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*  Robin Lovell-Badge
"Male development of chromosomally female mice transgenic for Sry". Nature. 351: 117-121. doi:10.1038/351117a0. "Robin Lovell- ...
*  Genetically modified mouse
Transgenic mice generated to carry cloned oncogenes and knockout mice lacking tumor suppressing genes have provided good models ... This method creates a transgenic mouse and is used to insert new genetic information into the mouse genome or to over-express ... Transgenic Mouse. Totowa, New Jersey: Humana Press. p. 1. ISBN 0-89603-915-3. "Knockout Mice". Nation Human Genome Research ... Douglas Hanahan; Erwin F. Wagner; Richard D. Palmiter (2007). "The origins of oncomice: a history of the first transgenic mice ...
*  TGF alpha
Greten FR, Wagner M, Weber CK, Zechner U, Adler G, Schmid RM (2002). "TGF alpha transgenic mice. A model of pancreatic cancer ... "Mouse PubMed Reference:". "Entrez Gene: TGFA transforming growth factor alpha". Ojeda, S. R.; Ma, Y. J.; Rage, F. (September ...
*  Swedish mutation
Transgenic mice (e.g. Tg2576) were made which overproduce human APP with the Swedish mutation. As a consequence, the mice can ... The other main effect the discovery of the Swedish mutation had was to provide one transgenic mouse model of Alzheimer's ... The Swedish mutation mice are used to study the effects of amyloid plaques and to develop potential treatments for Alzheimer's ... Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ (2014). "Using mice to model Alzheimer's dementia: an overview ...
*  IL18BP
2004). "Generation and characterization of mice transgenic for human IL-18-binding protein isoform a". J. Leukoc. Biol. 74 (5 ... Xiang Y, Moss B (1999). "Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... "Mouse PubMed Reference:". Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (Mar 1999). "Interleukin-18 ...
*  Janet Sawicki
Sawicki also generates transgenic mice. Using this technology, she has developed several cancer mouse models useful for her ... Chen, Y; Megosh, LC; Gilmour, SK; Sawicki, JA; O'Brien, TG (2015-09-28). "K6/ODC transgenic mice as a sensitive model for ... "Evidence for expression of the paternal genome in the two-cell mouse embryo". Nature. 294: 450-451. 1981-12-03. doi:10.1038/ ... Sawicki, JA; Rothman, CJ (2015-09-28). "Evidence for stem cells in cultures of mouse prostate epithelial cells". Prostate. 50: ...
*  Interleukin 10
in IL-10 transgenic mice. or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. More ... A study in mice has shown that IL-10 is also produced by mast cells, counteracting the inflammatory effect that these cells ... Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. and, ... Over time a more nuanced picture of IL-10's function has emerged as treatment of tumor bearing mice has been shown to inhibit ...
*  Monoclonal antibody
Two successful approaches have been identified: transgenic mice and phage display. As of November 2016, thirteen of the ... Lonberg N, Huszar D (1995). "Human antibodies from transgenic mice". Int. Rev. Immunol. 13 (1): 65-93. doi:10.3109/ ... who market their TRIANNI Mouse platform. Ablexis, LLC - who market their AlivaMab Mouse platform. Phage display can be used to ... human monoclonal antibody therapeutics on the market were derived from transgenic mice technology. Adopting organizations who ...
*  Elmezzi Graduate School of Molecular Medicine
Husain-Krautter, S; Kramer, JM; Li, W; Guo, B; Rothstein, TL (2015). "The osteopontin transgenic mouse". Clinical Immunology. ...
*  Huntingtin
"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation". ... It is essential for development, and absence of huntingtin is lethal in mice. The protein has no sequence homology with other ... "Mouse PubMed Reference:". The Huntington's Disease Collaborative Research Group (Mar 1993). "A novel gene containing a ...
*  Polio vaccine
Koike S, Choji T, Takeshi K, Shinobu A, Iku I, Hiromichi Y (1991). "Transgenic Mice Susceptible to Polio Virus". Proceedings of ... He retrieved a sample of mouse brain infected with polio virus and added it to the remaining test tubes, on the off chance that ... Koprowski's attenuated vaccine was prepared by successive passages through the brains of Swiss albino mice. By the seventh ...
*  Regeneron
Human Monoclonal Antibodies from Transgenic Mice. Chapter 13 in Human Monoclonal Antibodies: Methods and Protocols Ed. Michael ...
*  Thymic nurse cell
al in HY-TCR transgenic mice. Since HY is a male specific antigen, the developing thymocytes would be expected to undergo ... Furthermore, female mice TNCs were found to contain five times more thymocytes than male mice, and less than 4% of them were ... "Thymic nurse cell multicellular complexes in HY-TCR transgenic mice demonstrate their association with MHC restriction." ... found in their study that one-fourth of the nurse cells isolated from mice were double-positives for K5 and K8, while the rest ...
