The two most common types of genetically modified mice are knockout mice and oncomice. Knockout mice are a type of mouse model ... "Knockout Mice". National Human Genome Research Institute. August 27, 2015. Genetically modified mouse#cite note-8 Venken, K. J ... In order to create knockout mice, a transgene with the desired sequence is inserted into an isolated mouse blastocyst using ... Mouse cells were first transformed in 1979, followed by mouse embryos in 1980. Most of the very first transmutations were ...
The technology has also been used to generate mice with genes knocked out. The first recorded knockout mouse was created by ... "Knockout Mice". National Human Genome Research Institute. Hanahan, D.; Wagner, E. F.; Palmiter, R. D. (2007). "The origins of ... The mice appeared normal, but after using radioactive probes he discovered that the virus had integrated itself into the mice ... However the mice did not pass the transgene to their offspring. In 1981 the laboratories of Frank Ruddle, Frank Constantini and ...
"Knockout Mice". Nation Human Genome Research Institute. 2009. "GM pigs best bet for organ transplant". Medical News Today. 21 ... Gain of function experiments, the logical counterpart of knockouts. These are sometimes performed in conjunction with knockout ... In a simple knockout a copy of the desired gene has been altered to make it non-functional. Embryonic stem cells incorporate ... As well as inserting genes, the process can be used to remove, or "knock out", genes. The new DNA can be inserted randomly, or ...
Sakamoto K, Gurumurthy CB, Wagner K (2014), Singh SR, Coppola V (eds.), "Generation of Conditional Knockout Mice", Mouse ... "Generating conditional knockout mice". Transgenic Mouse Methods and Protocols. Methods in Molecular Biology. 693. pp. 205-31. ... Further, these knockouts can be inducible. In several mouse studies, tamoxifen is used to induce the Cre recombinase. In this ... Hall B, Limaye A, Kulkarni AB (September 2009). "Overview: generation of gene knockout mice". Current Protocols in Cell Biology ...
Studies with knockout mice". Cerebellum. 1 (4): 241-58. doi:10.1080/147342202320883551. PMID 12879963. S2CID 25917565. ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Cates MS, Teodoro ...
Cells in Cdk2 knockout mice likely undergo fewer divisions, contributing to the reduction in body size. Germ cells also stop ... "Cdk2 knockout mice are viable". Current Biology. 13 (20): 1775-85. doi:10.1016/j.cub.2003.09.024. PMID 14561402. S2CID 14320937 ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Tsai LH, Harlow E, ... When Cdk2 was deleted in mice, the animals remained viable despite a reduction in body size. However, meiotic function of both ...
In comparison with wild-type mice, double knockout mice exhibited different diseases course post brain injury. It indicated ... Knockout mice display cognition problems; there is disruption in memory consolidation as well as disruption between memory ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Jung JS, Bhat RV, ... The method that was used to discover the existence of the transport channels was through knockout experiments. With this ...
... mice (see Knockout mouse). About 95% of EP4(-/-) mice die within 3 days of birth due to the pulmonary congestion and heart ... mice to re-absorb bone when induced to do so and the infusion of PGE2 into mice failed to stimulate bone absorption. ... Mice lacking this receptor or treated with a selective EP4 antagonist proved to be far more susceptible to the development of ... In mice, this is accomplished by turning off the mechanism which maintains the ductus's patency. Continuous activation of EP4 ...
IP gene knockout mice (i.e. IP(-/-) mice) exhibit increased tendency to thrombosis in response to experimentally-induced ... IP(-/-) mice exhibit little or no writhing responses in an acetic acid-induced pain model. The mouse IP receptor also appears ... may underlie the ability of IP gene knockout in an ApoE(−/−) mouse model to cause an accelerated rate of developing ... IP receptor-deficient mice exhibited increased lung inflammation in a model of bleomycin-induced pulmonary fibrosis while mice ...
... (October 2001). "Knockout mice and test-tube babies". Nature Medicine. 7 (10): 1079-1080. doi:10.1038/ ...
