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*  Protein kinase, AMP-activated, alpha 1
"Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase". J. ... 1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the ... Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002). "AMP-activated protein kinase suppresses protein synthesis in rat ... AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. The protein ...
*  P38 mitogen-activated protein kinases
... are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress ... p38 Mitogen-Activated Protein Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) P38mapkPathway p38 ... MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to ... a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". J. Pharmacol. Exp. ...
*  Mitogen-activated protein kinase
Signal transduction MAP kinase kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 ... MAP Kinase Resource . Table of names for mitogen-activated kinases. MAPK cascade picture Mitogen-Activated Protein Kinases at ... A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine ... The closest relatives of MAPKs are the cyclin-dependent kinases (CDKs). The first mitogen-activated protein kinase to be ...
*  Mitogen-activated protein kinase 9
... is an enzyme that in humans is encoded by the MAPK9 gene. The protein encoded by this gene ... a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase ... virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human ... "The JIP group of mitogen-activated protein kinase scaffold proteins". Molecular and Cellular Biology. 19 (10): 7245-54. doi: ...
*  Mitogen-activated protein kinase kinase
Signal transduction MAP kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase Dérijard B, et al. (1995). "Independent ... Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a kinase enzyme which phosphorylates mitogen- ... Mitogen-Activated Protein Kinase Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... activated protein kinase (MAPK). MAP2K is classified as EC 2.7.12.2. There are seven genes: MAP2K1 (a.k.a. MEK1) MAP2K2 (a.k.a ...
*  Mitogen-activated protein kinase kinase kinase 15
... is a protein that in humans is encoded by the MAP3K15 gene. The protein ... Mitogen-activated protein kinase kinase kinase 15". Retrieved 2017-05-25. This article incorporates text from the United States ... where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates ... encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a ...
*  SOS1
"Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases". J. Biol. Chem. 272 (48 ... Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D (1996). "Identification of the mitogen-activated protein kinase ... "Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation ... nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases ...
*  Prostaglandin F receptor
... to activate the Rho family of GTPases signaling proteins and Gi-Gβγ G proteins to activateRaf/MEK/mitogen-activated kinase ... RAF/MEK/Mitogen-activated protein kinases; PKC/Ca2+/Calcineurin/Nuclear factor of activated T-cells; and the EGF cellular ... regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase ... phospholipase C/IP3/cell Ca2+ mobilization/diacylglycerol/protein kinase Cs; calmodulin-modulated myosin light chain kinase; ...
*  MAPK4
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor ... "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647-9. PMID 8290275. "Entrez Gene: MAPK4 mitogen- ... Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene. ... Robinson MJ, Cobb MH (1997). "Mitogen-activated protein kinase pathways". Curr. Opin. Cell Biol. 9 (2): 180-6. doi:10.1016/ ...
*  MAP3K8
... mitogen-activated protein kinase kinase kinase 8". Arthur JS, Ley SC (Sep 2013). "Mitogen-activated protein kinases in ... Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. This gene was ... This kinase can activate both the ERK1/2 and p38 MAP kinases. This kinase was shown to activate IkappaB kinases, and thus ... Chiariello M, Marinissen MJ, Gutkind JS (Mar 2000). "Multiple mitogen-activated protein kinase signaling pathways connect the ...
*  MAPK13
Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in ... mitogen-activated protein kinase 13". Efimova T, Broome AM, Eckert RL (2004). "Protein kinase Cdelta regulates keratinocyte ... 2008). "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection ... Efimova T (2010). "p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis". Cell Cycle. 9 (3): ...
*  MAPK12
Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress- ... Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal ... 2008). "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection ... Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular ...
*  NFATC4
Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW (Jun 2002). "Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases ... Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene. The product of ... NFATC4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The ...
*  Losmapimod
p38 mitogen-activated protein kinases are mediators of inflammation. A Phase II human clinical trial for the treatment of COPD ... Inhibition of p38 Mitogen-Activated Protein Kinase Improves Nitric Oxide-Mediated Vasodilatation and Reduces Inflammation in ... p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for ... by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases. ...
*  NLK
"Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent ... 2003). "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta- ... This enzyme is a member of the Mitogen-activated protein kinase (MAPK) family, although not explicitly designated as such (it ... Coulombe P, Meloche S (August 2007). "Atypical mitogen-activated protein kinases: structure, regulation and functions". Biochim ...
