Geiger B (September 1979). "A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in ... Vinculin is a 117-kDa cytoskeletal protein with 1066 amino acids. The protein contains an acidic N-terminal domain and a basic ... The recent discovery of the 3D structure sheds light on how this protein tailors its shape to perform a variety of functions. ... Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one ...

Such multi-tasking by, or "partner promiscuity" of, proteins has been referred to as protein moonlighting. Proteins such as ... Cell Motility and Shape I: Microfilaments. 18.2. The Dynamics of Actin Assembly". Molecular cell biology. San Francisco: W.H. ... This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also ... "protein NP_066932". NCBI. Hannappel E (September 2007). "beta-Thymosins". Annals of the New York Academy of Sciences. 1112 (1 ...

For example, many thousands of actin molecules assemble into a microfilament. A protein usually undergoes reversible structural ... The sequence of a protein is unique to that protein, and defines the structure and function of the protein. The sequence of a ... Bu Z, Callaway DJ (2011). "Proteins MOVE! Protein dynamics and long-range allostery in cell signaling". Protein Structure and ... and joining proteins sharing these fragments into protein superfamilies is no longer justified. Topology of a protein can be ...

... including analogs of microfilaments, and that proteins are directed by regulatory processes to locate to specific places within ... G Laloux and C Jacobs-Wagner (2014) "How do bacteria localize proteins to the cell pole? J Cell Science 127: 11-19. doi:10.1242 ... She also discovered the protein crescentin, which forms bacterial intermediate filaments, structures once thought to occur only ... and Borrelia are not simply bags of biochemicals but instead program the locations of their protein components via their ...

They and Elias Lazarides had previously found that they could tag the subunit proteins of microtubules, microfilaments, ... During this period he worked on protein chemistry of RNA phages, but was beginning to shift his focus to animal cells and their ... Together they produced the "Weber and Osborn" SDS-PAGE paper, which showed that proteins could be dissolved in sodium dodecyl ... the expression of major cellular proteins, work he performed with Thomas Tuschl and collaborators. A few weeks work in Weber's ...

It may be attached to the microfilament cytoskeleton. GKRP competes with glucose to bind with GK, but inactivates it when bound ... The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in ... CS1: long volume value, Protein pages needing a picture, Genes on human chromosome 2, Proteins). ... GKRP is a 68 kD protein of 626 amino acids. It is coded for by a 19 exon gene, GCKR, on the short arm of chromosome 2 (2p23). ...

Protein enabled homolog is a protein that in humans is encoded by the ENAH gene. ENAH has been shown to interact with ABI1, ZYX ... a possible link to the microfilament system". The Journal of Neuroscience. 23 (23): 8330-8339. doi:10.1523/JNEUROSCI.23-23- ... SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell ... Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (December 1997). "The WW domain of neural protein FE65 ...

... is a protein that in humans is encoded by the GPHN gene. This gene encodes a neuronal assembly protein that anchors ... a possible link to the microfilament system". J. Neurosci. 23 (23): 8330-9. doi:10.1523/JNEUROSCI.23-23-08330.2003. PMC 6740687 ... Gephyrin is a 93kDa multi-functional protein that is a component of the postsynaptic protein network of inhibitory synapses. It ... The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65-73. doi: ...

They contain microfilaments (also called actin filaments) cross-linked into bundles by actin-bundling proteins, such as fascin ... A study deploying protein imaging of adult mice showed that filopodia in the explored regions were by an order of magnitude ... Khurana S, George SP (September 2011). "The role of actin bundling proteins in the assembly of filopodia in epithelial cells". ... Rho activity also results in activation by phosphorylation of ezrin-moesin-radixin family proteins that link actin filaments to ...

Spectrin proteins and actin microfilaments are attached to transmembrane proteins by attachment proteins between them and the ... The actomyosin cortex is attached to the cell membrane via membrane-anchoring proteins called ERM proteins that plays a central ... Many proteins are involved in the cortex regulation and dynamics including formins with roles in actin polymerization, Arp2/3 ... The protein constituents of the cortex undergo rapid turnover, making the cortex both mechanically rigid and highly plastic, ...

