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*  Eplerenone
... is an antimineralocorticoid, or an antagonist of the mineralocorticoid receptor (MR). Eplerenone is also known ... "Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology". Kidney International. 57 (4): 1408-1411. ... Classed as a selective aldosterone receptor antagonist (SARA), it is similar to the diuretic spironolactone, though it is much ... the depletion of essential potassium and magnesium levels that are common amongst other mineralocorticoid receptor antagonists ...
*  7α-Thiomethylspironolactone
Kolkhof P, Bärfacker L (2017). "30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of ... Maron BA, Leopold JA (2008). "Mineralocorticoid receptor antagonists and endothelial function". Curr Opin Investig Drugs. 9 (9 ... Parthasarathy HK, MacDonald TM (2007). "Mineralocorticoid receptor antagonists". Curr. Hypertens. Rep. 9 (1): 45-52. PMID ... 7α-Thioprogesterone Yang J, Young MJ (2016). "Mineralocorticoid receptor antagonists-pharmacodynamics and pharmacokinetic ...
*  Canrenone
ISBN 978-1-4051-4370-7. Maron BA, Leopold JA (2008). "Mineralocorticoid receptor antagonists and endothelial function". Curr ... Fernandez, MD; Carter, GD; Palmer, TN (1983). "The interaction of canrenone with oestrogen and progesterone receptors in human ...
*  Esaxerenone
It acts as a highly selective silent antagonist of the mineralocorticoid receptor (MR), the receptor for aldosterone, with ... Kolkhof P, Nowack C, Eitner F (2015). "Nonsteroidal antagonists of the mineralocorticoid receptor". Curr. Opin. Nephrol. ... "Mineralocorticoid receptor antagonists-pharmacodynamics and pharmacokinetic differences". Curr Opin Pharmacol. 27: 78-85. doi: ... greater than 1,000-fold selectivity for this receptor over other steroid hormone receptors, and 4-fold and 76-fold higher ...
*  Apararenone
... acts as a highly selective antagonist of the mineralocorticoid receptor (Ki < 50 nM), the receptor for aldosterone ... Kolkhof P, Nowack C, Eitner F (2015). "Nonsteroidal antagonists of the mineralocorticoid receptor". Curr. Opin. Nephrol. ... "Mineralocorticoid receptor antagonists-pharmacodynamics and pharmacokinetic differences". Curr Opin Pharmacol. 27: 78-85. doi: ...
*  Finerenone
Mineralocorticoid Receptor Antagonist Tolerability Study-Diabetic Nephropathy (ARTS-DN) Study Group (2015). "Effect of ... "Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): A randomized study of ... Mineralocorticoid receptor inhibition is responsible for the desired action of the drugs, whereas inhibition of the other ... Finerenone blocks mineralocorticoid receptors, which makes it a potassium-sparing diuretic. This table compares inhibitory ( ...
*  Johann Bauersachs
Mineralocorticoid Receptor Activation and Mineralocorticoid Receptor Antagonist Treatment in Cardiac and Renal Diseases. ... Bauersachs J. The ARTS of third-generation mineralocorticoid receptor antagonists: achieving cardiovascular benefit with ... the mineralocorticoid receptor (MR) antagonist Eplerenone and a novel enhancer of endothelial NO synthase. The importance of ... Fraccarollo D, Galuppo P, Schraut S, Kneitz S, van Rooijen N, Ertl G, Bauersachs J (2008). Immediate Mineralocorticoid Receptor ...
*  Antimineralocorticoid
Aldosterone antagonists are, as the name suggests, receptor antagonists at the mineralocorticoid receptor. Antagonism of these ... and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear ... MRI which are both widely recognized medical acronyms as compared to the use of MRA for mineralocorticoid receptor antagonist ... is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often ...
*  Potassium canrenoate
"30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development". J. ... is an aldosterone antagonist of the spirolactone group. Like spironolactone, it is a prodrug, and is metabolized to active ...
*  Heart failure
Japp, D; Shah, A; Fisken, S; Denvir, M; Shenkin, S; Japp, A (9 January 2017). "Mineralocorticoid receptor antagonists in ... with the exception of mineralocorticoid antagonists such as spironolactone. Mineralocorticoid antagonists in those under 75 ... In people with markedly reduced ejection fraction, the use of an aldosterone antagonist, in addition to beta blockers and ACE-I ... For those with severe disease, aldosterone antagonists, or hydralazine with a nitrate may be used. Diuretics are useful for ...
*  SC-5233
It was the first antagonist of the mineralocorticoid receptor to have been identified and tested in humans. The drug was found ...