*  Alirocumab
Human Monoclonal Antibodies from Transgenic Mice. Chapter 13 in Human Monoclonal Antibodies: Methods and Protocols Ed. Michael ... Alirocumab was discovered by Regeneron Pharmaceuticals using its "VelocImmune" mouse, in which many of the genes coding for ... it took only about 19 months from when they first immunized mice with PCSK9 until they filed their IND. Alirocumab was co- ...
*  LBH
"Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh". ... "Entrez Gene: LBH limb bud and heart development homolog (mouse)". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... "Mouse PubMed Reference:". Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, ...
*  CEACAM8
Eades-Perner AM, Thompson J, van der Putten H, Zimmermann W (1998). "Mice transgenic for the human CGM6 gene express its ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... 2002). "Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes ...
*  Consortium for Functional Glycomics
Mouse Transgenics Core (F), formerly located at The Scripps Research Institute, is now closed. From 2001-2009, Core F generated ... At the discretion of the Mouse Subcommittee, Core G also occasionally evaluates mouse lines provided by investigators. Protein- ... Mouse Phenotype Core (G), located at the Sanford-Burnham Medical Research Institute, works with participating investigator " ... All Core F strains are now archived at the Mutant Mouse Regional Resource Center (MMRRC) at the University of California, Davis ...
*  GNLY
Mice do not have a granulysin homolog, but transgenic mice expressing human granulysin have been engineered. Granulysin has ... Huang LP, Lyu SC, Clayberger C, Krensky AM (January 2007). "Granulysin-Mediated Tumor Rejection in Transgenic Mice". J. Immunol ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...
*  ABCA1
Joyce C, Freeman L, Brewer HB, Santamarina-Fojo S (2004). "Study of ABCA1 function in transgenic mice". Arterioscler. Thromb. ... Human data from patients and controls were used to demonstrate the translation of mouse findings in human disease. Mutations in ... Knockout mouse models of AMD treated with agonists that increase ABCA1 in loss of function and gain of function experiments ... "Mouse PubMed Reference:". Luciani MF, Denizot F, Savary S, Mattei MG, Chimini G (May 1994). "Cloning of two novel ABC ...
*  TNNI3
Murphy AM, Kögler H, Georgakopoulos D, McDonough JL, Kass DA, Van Eyk JE, Marbán E (Jan 2000). "Transgenic mouse model of ... Over-expression of the C-terminal truncated cardiac TnI (cTnI1-192) in transgenic mouse heart resulted in a phenotype of ... cTnI begins to express in mouse heart at approximately embryonic day 10, and the level gradually increases to one-half of the ... cTnI completely replaces slow TnI in the mouse heart approximately 14 days after birth Based on in vitro structure-function ...
*  Lee-Boot effect
5 (213). "Mouse Husbandry, Breeding and Development: Pheromone Effects". Transgenic Mouse Facility, University of California. ... The Lee-Boot effect is a phenomenon concerning the suppression or prolongation of oestrous cycles of mature female mice (and ... This effect goes some way to explain why spontaneous pseudopregnancy can occur in mice. The same response is invoked from ... Whitten effect Menstrual synchrony Lee, S. van der; Boot, L.M (1956). "Spontaneous Pseudopregnancy in Mice". Acta Physiol. ...
*  Alpha-taxilin
2007). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676-86. PMID 17015757. Ewing RM, Chu ... "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676-86. PMID 17015757. Human TXLNA genome ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... "Mouse PubMed Reference:". Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). " ...
*  ADAM12
"ADAM 12 protease induces adipogenesis in transgenic mice". Am. J. Pathol. 160 (5): 1895-903. doi:10.1016/S0002-9440(10)61136-4 ... "Mouse PubMed Reference:". Gilpin BJ, Loechel F, Mattei MG, Engvall E, Albrechtsen R, Wewer UM (Feb 1998). "A novel, secreted ...
*  Mating plug
"Pronuclear injection for the production of transgenic mice". Nature Protocols. 2 (5): 1206-15. doi:10.1038/nprot.2007.145. PMID ... Mating plugs are used by many species, including several primates, kangaroos, bees, rats, reptiles, rodents, scorpions, mice, ...
*  PRND
2002). "Doppel-induced cerebellar degeneration in transgenic mice". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15288-93. doi: ... 1999). "Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel". J. ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... "Mouse PubMed Reference:". "Entrez Gene: PRND prion protein 2 (dublet)". Moore RC, Lee IY, Silverman GL, et al. ( ...
*  Susan K. Gilmour
Using skin-targeted transgenic mice, she demonstrated that elevated levels of ODC play a causal role in the development of ... Using ODC transgenic mouse models, Gilmour showed that elevated ODC and polyamines promote tumorigenesis via multiple ... Chen, Y; Megosh, LC; Gilmour, SK; Sawicki, JA; O'Brien, TG (2000). "K6/ODC transgenic mice as a sensitive model for carcinogen ... in ODC/Ras transgenic mice". Carcinogenesis. 26 (1): 119-24. doi:10.1093/carcin/bgh281. PMID 15375010. Hayes, CS; DeFeo, K; Lan ...