Major and Minor Histocompatibility Antigens to Non-Inherited Maternal Antigens (NIMA), Histocompatibility. INTECH. p. 146. ISBN ... Minor histocompatibility antigen (also known as MiHA) are peptides presented on the cellular surface of donated organs that are ... Minor histocompatibility antigens are due to normal proteins that are in themselves polymorphic in a given population. Even ... Minor+histocompatibility+antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Immune system). ...
... shows characteristics of being a minor histocompatibility antigen, as well as tumor suppressor capabilities. The high ... Roopenian D, Choi EY, Brown A (December 2002). "The immunogenomics of minor histocompatibility antigens". Immunological Reviews ... identification of hematopoietic-specific minor histocompatibility antigen UTA2-1". Leukemia. 27 (3): 642-9. doi:10.1038/leu. ...
... encoding two novel hematopoietic lineage-specific minor histocompatibility antigens". J Exp Med. 197 (11): 1489-500. doi: ...
2005). "Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1". Blood. ... "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens. 52 (4): 312 ... 2002). "Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a ... 2005). "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation". ...
Minor histocompatibility antigens, a conceptually similar antigen class are also correctly identified by MHC binding algorithms ... T-independent antigen - Antigens that stimulate B cells directly. Immunodominant antigens - Antigens that dominate (over all ... Antigen-presenting cells present antigens in the form of peptides on histocompatibility molecules. The T cells selectively ... A native antigen is an antigen that is not yet processed by an APC to smaller parts. T cells cannot bind native antigens, but ...
Minor histocompatibility antigen H13 is a protein that in humans is encoded by the HM13 gene. The minor histocompatibility ... "Entrez Gene: HM13 histocompatibility (minor) 13". "Entrez Gene: H13 histocompatibility (minor) 13". Snell GD, Cudkowicz G, ... If a related polymorphism exists, and if the HM13 serves as a Minor histocompatibility antigen, however, remains to be ... Mendoza LM, Paz P, Zuberi A, Christianson G, Roopenian D, Shastri N (Oct 1997). "Minors held by majors: the H13 minor ...
November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". ... November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". ... The STT3B protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1 ...
"The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing". The Journal ... "Feasibility of using genetic linkage analysis to identify the genes encoding T cell-defined minor histocompatibility antigens ... ". Tissue Antigens. 59 (4): 293-303. doi:10.1034/j.1399-0039.2002.590407.x. PMID 12135428. Scherl A, Couté Y, Déon C, Callé A, ...
"Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical ... 2001). "Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers". J. ... MHC pentamers have been used in the detection of antigen-specific CD8+ T cells in flow cytometry, and are cited in over 750 ... MHC multimers allow for ex vivo selection and proliferation of T-cells specific to viral or tumor-related antigens, which can ...
2004). "Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell ... 2002). "The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft- ...
A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor ... are immunodominant minor histocompatibility antigens after bone marrow transplantation". Transplantation. 66 (7): 910-6. doi: ... "Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease ... gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens". ...
... tandem linkage with the minor histocompatibility antigen HA-1 gene". Biochemical and Biophysical Research Communications. 278 ( ...
"A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y ...
This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative ... "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft ... March 2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen". Journal of Immunology. 164 (5): 2807-14. doi: ...
Lio HY, Tang JL, Wu J, Wu SJ, Lin CY, Yang YC (September 2010). "Minor histocompatibility antigen HA-1 and HA-2 polymorphisms ... "Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative ... "Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs ...
The Sidrón Cave Y chromosome coded for several minor histocompatibility antigen genes that differ from that of modern humans. ...
July 2003). "The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid ...
... tolerance can be established in vitro and in vivo for both MHC class I and II as well as minor histocompatibility antigens. ... This means that T-cells with a T-cell receptor specific to antigens presented on the veto cell, bind to the veto cell, and are ... Because veto cells can only suppress T-cell progenitors that are directed against antigens on the veto cells themselves, but ... Veto activity is thought to be a form of antigen-specific suppression that maintains continuous self-tolerance. Cells with veto ...
"The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B- ... An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells. ...
