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*  Gliosis
The population of activated microglia at the site of a CNS injury includes not only endogenous microglia of the CNS but also ... While in their activated state, microglia may serve a variety of beneficial functions. For example, active microglia are the ... In addition, active microglia release anti-inflammatory factors and other molecules, such as IL-6 and TGF-β, which regulate ... Unlike astrocytes and microglia, oligodendrocytes undergo a much more limited reaction to injury. Rather, in cases of CNS ...
*  Glial fibrillary acidic protein
Rinaman L, Card JP, Enquist LW (Feb 1993). "Spatiotemporal responses of astrocytes, ramified microglia, and brain macrophages ...
*  Microglia
... home page at microglia.net Creeping into your Head - A Brief Introduction to Microglia - A Review from the Science ... Like perivascular microglia, juxtavascular microglia can be distinguished mainly by their location. Juxtavascular microglia are ... Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord. Microglia account for 10-15% of ... Activation of microglia places a load on the anabolic and catabolic machinery of the cells causing activated microglia to die ...
*  Role of microglia in disease
When microglia interact with the deposited fibrillar forms of β-amyloid it leads to the conversion of the microglia into an ... Microglia have also been suggested as a possible source of secreted β amyloid. Microglia also have a role in neurodegenerative ... In mice, microglia accumulate in the parasite migratory tracks and around damaged or dying worms. In vitro, microglia produce ... Many activated microglia are found to be associated with amyloid deposits in the brains of Alzheimer's patients. Microglia ...
*  CD68
However, in some cell types it is detectable only when up-regulated, such as activated but not quiescent microglia, and can ... and activated microglia in rat tissues. In this species, it is expressed in most macrophage populations and thus ED1 is ... microglia). Human CD68 is a transmembrane glycoprotein, heavily glycosylated in its extracellular domain, with a molecular ...
*  LBT-3627
The drug also affects microglia. In addition, LBT-3627 is more durable in the body compared to VIP. Scientists at the ...
*  Pío del Río Hortega
He managed to identify microglia between 1919 and 1921 by staining the cells with silver carbonate. His method of staining also ... Pío del Río Hortega (1882 - 1945) was a Spanish neuroscientist who discovered microglia. Río Hortega was born in Portillo, ... whilst Rio Hortega discovered microglia. which are the cells that protect the brain from infection. ...
*  Glutamate aspartate transporter
2003). "Expression of excitatory amino acid transporter-1 in brain macrophages and microglia of HIV-infected patients. A ... neuroprotective role for activated microglia?". J. Neuropathol. Exp. Neurol. 62 (5): 475-85. PMID 12769187. Glutamate Aspartate ...
*  Neuroinflammation
Microglia are recognized as the innate immune cells of the central nervous system. Microglia actively survey their environment ... Activated microglia are seen in abundance in post-mortem AD brains. Current thought is that in the presence of inflammatory ... These activated microglia and macrophages play a role in the pathogenesis of SCI. Upon infiltration of the injury site's ... During this time, microglia generate reactive oxygen species and release signals to recruit peripheral immune cells for an ...
*  Beth Stevens
Stevens is exploring the role of microglia in disorders such as autism. Several studies suggest that microglia are more active ... She has helped to identify the role of microglia in the "pruning" or removal of synaptic cells during brain development and has ... "Looking Back: Microglia in synaptic pruning". Cell. Retrieved 2015-10-14. "Beth Stevens: Casting immune cells as brain ... Stevens' work has led her to the discovery of different aspects of microglia, and the implications of their relevancy to the ...
*  Rostral migratory stream
Microglia also actively regulate adult neurogenesis. Under basal conditions, apoptotic corpses of newly generated neurons are ... In one study, the activation of microglia and recruitment of T cells were suggested to be required for enriched environment- ... Under inflammatory conditions, reactivated microglia can have both beneficial and detrimental effects on different aspects of ... The dual role of microglia". Neuroscience. 158 (3): 1021-1029. doi:10.1016/j.neuroscience.2008.06.052. PMID 18662748. Curtis, ...
