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*  Evolution of molecular chaperones
Chaperones, also called molecular chaperones, are proteins that assist other proteins in assuming their three-dimensional fold ... Heat shock proteins (HSPs) are a diverse class of molecular chaperones that assist in folding under stress. While originally ... Since chaperones are mediators of this transition by assisting in the fold of the client protein, chaperone activity is thought ... Feder, ME; Hofmann, GE (1999). "Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological ...
*  Molecular chaperone therapy
... is one of the latest pharmacological approaches to lysosomal storage diseases. It fixes defective ... These chaperones are minute molecules that can enter the central nervous system ( via Blood Brain Barrier). Once in the CNS, ...
*  Non-chaperonin molecular chaperone ATPase
... (EC 3.6.4.10, molecular chaperone Hsc70 ATPase) is an enzyme with systematic name ATP ... Non-chaperonin molecular chaperone ATPase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Chaperone (protein) Sadis, S.; Hightower, L.E. (1992). "Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by ... Li, X.; Su, R.T.; Hsu, H.T.; Sze, H. (1998). "The molecular chaperone calnexin associated with the vacuolar H+-ATPase from oat ...
*  Hsp70
Lüders J, Demand J, Höhfeld J (February 2000). "The ubiquitin-related BAG-1 provides a link between the molecular chaperones ... Mayer M P (2010). "Gymnastics of Molecular Chaperones". Mol Cell. 39: 321-331. doi:10.1016/j.molcel.2010.07.012. PMID 20705236 ... The protein is then free to fold on its own, or to be transferred to other chaperones for further processing. HOP (the Hsp70/ ... Yoshimune K, Yoshimura T, Nakayama T, Nishino T, Esaki N (May 2002). "Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system ...
*  R. John Ellis
From 1990 until 2009, he organised annual meetings of the UK Molecular Chaperone Club at the Universities of Oxford, Cambridge ... doi:10.1016/0005-2787(80)90129-x. Ellis, R. J. (1987). "Proteins as molecular chaperones". Nature. 328 (6129): 378-9. doi: ... 1987: Formulation of the general concept of molecular chaperone function. 1988: Discovery of the chaperonins. 2000: First ... 1983: Five-year Senior Research Fellowship of the Science and Engineering Research Council to work on chaperone-assisted ...
*  T-complex 1
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the ... Yaffe MB, Farr GW, Miklos D, Horwich AL, Sternlicht ML, Sternlicht H (1992). "TCP1 complex is a molecular chaperone in tubulin ... Horwich AL, Willison KR (1993). "Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55 ... Burston SG, Clarke AR (1997). "Molecular chaperones: physical and mechanistic properties". Essays Biochem. 29: 125-36. PMID ...
*  Protein folding
Molecular chaperones are a class of proteins that aid in the correct folding of other proteins in vivo. Chaperones exist in all ... Chaperones may assist in folding even when the nascent polypeptide is being synthesized by the ribosome. Molecular chaperones ... Lee S, Tsai FT (2005). "Molecular chaperones in protein quality control". Journal of Biochemistry and Molecular Biology. 38 (3 ... Kim YE, Hipp MS, Bracher A, Hayer-Hartl M, Hartl FU (2013). "Molecular chaperone functions in protein folding and proteostasis ...
*  HSP90AB1
... is a molecular chaperone. Chaperones are proteins that bind to other proteins, thereby stabilizing them in an ATP- ... Hong DS, Banerji U, Tavana B, George GC, Aaron J, Kurzrock R (Jun 2013). "Targeting the molecular chaperone heat shock protein ... Young JC, Hoogenraad NJ, Hartl FU (Jan 2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial ... Craig EA, Gambill BD, Nelson RJ (Jun 1993). "Heat shock proteins: molecular chaperones of protein biogenesis". Microbiological ...