... especially regarding minor histocompatibility antigen, at Leiden University. Goulmy is an expert in the area of tissue typing ... Minor antigens can induce strong immune reactions. She discovered the H-Y minor antigen encoded by the Y-chromosome (1976) and ... Hereby minor antigens, such as HA-1, are used as 'vaccin' to boost the anti-blood cancer reaction in the patients' body. Els ... Crucial was her work on the differential expression of minor antigens showing either overall expression on all body cells, such ...
Her studies in the area of minor histocompatibility antigens showed that male-specific cytotoxic T cells recognize self-MHC and ... Simpson is particularly known for her elucidation of the nature of male-associated minor transplantation antigens, and their ... Alongside him, she studied the immunology of graft rejection by observing the antigens found on grafts from male mice. With ... She has made contributions to immunology by observing the interactions between T cells and Y chromosome antigens. ...
T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type". ... T Cells of Donor Origin Can Respond to Minor Histocompatibility Antigens in Association With Either Donor or Host H-2 Type". ... the article in which "professional antigen presenting cells" were first named) Fuchs E., Matzinger P. B. (1992). "B cells turn ... In her 1994 article "Tolerance, Danger, and the Extended Family", Matzinger extended the danger model, arguing that antigen- ...
... minor histocompatibility antigen, seemed to be encoded in the SMCY gene (acronym for 'selected mouse cDNA on Y'), later ... H-Y antigen is a male tissue specific antigen. Originally thought to trigger the formation of testes (via loci, an autosomal ... One theory to explain this involves H-Y antigens, which suggests that a maternal immune reaction to these antigens has, to an ... which would be expected since H-Y antigen is male tissue specific, the 'probable involvement of H-Y antigen in the development ...
... response is still not fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens ... Tissue Antigens. 81 (4): 183-93. doi:10.1111/tan.12090. PMC 3645301. PMID 23510414. Chang YJ, Zhao XY, Huang XJ (2018-12-21). " ... expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is ...
... called minor histocompatibility antigens) that can be presented by major histocompatibility complex (MHC) molecules to the ... Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival ... The T cells produce an excess of cytokines, including TNF-α and interferon-gamma (IFNγ). A wide range of host antigens can ... It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the ...
Immunization of mothers against male-specific minor histocompatibility (H-Y) antigens has a pathogenic role in many cases of ...
Other non-HLA proteins, known as minor histocompatibility antigens, do exist but generally are unable to cause acute rejection ... begin to recognize antigens on transplanted organ/graft. This recognition occurs due to the major histocompatibility complex ( ... These antigens are located on the endothelial lining of blood vessels within the transplanted organ and, once antibodies bind, ... In humans, this is known as the human leukocyte antigen (HLA) system and over 17,000 HLA alleles or genetic variants have been ...
In mice, a nonamer peptide originating from the SPP protein serves as minor histocompatibility antigen HM13 that plays a role ... "Entrez Gene: H13 histocompatibility (minor) 13". Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote ... Snell GD, Cudkowicz G, Bunker HP (Jun 1967). "Histocompatibility genes of mice. VII. H-13, a new histocompatibility locus in ...
He further suggested that H-Y antigen, a minor histocompatibility protein encoded by a gene on the Y chromosome and absent in ... Johnson, A. G.; Gaines, S.; Landy, M. (February 1, 1956). "Studies on the O antigen of Salmonella typhosa. V. Enhancement of ... In studying H-Y antigen, Beutler became conversant with immunology and mouse genetics during the 1970s. While a college student ... Later, an extracellular component of the LPS receptor complex, MD-2 (also known as lymphocyte antigen 96), was identified by R ...
Mimotope Minor histocompatibility antigen Mitogen Molecular mimicry Monoclonal antibody Monoclonal antibody therapy Monokine ... Herd immunity Heterophile Heterophile antigen Heterosubtypic immunity Histamine Histocompatibility Human leukocyte antigen ... opsonization Antibody-dependent cell-mediated cytotoxicity Antibody-dependent enhancement Antigen Antigen presentation Antigen ... Fc receptor Fc receptor-like molecule FcεRI Fibroblast-like synoviocyte FITkit FluoroSpot Forssman antigen Fragment antigen- ...