Current models can be divided into two categories: inside-out and outside-in. In the former, it is hypothesized that a problem ... There are three clinical phenotypes: relapsing-remitting MS (RRMS), characterized by periods of neurological worsening ... Some molecular biochemical models for relapses have been proposed. Normally, gadolinium enhancement is used to show BBB ... The theory of the trans-synaptic degeneration, is compatible with other models based in the CSF biochemistry. Others propose an ...

... receptor antagonists in animal models of Parkinson's disease". Journal of the Neurological Sciences. 248 (1-2): 9-15. doi: ...

An animal model of Duchenne muscular dystrophy: clinical studies". Journal of the Neurological Sciences. 88 (1-3): 69-81. doi: ... A number of models are used to facilitate research on DMD gene defects. These include the mdx mouse, GRMD (golden retriever ... Levels of dystrophin in this model is not zero: a variety of mutation alleles exist with measurable levels certain of ... Due to the hypertrophy, this model may have limited uses for DMD studies. Delandistrogene Moxeparvovec - Systemic Gene Transfer ...

Acta Psychiatr Scand 1996; 93(6):451-459 Sachdev P. Animal models of drug-induced akathisia. In LeDoux MS (Ed). Animal models ... Neurological Disease and Therapy Series. Macel Dekker, New York, 2005:129-164. Brodaty H, Sachdev P, Rose N, Rylands K, Prenter ... 2: A neurological, neuropsychological and MRI investigation. Br J Psychiatry 1999; 175:416-421. Sachdev P, Smith JS, Cathcart S ... Chronic repetitive transcranial magnetic stimulation is antidepressant but not anxiolytic in rat models of anxiety and ...

... reverses neuroinflammation while promoting neural repair in EAE model". Journal of the Neurological Sciences. 312 (1-2): 146-57 ... In adult models, PIF has multiple neurogenic effects: it promotes the growth of neurons and reduces neuroinflammation. It is ... In adult models, PIF also reverses the pathological neuroinflammation caused by autoimmune diseases such as multiple sclerosis ... correlates with early mammalian embryo development-bovine and murine models". Reproductive Biology and Endocrinology. 9 (1): 63 ...

Researchers have re-iterated that the results of Alexander's studies highlight issues with rat models kept in bare-bones lab ... Neurological Disorders Drug Targets. 12 (5): 587-592. doi:10.2174/1871527311312050007. ISSN 1871-5273. PMID 23574171. Lahvis, ... Alexander B.K. (1987). "The disease and adaptive models of addiction: A framework evaluation". Journal of Drug Issues. 17: 47- ... Burrows, Emma; Hannan, Anthony (2013-07-01). "Towards Environmental Construct Validity in Animal Models of CNS Disorders: ...

In a spinal trauma model, PEA reduced the resulting neurological deficit via the reduction of mast cell infiltration and ... "Palmitoylethanolamide relieves pain and preserves pancreatic islet cells in a murine model of diabetes". CNS & Neurological ... In a different model for bladder pain, the turpentine-induced urinary bladder inflammation in the rat, PEA also attenuated a ... PEA in this model also reduced the activation of microglia and astrocytes. Its activity as an inhibitor of inflammation ...

... using mathematical modeling to quantify glioma growth and invasion". Journal of the Neurological Sciences. 216 (1): 1-10. doi: ... Chapter 1: Continuous Population Models for Single Species Chapter 2: Discrete Population Models for a Single Species Chapter 3 ... Models for Interacting Populations Chapter 4: Temperature-Dependent Sex Determination (TSD) Chapter 5: Modelling the Dynamics ... Källén, A.; Arcuri, P.; Murray, J. D. (1985-10-07). "A simple model for the spatial spread and control of rabies". Journal of ...

eds.). Neuromethods: Animal Models of Neurological Disease. Totowa, NJ: Humana Press. pp. 153-155. ISBN 0-89603-211-6. PK Sahoo ... The kindling model was first proposed in the late 1960s by Graham V. Goddard and colleagues. Although kindling is a widely used ... Kindling is also referred as an animal visual model of epilepsy that can be produced by focal electrical stimulation in the ... However, in both human epilepsy and in some animal models, evidence suggests that a process like that found in kindling does ...