*  Nucleoplasmin
Dingwall, C.; Laskey, R. A. (1990). "Nucleoplasmin: the archetypal molecular chaperone". Seminars in cell biology. 1 (1). ... Nucleoplasmin, the first identified molecular chaperone is a thermostable acidic protein with a pentameric structure. The ... C, Dingwall; RA., Laskey (Feb 1990). "Nucleoplasmin: the archetypal molecular chaperone". Seminars in Cell Biology. 1 (1): 11- ... "InterPro". EMBL-EBI, Wellcome Trust Genome Campus,European Molecular Biology Laboratory. Philpott, Anna; Leno, Gregory H. (1992 ...
*  HSPA4L
"Characterization of the 105-kDa molecular chaperone. Identification, biochemical properties, and localization". Eur. J. Biochem ...
*  Richard I. Morimoto
Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin CyP-40 and the Steroid Aporeceptor Associated Protein p23 ... The Human Molecular Chaperones HSP90, HSP70 (HSC70) and HDJ-1 have Distinct Roles in Recognition of a Non-native Protein and ... Molecular Chaperones as HSF1 Specific Transcriptional Repressors. Genes and Development 12: 654-666 (1998). Morimoto, R.I. ... Regulation of Longevity in C. elegans by Heat Shock Factor and Molecular Chaperones. Mol. Biol. Cell 15: 657-664 (2004). ...
*  SecDF protein-export membrane protein
Driessen AJ (May 2001). "SecB, a molecular chaperone with two faces". Trends Microbiol. 9 (5): 193-6. doi:10.1016/S0966-842X(01 ... Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase ... The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane ... The chaperone protein SecB is a highly acidic homotetrameric protein that exists as a "dimer of dimers" in the bacterial ...
*  DNAJB1
Anwar A, Siegel D, Kepa JK, Ross D (2002). "Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone ... Freeman BC, Morimoto RI (1996). "The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in ... Shi Y, Mosser DD, Morimoto RI (1998). "Molecular chaperones as HSF1-specific transcriptional repressors". Genes Dev. 12 (5): ... Hernández MP, Chadli A, Toft DO (2002). "HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone ...
*  Prefoldin
Unlike many other molecular chaperones, prefoldin does not use chemical energy, in the form of adenosine triphosphate (ATP), to ... Pockley, A.: "Molecular Chaperones and Cell Signaling." Cambridge University Press, Cambridge, 2005. Leroux M.R., et al.. (1999 ... Clark, D. S., Whitehead, T.A., et al.. (2007). A filamentous molecular chaperone of the prefoldin family from the deep-sea ... Siegert, R., Leroux, M. R., Scheufler, C., Hartl, F. U., and Moarefi, I. (2000). Structure of the molecular chaperone prefoldin ...
*  HSF1
Shi Y, Mosser DD, Morimoto RI (March 1998). "Molecular chaperones as HSF1-specific transcriptional repressors". Genes & ... Shi Y, Mosser DD, Morimoto RI (March 1998). "Molecular chaperones as HSF1-specific transcriptional repressors". Genes & ... In the event of proteotoxic stress such as heat shock, these chaperones are released from HSF1 to perform their protein-folding ... In its monomeric form, HSF1 activation is repressed by interaction with chaperones such as heat shock proteins Hsp70 and Hsp90 ...
*  Heat shock protein
Biology portal Molecular and cellular biology portal Cellular stress response Chaperone Chaperonin Co-chaperone FourU ... Beginning in the mid-1960s, investigators recognized that many HSPs function as molecular chaperones and thus play a critical ... Benjamin IJ, McMillan DR (July 1998). "Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease ... Walter S, Buchner J (April 2002). "Molecular chaperones--cellular machines for protein folding". Angewandte Chemie. 41 (7): ...
*  Macromolecular crowding
Ellis RJ (2007). "Protein misassembly: macromolecular crowding and molecular chaperones". Adv. Exp. Med. Biol. 594: 1-13. doi: ... The size of the crowding effect depends on both the molecular mass and shape of the molecule involved, although mass seems to ... Crowding may also increase the effectiveness of chaperone proteins such as GroEL in the cell, which could counteract this ... Sapir, L; Harries, D. (2015). "Is the depletion force entropic? Molecular crowding beyond steric interactions". Curr. Opin. ...