*  PELI1
Jensen LE, Whitehead AS (2003). "Pellino2 activates the mitogen activated protein kinase pathway". FEBS Lett. 545 (2-3): 199- ... Protein pellino homolog 1 is a protein that in humans is encoded by the PELI1 gene. GRCh38: Ensembl release 89: ENSG00000197329 ... Butler MP, Hanly JA, Moynagh PN (2007). "Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and ... direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases". J. Biol. Chem. 282 (41): 29729-29737. doi: ...
*  MAPK6
... and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal- ... Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene. The protein encoded by this gene ... "Entrez Gene: MAPK6 mitogen-activated protein kinase 6". MAP Kinase Resource . Boulton TG, Nye SH, Robbins DJ, et al. (1991). " ... Robinson MJ, Xu Be BE, Stippec S, Cobb MH (2002). "Different domains of the mitogen-activated protein kinases ERK3 and ERK2 ...
*  MAPK15
The protein encoded by this gene is a member of the MAP (mitogen-activated protein) kinase family. MAP kinases are also known ... including cyclin-dependent kinase 2 (CDK2), mitogen-activated protein kinase 12 (MAPK12), and lactotransferrin (LTF), among ... Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 ... "Entrez Gene: MAPK15 mitogen-activated protein kinase 15". Chia J, Tham KM, Gill DJ, Bard-Chapeau EA, Bard FA (2014). "ERK8 is a ...
*  MAPK3
Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene. The protein encoded by this gene ... "Entrez Gene: MAPK3 mitogen-activated protein kinase 3". Buggele WA, Johnson KE, Horvath CM (2012). "Influenza A virus infection ... Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S- ... "The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding ...
*  Cell division control protein 4
Huang CY, Ferrell JE (Sep 1996). "Ultrasensitivity in the mitogen-activated protein kinase cascade". Proceedings of the ... This results in proteins that differ only at their N-termini. Cdc4 protein interacts with Cdc34, an ubiquitin-conjugating ... Cdc4 (cell division control protein 4) is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ... cytoskeletal scaffold protein Far1, the transcription factor Gcn4, and the replication protein Cdc6. In addition to those ...
*  PELI2
Jensen LE, Whitehead AS (2003). "Pellino2 activates the mitogen activated protein kinase pathway". FEBS Lett. 545 (2-3): 199- ... Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene. GRCh38: Ensembl release 89: ENSG00000139946 ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by ...
*  MAPK7
This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the ... "Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases". J. ... Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene. MAPK7 ... "Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein". J. ...
*  Mitogen
Mitogens trigger signal transduction pathways in which mitogen-activated protein kinase (MAPK) is involved, leading to mitosis ... "The role of mitogen-activated protein (MAP) kinase in breast cancer". February 2002, The Journal of Steroid Biochemistry and ... "Hyperexpression of mitogen-activated protein kinase in human breast cancer." 1 April 1997, The Journal of Clinical ... One system particularly important in the proliferation of cancers is the mitogen-activated protein kinase, or MAPK, system. ...
*  U0126
8, 2839-2844, (1998) Fukazawa, H., et al., Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) ... Smith, 2007) Favata, M., et al., Identification of a novel inhibitor of mitogen-activated protein kinase. J. Biol. Chem. 273, ... Inhibition of mitogen-activated protein kinase blocks T cell proliferation but does not induce or prevent anergy. J. Immunol. ... U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. U0126 was found to functionally ...
*  IQGAP1
Roy M, Li Z, Sacks DB (September 2005). "IQGAP1 is a scaffold for mitogen-activated protein kinase signaling". Mol. Cell. Biol ... Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is ... or poly-proline protein-protein domain, so named because of two functionally conserved tryptophans, W, is a protein-protein ... It was hypothesized that IQGAP1 would act as a GTPase activating protein (GAP) protein, promoting the switch of ras GTPases ...
*  MAPK8IP3
"Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3". Matsuura, Hiroshi; Nishitoh Hideki; Takeda ... "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol Cell Biol. 20 (3): 1030 ... MAPK8IP3 has been shown to interact with ASK1, C-Raf, PTK2, MAPK10, Mitogen-activated protein kinase 9, MAPK8, MAP2K1, KLC2, ... 2002). "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and ...
*  Ralimetinib
It is a p38 mitogen-activated protein kinase inhibitor. A phase II trial for treatment of ovarian cancer is expected to be ...