"Modeling human lymphoid precursor cell gene therapy in the SCID-hu mouse". Blood. 84 (5): 1393-1398. doi:10.1182/blood.V84.5. ...

... administration of the antibody prolonged survival of SCID mice implanted with JOK-1 cells. Apoptosis induction appears to be ... In a mouse model of multiple myeloma, tumor metastasis to bone was decreased in CD47-deficient mice compared with wild type ... CD47 knockout mice show reduced recruitment of blood T cells as well as neutrophils and monocytes in areas of inflammation. ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: CD47 ...

"Gene therapy for human immunodeficiency virus infection in the humanized SCID mouse model". The Israel Medical Association ... After having created a mouse with a human immune system, Touraine used it to test several gene therapies for HIV/AIDS. The ...

"Overexpression of plasminogen activator inhibitor 2 in human melanoma cells inhibits spontaneous metastasis in scid/scid mice ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Schroder WA, Major ...

Both ESC and EpiSC induce teratoma when injected in the test animals (scid mice) which proves pluripotency. EpiSC display ... Scientists have been able to demonstrate the induction of EpiSC-like cells in vitro from mouse ESCs, which are referred to as ... Hanna, J (2010). "Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs". ... is similar to primed state mouse stem cells rather than naïve state. Table 1. Comparison of naïve and primed pluripotent states ...

... nude and SCID) mice". Infect Immun. 60 (8): 3325-31. doi:10.1128/IAI.60.8.3325-3331.1992. PMC 257318. PMID 1639500. Lupo PJ, ... first isolated from the gastric glands of the common mouse.Cryptosporidium does originate in common mice, specifically ... Nov.), of the gastric Glands of the Common Mouse". J Med Res. 23 (3): 487-510.3. PMC 2098948. PMID 19971982. Gatei, Wangeci; ... Cryptosporidium muris has prevalence in the following species in the following amount: Dairy Cows -68% Feedlot Cows- 80% Mice- ...

Experiments in animal models have shown X-SCID to occur similarly in dogs, but not in mice. Alterations in the immune response ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Russell SM, Keegan ... SCID). Most of these mutations involve changes in one or a few nucleotides (DNA building blocks) in the gene. These changes ...

B-17 scid mice". International Immunology. 5 (11): 1461-71. doi:10.1093/intimm/5.11.1461. PMID 7903159. Powrie F, Leach MW, ... CD45RBhi T cells to Rag deficient or SCID mice led to the development of severe intestinal inflammation and wasting disease. ... Mauze S, Menon S, Caddle LB, Coffman RL (1994). "Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice ... This work identified that CD4+OX22hi (OX22 is CD45RC in rats and the equivalent of CD45RB in mice, both isoforms of CD45) T ...

"Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system". Mol. Ther. 17 (7): ... When a gene is inactivated by insertion of a transposon (or other mechanism), that gene is "knocked out". Knockout mice and ... Dupuy AJ (August 2010). "Transposon-based screens for cancer gene discovery in mouse models". Semin. Cancer Biol. 20 (4): 261- ... Carlson CM, Largaespada DA (July 2005). "Insertional mutagenesis in mice: new perspectives and tools". Nat. Rev. Genet. 6 (7): ...

S1P has protected ovarian tissue xenografts in SCID mouse models from radiation induced atresia. In animal models these ... Fukuda, Yu; Kihara, Akio; Igarashi, Yasuyuki (12 September 2003). "Distribution of sphingosine kinase activity in mouse tissues ... September 2002). "Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in ... September 2006). "Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through ...

... from peripheral blood and characterizing its growth in Nod/SCID mice". Blood. 91 (5): 1671-9. doi:10.1182/blood.V91.5.1671. ...

Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice. Mol Ther ... Intravenously injected human bone marrow-derived Muse cells are able to repair an immunodeficient mouse (SCID) model of CCL4- ... Therapeutic efficacy of intravenous injection of human bone marrow-Muse cells into a SCID mouse aortic aneurysm model was ... Human bone marrow-derived Muse cells injected intravenously repair SCID and BALB/c mouse models of focal segmental ...