*  HSPA1A
"Hsp70 chaperones: cellular functions and molecular mechanism". Cellular and Molecular Life Sciences. 62 (6): 670-684. doi: ... Shi Y, Mosser DD, Morimoto RI (March 1998). "Molecular chaperones as HSF1-specific transcriptional repressors". Genes Dev. 12 ( ... The unstructured region at the very end of the C-terminal is believed to be the docking site for co-chaperones. This protein is ... As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated ...
*  Gene product
Hartl, F. Ulrich; Bracher, Andreas; Hayer-Hartl, Manajit (2011). "Molecular chaperones in protein folding and proteostasis". ... Chaperone proteins work to stabilize newly synthesized proteins. They ensure the new protein folds into its correct functional ... 2002). Molecular Biology of the Cell (4 ed.). New York: Garland Science. "General Transcription Factor / Transcription Factor ...
*  Proteostasis
Expression of the chaperome, the ensemble of chaperones and co-chaperones that interact in a complex network of molecular ... "Structure and function of the molecular chaperone Trigger Factor". Biochimica et Biophysica Acta (BBA) - Molecular Cell ... Molecular chaperone therapy Powers, E.T.; Morimoto, R.I.; Dillin, A.; Kelly, J.W.; Balch, W.E. (2009). "Biological and Chemical ... 2013). "Molecular Chaperone Functions in Protein Folding and Proteostasis". Annual Review of Biophysics. 82: 323-355. doi: ...
*  CRYAA
They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; ... Derham BK, Harding JJ (1999). "Alpha-crystallin as a molecular chaperone". Progress in retinal and eye research. 18 (4): 463- ... Lindner RA, Kapur A, Carver JA (1997). "The interaction of the molecular chaperone, alpha-crystallin, with molten globule ... Andley UP, Mathur S, Griest TA, Petrash JM (1997). "Cloning, expression, and chaperone-like activity of human alphaA-crystallin ...
*  CRYAB
They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; ... It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins ... Derham BK, Harding JJ (July 1999). "Alpha-crystallin as a molecular chaperone". Progress in Retinal and Eye Research. 18 (4): ... "Prevention of aberrant protein aggregation by anchoring the molecular chaperone αB-crystallin to the endoplasmic reticulum". ...
*  PTGES3
Freeman BC, Felts SJ, Toft DO, Yamamoto KR (2000). "The p23 molecular chaperones act at a late step in intracellular receptor ... "Disassembly of transcriptional regulatory complexes by molecular chaperones". Science. 296 (5576): 2232-2235. doi:10.1126/ ... The protein encoded by this gene is also known as p23 which functions as a chaperone which is required for proper functioning ... Donzé O, Abbas-Terki T, Picard D (2001). "The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA- ...
*  HSPA4
Anwar A, Siegel D, Kepa JK, Ross D (Apr 2002). "Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone ... Freeman BC, Yamamoto KR (Jun 2002). "Disassembly of transcriptional regulatory complexes by molecular chaperones". Science. 296 ... O'Keeffe B, Fong Y, Chen D, Zhou S, Zhou Q (Jan 2000). "Requirement for a kinase-specific chaperone pathway in the production ... Nair SC, Toran EJ, Rimerman RA, Hjermstad S, Smithgall TE, Smith DF (Dec 1996). "A pathway of multi-chaperone interactions ...
*  Hsp90
Imai J, Maruya M, Yashiroda H, Yahara I, Tanaka K (July 2003). "The molecular chaperone Hsp90 plays a role in the assembly and ... Csermely P, Schnaider T, Soti C, Prohászka Z, Nardai G (August 1998). "The 90-kDa molecular chaperone family: structure, ... Pratt WB, Galigniana MD, Morishima Y, Murphy PJ (2004). "Role of molecular chaperones in steroid receptor action". Essays ... Pearl LH, Prodromou C (2001). "Structure, function, and mechanism of the Hsp90 molecular chaperone". Adv. Protein Chem. ...
*  Methionine synthase) reductase
"Human methionine synthase reductase is a molecular chaperone for human methionine synthase". Proceedings of the National ...