... inbred mouse strain and initiated the systematic generation of inbred strains. The mouse has since been used extensively as a ... were C57BL/6 laboratory mice. Sequencing of the laboratory mouse genome was completed in late 2002 using the C57BL/6 strain. ... "Dirty" mice are possibly better suitable for mimicking human pathologies. In addition, inbred mouse strains are used in the ... "BALB/c". Inbred Strains of Mice. Jackson Laboratory. Retrieved 2007-04-16. "BALB/cByJ". Jax Mice Data Sheet. Jackson Laboratory ...
Schwartz WJ, Zimmerman P. Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains. J Neurosci. 1990; 10: 3685-3694. ...
C57BL/6J) mouse. The offspring of the mutated mouse with the inbred strain has a 50% chance of carrying the mutation. From this ... To create a coisogenic strain through breeding, a mouse with the specific mutation on a locus is mated to an inbred strain (e.g ... There are numerous ways to create an inbred strain and each of these strains are unique. Genetically engineered mice can be ... Bult, CJ; Eppig, JT; Blake, JA; Kadin, JA; Richardson, JE; Mouse Genome Database, Group (4 January 2016). "Mouse genome ...
... of the Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone in DBA/2J and C57BL/6J Inbred Mice". Journal of ...
Some inbred laboratory mouse strains, such as BALB/c and C57BL/6, also have different proteins expressed in their urine. ... using white-footed mice, it was found that when mice derived from wild populations were inbred, there was reduced survival when ... Wild mice breeding freely in semi-natural enclosures showed inbreeding avoidance. This avoidance resulted from a strong deficit ... These findings suggest that inbreeding reduces fitness, and that scent signal recognition has evolved in mice as a means of ...
In 1921, he inbred the mouse strain C57BL/6 or "black 6", which is the most popular laboratory mouse to date. His most ... C. C. Little, Cancer and Inbred Mice by James F. Crow, "Genetics", Vol. 161, 1357-1361, August 2002. Clarence Cook Little (1888 ... The lab was quickly rebuilt and most mouse strains were recovered from other labs around the world. By 1950, the lab was ... Little energetically developed both the lab and the ACS, and by 1944 they were shipping 9000 mice a week to other laboratories ...
The cell line is a luteinizing hormone-dependent steroidogenic cell line that was generated from a mice inbred strain C57BL/6J ... MA-10 cells are a model cell line derived from the mouse Leydig cell tumor used in biomedical research. ...
"Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet ... In the strain of mice most commonly used for DIO models, C57BL/6J, mice who started the diet at 10 weeks old showed lower ... For example, mice were put on a high-fat diet, but given either tap water, green tea, or Goishi tea to drink. The mice who ... West, D. B.; Boozer, C. N.; Moody, D. L.; Atkinson, R. L. (1992-06-01). "Dietary obesity in nine inbred mouse strains". The ...
C57BL/6 mice are highly resistant to the virus, while DBA/2J mice are sensitive. C57BL/6 mice showed slight loss of body weight ... Inbred and outbred mouse and rat strains have very different susceptibility to Sendai virus infection. Visualization of SeV ... It was suggested that the mice used to passage the virus were infected with the mouse virus. Thus, mouse virus was later ... Only 10% mortality rate was observed in C57BL/6 mice after the administration of very high virulent dose of 1*105 TCID50. It ...
"Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by δ2 ... female mice are more sensitive to itch than male mice; pain reduces sexual desire in male but not female mice; sex differences ... They showed that mice display more pain behavior if they are tested in close proximity to other mice also in pain, but only if ... In 1999, they showed that different inbred strains of mice displayed very different pain sensitivity. Chief among these ...
N.M Haldane identified first linkage in mouse between Albino mice and pink eye dilution on chromosome seven. In 1921, C57BL ... In 1909, Clarence C. Little developed the first inbred strain, the DBA (Dilute, brown non-Agouti) mouse. In 1915, ... Mice have relatively short gestation periods. Mice take a brief time to reach sexual maturity. Mice have large litter sizes. ... The number of mouse genes without a corresponding human homologue is less than 1%. 90% of the human and mouse genomes are ...
C57BL, C57BR and C57L). Many of the most popular strains of mice were developed during the next decade, and some are closely ... and only three un-pedigreed mice remained alive. Soon after World War I, inbreeding in mice was started on a much larger scale ... A/J C3H C57BL/6 CBA DBA/2 BALB/c G. M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. Strain 2 ... "The period before World War I led to the initiation of inbreeding in rats by Dr Helen King in about 1909 and in mice by Dr C. C ...
He trained C. C. Little who bred C57BL/6J ("Black 6") from Lathrop's mouse number 57. Black 6 became the most frequently used ... Abbie E. C. Lathrop (1868 - 1918) was a rodent fancier who bred fancy mice and inbred strains for animal models, particularly ... She bred Japanese waltzing mice as well as fancy mice. The mice had straw bedding and lived in wooden boxes. They were fed a ... Lathrop started out with a pair of waltzing mice she obtained in Granby and her farm grew to hold over 11,000 mice at one point ...