*  Valladolid Science Museum
He was responsible for discovering microglia. There is a statue of him outside (and a permanent exhibition inside about neurons ...
*  Glutamate hypothesis of schizophrenia
... leading to inflammatory response and microglia activation. Similarly, toxoplasmosis infection in the CNS (positively correlated ...
*  Pathology of multiple sclerosis
Small increase in microglia and T cells. Active layer: Phagocytic demyelinating areas: There is myelin debris taken up by local ... NAWM is the place where lesions appear and the process seems to be made by microglia, in absence of leukocyte infiltration, ... At the final stage of the process, these microglia develop into active demyelinating MS lesion Gray matter tissue damage ... Inactive layer: Again activated microglia and dendritic cells were also found around blood vessels. Some lesions named "slowly ...
*  Sam Schmidt Paralysis Foundation
Microglia are immune cells for the spinal cord. After injury, they migrate to the site of injury to help clear away dead and ... 3. Within several weeks of the initial injury, the area of tissue damage has been cleared away by microglia, and a fluid-filled ...
*  Neuroglia
The exception is microglia, which are derived from hemopoietic stem cells. In the adult, microglia are largely a self-renewing ... Microglia are specialized macrophages capable of phagocytosis that protect neurons of the central nervous system. They are ... Most cerebral cortex glia are oligodendrocytes (75.6%); astrocytes account for 17.3% and microglia for 6.5%. Most glia are ... CS1 maint: Uses authors parameter (link) Brodal, 2010: p. 19 Never-resting microglia: physiological roles in the healthy brain ...
*  Effector cell
Microglia are located throughout the brain and spinal cord. They are the first line of immune defense in the CNS. Microglia are ... Microglia must always be capable of recognizing any foreign bodies, engulf them, and activate T-cells. Microglia can be found ... Microglia take on a unique phenotype when they detect local chemical signals. Microglia have a variety of different functions ... The vast amount of shapes are required for the microglia to carry out their primary function. Microglia are distinguishable ...
*  Astrocyte
"Neurotoxic reactive astrocytes are induced by activated microglia". Nature. 541 (7638): 481-487. doi:10.1038/nature21029. PMID ...
*  Pathophysiology of multiple sclerosis
Also B-cells and microglia could be involved It has been reported several times that CSF of some MS patients can damage myelin ... "Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation". Journal of ... The evolution of a preactive lesion is related to its microglia structure. Current models can be divided into two groups: ... This observation has been linked to the activity of the infiltrating leukocytes and activated microglia, and to the damage to ...
*  Lacunarity
Jelinek, Herbert; Karperien, Audrey; Milosevic, Nebojsa (June 2011). "Lacunarity Analysis and Classification of Microglia in ...
*  Purinergic signalling
In microglia, P2X and P2Y receptors are expressed. The P2Y6 receptor, which is primarily mediated by uridine diphosphate (UDP ...
*  Causes of Parkinson's disease
Teismann, P; Schulz, JB (Oct 2004). "Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation". Cell ...
*  Cathepsin S
... is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. ... Immune cells, including macrophages and microglia, secrete cathepsin S in response to inflammatory mediators including ... "Contribution of extracellular proteolysis and microglia to intracerebral hemorrhage". Neurocrit Care. 3 (1): 77-85. doi:10.1385 ...
*  Pancreatic islet macrophage
Pancreas Macrophage Islet of Langerhans Microglia Calderon, B (2016). "The pancreas anatomy conditions the origin and ...
*  HIV-associated neurocognitive disorder
Infected microglia add to the production of the virus. This activation of the microglia may contribute to the process of ... The main cells infected by HIV-1 in the nervous tissue are the microglia, astrocytes and macrophages, whereas infected neurons ... According to one theory, HIV either infects or activates cells that protect the brain, known as macrophages and microglia. ... The infected macrophages and microglia also appear to produce additional factors such as chemokines and cytokines that can ...