... is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all ... Intermediate filaments, along with tubulin-based microtubules and actin-based microfilaments, comprises the cytoskeleton. All ... Herrmann H, Wiche G (January 1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 ... October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-1178. ...

... mitogen-activated protein kinases that phosphorylate heat shock proteins such as Hsp27 to stabilise microfilaments, and casein ...

Motor proteins utilizing the cytoskeleton for movement fall into two categories based on their substrate: microfilaments or ... MBInfo - What are Motor Proteins? Ron Vale's Seminar: "Molecular Motor Proteins" Biology of Motor Proteins Institute for ... Besides the motor proteins above, there are many more types of proteins capable of generating forces and torque in the cell. ... The muscle protein myosin "motors" the contraction of muscle fibers in animals. The importance of motor proteins in cells ...

Actin microfilaments are linked to the transport of viral movement proteins to plasmodesmata which allow for cell to cell ... Larger molecules, including proteins (for example green fluorescent protein) and RNA, can also pass through the cytoplasmic ... High amounts of myosin proteins are found at the sites of plasmodesmata. These proteins are involved in directing viral cargoes ... One example of a viral movement proteins is the tobacco mosaic virus MP-30. MP-30 is thought to bind to the virus's own genome ...

Focal adhesions are multi-protein intracellular signalling complexes that link the cellular actin microfilament cytoskeleton, ... Programmed cell death protein 10 (PDCD10)/Cerebral Cavernous Malformation protein 3 (CCM3) and GIT1/GIT2. Hayashi I, Vuori K, ... In structural and cell biology, the focal adhesion targeting domain is a conserved protein domain that was first identified in ... FAT domains with a similar 4-helix bundle structure are also found in other proteins that localize to paxillin-containing focal ...

The first eukaryotic proteins identified were actin and actin-related proteins (Arp) 2 and 3 in Crenarchaeota, perhaps ... cytoskeletal microfilament involved in cell motility), tubulin (component of the large cytoskeleton, microtubule) and the ... Ubiquitin-related protein called Urm1 is also present in Crenarchaeota. DNA replication system (GINS proteins) in Crenarchaeota ... However, Asgards are found to contain genes that codes for several of such unique proteins, indicating that the proteins ...

... a mechanism for disruption of actin microfilament structure". Molecular Microbiology. 36 (3): 737-748. doi:10.1046/j.1365- ... Mattoo, Seema; Lee, Yvonne M; Dixon, Jack E (August 2007). "Interactions of bacterial effector proteins with host proteins". ... leading to protein aggregation, blockage of phosphorylation or inhibition of ATP binding. In plants, this kind of protein ... Bacterial effectors are proteins secreted by pathogenic bacteria into the cells of their host, usually using a type 3 secretion ...

1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal ... These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in ... proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. ... Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded ...

Vinculin is a eukaryotic protein that seems to be involved in the attachment of the actin-based microfilaments to the plasma ... Protein pages needing a picture, Protein domains, Protein families, Membrane proteins). ... Vinculin is a large protein of 116 kDa (about a 1000 residues). Structurally the protein consists of an acidic N-terminal ... Alpha-catenins are proteins of about 100 kDa which are evolutionary related to vinculin. In terms of their structure the most ...

May 1992). "A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with ... ActA is a protein which acts as a mimic of Wiskott-Aldrich syndrome protein (WASP), a nucleation promoting factor (NPF) present ... ActA has a molecular weight of 70,349 Da and is a surface protein. ActA is a natively unfolded protein which can be divided ... The Actin assembly-inducing protein (ActA) is a protein encoded and used by Listeria monocytogenes to propel itself through a ...

... tag triggers the dissociation of the cargo from motor protein and somehow guides it to dynamically formed microfilaments Since ... stating that the proteins captured by the synaptic tag are actually local proteins that are translated from mRNAs located in ... or repeated tetanization in the presence of protein-synthesis inhibitors, each results in protein-synthesis-dependent late LTP ... When they blocked protein synthesis prior to the delivery of strong S2 stimulation, the conversion to L-LTP was prevented, ...