Buckmaster, Paul S. (2006). "Inherited Epilepsy in Mongolian Gerbils". Models of Seizures and Epilepsy. pp. 273-294. doi: ... The Italian Journal of Neurological Sciences. 16 (1-2): 101-106. doi:10.1007/BF02229081. PMID 7642342. S2CID 4551801. "Scent ... A simple model to study hair cell loss and regeneration". Hearing Research. 325: 12-26. doi:10.1016/j.heares.2015.03.002. PMC ... from detection of low frequency foot drumming to higher frequency chirps and therefore may be a more suitable model of human ...

eds.). Neuromethods: Animal Models of Neurological Disease. Totowa, NJ: Humana Press. pp. 153-155. ISBN 0-89603-211-6. Menkes ... No animal model has all the characteristics of epileptogenesis in humans, so research efforts aim to identify one. Such a model ... Abel MS, McCandless DW (1992). "The kindling model of epilepsy". In Adams RN, Baker GB, Baker JM, Bateson AN, Boisvert DP, ... People with PTE have follow-up visits, in which health care providers monitor neurological and neuropsychological function and ...

Bauman, M. L. (1999). Autism: Clinical features and neurological observations. In Helen Tager-Flusberg (Ed.) Neurological ... These researchers conducted a meta-analyses of all forms of video modeling and concluded that both peer and self-modeling met ... Bandura made two fundamental findings that relate directly to self modeling. The first is that the best models are those as ... Bellini, S. & Akullian, J., (2007). A meta-analysis of video modeling and video self-modeling interventions for children and ...

... , also referred to as "Simple Allochiria", is a neurological disorder in which a patient is unable to recognise or ... 183-201, doi:10.1016/s0166-4115(08)61713-6, ISBN 978-0-444-70193-0 Kinsbourne, Marcel (1970-07-20). "A model for the mechanism ... "A Model for the Mechanism of Unilateral Neglect of Space". In the study, Kinsbourne briefly mentioned the lack of awareness to ... of unilateral neglect of space". Transactions of the American Neurological Association. 95: 143-6. PMID 5514359. Bisiach, ...

Although the term "neurological reparative therapy" is new, the foundation of this model is not. NRT is not a proscriptive ... Although the term neurological reparative therapy is relatively new, the history of the model goes back many decades. NRT has ... Neurological reparative therapy (NRT) is a new model of treatment synthesized from a compilation of literature and research on ... On the continuum of evidence-based practices and practice-based evidence, the neurological reparative therapy model is in the ...

... that occurs in human brains has been modeled in a variety of animal models and cell culture models. ... Encyclopedia of the Neurological Sciences (Second Edition). Vol. 2 (Second ed.). London: Academic Press. pp. 196-199. ISBN 978- ... Kindling model Post-traumatic epilepsy Post-traumatic seizure Lukasiuk, K. (2014). "Epileptogenesis". In Aminoff, Michael J; ... BBB disruption imaging was shown capacity in animal model to serve as a biomarker of epileptogenesis and specific EEG patterns ...

The purpose of creating an in vitro neurological model is to study these diseases in a more simple and variable space. This 3D ... The varying physiology between human and other mammalian models limits the scope of study in neurological disorders. Cerebral ... Such models can be used to model human brain development and, as demonstrated, to investigate diseases (and their potential ... Wang H (2018-06-08). "Modeling Neurological Diseases With Human Brain Organoids". Frontiers in Synaptic Neuroscience. 10: 15. ...

New Animal Models of Human Neurological Diseases. Biovalley Monographs. pp. 66-80. doi:10.1159/000117724. ISBN 978-3-8055-8405- ... James W. Albers; Stanley Berent (15 August 2005). Neurobehavioral Toxicology: Neurological and Neuropsychological Perspectives ... Therapeutic Advances in Neurological Disorders. 12: 175628641986636. doi:10.1177/1756286419866367. PMC 6691669. PMID 31447934 ...

From molecular understanding to the development of diagnostics and model organisms". DNA Repair (Amst.). 81: 102669. doi: ... A neurological examination can, to some extent, assess the impact of neurological damage and disease on brain function in terms ... There are many recognized neurological disorders, some relatively common, but many rare. They may be assessed by neurological ... There are also conditions viewed as neurological where a person appears to consciously register neurological stimuli that ...

2000). "A reductionist approach to creating and using neuromusculoskeletal models". In JMC Winters, P.E. (ed.). Biomechanical ... and neurological control of posture and movements. New York: Springer. pp. 148-63. ISBN 978-0-471-50908-0. Nishikawa, K.; ...

"Brain Disease Model of Drug & Alcohol Addiction , Hazelden Betty Ford". Archived from the original on 2017-10-27. Korczyn, AD; ... Vakhapova, V; Grinberg, LT (2012-11-15). "Vascular dementia". Journal of the Neurological Sciences. 322 (1-2): 2-10. doi: ...