Crawley, Jacqueline N. (2007-05-11). What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice. John ... Crusio, Wim E. (March 2013). "Mouse behavioral testing. How to use mice in behavioral research - by Douglas Wahlsten". Genes, ... He is known for his laboratory research on the behavior of mice, and for his theoretical writings on a wide range of other ... doi:10.1111/j.1601-183X.2012.00864.x. CS1 maint: discouraged parameter (link) Wahlsten, Douglas (2010-10-22). Mouse Behavioral ...
Knockout mice have been generated for FANCA. However, both single and double knockout murine models are healthy, viable, and do ... Immunochemical study of mouse tissue indicates that FANCA is present at a higher level in lymphoid tissues, the testis and the ... Cheng NC, van de Vrugt HJ, van der Valk MA, Oostra AB, Krimpenfort P, de Vries Y, Joenje H, Berns A, Arwert F (2000). "Mice ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: FANCA ...
What's wrong with my mouse: Behavioral phenotyping of transgenic and knockout mice, Wiley-Interscience, Hoboken, NJ (2007) 523 ... She has co-edited 4 books and is the author of What's Wrong With my Mouse? Behavioral Phenotyping of Transgenic and Knockout ... especially mice. Early in her career, she developed the light-dark mouse exploration test, and showed that it is a valid test ... Behavioral phenotyping of transgenic and knockout mice". Genes, Brain and Behavior. 1 (2): 131. doi:10.1034/j.1601-183X. ...
Per2 knockout mice show arrhythmic locomotor activity. The gene ASB1, associated with eveningness and a tendency to day-napping ... In mice, gene ablation of Rgs16 lengthens the circadian period of behavioural rhythm. By temporally regulating cAMP signalling ... Chronotypes have also been investigated in other species, such as fruit flies and mice. Normal variation in chronotype ... "High-fat diet disrupts behavioral and molecular circadian rhythms in mice". Cell Metabolism. 6 (5): 414-421. doi:10.1016/j.cmet ...
... knockout mice have been used as an animal model of autism. Mice without the Eif4ebp2 gene exhibited autism-like ... Knockout mice have high levels of Neuroligins. EIF4EBP2 has been shown to interact with EIF4E. GRCh38: Ensembl release 89: ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Pause A, Belsham GJ ... and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2". Genomics. 38 (3): 353-63. ...
"Delayed wound healing in CXCR2 knockout mice". The Journal of Investigative Dermatology. 115 (2): 234-44. doi:10.1046/j.1523- ... An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro- ... in mice or cytokine-induced neutrophil chemoattractant type-1 (CINC-1) in rats. In humans, this protein is encoded by the gene ... "Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1". The American ...
... knockout mice show seemingly normal development. "Thus SGK1 is either not a crucial element in the regulation of cell ... can effectively replace SGK1 function in the SGK1 knockout mice". It has been suggested that this kinase plays a critical role ...
... knockout mice die right after birth. The mice showed no developing organs such as lungs, salivary glands, kidney or ... Studies of the mouse homolog suggested that this gene is required for embryonic epidermal morphogenesis including brain ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Emoto H, Tagashira ... "Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human ...
Knock-out mice with the targeted inactivation of the expression of alpha-synuclein show impaired spatial learning and working ... In addition, alpha-synuclein knockout mice display a higher level of DSBs, and this problem can be alleviated by transgenic ... Kokhan VS, Afanasyeva MA, Van'kin GI (May 2012). "α-Synuclein knockout mice have cognitive impairments". Behavioural Brain ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Genetics Home ...
A conditional knockout mouse line, called Rhoutm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse ... Mouse Resources Portal, Wellcome Trust Sanger Institute. "International Knockout Mouse Consortium". "Mouse Genome Informatics ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. ...
A conditional knockout mouse line, called Myd88tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse ... Mouse Resources Portal, Wellcome Trust Sanger Institute. "International Knockout Mouse Consortium".[permanent dead link] "Mouse ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337-42. doi ...