Due to its homology with other proteins of similar function, as well as the location of the gene between tcdA and tcdB, tcdE is ... Distinct changes in the microfilament system lead to cell rounding and cell death. These changes result from the inactivation ... The protein contains three domains. The amino N-terminal domain contains the active site, responsible for the glucosylating ... Just I, Selzer J, von Eichel-Streiber C, Aktories K (March 1995). "The low molecular mass GTP-binding protein Rho is affected ...

In Dictyostelium discoideum (social amoeba), CAP is involved in microfilament reorganisation near the plasma membrane in a PIP2 ... Proteins that bind F-actin often regulate F-actin assembly and its interaction with other proteins, while proteins that ... In molecular biology, the cyclase-associated protein family (CAP) is a family of highly conserved actin-binding proteins ... Yeast CAPs are unique among the CAP family of proteins, because they are the only ones to directly interact with and activate ...

... which contain ERMs and EBP50 that may provide a connection to actin microfilaments. Several extracellular matrix proteins are ... All of these proteins, including ankyrin, are enriched in the initial segment of axons which suggests a functional relationship ... The proteins in these excitable domains of neuron when injured may result in cognitive disorders and various neuropathic ... The extra-cellular region of β subunits can associate with itself and other proteins, such as tenascin R and the cell-adhesion ...

... contains both the mRNA and ribonuclearprotein required for axonal protein synthesis. Axonal protein synthesis has been ... The axoplasm contains a high concentration of elongated mitochondria, microfilaments, and microtubules. Axoplasm lacks much of ... As a result, most enzymes and large proteins are transported from the soma through the axoplasm. Axonal transport occurs either ... Fast transport involves vesicular contents (like organelles) being moved along microtubules by motor proteins at a rate of 50- ...

The actin microfilaments also define the stromule shape through their interactions. This dynamic random walk-like movement is ... Köhler RH, Cao J, Zipfel WR, Webb WW, Hanson MR (1997). "Exchange of protein molecules through connections between higher plant ... This highly dynamic nature is caused by the close relationship between plastid stromules and actin microfilaments, which are ... Kwok EY, Hanson MR (February 2004). "In vivo analysis of interactions between GFP-labeled microfilaments and plastid stromules ...

One end of the motor proteins attaches to the vesicle while the other end attaches to either microtubules or microfilaments. ... RAB proteins in the vesicle membrane interact with docking proteins at the destination site. These docking proteins bring the ... These cargo receptors then recruit a variety of proteins including other cargo receptors and coat proteins such as clathrin, ... The motor proteins then move by hydrolyzing ATP, which propels the vesicle towards its destination. As a vesicle nears its ...

The triplet proteins are named based upon their relative size (low, medium, high). The apparent molecular mass of each protein ... Together with microtubules (~25 nm) and microfilaments (7 nm), they form the neuronal cytoskeleton. They are believed to ... The proteins that form neurofilaments are members of the intermediate filament protein family, which is divided into six types ... Type III contains the proteins vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP). Type IV consists of the ...

There are four proteins classed as type III intermediate filament proteins, which may form homo- or heteropolymeric proteins. ... The anti-parallel orientation of tetramers means that, unlike microtubules and microfilaments, which have a plus end and a ... Animal IFs are subcategorized into six types based on similarities in amino acid sequence and protein structure: These proteins ... Quinlan R, Hutchison C, Lane B (1995). "Intermediate filament proteins". Protein Profile. 2 (8): 795-952. PMID 8771189. Helfand ...

TNFR1 binding protein TNFR-associated death protein TRADD and TNF receptor-associated factor 2 TRAF2 signals to RIPK1 which ... leading to the formation of a microfilament-like complex called the necrosome. The necrosome then activates the pro-necroptotic ... Wang H, Sun L, Su L, Rizo J, Liu L, Wang LF, Wang FS, Wang X (April 2014). "Mixed lineage kinase domain-like protein MLKL ... The RIPK1 protein can also signal for both apoptosis and necroptosis depending on post-translational modifications mediated by ...