In SCID mice that have no adaptive immune system, BCG reduced mortality from an otherwise lethal candida infection. The effects ...

"Development of an orthotopic SCID mouse-human tumor xenograft model displaying the multidrug-resistant phenotype". Cancer ... WEINSTEIN, R (1972). "Effects of continuous inhalation of dichloromethane in the mouse: Morphologic and functional observations ...

Jiang HQ, Kushnir N, Thurnheer MC, Bos NA, Cebra JJ (May 2002). "Monoassociation of SCID mice with Helicobacter muridarum, but ... Feng, S.; Ku, K.; Hodzic, E.; Lorenzana, E.; Freet, K.; Barthold, S. W. (2005). "Differential Detection of Five Mouse-Infecting ... with Enterohepatic Helicobacter Species Can Ameliorate or Promote Helicobacter pylori-Induced Gastric Pathology in C57BL/6 Mice ...

The discovery of the athymic mouse, commonly known as the nude mouse, and that of the SCID mouse were major events that paved ... This resulted in the creation of the NOD-scid mice which lacked T cells, B cells, and NK cells. This mouse model permitted for ... A humanized mouse is a mouse carrying functioning human genes, cells, tissues, and/or organs. Humanized mice are commonly used ... gene in the NOD-scid model. This accounted for the creation of the NOD-scid-γcnull mice (NCG, NSG or NOG) models which were ...

... and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice". ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: CD34 ... It is important to mention that Long-Term Haematopoietic Stem Cells (LT-HSCs) in mice and humans are the haematopoietic cells ... Antigens,+CD34 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ...

The transgenic mice were not susceptible to HBV, but mice with severe combined immunodeficiency (SCID) can develop chronic ... Mice: Several researchers developed transgenic mice in order to study the expression of coding regions for the surface antigens ... In addition, they permitted HBV to replicate in human hepatocytes that were able to proliferate in these mice. In general, ...

"Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome". ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: LIG4 ... Lig4 deficiency in the mouse causes a progressive loss of haematopoietic stem cells and bone marrow cellularity during aging. ...

Zhou, G. (2014). "Humanized NOD-SCID IL2rg(-/-) mice as a preclinical model for cancer research and its potential use for ... The Mouse Models of Human Cancer database (MMHCdb) is a unique, comprehensive online knowledgebase of mouse models of human ... Bult, C.J. (Jan 2015). "Mouse Tumor Biology (MTB): a database of mouse models for human cancer". Nucleic Acids Research. 43 (D1 ... Bult, C.J. (1999). "Electronic access to mouse tumor data: the Mouse Tumor Biology Database (MTB) project". Nucleic Acids Res. ...

"Postexposure prophylaxis with zidovudine suppresses human immunodeficiency virus type 1 infection in SCID-hu mice in a time- ...

PCT/EP2011/052945 Available online Human Liver Stem Cell-Derived Microvesicles Inhibit Hepatoma Growth in SCID Mice by ... CD154 knockout mice are incapable of producing IgG, IgE, or IgA as a response to antigens. Microvesicles can also transfer ... "Monocytic microparticles promote atherogenesis by modulating inflammatory cells in mice". Journal of Cellular and Molecular ...

2008). "Cochlear repair by transplantation of human cord blood CD133+ cells to nod-scid mice made deaf with kanamycin and noise ...

Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID). Several ... Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and ...

... production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Ueno N, Ling N, ... Follistatin is being studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as ... Mighty mice' made mightier". Retrieved 2008-02-26. "Success Boosting Monkey Muscle Could Help Humans". NPR. 11 Nov 2009. ...

JDP2 inhibits Ras-dependent cell transformation in NIH3T3 cells and tumor development in xenografts transplanted into SCID mice ... Gene knockout mice have a shorter tail, are smaller, have low neutrophil count. and cell proliferation, and commit to cell ... Mouse p53 protein negatively regulates the JDP2 promoter in F9 cells as part of the JDP2˗p53 autoregulatory circuit. By ... JDP2-transgenic mice display potentiation of liver cancer, higher mortality and increase number and size of tumors, especially ...