A conditional knockout mouse line, called Ptges2tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse ... Mouse Resources Portal, Wellcome Trust Sanger Institute. "International Knockout Mouse Consortium". "Mouse Genome Informatics ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins ...
A conditional knockout mouse line, called Dctn5tm2a(KOMP)Wtsi was generated as part of the International Knockout Mouse ... Mouse Resources Portal, Wellcome Trust Sanger Institute. "International Knockout Mouse Consortium".[permanent dead link] "Mouse ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins FS ...
A conditional knockout mouse line, called Mcph1tm1a(EUCOMM)Wtsi[31][32] was generated as part of the International Knockout ... Mouse Resources Portal, Wellcome Trust Sanger Institute. *^ "International Knockout Mouse Consortium". Archived from the ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718.. ...
A conditional knockout mouse line, called Prmt5tm2a(EUCOMM)Wtsi[14][15] was generated as part of the International Knockout ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718.. ... "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337-342. doi:10.1038/ ...
A conditional knockout mouse line, called Myh9tm1a(EUCOMM)Wtsi[78][79] was generated as part of the International Knockout ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... and mice specifically ablated for NM IIA in the mouse trophoblast-lineage cells demonstrate placental defects similar to mice ... Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718.. ...
A conditional knockout mouse line, called Pnpt1tm1a(KOMP)Wtsi[12][13] was generated as part of the International Knockout Mouse ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718.. ... "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337-42. doi:10.1038/ ...
Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta ... A conditional knockout mouse line called Klf17tm1b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and ... "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718.. ... "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337-42. doi:10.1038/ ...
A conditional knockout mouse line, called Gap43tm1a(EUCOMM)Wtsi[16][17] was generated as part of the International Knockout ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718.. ... Studies on another homozygous GAP43 knockout mouse line found it to be lethal days after birth because it plays a critical role ...
J. Sprent: Migration and Lifespan of Circulating B-Lymphocytes of Nude (nu/nu) Mice. In: Proc. First Intern. Workshop Nude Mice ... Knockout-Mäuse mit einer Deletion in FOXN1 zeigen den gleichen Phänotyp. Nacktmaus-Weibchen haben unterentwickelte Brustdrüsen ... B. J. Braakhuis u. a.: The potential of the nude mouse xenograft model for the study of head and neck cancer. In: Archives of ... S. Loisel u. a.: Establishment of a novel human B-CLL-like xenograft model in nude mouse. In: Leukemia Research 29/2005, S. ...
"Absence of the SP/SP receptor circuitry in the substance P-precursor knockout mice or SP receptor, neurokinin (NK)1 knockout ... analgesia and aggression in mice lacking the receptor for substance P". Nature. 392 (6674): 394-7. doi:10.1038/32904. PMID ... mice leads to an inhibited cytokine response in granulomas associated with murine Taenia crassiceps infection". The Journal of ...
... mice". PLoS One 4 (1): e4226. PMC 2627485 /journal.pone.0004226 Check ,pmc=. value (juhend). PMID 19156219. ... tuntud kui knockout-hiir) väljatöötamise eest. [33] ... Derived from in Vitro Primordial Germ Cell-like Cells in Mice ...
General gene knock out of the TGF-β resulted in death. Conditional inactivation of TGF-βr2 of osteochondroprogenitor cells in ... Data based on a 10.5-day-old mouse embryo. Included are the multiple factors for differentiation.[2] ... Knock out of the entire pathway results in early embryonic death, therefore most research of this nature utilised conditional ... The disease has symptoms similar to those resulting from Trsp gene knockout.[12] ...
Clinical trials have been conducted on mice using tomatoes expressing antibodies or proteins that stimulate antibody production ...
Knockout mice of the PR have been found to have severely impaired lobuloalveolar development of the mammary glands[17] as well ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.. ... Selective ablation of PR-A in a mouse model, resulting in exclusive production of PR-B, unexpectedly revealed that PR-B ... As demonstrated in progesterone receptor-deficient mice, the physiological effects of progesterone depend completely on the ...
