Transgenic mice generated to carry cloned oncogenes and knockout mice lacking tumor suppressing genes have provided good models ... This method creates a transgenic mouse and is used to insert new genetic information into the mouse genome or to over-express ... A genetically modified mouse or genetically engineered mouse model (GEMM) is a mouse (Mus musculus) that has had its genome ... Transgenic Mouse. Totowa, New Jersey: Humana Press. pp. 1. ISBN 0-89603-915-3. "Knockout Mice". Nation Human Genome Research ...
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Transgenic mice (e.g. Tg2576) were made which overproduce human APP with the Swedish mutation. As a consequence, the mice can ... The other main effect the discovery of the Swedish mutation had was to provide one transgenic mouse model of Alzheimer's ... The Swedish mutation mice are used to study the effects of amyloid plaques and to develop potential treatments for Alzheimer's ... Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ (2014). "Using mice to model Alzheimer's dementia: an overview ...
... knockout gene alleles and any mutation associated to a genetically modified mouse strain". Transgenic Research. 20 (2): 435-440 ... "International Society for Transgenic Technologies - International Society for Transgenic Technologies". www.transtechsociety. ... "Program and abstracts of the 6th Transgenic Technology Meeting (TT2005)". Transgenic Research. 14 (4): 483-529. 2005-08-01. doi ... Williams, Elizabeth (2006-11-24). "Program and Abstracts of the 7th Transgenic Technology Meeting (TT2007)". Transgenic ...
Koike S, Taya C, Kurata T, Abe S, Ise I, Yonekawa H, Nomoto A (February 1991). "Transgenic mice susceptible to poliovirus". ... He retrieved a sample of mouse brain infected with poliovirus and added it to the remaining test tubes, on the off chance that ... Koprowski's attenuated vaccine was prepared by successive passages through the brains of Swiss albino mice. By the seventh ...
Lonberg, Nils; Huszar, Dennis (January 1995). "Human Antibodies from Transgenic Mice". International Reviews of Immunology. 13 ...
Afterwards, it is reimplanted into a host mother, who then births a transgenic mouse. The transgenic mouse carries one copy of ... Bernstein, A.; Breitman, M. (1989). "Genetic ablation in transgenic mice". Molecular Biology & Medicine. 6 (6): 523-530. ISSN ... From these mice, a homozygous colony can be created through breeding. In 1990, the gene knockout technique was just developing ... An example of this method in action can be seen through the production of a knockout mouse. This is accomplished through the ...
Friedel RH, Wurst W, Wefers B, Kühn R (2011). "Generating Conditional Knockout Mice". Transgenic Mouse Methods and Protocols. ... Schwenk F, Baron U, Rajewsky K (December 1995). "A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene ... Moreover, animals such as mice can be used as models to study human disease. Therefore, Cre-lox system can be used in mice to ... Sakamoto K, Gurumurthy CB, Wagner K (2014), Singh SR, Coppola V (eds.), "Generation of Conditional Knockout Mice", Mouse ...
in HY-TCR transgenic mice. Since HY is a male specific antigen, the developing thymocytes would be expected to undergo ... Furthermore, female mice TNCs were found to contain five times more thymocytes than male mice, and less than 4% of them were ... "Thymic nurse cell multicellular complexes in HY-TCR transgenic mice demonstrate their association with MHC restriction." ... found in their study that one-fourth of the nurse cells isolated from mice were double-positives for K5 and K8, while the rest ...
Lonberg N, Huszar D (1995). "Human antibodies from transgenic mice". International Reviews of Immunology. 13 (1): 65-93. doi: ... Several successful approaches have been proposed: transgenic mice, phage display and single B cell cloning. Monoclonal ... While mouse and human antibodies are structurally similar, the differences between them were sufficient to invoke an immune ... They can also be injected into mice (in the peritoneal cavity, surrounding the gut). There, they produce tumors secreting an ...