Decoys have been successfully demonstrated to inhibit oncogenic KRAS in SCID mice leading to reduced tumour growth and ... Analysis of human, chimpanzee, mouse and rat genomes showed enormous number of potential G-quadruplex (pG4)-forming sequences ... mouse, and rat - presented in the First International G-quadruplex Meeting held in April 2007 in Louisville, Kentucky. In 2006 ... Mouse and Rat Promoters and 146 Microbes". Nucleic Acids Research. 36 (Database): D381‐D385. doi:10.1093/nar/gkm781. PMC ...

"Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity". The ... Different primitive and metastatic TNBC cancer mouse models were established in mice, and the treatment CIK cells plus ... CIK cells, along with the administration of IL-2 have been experimentally used to treat cancer in mice and humans with low ... CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency". Journal ...

Valproic scid Valproic acid in mice studies restored histone acetylation levels, increased levels of pro-survival factors, and ... are first tested in mouse models of SMA created through a variety of mutations in the mouse SMN1 gene. If the mice show ... Sodium butyrate Sodium butyrate was the first HDAC inhibitor tested in SMA mouse models. It prolonged SMA mouse life span by 35 ... For early-onset Huntington's (ages 5-15), both transgenic mice and mouse striatal cell lines show brain specific histone H3 ...

MODV causes flavivirus-like encephalitis in SCID (severe combined immunodeficiency) mice and in hamsters with histopathological ... While deer mice are accepted as the main host organism, the presence of antibodies in chipmunks (Tamias minimus) and red ... In immunocompetent mice, MODV causes 100% morbidity and mortality when the virus was inoculated directly into the brain. ... virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice". ...

"DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts". Chromosoma. 126 (2): 287- ... Tian M, Jones DA, Smith M, Shinkura R, Alt FW (2004). "Deficiency in the nuclease activity of xeroderma pigmentosum G in mice ... Bonsignore LA, Tooley JG, Van Hoose PM, Wang E, Cheng A, Cole MP, Schaner Tooley CE (2015). "NRMT1 knockout mice exhibit ... Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (February 2003). "Aging and genome maintenance: lessons from the mouse ...

All NHEJ mutant mice show a SCID phenotype, sensitivity to ionizing radiation, and neuronal apoptosis. A system was developed ... NHEJ efficiency could be compared across tissues of the same mouse and in mice of different age. Efficiency was higher in the ... SCID) due to defective V(D)J recombination. Loss-of-function mutations in Artemis also cause SCID, but these patients do not ... Many NHEJ genes have been knocked out in mice. Deletion of XRCC4 or LIG4 causes embryonic lethality in mice, indicating that ...

Myeloma cells overexpressing Sulf1 and 2 were subcutaneously injected in severe combined immunodeficient (SCID) mice. Enhanced ... deficient mice, BMP deficient mice and hypermorphic Fgfr1 and 3 mice. This provides evidence that Sulf1 and 2 is linked to HS ... Sulf null mice and other model systems implicated Sulfs in other developmental and disease systems. For example, studies ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: SULF1 ...

To study biology of T. regenti in mammals, C57BL/6, BALB/c a SCID mouse strains are used as accidental hosts. When cercariae of ... and T-cells develops in immunocompetent mice especially around the damaged schistosomula. CD3-deficient mice develop no or just ... In mice, the first schistosomula are found in a lumbar spinal cord as early as 2 DPI and medulla oblongata is invaded the day ... Schistosomula development in mice is suppressed likely due to the host immune response and/or the presence/absence of some ...

At the same department, the SCID mouse model was demonstrated as "an excellent model system" for studying interaction between ... a SCID mouse model". Int. J. Cancer. 77 (3): 476-480. doi:10.1002/(SICI)1097-0215(19980729)77:3. 3.0.CO;2-4. PMID 9663614. ... into the draining lymph node in mice, further enhancing immune response through activation of CTLs. Tumor antigens are ...