In order to achieve a mouse strain that is considered inbred, a minimum of 20 sequential generations of sibling matings must ... guarantees a consistent and uniform animal model for experimental purposes and enables genetic studies in congenic and knock-out ... Systematic inbreeding and maintenance of inbred strains of laboratory mice and rats is of great importance for biomedical ... "Male-male competition magnifies inbreeding depression in wild house mice". Proceedings of the National Academy of Sciences of ...
Studies in y2 knockout mice have shown that they display increased anxiety and depressive-like symptoms in despair based tests ... Other studies with α2 knockout mice have displayed increased anxiety and depression-like symptoms in conflict based feeding ... The mice also had increased corticosterone concentration which is a symptom in major depression in humans. The y2 subunit is ... Additionally, studies in α5 mice showed that the spinal α5-containing GABAA receptor has a minor role in inflammatory pain. An ...
... which could carry the GAR-1 Falcon in addition to Mighty Mouse rockets. The squadron soon upgraded to the F-89J.[19] On 1 ... thus making it more difficult for the Soviet Union to knock out the entire fleet with a surprise first strike.[24] As part of ... These two seat interceptor aircraft were radar equipped and armed with Mighty Mouse rockets. The 412th was also assigned ...
Experiments with strains of mice engineered to remove (knockout) CYP1A1 and CYP1B1 reveal that CYP1A1 primarily acts to protect ... "Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract". Free Radic ...
The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as ... 1996). "The gene encoding protein kinase SEK1 maps to mouse chromosome 11 and human chromosome 17". Genomics. 34 (3): 430-2. ... "Mouse PubMed Reference:". Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M (May 1995 ...
Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta ... A conditional knockout mouse line called Sqletm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and ... Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins ... "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337-42. doi:10.1038/ ...
Knockout mice also exhibit cerebellar abnormalities and an increase in the number of sympathetic neurons.[20] ... The phenotype for BDNF knockout mice can be severe, including postnatal lethality. Other traits include sensory neuron losses ... Similar effects could be obtained in BDNF knockout mice, but these effects were reversed by local application of BDNF.[55] This ... "Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice". The International ...
Knockout mice of any SOD enzyme are more sensitive to the lethal effects of superoxide-generating compounds, such as paraquat ... Mice lacking SOD2 die several days after birth, amid massive oxidative stress.[26] Mice lacking SOD1 develop a wide range of ... Knockout or null mutations in SOD1 are highly detrimental to aerobic growth in the budding yeast Saccharomyces cerevisiae and ... Mice lacking SOD3 do not show any obvious defects and exhibit a normal lifespan, though they are more sensitive to hyperoxic ...
Guan, Chunmei; Ye, Chao; Yang, Xiaomei; Gao, Jiangang (2010). "A review of current large-scale mouse knockout efforts". Genesis ... "The Knockout Mouse Project". Nature Genetics 36 (9): 921-924. doi:10.1038/ng0904-921. ISSN 1061-4036. PMC 2716027. PMID ... Georgi, B; Voight, BF; Bućan, M (May 2013). "From mouse to human: evolutionary genomics analysis of human orthologs of ... single-gene knockout mutants: the Keio collection.". Molecular systems biology 2: 2006.0008. doi:10.1038/msb4100050. PMC ...
... and the technique behind gene targeting and knockout mice.[325]. *George Smoot (1945-): American astrophysicist and cosmologist ...
... knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time". Neurobiol. Dis. 14 (1 ... transgenic mouse model of Alzheimer's disease". Neurobiol. Dis. 39 (3): 409-22. PMC 2913404. PMID 20493257. doi:10.1016/j.nbd. ... "The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease". The Journal of ... "Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice". EMBO J. 27 (1): 224-33. PMC ...
Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... In addition, full knockout of Beclin1 is embryonic lethal whereas knockout of Atg7 or Atg5 is not. ... as mice studies have shown that starvation-induced autophagy was impaired in atg7-deficient mice.[60] ... The study in mice fed with olive oil resulted in an increase in nerve cell autophagy activation compared to controls that had ...
