"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ... Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (Sep 2003). "GC-GAP, a Rho family GTPase-activating protein that ... Zhang B, Chernoff J, Zheng Y (Apr 1998). "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A ...

August 1993). "Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by ... Lackie JM (2013). The Dictionary of Cell and Molecular Biology. Academic Press. p. 119. Cammack R, Atwood T, Campbell P, Parish ... α1-Chimerin is a GTPase-activating protein in the brain that effects the ras related p21rac. α1-Chimerin is also able to ... Mutations found in α-chi-merin lead to the Duane retraction syndrome 2. Beta-chimerin (Rho GTPase-activating protein 3, 468aa) ...

"Epigenetic Silencing of a Ca2+-Regulated Ras GTPase-Activating Protein RASAL Defines a New Mechanism of Ras Activation in Human ... "How Regulators of G Protein Signaling Achieve Selective Regulation". Journal of Molecular Biology. 366 (2007): 349-365. Das S, ... EIF5 is a GTPase-activating protein. Furthermore, YopE is a protein domain that is a Rho GTPase-activating protein (GAP), which ... GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to ...

"Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein". Mol. ... RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human ... "Entrez Gene: RASA1 RAS p21 protein activator (GTPase activating protein) 1". Chow A, Gawler D (October 1999). "Mapping the site ... 1997). "Ras-GTPase activating protein (GAP): a putative effector for Ras". Cell. Signal. 9 (2): 153-8. doi:10.1016/S0898-6568( ...

"The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science. 305 (5685): 862-5. Bibcode:2004Sci... ... "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Molecular and Cellular ... "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Molecular and Cellular ... Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family ...

... these proteins are said to be down-regulators of ras. The Ras GTPase-activating proteins are quite large (from 765 residues for ... Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. This intrinsic ... GTPase activity of ras is stimulated by a family of proteins collectively known as 'GAP' or GTPase-activating proteins. As it ... GTPase-activator protein for Ras-like GTPase is a family of evolutionarily related proteins. ...

"Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP". The Journal of ... "Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein". ... "Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins". The Journal ... Rab3 GTPase-activating protein catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP1 gene. Members of the ...

The RASA3 (RAS p21 Protein Activator 3) gene encodes the Ras GTPase activating protein. This protein binds inositol 1,3,4,5- ... C13orf46 Isoform X1 has a theoretical isoelectric point of 9.33 and a predicted molecular weight of 66.7 kDA. C13orf46 Isoform ... "RASA3 RAS p21 protein activator 3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-12-15. "UniProt ... The most common protein product encoded by C13orf46 is isoform 1, which is 212 amino acids long. The primary protein isoform of ...

"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with ... a new family of Cdc42 and TC10 GTPase-interacting proteins". Molecular and Cellular Biology. 19 (10): 6585-97. doi:10.1128/MCB. ... Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (September 2003). "GC-GAP, a Rho family GTPase-activating protein ... Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein ...

... two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages". Molecular and ... The ABR gene is an inhibitor of ras-related C3 botulinum toxin substrate 1 (RAC1), a protein found to influence cell growth, ... ABR, RhoGEF and GTPase activating protein is a protein that in humans is encoded by the ABR gene. The ABR activator of RhoGEF ... Additionally, the protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the ...

Ras where he showed how the protein looks in 3D and how it interacts with downstream components and its GTPase Activating ... GTP-binding Proteins as Molecular Switches". YouTube. iBiology. June 19, 2011. "Alfred Wittinghofer (MPI) Part 2: GTPase ... "The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants". Science. 277 (5324): 333 ... Valencia, Alfonso; Chardin, Pierre; Wittinghofer, Alfred; Sander, Chris (1991). "The ras protein family: Evolutionary tree and ...

... proteins, and functions as a GTPase-activating protein (GAP) with a broad specificity. Measurement of in vitro Rab-GAP activity ... Known and Predicted Protein-Protein Interactions NUDT18 and EVI5L interaction IntAct: molecular interaction data SRPK2 and ... EVI5L is a member of the Ras superfamily of monomeric guanine nucleotide-binding (G) ... Zebrafish deficient for Rab23 or its GTPase-activating protein, EVI5L, exhibit abnormal heart formation. This is attributed to ...

1995). "Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell ... The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras- ... 1999). "Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion". J. Biol. Chem. 274 (26): 18463-9. doi:10.1074 ... 2004). "Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization". Mol. ...

Ras GTPase-activating protein-binding protein 2 is an enzyme that in humans is encoded by the G3BP2 gene. G3BP2 has been shown ... Molecular & Cellular Proteomics. 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. Prigent M, Barlat I, Langen H ... Proteins & Nucleic Acids. 2 (3): 93-9. PMID 9575347. "Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein ... of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain ...

The rate of conversion is usually slow but can be sped up dramatically by an accessory protein of the GTPase activating protein ... McCormick F (Dec 1995). "Ras-related proteins in signal transduction and growth control". Molecular Reproduction and ... HRAS acts as a molecular on/off switch, once it is turned on it recruits and activates proteins necessary for the propagation ... HRas is a small G protein in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H ...

Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 ... Molecular Systems Biology. 9: 652. doi:10.1038/msb.2013.9. ISSN 1744-4292. PMC 3658277. PMID 23549480. Tonikian, Raffi; Xin, ... It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and ... the Ras protein, and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. ...

