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*  Knockout mouse
A knockout mouse or knock-out mouse is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or " ... The website for ordering ES cells and mice generated by TIGM Creating Knockout Mice for Targeting Vector from Knockout Mice ... Millions of knockout mice are used in experiments each year. There are several thousand different strains of knockout mice. ... Studying Gene Function: Creating Knockout Mice - a review from the Science Creative Quarterly The Knock Out Mouse Project (KOMP ...
*  International Knockout Mouse Consortium
... Knockout Mouse Project (KOMP) Repository North American Conditional Mouse Mutagenesis ( ... The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem ... International Mouse Knockout Consortium (2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018 ... 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337-42. doi: ...
*  Mouse Genetics Project
... the project uses knockout mice most of which were generated by the International Knockout Mouse Consortium. For each mutant ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Karp NA, Melvin D, Mott RF (2012). "Robust and sensitive analysis of mouse knockout phenotypes". PLoS ONE. 7 (12): e52410. doi: ... July 2013). "Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes". Cell. 154 (2 ...
*  Gene
For example, genes are easily added to bacteria and lineages of knockout mice with a specific gene's function disrupted are ... Guan, Chunmei; Ye, Chao; Yang, Xiaomei; Gao, Jiangang (2010). "A review of current large-scale mouse knockout efforts". Genesis ... "The Knockout Mouse Project". Nature Genetics. 36 (9): 921-924. doi:10.1038/ng0904-921. ISSN 1061-4036. PMC 2716027 . PMID ... Georgi, B; Voight, BF; Bućan, M (May 2013). "From mouse to human: evolutionary genomics analysis of human orthologs of ...
*  Conditional gene knockout
... mice bred in the laboratory. Conditional gene knockouts in mice are often used to study human diseases because many genes ... "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337-342. doi:10.1038/ ... Scientists used conditional gene knockout to delete the BRCA1 allele in mammary gland tissue in mice and found that it plays an ... Guan, Chunmei; Ye, Chao; Yang, Xiaomei; Gao, Jiangang (2010). "A Review of Current Large-Scale Mouse Knockout Efforts". Genesis ...
*  Transgene
The two most common types of genetically modified mice are knockout mice and oncomice. Knockout mice are a type of mouse model ... "Knockout Mice". National Human Genome Research Institute. August 27, 2015. Genetically modified mouse#cite note-8 Venken, K. J ... In order to create knockout mice, a transgene with the desired sequence is inserted into an isolated mouse blastocyst using ... Mouse cells were first transformed in 1979, followed by mouse embryos in 1980. Most of the very first transmutations were ...
*  History of genetic engineering
The technology has also been used to generate mice with genes knocked out. The first recorded knockout mouse was created by ... "Knockout Mice". National Human Genome Research Institute. Hanahan, D.; Wagner, E. F.; Palmiter, R. D. (2007). "The origins of ... The mice appeared normal, but after using radioactive probes he discovered that the virus had integrated itself into the mice ... However the mice did not pass the transgene to their offspring. In 1981 the laboratories of Frank Ruddle, Frank Constantini and ...
*  Genetic engineering
"Knockout Mice". Nation Human Genome Research Institute. 2009. "GM pigs best bet for organ transplant". Medical News Today. 21 ... Gain of function experiments, the logical counterpart of knockouts. These are sometimes performed in conjunction with knockout ... In a simple knockout a copy of the desired gene has been altered to make it non-functional. Embryonic stem cells incorporate ... As well as inserting genes, the process can be used to remove, or "knock out", genes. The new DNA can be inserted randomly, or ...
*  Genetically modified mouse
Transgenic mice generated to carry cloned oncogenes and knockout mice lacking tumor suppressing genes have provided good models ... The most common type is the knockout mouse, where the activity of a single (or in some cases multiple) genes are removed. They ... p. 1. ISBN 0-89603-915-3. "Knockout Mice". Nation Human Genome Research Institute. 2009. McPherron, A.; Lawler, A.; Lee, S. ( ... A genetically modified mouse (Mus musculus) is a mouse that has had its genome altered through the use of genetic engineering ...
*  PDGFC
Mouse knockout studies show that PDGF-C is required for palatogenesis. Although human studies support an etiologic role for ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... "Mouse PubMed Reference:". Hamada T, Ui-Tei K, Miyata Y (June 2000). "A novel gene derived from developing spinal cords, SCDGF, ... several genes in cleft lip and palate etiology (PVRL1, IRF6, and MSX1), expression levels of the mouse homologs of these genes ...
