*  Protein kinase, AMP-activated, alpha 1
"Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase". J. ... 1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the ... Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002). "AMP-activated protein kinase suppresses protein synthesis in rat ... prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase ...
*  MAPK1
"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 ( ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909-20. doi:10.1093/ ... "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine ... "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal ...
*  YWHAB
Zheng Q, Yin G, Yan C, Cavet M, Berk BC (March 2004). "14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) ... 14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene. This gene encodes a protein belonging to ... Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid ... "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem ...
*  MAP3K3
... and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase ... Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on ... "Entrez Gene: MAP3K3 mitogen-activated protein kinase kinase kinase 3". Gilmore PM, McCabe N, Quinn JE, Kennedy RD, Gorski JJ, ... "BRCA1 interacts with and is required for paclitaxel-induced activation of mitogen-activated protein kinase kinase kinase 3". ...
*  Cell Signaling Technology
"Hepatic Mitogen-Activated Protein Kinase Phosphatase 1 Selectively Regulates Glucose Metabolism and Energy Homeostasis". ... mouse and rat proteins. The types of PTMs curated include phosphorylation, acetylation, methylation, ubiquitylation, ... "PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells". Cell. 155 (2): 397-409. ... 35 (1): 26-40. doi:10.1128/MCB.00503-14. PMC 4295383 . PMID 25312648. Israelsen, William J.; Dayton, Talya L.; Davidson, Shawn ...
*  DUSP1
"Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the ... and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its ... "Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma". International Journal ... "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual ...
*  Histone deacetylase inhibitor
"Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1 ... HDACs are involved in the pathway by which the retinoblastoma protein (pRb) suppresses cell proliferation. The pRb protein is ... Non-histone proteins such as transcription factors are also targets for acetylation with varying functional effects. ... Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T (February 1998). "Retinoblastoma protein recruits histone ...
*  MAPK7
This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the ... "Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases". J. ... Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene. MAPK7 ... "Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein". J. ...
*  MAP2K1IP1
Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene. The ... "Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1". Wunderlich W, Fialka I, Teis D, Alpi A ... "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal ... "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal ...
*  Mothers against decapentaplegic homolog 3
... particularly to the activity of mitogen-activated protein kinase kinase-1 (MEK1). Studies have demonstrated that inhibition of ... "SMAD3 expression is regulated by mitogen-activated protein kinase kinase-1 in epithelial and smooth muscle cells". Cellular ... The expression of SMAD3 has been related to the mitogen-activated protein kinase (MAPK/ERK pathway), ... The SMAD3 complex with the GGCGC site reveals that the protein-DNA interface is highly complementary and that one MH1 protein ...
*  MAP2K1
... is also known as MEK1 (see Mitogen-activated protein kinase kinase). MEK1 is a meiotic chromosome-axis-associated kinase ... The protein encoded by this gene is a member of the dual-specificity protein kinase family that acts as a mitogen-activated ... Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. ... "Entrez Gene: MAP2K1 mitogen-activated protein kinase kinase 1". Goldfarb T, Lichten M (2010). "Frequent and efficient use of ...
*  MAPK phosphatase
"Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete ... Wu, J. J.; Zhang, L.; Bennett, A. M. (16 May 2005). "The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase ... Wu, J. J.; Zhang, L.; Bennett, A. M. (16 May 2005). "The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase ... Wu, J. J.; Zhang, L.; Bennett, A. M. (16 May 2005). "The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase ...
*  Angiostatin
Redlitz A, Daum G, Sage EH (1999). "Angiostatin diminishes activation of the mitogen-activated protein kinases ERK-1 and ERK-2 ... Angiostatin is a 38 kDa fragment of a larger protein, plasmin (itself a fragment of plasminogen) enclosing three to five ... Angiostatin is known to bind many proteins, especially to angiomotin and endothelial cell surface ATP synthase but also ... Angiostatin is a naturally occurring protein found in several animal species, including humans. It is an endogenous ...