Decreases Stroke Size and Improves Neurological Scores in a Permanent Occlusion Rat Stroke Model". The Open Neurology Journal. ... Singhal AB, Wang X, Sumii T, Mori T, Lo EH (July 2002). "Effects of normobaric hyperoxia in a rat model of focal cerebral ... Many of the drugs with the strongest signals in pre-clinical models were not the ones later brought into clinical trials. ... Improve pre-clinical testing Others proposed that the lack of standardization in pre-clinical models made it difficult to ...

Bove GM, Harris MY, Zhao H, Barbe MF (February 2016). "Manual therapy as an effective treatment for fibrosis in a rat model of ... upper extremity overuse injury". Journal of the Neurological Sciences. 361: 168-80. doi:10.1016/j.jns.2015.12.029. PMC 4729290 ... Myklebust M, Iler J (May 2007). "Policy for therapeutic massage in an academic health center: a model for standard policy ... Chairs may be either stationary or portable models. Massage chairs are easier to transport than massage tables, and recipients ...

In her model, desire feeds arousal and orgasm, and is in turn fueled by the rest of the orgasmic cycle. Rather than orgasm ... Portner, Martin (May 15, 2008). "The Orgasmic Mind: The Neurological Roots of Sexual Pleasure". Scientific American. Archived ... Basson R (2000). "The female sexual response: a different model". Journal of Sex & Marital Therapy. 26 (1): 51-65. doi:10.1080/ ... Portner, Martin (May 15, 2008). "The Orgasmic Mind: The Neurological Roots of Sexual Pleasure". Scientific American. Archived ...

Maia TV, Frank MJ (February 2011). "From reinforcement learning models to psychiatric and neurological disorders". Nature ... However, the second model proposes that the actions do not originate in the basal ganglia, and instead originate in the cortex ... These models of the basal ganglia are thought to be relevant to the study of OCD, ADHD, Tourette syndrome, Parkinson's disease ... The first model suggests a "critic" which encodes value, and an actor which encodes responses to stimuli based on perceived ...

Journal of the neurological sciences 362 (2016): 232-239. Rizzo, John-Ross, et al. "Sensor fusion for ecologically valid ... 2017 7th International Conference on Modeling, Simulation, and Applied Optimization (ICMSAO). IEEE, 2017. Rizzo, John-Ross, et ...

Brandt, Thomas; Dieterich, Marianne; Strupp, Michael; Glasauer, Stefan (2012). "Model Approach to Neurological Variants of ... 2003). Neurological foundations of cognitive neuroscience ([Online-Ausg.] ed.). Cambridge, Mass.: MIT. pp. 1-19. ISBN 978- ...

Journal of the Neurological Sciences, 283, 235-2009. Abenavoli, R. & Henkel, L.A. (2009). Remembering When We Last Remembered ... In Conway, M.A. (Ed.), Cognitive Models of Memory(247-272). Cambridge: MIT Press. Wheeler, M. A., Stuss, D. T., & Tulving, E. ( ... Jones (2010) researched a pure mediated priming effect and wanted to discover which model accounted for it. Pure priming refers ... Each of three potential models (spreading activation, compound-cue and semantic matching) were tested with the results ...

Researchers are using this animal model of narcolepsy to study the disease. Narcolepsy results in excessive daytime sleepiness ... some neurological conditions and disorders; and severe early-onset mental disorders). Orexin/hypocretin system dysfunction ... Orexin/hypocretin system dysfunction has been proposed as a novel pathophysiological model of Takotsubo syndrome (acute failure ...

March 2009). "NNZ-2566: a Gly-Pro-Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke". Journal of ... the Neurological Sciences. 278 (1-2): 85-90. doi:10.1016/j.jns.2008.12.003. PMID 19157421. S2CID 7789415. Cartagena CM, ...

Therefore, in models of prenatal cocaine exposure both migration and maturation of these progenitor cells is delayed. TBR1 is ... Studies show that TBR1 may play a role in major neurological diseases such as Alzheimer's disease (AD), Parkinson's disease (PD ... Prenatal cocaine exposure in a mouse model caused a decrease in both GABA neuron migration from the basal to the dorsal ... Kishimoto N, Shimizu K, Sawamoto K (Mar 2012). "Neuronal regeneration in a zebrafish model of adult brain injury". Disease ...

Mischel and colleagues integrated whole genome sequencing, cytogenetics and structural modeling to accurately and globally ... top brain tumor research award given jointly by the American Association of Neurological Surgeons and the Society for ...

Third-party payers (public and private health insurance) advocated an improved model to replace the UCR fees, which had been ... MD American Association of Neurological Surgeons - Gregory Przybylski, MD American College of Allergy, Ashma & Immunology: ... payment model (a "charge-based" payment system). Physician services were largely considered to be misvalued under this system, ...