Capecchi, Mario R. (2001). "Generating mice with targeted mutations". Nature Medicine. 7 (10): 1086-90. doi:10.1038/nm1001-1086 ... genetika digunakan untuk mengeluarkan materi genetik dari target maka organisme yang dihasilkan disebut organisme knockout.[12] ... "Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA" ...
Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... In addition, full knockout of Beclin1 is embryonic lethal whereas knockout of Atg7 or Atg5 is not. ... as mice studies have shown that starvation-induced autophagy was impaired in atg7-deficient mice.[68] ... A study of mice shows that autophagy is important for the ever-changing demands of their nutritional and energy needs, ...
Weissmann C, Flechsig E (2003). "PrP knock-out and PrP transgenic mice in prion research". Br. Med. Bull. 66: 43-60. doi: ... In mice, this same deletion phenotypically varies between Alzheimer's mouse lines, as hAPPJ20 mice and TgCRND8 mice show a ... In the case of direct injection of Aβ oligomers into the hippocampus, PRNP-knockout mice were found to be indistinguishable ... A common approach is using PrP-knockout and transgenic mice to investigate deficiencies and differences.[27] Initial attempts ...
GPERKO mice[edit]. GPER knockout mice have also been generated, and exhibit obesity, cardiovascular dysfunction, insulin ... EIS can be experimentally induced in animals via knockout of the ER.[14] In these so-called ERKO mice, different ERs can be ... lessons from knockout mouse models" (PDF). Semin. Reprod. Med. 27 (3): 218-28. doi:10.1055/s-0029-1216275. hdl:11343/57379. ... "What have we learned about GPER function in physiology and disease from knockout mice?". J. Steroid Biochem. Mol. Biol. 153: ...
"Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice". Journal of Physiology. 568 (1): 83-95. doi: ... Lin, Min; Zhang, Min; Abraham, Michael; Smith, Susan M.; Napoli, Joseph L. (2003). "Mouse Retinal Dehydrogenase 4 (RALDH4), ...
"White Matter Damage and the Effect of Matrix Metalloproteinases in Type 2 Diabetic Mice After Stroke". Department of Neurology ... "Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components ...
Mice were trained, using foot shocks, to fear a cherry blossom odor. The investigators reported that the mouse offspring had an ... and therefore a single gene knock out is sufficient to cause the disease, where most cases would require both copies to be ... Studies on mice have shown that certain conditional fears can be inherited from either parent. In one example, mice were ... The authors also did not indicate which mice were siblings, and treated all of the mice as statistically independent.[95] The ...
"Adaptation of the myoglobin knockout mouse to hypoxic stress". Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 (4): R786-92. ... "Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice". American Journal of Physiology. Heart and ...
SAP97's function has been investigated by reducing its expression by knockout or increasing its expression heterologously. Mice ... "Mouse PubMed Reference:".. *^ Müller BM, Kistner U, Veh RW, Cases-Langhoff C, Becker B, Gundelfinger ED, Garner CC (Mar 1995). ... "Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter". Proceedings of the National Academy of ... "Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene". Molecular ...
3] Navíc AANAT u knockout myšíi vykazuje signifikantně větší dobu její nehybnosti oproti kontrolním myším u modelů deprese na ... N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice. Proc. Natl. Acad. Sci. U.S.A. ...
Laboratory work with GMOs classified as low risk, which include knockout mice, are carried out in PC1 lab. This is the case for ...
Alox5 gene knockout mice exhibit an increase in the lung tumor volume and liver metastasis of Lewis lung carcinoma cells that ... Alox5 Gene knockout mice are more susceptible to the development and pathological complications of experimental infection with ... ALOX5 gene knockout mice exhibited a decrease in the number of neutrophils and an increase in the number of bacteria that ... ALOX5 gene knockout mice demonstrate an enhanced resistance and lessened pathology to Brucella abortus infection[31] and, at ...