Mammalian Ras GTPase-activating proteins (RasGAP), which regulate the activation of inactive GDP-bound Ras by converting GDP to ... In molecular biology, the Btk-type zinc finger or Btk motif (BM) is a conserved zinc-binding motif containing conserved ... Mammalian Tec, Bmx, and Itk proteins, which are tyrosine protein kinases of the Tec subfamily. Drosophila tyrosine-protein ... while PRRs are commonly involved in protein-protein interactions, including interactions with G proteins. The TH domain may be ...

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene. This gene encodes one ... Molecular Basis of Disease. 1863 (4): 884-895. doi:10.1016/j.bbadis.2016.12.022. ISSN 0925-4439. PMID 28095315. Soncini, C; ... 1999). "Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells". J. Cell. ... "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561-9. doi:10.1128/MCB.16.6.2561. PMC ...

... and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly ... Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2. This protein is one ... "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J. Biol. Chem. ... "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J. Biol. Chem. ...

... and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly ... Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one ... "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". The Journal of ... "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". The Journal of ...

Raf is activated via the second messenger DAG, SOS, and Ras. DAG recruits among other proteins the RAS guanyl nucleotide- ... RasGRP activates the small GTPase Ras by exchanging Guanosine diphosphate (GDP) bound to Ras against Guanosine triphosphate ( ... Relationship to the T3 molecular complex". The Journal of Experimental Medicine. 157 (2): 705-719. doi:10.1084/jem.157.2.705. ... which then activates the GTPase Rac. Rac and Ras activate MEKK1 and thereby initiate the MAPK cascade. B-cell receptor Co- ...

Activation of the receptor tyrosine kinases generates a signaling cascade where the Ras GTPase proteins are activated to a GTP- ... Yarden, Y.; Sliwkowski, M. X. (2001-02-01). "Untangling the ErbB signalling network". Nature Reviews Molecular Cell Biology. 2 ... The RAS pathway can couple with the mitogen-activated protein kinase pathway or a number of other possible effectors. The PI3K/ ... Genetic Ras mutations are infrequent in breast cancer but Ras may be pathologically activated in breast cancer by ...

... a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras ... "The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain". Molecular and Cellular ... Afadin is a protein that in humans is encoded by the AFDN gene. Afadin is a Ras (see HRAS; MIM 190020) target that regulates ... Yamamoto T, Harada N, Kawano Y, Taya S, Kaibuchi K (May 1999). "In vivo interaction of AF-6 with activated Ras and ZO-1". ...

GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic ... There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO (see MIM 165370), RAC (see RAC1; MIM 602048 ... Molecular Oncology. 15 (2): 543-559. doi:10.1002/1878-0261.12866. ISSN 1574-7891. PMC 7858103. PMID 33252198. Ren, Kehan; Zhou ... Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene. Rho GTPases control a variety of ...

SOS1 activates the small G protein Ras. eIF-2b is a eukaryotic initiation factor necessary to initiate protein translation. eIF ... GAPs (GTPase-activating protein) act antagonistically to inactivate GTPases by increasing their intrinsic rate of GTP ... are proteins or protein domains involved in the activation of small GTPases. Small GTPases act as molecular switches in ... The GEF SOS1 activates Ras, whose target is the kinase Raf. Raf is a proto-oncogene because mutations in this protein have been ...

Neurofibromin, a GTPase-activating protein, primarily regulates the protein Ras. NF1 is located on the long arm of chromosome ... ISBN 978-3-642-32864-0. Pasmant E, Vidaud D (May 2016). "Neurofibromatosis Type 1 Molecular Diagnosis: The RNA Point of View". ... a GTPase-activating protein that negatively regulates RAS/MAPK pathway activity by accelerating the hydrolysis of Ras-bound GTP ... Neurofibromin is a GTPase-activating protein (GAP) that negatively regulates Ras pathway activity by accelerating hydrolysis of ...

Ras is a small GTPase that hydrolyses GTP into GDP and phosphate. Ras is activated by growth factor signaling (i.e., EGF, ... the MAPK-activated protein kinases". Microbiology and Molecular Biology Reviews. 75 (1): 50-83. doi:10.1128/MMBR.00031-10. PMC ... half of the protein). The unregulated expression of this protein activates other proteins that are involved in cell cycle and ... Downstream effectors of Ras include three mitogen-activated protein kinases Raf a MAP Kinase Kinase Kinase (MAPKKK), MEK a MAP ...

... a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras ... Karnoub AE, Weinberg RA (July 2008). "Ras oncogenes: split personalities". Nature Reviews Molecular Cell Biology. 9 (7): 517-31 ... a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras ... it is activated by Ras guanine nucleotide exchange factors and can bind/activate some Ras protein effectors. M-Ras also weakly ...

"Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein ( ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. ... October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. ... Caprin-1 is a protein that in humans is encoded by the CAPRIN1 gene. It is suggested that Caprin1 (a.k.a. RNG105) is essential ...

... tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein". J. Biol. Chem. 276 (16): 13087-95. doi: ... 2002). "Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70". Curr ... tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein". J. Biol. Chem. 276 (16): 13087-95. doi: ... This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to ...

... allowing Epac to activate small Ras-like GTPase proteins, such as Rap1. In the species Dictyostelium discoideum, cAMP acts ... Molecular Cell Research. 1863 (9): 2135-46. doi:10.1016/j.bbamcr.2016.05.006. PMID 27178543. Bos, Johannes L. (December 2006 ... The phosphorylated proteins may act directly on the cell's ion channels, or may become activated or inhibited enzymes. Protein ... In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase). PKA is normally ...