Built on the Humboldtian model of higher education, Johns Hopkins was inspired particularly from Germany's historic Heidelberg ... Neurological disease deaths in Washington, D.C., New Jersey Democrats, Nobel Peace Prize laureates, People from Kalorama ( ...

... "scientific models," as that phrase is understood in philosophy. He showed that one popular class of connectionist networks, ... seemed to perform worse rather than better as more realistic neurological assumptions were built into their operation. Having ...

2002). "Modelling HIV/AIDS epidemics in Botswana and India: impact of interventions to prevent transmission". Bull. World ... Prostitution is seen by some people with disabilities, or some people with neurological differences - such as some on the ... Some remain in apartments that have hints or clues outside such as posters with "model" written on them to lure potential ... Some critics of prostitution as an institution are supporters of the "Nordic model" that decriminalizes the act of selling sex ...

Modelling done for the government suggests that COVID cases are set to fall dramatically in the coming weeks. Face coverings ... "Covid: Vaccine study links virus to rare neurological illness". BBC News. 25 October 2021. Retrieved 26 October 2021. "Budget ... Premier Foods announce the adoption of a hybrid working model for its 800 office staff, enabling them to choose whether to work ... But the scientists behind the study say its modelling is uncertain, while its worst case scenario is dismissed by infectious ...

Hemelsoet D, Hemelsoet K, Devreese D (March 2008). "The neurological illness of Friedrich Nietzsche". Acta Neurol Belg. 108 (1 ... insights from 3D molecular modelling and evolutionary analyses". Journal of Molecular Biochemistry. 3 (3): 97-105. Ropper AH, ...

The onset of this neurological disease is (on average) at age 45 and is invariably fatal within 10-20 years. Haldane assumed ... A number of genetic components of aging have been identified using model organisms, ranging from the simple budding yeast ...

... , MAM, is a neurotoxin which reduces DNA synthesis used in making animal models of neurological ... In rat models, the specific effect of MAM on neural development depends on the gestational age of the subject. At the ... Prenatal MAM exposure in rats results in a model of brain malformation. In some MAM animals, video-EEG monitoring has ... At the cellular level, dysplastic hippocampal neurons in the MAM model were shown to have reduced potassium current function ...

These included a lay directorship of the Australian Neurological Foundation, chairmanship of the Keep Australia Beautiful ... His business model was essentially discounted trading margins and a no-frills service- he applied a 10% markup as opposed to ...

Expanding Satir's Model Through" (PDF). Couple Congruence and Spirituality: Expanding Satir's Model Through. University of ... "had a dramatic neurological change that has affected his mobility, stamina, and expression", and "his physicians have conducted ...

Since we do not currently have a solid cognitive model of the belief formation process, this second factor is still somewhat of ... The first factor being the anomalous experience-often a neurological defect-which leads to the delusion, and the second factor ... As studies have shown, these neurological defects are not enough on their own to cause delusional thinking.[citation needed] An ... They believe that there must be some additional unknown neurological defect in the patient's belief system (probably in the ...

From a neurological perspective, dissociation during times of extreme stress or trauma can invoke neural mechanisms resulting ... Models of attachment-based dissociative disorders and trauma-related disorders involving betrayal trauma have been indicated in ... He referred to internal representations as Internal Working Models (IWM) with which one can discern which internal content is ... PhD, Giovanni Liotti (2006-11-21). "A Model of Dissociation Based on Attachment Theory and Research". Journal of Trauma & ...

Severe allergies occur in about eight per million doses, serious neurological problems occur in about four per million doses, ... World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World ... World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World ...

In humans, models of stress have been closely linked to the context depression. Changes in sleep patterns in depression are ... "Brain Basics: Understanding Sleep". Office of Communications and Public Liaison, National Institute of Neurological Disorders ... Stressors can be categorized into the Challenge/Hindrance stressor model. Challenge stressors, while unpleasant, allow for ... Changes in sleep phase vary in animal models depending on the stressor but do not alter total sleep duration except for novelty ...

"Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model - Fonds de recherche du ... suggesting compounds of the kind could be used as novel therapeutics for chronic pain and other neurological diseases in which ... Restoring KCC2 function in experimental models with nerve injury conversely restored the threshold. Guillaume Lavertu, first ... Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model. Brain. 2014 Mar;137(Pt 3 ...

Fox, A. W. (2004). "Onset of effect of 5-HT1B/1D agonists: a model with pharmacokinetic validation". Headache. 44 (2): 142-147 ... neurological events (vertigo) reported by less than 1% in the placebo group and less than 1% to 2% in the sumatriptan groups. ... World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World ...

