Moreover, SCID mice and Mongolian gerbil can be experimentally infected. The life cycle is basically similar to those of other ...
Myles MH, Livingston RS, Franklin CL (October 2004). "Pathogenicity of Helicobacter rodentium in A/JCr and SCID mice". ... Its type strain is MIT 95-1707 (= ATCC 700285). Its name refers to the species first being isolated from mice. Shen, Z.; Fox, J ... Feng, S.; Ku, K.; Hodzic, E.; Lorenzana, E.; Freet, K.; Barthold, S. W. (2005). "Differential Detection of Five Mouse-Infecting ... nov., a Urease-Negative Helicobacter Species Isolated from Laboratory Mice". International Journal of Systematic Bacteriology. ...
Valproic scid. Valproic acid in mice studies restored histone acetylation levels, increased levels of pro-survival factors, and ... are first tested in mouse models of SMA created through a variety of mutations in the mouse SMN1 gene. If the mice show ... Tested on: mouse (M), only mouse cells (MC), human (H), Drosophila (D), rat (R). Successful treatment: yes (y), yes but with ... Sodium butyrate was the first HDAC inhibitor tested in SMA mouse models. It prolonged SMA mouse life span by 35% and showed ...
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. „Nature". 367 (6464), s. 645-8, Feb 1994 ... Homeobox gene expression in the intestinal epithelium of adult mice. „J Biol Chem". 266 (5), s. 3246-51, Feb 1991. PMID: ... An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion ... OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse ...
SCID chimeric mice. In 28th Cologne workshop on Dope Analysis (Manfred Donike workshop) (Vol. 18, pp. 52-61). Sportverlag ...
Smith, C. I., Hassan, M. S. (1991). "Biological half-life of normal and truncated human IgG3 in scid mice". Eur J Immunol. ...
"Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora". Infection and Immunity. 65 (11): 4858- ... 2000]. H. rappini has also been isolated from the feces of healthy people, dogs, and mice, as well as from patients with ... Like Helicobacter hepaticus, it colonizes the bile, liver, and intestine of mice, and is associated with multifocal chronic ... nov., a novel Helicobacter species isolated from bile, livers, and intestines of aged, inbred mice". Journal of Clinical ...
"High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid ... "A cell initiating human acute myeloid leukaemia after transplantation into SCID mice". Nature. 367 (6464): 645-648. doi:10.1038 ... Cancer stem cell Somatic evolution in cancer Genome instability Mouse models of breast cancer metastasis Marusyk, A; Polyak, K ...
Dick developed an in vivo repopulation assay using the NOD/SCID mouse. This technique of using an immune-deficient mouse to ... "A cell initiating human acute myeloid leukaemia after transplantation into SCID mice". Nature. 367 (6464): 645-8. doi:10.1038/ ... "Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene ... Dick is also known for his demonstration of a blood stem cell's ability to replenish the blood system of a mouse, his ...
"Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice". Nature Medicine. 3 (4 ... the lymph node metastasis of a male patient with hormone refractory prostate cancer which was then xenografted into SCID mice ...
"Establishment of a Human Cutaneous T-Cell Lymphoma in C.B-17 SCID Mice". Journal of Investigative Dermatology. 94: 381-384. doi ...
1985 - Started producing BALB/c mice. 1991 - Became the first commercial provider of the C.B-17 SCID mouse model. 1994 - ... They continue to supply NCI with BDF1 mice. 1975 - Began offering the SHR hypertensive rat and the WKY control strain. 1980 - ... 1949 - Robert Phelan began shipping mice from his garage in Canajoharie, NY. 1952 - Taconic Farms is officially founded in ... 1963 - Contracted to provide BDF1 mice for the National Cancer Institute. 1969 - Began offering rats, including Sprague Dawley ...
KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice. JOURNAL OF CLINICAL ...
"DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts". Chromosoma. 126 (2): 287- ... However, in mice there is no increase in mutation in the brain with aging. Mice defective in a gene (Pms2) that ordinarily ... mutant mice defective in Ku70, or Ku80, or double mutant mice deficient in both Ku70 and Ku80 exhibit early aging. The mean ... and the three mutant mice were found to display the same aging signs as the control mice, but at a much earlier age. Cancer ...
"Development of an orthotopic SCID mouse-human tumor xenograft model displaying the multidrug-resistant phenotype". Cancer ... WEINSTEIN, R. "Effects of continuous inhalation of dichloromethane in the mouse: Morphologic and functional observations*1". ...
"Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice". PLoS ONE. 2 (11): e1251. doi:10.1371/ ...
"DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts". Chromosoma. 126 (2): 287- ... Tian M, Jones DA, Smith M, Shinkura R, Alt FW (2004). "Deficiency in the nuclease activity of xeroderma pigmentosum G in mice ... Bonsignore LA, Tooley JG, Van Hoose PM, Wang E, Cheng A, Cole MP, Schaner Tooley CE (2015). "NRMT1 knockout mice exhibit ... Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (February 2003). "Aging and genome maintenance: lessons from the mouse ...
All NHEJ mutant mice show a SCID phenotype, sensitivity to ionizing radiation, and neuronal apoptosis. A system was developed ... NHEJ efficiency could be compared across tissues of the same mouse and in mice of different age. Efficiency was higher in the ... SCID) due to defective V(D)J recombination. Loss-of-function mutations in Artemis also cause SCID, but these patients do not ... Many NHEJ genes have been knocked out in mice. Deletion of XRCC4 or LIG4 causes embryonic lethality in mice, indicating that ...
Myeloma cells overexpressing Sulf1 and 2 were subcutaneously injected in severe combined immunodeficient (SCID) mice. Enhanced ... deficient mice, BMP deficient mice and hypermorphic Fgfr1 and 3 mice. This provides evidence that Sulf1 and 2 is linked to HS ... Sulf null mice and other model systems implicated Sulfs in other developmental and disease systems. For example, studies ... In adult mice, Sulf1 and Sulf2 have overlapping functions in regulating muscle regeneration. Functionally, Sulfs cooperatively ...
"Overexpression of plasminogen activator inhibitor 2 in human melanoma cells inhibits spontaneous metastasis in scid/scid mice" ... "Mouse PubMed Reference:".. *^ Schroder WA, Major L, Suhrbier A (2011). "The role of SerpinB2 in immunity". Critical Reviews in ...
1980 Discovery of the SCID mouse, a mouse strain with no natural immunity, by Melvin Bosma. The SCID mouse is an essential ... 1981 Beatrice Mintz's laboratory is one of the first to introduce a cloned gene into fertilized mouse eggs and prove that it is ... 1979 Beatrice Mintz shows that a fatal genetic anemia of mice can be prevented in utero by injecting normal blood-forming stem ... 1993 Beatrice Mintz produces the first mouse model of human malignant melanoma, in which the disease resembles the human ...
Genetically modified mice are the most common genetically engineered animal model. They have been used to study and model ... September 2009). "Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease". Nucleic Acids Res. 37 ... "Knockout Mice". Nation Human Genome Research Institute. 2009. "GM pigs best bet for organ transplant". Medical News Today. 21 ... Rudolf Jaenisch created the first GM animal when he inserted foreign DNA into a mouse in 1974. The first company to focus on ...
... administration of the antibody prolonged survival of SCID mice implanted with JOK-1 cells. Apoptosis induction appears to be ... In a mouse model of multiple myeloma, tumor metastasis to bone was decreased in CD47-deficient mice compared with wild type ... In mice xenografted with human non-Hodgkin lymphoma (NHL) cells, blocking CD47 function with shRNA or antibodies led to a ... CD47 knockout mice show reduced recruitment of blood T cells as well as neutrophils and monocytes in areas of inflammation. ...
... nude and SCID) mice". Infect Immun. 60 (8): 3325-31. PMC 257318 . PMID 1639500. Lupo PJ, Langer-Curry RC, Robinson M, Okhuysen ... Nov.), of the gastric Glands of the Common Mouse". J Med Res. 23 (3): 487-510.3. PMC 2098948 . PMID 19971982. Palmer, Carol J ... Cryptosporidium muris is a species of coccidium, first isolated from the gastric glands of the common mouse. Tyzzer EE (1910 ...
Experiments in animal models have shown X-SCID to occur similarly in dogs, but not in mice. Alterations in the immune response ... SCID). Most of these mutations involve changes in one or a few nucleotides (DNA building blocks) in the gene. These changes ... "Mouse PubMed Reference:". Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, ...
T细胞缺陷可能意味着T细胞数量的减少或者T细胞功能的缺失。完全的T细胞缺陷可能来自于一些遗传因素,例如严重复合型免疫缺乏症(SCID)、欧门氏症候群或软骨毛发发育不全