This is because the genes responsible for building and operating both mouse and human brain are 90% identical. Transgenic mouse ... Mouse brain, dorsal view Mouse brain, lateral view Mouse brain slices Mouse cingulate cortex neurons A biophysically realistic ... Haruyama, Naoto; Cho, Andrew; Kulkarni, Ashok B. (2009). "Overview: Engineering Transgenic Constructs and Mice". Current ... "ISH Data :: Allen Brain Atlas: Mouse Brain". ISH Data. Retrieved 2019-02-07. "Search the library". The Mouse Brain Library. ...
"Human Monoclonal Antibodies from Transgenic Mice". Chapter 13 in Human Monoclonal Antibodies: Methods and Protocols Ed. Michael ...
Proof of concept in transgenic mice". PLOS ONE. 13 (1): e0190212. Bibcode:2018PLoSO..1390212L. doi:10.1371/journal.pone.0190212 ... Iwagawa T, Ohuchi SP, Watanabe S, Nakamura Y (January 2012). "Selection of RNA aptamers against mouse embryonic stem cells". ...
Mompó SM, González-Fernández Á (2014). "Human Monoclonal Antibodies from Transgenic Mice." (PDF). In Steinitz M (ed.). Human ... "Antigen-specific human monoclonal antibodies from transgenic mice". Human Monoclonal Antibodies. Methods in Molecular Biology ( ... Alirocumab was discovered by Regeneron Pharmaceuticals using its "VelocImmune" mouse, in which many of the genes coding for ... it took only about 19 months from when they first immunized mice with PCSK9 until they filed their IND.: Slide 26 Alirocumab ...
To produce activation transgenic mice were infected with channelrhodopsin-2 with a TH-Cre promoter and to produce inhibition ... Transgenic mice infected with channel-rhodopsin Thy1-ChR2, were stimulated with a 473 nm laser transcranially positioned over ... Transgenic mice were introduced with channelrhodoposin-2 attached with a parvalbumin-Cre promoter that selectively infected ... A more specific approach is based on transgenic "driver" mice which express Cre recombinase, an enzyme that catalyzes ...
Joyce C, Freeman L, Brewer HB, Santamarina-Fojo S (June 2003). "Study of ABCA1 function in transgenic mice". Arteriosclerosis, ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Luciani MF, Denizot ... Human data from patients and controls were used to demonstrate the translation of mouse findings in human disease. Mutations in ... Knockout mouse models of AMD treated with agonists that increase ABCA1 in loss of function and gain of function experiments ...
Crawley, Jacqueline N. (2007-05-11). What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice. John ... doi:10.1111/j.1601-183X.2012.00864.x. Wahlsten, Douglas (2010-10-22). Mouse Behavioral Testing: How To Use Mice in Behavioral ... Crusio, Wim E. (March 2013). "Mouse behavioral testing. How to use mice in behavioral research - by Douglas Wahlsten". Genes, ... He is known for his laboratory research on the behavior of mice, and for his theoretical writings on a wide range of other ...
Heard, E (1 April 1996). "Transgenic mice carrying an Xist-containing YAC". Human Molecular Genetics. 5 (4): 441-450. doi: ... Okamoto, I. (30 January 2004). "Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development". Science. 303 ( ... from mouse to man. Heard has also performed pioneering work revealing that in addition to epigenetic modifications, chromosome ... from mouse to man. Heard has also performed pioneering work revealing that in addition to epigenetic modifications, chromosome ...
Wolfer, D. P. (2002). "J.N. Crawley: What's wrong with my mouse? Behavioral phenotyping of transgenic and knockout mice". Genes ... What's wrong with my mouse: Behavioral phenotyping of transgenic and knockout mice, Wiley-Interscience, Hoboken, NJ (2007) 523 ... She has co-edited 4 books and is the author of What's Wrong With my Mouse? Behavioral Phenotyping of Transgenic and Knockout ... Behavioral Phenotyping of Transgenic and Knockout Mice". Genes, Brain and Behavior. 7 (7): 831. doi:10.1111/j.1601-183X. ...