*  Amlodipine
... has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an ... Olmesartan is an angiotensin II receptor antagonist and blocks part of the RAAS pathway. Amlodipine/perindopril if using ... Luther, James M. (2014). "Is there a new dawn for selective mineralocorticoid receptor antagonism?". Current Opinion in ... Amlodipine/valsartan or amlodipine/valsartan/hydrochlorothiazide, where valsartan is an angiotensin II receptor antagonist. The ...
*  Felodipine
... has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an ... Luther, James M. (2014). "Is there a new dawn for selective mineralocorticoid receptor antagonism?". Current Opinion in ...
*  Nifedipine
... has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an ... Luther, James M. (2014). "Is there a new dawn for selective mineralocorticoid receptor antagonism?". Current Opinion in ... The use of nifedipine and related calcium channel antagonists was much reduced in response to 1995 trials that mortality was ... although calcium channel antagonists, along with thiazide diuretics, are still favoured as primary treatment for patients over ...
*  Nitrendipine
... has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an ... 271: 5293-6 Luther, James M. (2014). "Is there a new dawn for selective mineralocorticoid receptor antagonism?". Current ...
*  Central serous retinopathy
Epleronone is a mineralocorticoid receptor antagonist that has been proven to reduce the subretinal fluid that is present in ... Spironolactone is a mineralocorticoid receptor antagonist that has been proven to help reduce the fluid associated with Central ...
*  Exelixis
"Press release: Daiichi Sankyo Initiates Phase 3 study of CS-3150, a Novel Mineralocorticoid Receptor Antagonist for Treatment ... In 2006 Exelixis partnered with Daiichi Sankyo on compounds that targeted mineralocorticoid receptors; esaxerenone was part of ...
*  Progesterone (medication)
It is also a potent antimineralocorticoid (antagonist of the mineralocorticoid receptor (MR)), as well as a very weak ... it is an antagonist of the sigma σ1 receptor, a negative allosteric modulator of nicotinic acetylcholine receptors, and, via ... Progesterone does not bind to the androgen receptor (AR) or to the estrogen receptor (ER). In addition to its activity as a ... Progesterone is a weak but significant agonist of the pregnane X receptor (PXR), and has been found to induce several hepatic ...
*  Neurocardiology
Aldosterone antagonist Spironolactone This medication acts by inhibiting binding to mineralocorticoid receptors. This has shown ... doi:10.1111/j.1755-5922.2010.00244.x. Maron, Bradley (2010). "Aldosterone Receptor Antagonists: Effective but Often Forgotten ... Aldosterone antagonists are usually a form of combined treatment with other cardiac medications, but it appears to induce ...
*  18-Deoxyaldosterone
... antimineralocorticoid with mixed agonist-antagonist but predominantly antagonistic activity at the mineralocorticoid receptor. ... "Molecular structure of 18-deoxyaldosterone and its relationship to receptor binding and activity". Journal of the American ...
*  Spirolactone
... or antagonists of the mineralocorticoid receptor (which is activated predominantly by the mineralocorticoid steroid hormone ... 82-. ISBN 978-0-8493-4724-5. Luther, James M. (2014). "Is there a new dawn for selective mineralocorticoid receptor antagonism ...
*  SC-8109
It is a potent antagonist of the mineralocorticoid receptor and is more potent than the related drug SC-5233 (of which SC-8109 ...
*  Tibolone
... and 3β-hydroxytibolone act as antagonists of the glucocorticoid and mineralocorticoid receptors, with preference for the ... act as antagonists of these receptors. Lastly, tibolone, 3α-hydroxytibolone, ... mineralocorticoid receptor. Tibolone has tissue-selective estrogenic effects, with desirable effects in bone, the brain, and ... Tibolone and its metabolite Δ4-tibolone act as agonists of the progesterone and androgen receptors, while 3α-hydroxytibolone ...
*  Mineralocorticoid receptor
Spironolactone and eplerenone are steroidal MR antagonists of the spirolactone group. Activation of the mineralocorticoid ... The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group ... MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids. It belongs to the nuclear receptor family ... Mineralocorticoid receptor has been shown to interact with: Glucocorticoid receptor and TRIM24. Aldosterone Glucocorticoid ...
*  Guggulsterone
Mineralocorticoid receptor antagonist (Ki = 39 nM) Progesterone receptor partial agonist (Ki = 201 nM) Glucocorticoid receptor ... Androgen receptor antagonist (Ki = 240 nM) Estrogen receptor agonist (Ki > 5 μM; EC50 > 5 μM) Farnesoid X receptor antagonist ( ... In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol ... "Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor". Journal ...
*  7α-Thioprogesterone
A potent mineralocorticoid antagonist with reduced affinity for the 5 alpha-dihydrotestosterone receptor of human and rat ... of spironolactone and its active metabolites like 7α-thiomethylspironolactone for the rat ventral prostate androgen receptor ( ...