therapies". Scientific American. 259 (4): 110-9. Bibcode:1988SciAm.259d. ...
Reubi, Jean Claude (August 2003). "Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy". Endocrine Reviews ... Peptide receptor radionuclide therapy (PRRT) is a type of radionuclide therapy, using a radiopharmaceutical that targets ... "Production of 177Lu for Targeted Radionuclide Therapy: Available Options". Nuclear Medicine and Molecular Imaging. 49 (2): 85- ... Nuclear medicine Targeted alpha-particle therapy Zaknun, John J.; Bodei, L.; Mueller-Brand, J.; Pavel, M. E.; Baum, R. P.; ...
"Predictive molecular signature in lymphoma may direct targeted therapy". Dana-Farber Cancer Institute. September 10, 2012. ... In this role, she found a molecular "signature" in a form of lymphoma that identified patients unlikely to respond well to ... "breakthrough therapy" for treating relapsed Hodgkin lymphoma. By the start of 2017, nivolumab had been FDA-approved for use on ... standard chemotherapy, and who could benefit from treatment with certain experimental targeted drugs. Following this, Shipp's ...
"Emerging Drug Targets for Antiretroviral Therapy". Drugs. 65 (13): 1747-1766. doi:10.2165/00003495-200565130-00002. PMID ... Adams, James (May 2004). "MOLECULAR, GENETIC AND PHYSIOLOGICAL CHARACTERIZATION OF A CHLAMYDOMONAS REINHARDTII INSERTIONAL ... Recently Biomedical Engineers have included the D66 strain in their research for HIV Antiretroviral Therapy Drugs. Studies show ...
"Targeted Therapies for Brain Metastases from Breast Cancer". International Journal of Molecular Sciences. 17 (9): 1543. doi: ... hormonal therapy, and targeted therapy. Types of surgery vary from breast-conserving surgery to mastectomy. Breast ... Medications used after and in addition to surgery are called adjuvant therapy. Chemotherapy or other types of therapy prior to ... If hormone replacement is necessary after breast cancer, estrogen-only therapy or estrogen therapy with an intrauterine device ...
Olivieri A, Manzione L (June 2007). "Dasatinib: a new step in molecular target therapy". Annals of Oncology. 18 (Suppl 6): vi42 ... Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of ... Braun TP, Eide CA, Druker BJ (2020). "Response and Resistance to BCR-ABL1-Targeted Therapies". Cancer Cell. 37 (4): 530-542. ... The main targets of dasatinib are BCR/Abl (the "Philadelphia chromosome"), Src, c-Kit, ephrin receptors, and several other ...
Merlini G (December 2017). "AL amyloidosis: from molecular mechanisms to targeted therapies". Hematology. American Society of ... "Press Announcements - FDA approves first-of-its kind targeted RNA-based therapy to treat a rare disease". www.fda.gov. Archived ... New therapies include diflunisal, inotersen, and patisiran. Diflunisal binds to misfolded mutant TTR protein to prevent its ... October 2020). "Specific Therapy for Transthyretin Cardiac Amyloidosis: A Systematic Literature Review and Evidence-Based ...
Because of this, there has been a lot of interest in studying the efficacy of HER2-targeted therapies within a range of cancer ... Molecular BioSystems. 12 (6): 1818-30. doi:10.1039/C6MB00115G. PMID 27066891. Oh DY, Bang YJ (January 2020). "HER2-targeted ... Methods in Molecular Biology. Vol. 629. pp. 141-58. doi:10.1007/978-1-60761-657-3_10. ISBN 978-1-60761-656-6. PMC 3679364. PMID ... Methods in Molecular Biology. Vol. 942. pp. 205-32. doi:10.1007/978-1-62703-119-6_12. ISBN 978-1-62703-118-9. PMID 23027054. ...
reported a targeted therapy for chronic myelogenous leukemia. Based on the knowledge that BCR-ABL, a constitutively activated ... The finding helped begin the era of designing cancer drugs to target specific molecular abnormalities. In October 2020, the ... the authors tested with success an inhibitor of this tyrosine kinase in patients who had failed first-line therapy. ...
"Targeted Imaging and Therapy of Brain Cancer Using Theranostic Nanoparticles". Molecular Pharmaceutics. 7 (6): 1921-1929. doi: ... Ligands can also be attached to the surface of a nanoparticle to target certain receptors located within the brain. Once the ... Nanoparticles are synthesized to encapsulate a target drug. The surface of the nanoparticle, if not already hydrophobic, may ...
Lu for Targeted Radionuclide Therapy: Available Options". Nuclear Medicine and Molecular Imaging. 49 (2): 85-107. doi:10.1007/ ... Practical Molecular Imaging and Radionuclide Therapies. Society of Nuclear Medicine. ISBN 978-0-9726478-8-5. Ell P, Gambhir S ( ... Most nuclear medicine therapies can be performed as outpatient procedures since there are few side effects from the treatment ... Radionuclide therapy can be used to treat conditions such as hyperthyroidism, thyroid cancer, skin cancer and blood disorders. ...
Cao, Yihai (2009). "Tumor angiogenesis and molecular targets for therapy". Frontiers in Bioscience. 14 (14): 3962-73. doi: ... In patients with the retinal disorder, neovascular age-related macular degeneration, local anti-VEGF therapy to limit the bio- ... Bird, Alan C. (2010). "Therapeutic targets in age-related macular disease". Journal of Clinical Investigation. 120 (9): 3033-41 ... Journal of Cellular and Molecular Medicine. 14 (5): 1056-60. doi:10.1111/j.1582-4934.2010.01077.x. PMC 3822740. PMID 20646126. ...
Immune gene therapy is a targeted approach to cancer therapy where actual immune cells of the patient and their genes are ... Also the development and application of molecularly targeted therapies. Molecular oncology has identified genes that are ... In the past few decades, gene therapy has emerged as a targeted way to treat cancer. Gene therapy introduces foreign genetic ... Oncology Molecular medicine Molecular oncology, University of British Columbia Tazawa, Hiroshi; Kagawa, Shunsuke; Fujiwara, ...
"Acquired resistance to EGFR-targeted therapies in colorectal cancer". Molecular Oncology. 8 (6): 1084-1094. doi:10.1016/j. ... In the last years his studies uncovered the molecular bases of primary and acquired resistance to anti-EGFR therapies in ... molecular heterogeneity and clonal evolution, both inter-patient and intra-tumour, to overcome the resistance to targeted ... "The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets". Nature Communications. 6 ...
... update on molecular classification driving targeted therapies". Frontiers in Oncology. 4: 176. doi:10.3389/fonc.2014.00176. PMC ... July 2006). "Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates". Human Molecular ... Interactions of SHH with Fgf and RA have not yet been studied in molecular detail. The concentration- and time-dependent, cell- ... April 2012). "Molecular subgroups of medulloblastoma: the current consensus". Acta Neuropathologica. 123 (4): 465-472. doi: ...
"A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID 19". Molecular Therapy. 7 (29): 2219-2226. doi:10.1016/j.xphs. ...