Murphy AM, Kögler H, Georgakopoulos D, McDonough JL, Kass DA, Van Eyk JE, Marbán E (Jan 2000). "Transgenic mouse model of ... Over-expression of the C-terminal truncated cardiac TnI (cTnI1-192) in transgenic mouse heart resulted in a phenotype of ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Mogensen J, Kruse ... cTnI begins to express in mouse heart at approximately embryonic day 10, and the level gradually increases to one-half of the ...
"Mouse Husbandry, Breeding and Development: Pheromone Effects". Transgenic Mouse Facility, University of California. Ma W, Miao ... The Lee-Boot effect is a phenomenon concerning the suppression or prolongation of oestrous cycles of mature female mice (and ... This effect goes some way to explain why spontaneous pseudopregnancy can occur in mice. The same response is invoked from ... Menstrual synchrony Whitten effect Lee, S. van der; Boot, L.M (1956). "Spontaneous Pseudopregnancy in Mice". Acta Physiol. ...
2007). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676-86. doi:10.4049/jimmunol.177.8. ... "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676-86. doi:10.4049/jimmunol.177.8.5676. PMID ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Nogami S, Satoh S, ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...
"ADAM 12 protease induces adipogenesis in transgenic mice". Am. J. Pathol. 160 (5): 1895-903. doi:10.1016/S0002-9440(10)61136-4 ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Gilpin BJ, Loechel ...
"Pronuclear injection for the production of transgenic mice". Nature Protocols. 2 (5): 1206-1215. doi:10.1038/nprot.2007.145. ... Mating plugs are used by many species, including several primates, kangaroos, bees, reptiles, rats, rodents, scorpions, mice, ...
2002). "Doppel-induced cerebellar degeneration in transgenic mice". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15288-93. doi: ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: PRND ... 1999). "Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel". J. ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...
Bordone L, Cohen D, Robinson A, Motta MC, Guarente L (2007). "SIRT1 transgenic mice show phenotypes resembling calorie ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Aksoy S, Brandriff ... Overexpression of SIRT1 in mice has been shown to reduce insulin and fasting glucose, as well as increased metabolism and ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...
"Mouse Husbandry, Breeding and Development". University of Carolina, Irvine, Transgenic Mouse Facility Guidelines. University of ... The house mouse has been domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most ... A region of mouse chromosome 16 is associated with thyroid function in mice. However, mice with a knockout of 16 genes - 550kb ... Western European house mouse (Mus musculus domesticus); includes the fancy mouse and the laboratory mouse (Western Europe, ...
Dankort DL, Muller WJ (2000). "Signal transduction in mammary tumorigenesis: a transgenic perspective". Oncogene. 19 (8): 1038- ... The majority of mammary tumors in mice are caused by mouse mammary tumor virus. Several mouse strains carry the virus ... Muñoz, B.; Bolander Jr, F. F. (1989). "Prolactin regulation of mouse mammary tumor virus (MMTV) expression in normal mouse ... "Acquisition of Proviral DNA of mouse mammary tumor virus in thymic leukemi cells from GR mice". Journal of Virology. 43 (3): ...
Peppel K, Poltorak A, Melhado I, Jirik F, Beutler B (November 1993). "Expression of a TNF inhibitor in transgenic mice". ...
The first transgenic mouse expressing GCaMP1 was reported in 2004. However, at 37 ˚C (physiological temperature in mammals), ... October 2012). "Imaging neural activity using Thy1-GCaMP transgenic mice". Neuron. 76 (2): 297-308. doi:10.1016/j.neuron. ... May 2004). "Ca2+-sensing transgenic mice: postsynaptic signaling in smooth muscle". The Journal of Biological Chemistry. 279 ( ... 2008) used a transgenic cardiac-specific GCaMP zebrafish line to image cardiomyocyte activation throughout the cardiac cycle; ...
2002). "Craniosynostosis in transgenic mice overexpressing Nell-1". J. Clin. Invest. 110 (6): 861-70. doi:10.1172/JCI15375. PMC ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Watanabe TK, ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...