*  Microcephalin
A conditional knockout mouse line, called Mcph1tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse ... "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. International Mouse Knockout ... "International Knockout Mouse Consortium". "Mouse Genome Informatics". Skarnes, William C.; Rosen, Barry; West, Anthony P.; ... Gerdin, AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ...
*  JMJD1C
In addition, the JMJD1c gene has a role in mouse spermatogenesis. In male homozygous Jmjd1C mouse knockouts are unable to ... "Mouse PubMed Reference:". "Entrez Gene: Jumonji domain containing 1C". Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo ...
*  Parvalbumin
Studies with knockout mice". Cerebellum. 1 (4): 241-58. doi:10.1080/147342202320883551. PMID 12879963. Klausberger T, Marton LF ...
*  IRGs
Dependency on the IRGs is best exemplified in mouse studies. Multiple studies have been done using mouse knockout models to ... Irg1 knockout mice infected with Mycobacterium resulted in pancytopenia as a result of inadequate hematopoietic stem cell ... Studies in mice have characterized the importance of the type 2 effector molecule IFNγ in various cell types and gone on to ... The C57BL/6 mouse has 23 IRG genes of which 21 may be functional in resistance to pathogens (6 are well characterized), whereas ...
*  Cyclin-dependent kinase 2
"Cdk2 knockout mice are viable". Curr. Biol. 13 (20): 1775-85. doi:10.1016/j.cub.2003.09.024. PMID 14561402. Levkau B, Koyama H ... "Mouse PubMed Reference:". Tsai LH, Harlow E, Meyerson M (September 1991). "Isolation of the human cdk2 gene that encodes the ... "A distinct cyclin A is expressed in germ cells in the mouse". Development. 122 (1): 53-64. PMID 8565853. Yang R, Morosetti R, ...
*  Aquaporin 4
In comparison with wild-type mice, double knockout mice exhibited different diseases course post brain injury. It indicated ... Knockout mice display cognition problems; there is disruption in memory consolidation as well as disruption between memory ... The method that was used to discover the existence of the transport channels was through knockout experiments. With this ... "Mouse PubMed Reference:". Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P (December 1994). "Molecular ...
*  KREMEN1
A mouse knock out of Kremen1 and its paralog Kremen2 is viable and fertile. GRCh38: Ensembl release 89: ENSG00000183762 - ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000020393 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed ...
*  Wrch1
A conditional knockout mouse line, called Rhoutm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse ... "International Knockout Mouse Consortium". "Mouse Genome Informatics". Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. ...
*  PDCD10
A conditional knockout mouse line, called Pdcd10tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse ... "International Knockout Mouse Consortium". "Mouse Genome Informatics". Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins ...
*  PRMT8
A conditional knockout mouse line, called Prmt8tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse ... "International Knockout Mouse Consortium". "Mouse Genome Informatics". Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins FS ...
*  24-Dehydrocholesterol reductase
A conditional knockout mouse line, called Dhcr24tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse ... Mouse Resources Portal, Wellcome Trust Sanger Institute. "International Knockout Mouse Consortium". "Mouse Genome Informatics ... Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins FS ... July 2013). "Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes". Cell. 154 (2 ...
*  Insulin-degrading enzyme
A conditional knockout mouse line, called Idetm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse ... "International Knockout Mouse Consortium". "Mouse Genome Informatics". Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins ...
*  GIT2
A conditional knockout mouse line, called Git2Gt(XG510)Byg was generated as part of the International Knockout Mouse Consortium ... "International Knockout Mouse Consortium". "Mouse Genome Informatics". Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Mutant mice had differences in their clinical blood chemistry compared to wildtype control mice. Mutant male mice had a ...
*  AKAP9
A conditional knockout mouse line, called Akap9tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse ... 88: 925-7. doi:10.1111/j.1755-3768.2010.4142.x. "International Knockout Mouse Consortium". "Mouse Genome Informatics". Skarnes ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins FS ...
*  Protein arginine methyltransferase 5
A conditional knockout mouse line, called Prmt5tm2a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse ... "International Knockout Mouse Consortium". "Mouse Genome Informatics". Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, ... Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta ... Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins FS ...