In a mouse model, researchers also found RAD51 products in corticospinal tract axons at the pyramidal decussation. They ... Congenital mirror movement disorder (CMM disorder) is a rare genetic neurological disorder which is characterized by mirrored ... These findings are corroborated by evidence from mice models, Kanga mice with a deletion of DCC, whose CST has been shown not ... First, some researchers believe that this neurological disorder is due to abnormal communication between cerebral hemispheres. ...

Neurological problems which began in 1909 led to the removal of a brain tumor in 1911. As a result of the operation, Putnam was ... Putnam enjoyed drawing animals and modeling them in clay during this period. He experienced a serious accident as a child, ...

... has also been implicated in neurological diseases. PM20D1 expression is increased both in vitro and in vivo following ... Forced overexpression of PM20D1 in the hippocampus results in improved learning performance in a mouse model of Alzheimer's ...

Mouse-models and other research demonstrated that reducing histamine concentration in the H3R causes tics, but adding histamine ... H3 receptor ligands are being investigated for the treatment of numerous neurological conditions, including obesity (because of ... "Activation of histamine H3 receptors inhibits carrier-mediated norepinephrine release in a human model of protracted myocardial ... histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models ...

... focusing on ocean process modelling. During these years he established the journal Ocean Modelling, which rapidly became one of ... Neurological disease deaths in England, Deaths from motor neuron disease, 1946 births, 2008 deaths, People from Birmingham, ... In Oxford he "built and led a research team at the forefront of numerical ocean modelling". With the closure of the Institute, ... applying mathematical modelling to anthropological empirical research. His work in this area began in 1972, when he met ...

The familiar model of care for people with advanced dementia and dysphagia is the revolving door of recurrent chest infections ... Most aspiration events occur in patients with a defective swallowing mechanism, such as a neurological disease or as the result ... Hansjee, Djaromee (2018). "An Acute Model of Care to Guide Eating & Drinking Decisions in the Frail Elderly with Dementia and ... Owing to multiple factors, such as frailty, impaired efficacy of swallowing, decreased cough reflex and neurological ...

"A review of functional neurological symptom disorder etiology and the integrated etiological summary model". Journal of ... Within DSM 5, patients presenting with PNES may meet the criteria for functional neurological disorder and in some cases, ... PNES fall under the category of disorders known as functional neurological disorders (FND), also known as conversion disorders ... Clinical findings provide evidence of incompatibility between the symptom and recognized neurological or medical conditions. ...

Savastano (2014). "Sciatic nerve injury: A simple and subtle model for investigating many aspects of nervous system damage and ... Neurological Research. 17 (4): 307-311. doi:10.1080/01616412.1995.11740333. PMID 7477749. Sunderland (1968). Nerves and Nerve ...

Consequently, these three cyclopentenone-PGs and the two epoxyisoprostanes are suggested to be models for the development of ... neurological, and other cell types. The three PGJ2 cyclopentenone prostaglandins induce apoptosis in rodent cultured neuron ... appears to cause the dilation of coronary arteries and thereby protect against cardiac ischemia and heart attack in a rat model ... prostaglandins by the brain has been suggested to contribute to the neuron injury observed in various rodent models of ...

In animal models and a very small clinical trial, meldonium has been shown to reduce blood glucose concentrations, exhibit ... Sjakste, N; Gutcaits, A; Kalvinsh, I (2004). "Mildronate: an antiischemic drug for neurological indications". CNS Drug Reviews ... In a study in a transgenic mouse model of Alzheimer's disease, meldonium increased cognition and mental performance by reducing ... "Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats". British Journal of ...

A model-based prediction by Leighton et al. (2012) suggests that the range of the I. scapularis tick will expand into Canada by ... Neurological problems following tick bites were recognized starting in the 1920s. French physicians Garin and Bujadoux ... Leighton PA, Koffi JK, Pelcat Y, Lindsay LR, Ogden NH (2012). "Predicting the speed of tick invasion: An empirical model of ... In 1930, the Swedish dermatologist Sven Hellerström was the first to propose EM and neurological symptoms following a tick bite ...

"Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome". Nature ... a Key Contributor to Neurological Disease, Activates and Represses Transcription". Science. 320 (5880): 1224-1229. Bibcode: ...

Aghajanian GK, Marek GJ (March 2000). "Serotonin model of schizophrenia: emerging role of glutamate mechanisms". Brain Research ... Journal of the Neurological Sciences. 229-230: 201-9. doi:10.1016/j.jns.2004.11.028. PMID 15760640. S2CID 39812016. Bruno V, ... "Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression". Journal of Neurogenetics. 25 (4 ... "Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery ...