Unlike normal mice, transgenic poliovirus receptor (TgPVR) mice are susceptible to poliovirus injected intravenously or ... In TgPVR1 mice, the transgene encoding the human PVR was incorporated into mouse chromosome 4. These mice express the highest ... PVR transgenic mouse[edit]. Although humans are the only known natural hosts of poliovirus, monkeys can be experimentally ... The newly minted synthetic virus was injected into PVR transgenic mice, to determine if the synthetic version was able to cause ...
"Mouse Husbandry, Breeding and Development: Pheromone Effects". Transgenic Mouse Facility, University of California.. ... The Lee-Boot effect is a phenomenon concerning the suppression or prolongation of oestrous cycles of mature female mice (and ... Lee, S. van der; Boot, L.M (1956). "Spontaneous Pseudopregnancy in Mice". Acta Physiol. Pharmacol. Neer. 5 (213).. .mw-parser- ... This effect goes some way to explain why spontaneous pseudopregnancy can occur in mice. The same response is invoked from ...
Peppel K, Poltorak A, Melhado I, Jirik F, Beutler B (November 1993). "Expression of a TNF inhibitor in transgenic mice". ...
Ren, R. B.; F. Costantini; E. J. Gorgacz; J. J. Lee; V. R. Racaniello (1990-10-19). "Transgenic mice expressing a human ... Hughes, Scott A.; Harshwardhan M. Thaker; Vincent R. Racaniello (2003-12-23). "Transgenic Mouse Model for Echovirus Myocarditis ... Mice producing the human CD155 protein were generated and infected with poliovirus. These mice exhibited all symptoms and ... These mice today are used not only to continue to understand poliovirus pathogenesis but as a means to test the safety of ...
Graham M, Shutter JR, Sarmiento U, Sarosi I, Stark KL (Nov 1997). "Overexpression of Agrt leads to obesity in transgenic mice ... AgRP induces obesity by chronic antagonism of the MC4-R. Overexpression of AgRP in transgenic mice (or intracerebroventricular ... AGRP maps to human chromosome 16q22 and Agrp to mouse chromosome 8D1-D2. Agouti-related protein is expressed primarily in the ... "Mouse PubMed Reference:". Bäckberg M, Madjid N, Ogren SO, Meister B (Jun 2004). "Down-regulated expression of agouti-related ...
doi:10.1016/s0361-9230(01)00639-6. Rondi-Reig, L (2001). "Transgenic mice with neuronal overexpression of bcl-2 gene present ... Martinou, JC (1994). "Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and ... Gianfranceschi, L (1999). "Behavioral visual acuity of wild type and bcl2 transgenic mouse". Vision Research Journal. 39: 569- ... Behavior of transgenic mice reveals a role for developmental cell death". Brain Research Bulletin. 57: 85-91. ...
Greten FR, Wagner M, Weber CK, Zechner U, Adler G, Schmid RM (2002). "TGF alpha transgenic mice. A model of pancreatic cancer ... "Mouse PubMed Reference:". "Entrez Gene: TGFA transforming growth factor alpha". Ojeda, S. R.; Ma, Y. J.; Rage, F. (September ...
Transgenic mice (e.g. Tg2576) were made which overproduce human APP with the Swedish mutation. As a consequence, the mice can ... The other main effect the discovery of the Swedish mutation had was to provide one transgenic mouse model of Alzheimer's ... The Swedish mutation mice are used to study the effects of amyloid plaques and to develop potential treatments for Alzheimer's ... Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ (2014). "Using mice to model Alzheimer's dementia: an overview ...
Transgenic mice: *. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, ... and amyloid plaques in transgenic mice". Science. 274 (5284): 99-102. doi:10.1126/science.274.5284.99. PMID 8810256.. ... and motor coordination in female APP23 transgenic mice with the Swedish mutation". Brain Research. 956 (1): 36-44. doi:10.1016/ ... in a cellular model and reverses tau pathology in transgenic mouse models of Alzheimer's disease". Alzheimer's & Dementia. 4 (4 ...
"Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice". Proc. Natl. Acad. Sci. U.S.A. 91 (12): 5359 ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... "Mouse PubMed Reference:".. *^ Wang DD, Bordey A (December 2008). "The astrocyte odyssey". Prog. Neurobiol. 86 (4): 342-67. doi: ... "Mouse Genome Informatics".. *^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, ...
Lalonde R, Eyer J, Wunderle V, Strazielle C (May 2003). "Characterization of NFH-LacZ transgenic mice with the SHIRPA primary ... The protocol has been used to test several mutant mice, including dystrophin-deficient mutants, transgenic models of ... Lalonde R, Dumont M, Staufenbiel M, Strazielle C (February 2005). "Neurobehavioral characterization of APP23 transgenic mice ... This protocol became known as the "modified SHIRPA" and has been used to screen for dominant phenotypes in mice. Sanger Mouse ...
... synaptic and behavioral deficits in aged human tau transgenic mice" (PDF). Journal of Biological Chemistry. 288 (6): 4056-65. ... and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model. [Article]". Journal of ... "Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice". Journal of Neuroscience. 30 (42): 13966- ... "Lithium Treatment Arrests the Development of Neurofibrillary Tangles in Mutant Tau Transgenic Mice with Advanced ...
Cardiac dysfunction in the HIV-1 transgenic mouse treated with zidovudine. Lab Invest 2000;80:187-97. Lewis W, Simpson JF, ...
Sawicki also generates transgenic mice. Using this technology, she has developed several cancer mouse models useful for her ... Chen, Y; Megosh, LC; Gilmour, SK; Sawicki, JA; O'Brien, TG (2015-09-28). "K6/ODC transgenic mice as a sensitive model for ... "Evidence for expression of the paternal genome in the two-cell mouse embryo". Nature. 294: 450-451. 1981-12-03. doi:10.1038/ ... Sawicki, JA; Rothman, CJ (2015-09-28). "Evidence for stem cells in cultures of mouse prostate epithelial cells". Prostate. 50: ...
in IL-10 transgenic mice. or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. More ... A study in mice has shown that IL-10 is also produced by mast cells, counteracting the inflammatory effect that these cells ... Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. and, ... Over time a more nuanced picture of IL-10's function has emerged as treatment of tumor bearing mice has been shown to inhibit ...
Two successful approaches have been identified: transgenic mice and phage display. As of November 2016, thirteen of the ... Lonberg N, Huszar D (1995). "Human antibodies from transgenic mice". Int. Rev. Immunol. 13 (1): 65-93. doi:10.3109/ ... who market their TRIANNI Mouse platform. Ablexis, LLC - who market their AlivaMab Mouse platform. Phage display can be used to ... human monoclonal antibody therapeutics on the market were derived from transgenic mice technology. Adopting organizations who ...
For early-onset Huntington's (ages 5-15), both transgenic mice and mouse striatal cell lines show brain specific histone H3 ... are first tested in mouse models of SMA created through a variety of mutations in the mouse SMN1 gene. If the mice show ... Trichostatin A is also a class I and II HDACi that rescues fear learning in a fear conditioning paradigm in transgenic AD mice ... Tested on: mouse (M), only mouse cells (MC), human (H), Drosophila (D), rat (R). Successful treatment: yes (y), yes but with ...
Koike S, Choji T, Takeshi K, Shinobu A, Iku I, Hiromichi Y (1991). "Transgenic Mice Susceptible to Polio Virus". Proceedings of ... He retrieved a sample of mouse brain infected with polio virus and added it to the remaining test tubes, on the off chance that ... Koprowski's attenuated vaccine was prepared by successive passages through the brains of Swiss albino mice. By the seventh ...
Human Monoclonal Antibodies from Transgenic Mice. Chapter 13 in Human Monoclonal Antibodies: Methods and Protocols Ed. Michael ...
al in HY-TCR transgenic mice. Since HY is a male specific antigen, the developing thymocytes would be expected to undergo ... Furthermore, female mice TNCs were found to contain five times more thymocytes than male mice, and less than 4% of them were ... "Thymic nurse cell multicellular complexes in HY-TCR transgenic mice demonstrate their association with MHC restriction." ... found in their study that one-fourth of the nurse cells isolated from mice were double-positives for K5 and K8, while the rest ...
Human Monoclonal Antibodies from Transgenic Mice. Chapter 13 in Human Monoclonal Antibodies: Methods and Protocols Ed. Michael ... Alirocumab was discovered by Regeneron Pharmaceuticals using its "VelocImmune" mouse, in which many of the genes coding for ... it took only about 19 months from when they first immunized mice with PCSK9 until they filed their IND. Alirocumab was co- ...
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. „Science". 274 (5284), s. 99-102, 10 1996 ... Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. „Nature". 373 (6514), s. ... Simon A.S.A. James Simon A.S.A. i inni, Iron, Copper, and Zinc Concentration in Aβ Plaques in the APP/PS1 Mouse Model of ... and motor coordination in female APP23 transgenic mice with the Swedish mutation. „Brain Research (journal)". 956 (1), s. 36-44 ...
... and sudden death in ACE2 transgenic mice with downregulated connexins (англ.) // Journal of Molecular and Cellular Cardiology ( ...
"Transgenic mice with a reduced core body temperature have an increased life span". Science. 314 (5800): 825-8. Bibcode:2006Sci ... The life extension varies for each species, but on average there was a 30-40% increase in life span in both mice and rats.[28] ... Mice, which are warm blooded, have been engineered to have a reduced core body temperature which increased the lifespan ... Faulks, SC; Turner, N; Else, PL; Hulbert, AJ (Aug 2006). "Calorie restriction in mice: effects on body composition, daily ...
... topical application of IGF-1 in a liposomal vehicle led to thicker and more rapid hair growth in transgenic mice with ... Dietary isoflavones increase IGF production in scalp dermal papillae in transgenic mice.[55] Topical capsaicin also stimulates ... thereby promoting hair growth in mice". The Journal of Nutritional Biochemistry. 22 (3): 227-233. doi:10.1016/j.jnutbio.2010.01 ... with its disruption causing cyclical alopecia in mice models.[68] Deletion of SOX21 dramatically affects hair lipids.[69] ...
Transgenic mice generated through exogenous DNA microinjection of an embryo's pronucleus are also considered to be hemizygous ... A transgenic can later be bred to homozygosity and maintained as an inbred line to reduce the need to confirm the genotypes of ...