*  MAPKAP1
"Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1". Colicelli J, Nicolette C, Birchmeier C, et al. ( ... This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively ... Schroder W, Bushell G, Sculley T (2005). "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
*  Ro-318220
"The Selective Protein Kinase C Inhibitor, Ro-31-8220, Inhibits Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) ... Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. Beltman, Jerlyn; Frank McCormick; Simon J. ... and Activates Jun N-terminal Kinase". Journal of Biological Chemistry. 271: 27018-27024. doi:10.1074/jbc.271.43.27018. ...
*  MKNK2
Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909-20. doi: ... "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high ... "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Mol. Cell. Biol. ...
*  STK10
The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 ... and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, ... Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene. This gene encodes a member of the ... 1997). "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes". J. Biol. Chem. 272 (36 ...
*  MAPK8IP1
"Entrez Gene: MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1". Yasuda, J; Whitmarsh A J; Cavanagh J; Sharma M ... 2000). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10): 7245-54. doi:10.1128/ ... Davis R J (October 1999). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. UNITED STATES ... "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. 20 (3): ...
*  Viral infectivity factor
Yang, X; Gabuzda D (1998). "Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif protein". J. Biol. Chem ... Vif is a 23-kilodalton protein that is essential for viral replication. Vif inhibits the cellular protein, APOBEC3G, from ... Viral infectivity factor, or Vif, is a protein found in HIV and other retroviruses. Its role is to disrupt the antiviral ... Vif was considered as a phospho-protein and phosphorylation seemed to be required for viral infectivity. But recent studies ...
*  PDCD4
"Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress ... Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene. It is one of the targets of an ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... Göke R, Gregel C, Göke A, Arnold R, Schmidt H, Lankat-Buttgereit B (2004). "Programmed Cell Death Protein 4 (PDCD4) Acts As a ...
*  MAP4K1
Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is ... "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. 272 (44): 27804-11 ... "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of ... a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev. 10 (18): 2251-64. doi: ...
*  RPS6KA5
... coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase". ... Markou T, Lazou A (2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat ... 1999). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)". Oncogene. 17 (24): 3157-67. doi ... "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation ...
*  ETV1
"Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase ... "Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins". Genes ... and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746-55. doi:10.1038/sj.onc.1206185. PMID 12569367. Goel A, ... Wu J, Janknecht R (Nov 2002). "Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein ...
*  Prostaglandin EP4 receptor
Desai S, Ashby B (July 2001). "Agonist-induced internalization and mitogen-activated protein kinase activation of the human ... regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in ... Agents which activate certain isoforms of protein kinase C can also desensitize EP4 by a process termed heterologous ... a kinase which in turn activates signaling molecules, in particular, the transcription factor, CREB. Activated CREB stimulates ...
*  RELA
"Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)". The EMBO ... including glycogen-synthase kinase-3β (GSK3β), AKT/phosphatidylinositol 3-kinase (PI3K) and NF-κB activating kinase (NAK, i.e. ... On the other hand, mitogen and stress-activated kinase 1 (MSK1) are also able to phosphorylate RELA at residue 276 under TNFα ... Phosphorylation of serine 311 by protein kinase C zeta type (PKCζ) serves the same purpose. Two residues in the TAD region are ...
*  MAPK8IP3
"Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3". Matsuura, Hiroshi; Nishitoh Hideki; Takeda ... "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol Cell Biol. 20 (3): 1030 ... MAPK8IP3 has been shown to interact with ASK1, C-Raf, PTK2, MAPK10, Mitogen-activated protein kinase 9, MAPK8, MAP2K1, KLC2, ... 2002). "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and ...
*  HSPB2
Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated ... a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase". J Cell Biol ... Heat shock protein beta-2 is a protein that in humans is encoded by the HSPB2 gene. HSPB2 has been shown to interact with: ... Park KJ, Gaynor RB, Kwak YT (2003). "Heat shock protein 27 association with the I kappa B kinase complex regulates tumor ...