... mice, inbred balb c MeSH B01.050.157.520.388 - mice, inbred c3h MeSH B01.050.157.520.420 - mice, inbred c57bl MeSH B01.050. ... mice, inbred balb c MeSH B01.050.199.520.520.388 - mice, inbred c3h MeSH B01.050.199.520.520.420 - mice, inbred c57bl MeSH ... mice, inbred cba MeSH B01.050.157.520.445 - mice, inbred cftr MeSH B01.050.157.520.460 - mice, inbred dba MeSH B01.050.157.520. ... 480 - mice, inbred hrs MeSH B01.050.157.520.510 - mice, inbred icr MeSH B01.050.157.520.555 - mice, inbred mrl lpr MeSH B01.050 ...
... a subgroup of the Anatomical Therapeutic Chemical Classification System C57BL/6, an inbred mouse strain B6 (musician), a ...
... be alleviated by transferring a sample of H2 haplotypes from wild mice onto inbred (C57BL/10 or B10) background and thus ... Typing of inbred strains suggested that the Mhc might manifest unusually high variability (polymorphism). Inbred strains were, ... The karyotype of the house mouse normally consists of 40 telocentric chromosomes, but in certain regions in Europe, mice with ... Genetic mapping of the loci controlling the class I and class II antigens of the mouse showed them to be part of a cluster, ...
... and a male C57BL/6By mouse in the 1960s. The small panel of 8 CXB strains was originally used to determine if the Major ... Recombinant inbred strains or lines were first developed using inbred strains of mice but are now used to study a wide range of ... pairs of the F2 progeny are then mated to establish inbred strains through long-term inbreeding. Families of recombinant inbred ... In the case of a typical mouse recombinant inbred strain made by crossing maternal strain BALB/cBy (C) with paternal strain ...
... a barred irregular galaxy C57BL/6, a common inbred strain of lab mouse Fried Liver Attack, a chess opening HMS Cumberland (C57 ...
It has genetic similarity to C57BL/6N, and generally differs from other inbred stains. It has been used as a model in the study ... It is among the smallest house mice. Different strains such as MSM/Ms, JF1, Japanese waltzing mouse, C57BL/6J and MSKR exist ... The Japanese house mouse or Japanese wild mouse (Mus musculus molossinus) is a type of house mouse that originated in Japan. ... fancy mouse) in the 19th century. This black coloured mouse is a sub-strain of C57BL/6 created in 1921 by C. C. Little at the ...
Rhodes, JS; Ford, MM; Yu, CH; Brown, LL; Finn, DA; Garland Jr, T; Crabbe, JC (2007). "Mouse inbred strain differences in ... "Acute effects of acamprosate and MPEP on ethanol Drinking-in-the-Dark in male C57BL/6J mice". Alcoholism: Clinical and ... Rhodes was one of the developers of the Drinking in the Dark model in mice. In this model, a specific mouse strain is found to ... "Acute effects of naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice". Psychopharmacology. 192 (2): 207- ...
Among the earliest references to the use of inbred mice in cancer was the observed susceptibility of the A family of inbred ... For example, transgenic mice on a mixed C57BL/6J and SJL background expressing human HRAS have a mammary gland carcinoma ... MMHCdb contains genetic and genomic information about inbred mouse strains, genetically engineered mouse models (GEMMs) and ... Inbred mouse strains are the result of at least 20 generations of successive brother/sister matings which lead to a population ...
The NOG mouse was generated in CIEA in 2000 by back-cross mating of C57BL/6J-IL-2Rγnull mouse that was originally developed by ... The NOD/Shi inbred strain was first discovered by Makino et al. as autoimmune non-obese-type diabetes mice. Lack of functional ... Cancer Infectious Diseases Regenerative Medicine Hematology Humanized mouse Nude mouse SCID mouse M. Ito and, et al. (2002). " ... such as nude mouse and NOD/scid mouse. Thus, the mouse can be the best model as a highly efficient recipient of human cells to ...
nov., a novel Helicobacter species isolated from bile, livers, and intestines of aged, inbred mice". Journal of Clinical ... "Concurrent Helicobacter bilis Infection in C57BL/6 Mice Attenuates Proinflammatory H. pylori-Induced Gastric Pathology". ... 2000]. H. rappini has also been isolated from the feces of healthy people, dogs, and mice, as well as from patients with ... Like Helicobacter hepaticus, it colonizes the bile, liver, and intestine of mice, and is associated with multifocal chronic ...
"Dirty" mice are possibly better suitable for mimicking human pathologies. In addition, inbred mouse strains are used in the ... Animal testing Animal model BALB/c C57BL/6 Fe, Fi, Fo, Fum, and Phooey, five mice who orbited the Moon in 1972 Mouse models of ... Mice differ from humans in several immune properties: mice are more resistant to some toxins than humans; have a lower total ... Thirty to fifty live mice are normally born from this number of injected blastocysts. Normally, the skin color of the mice from ...
... and Leads to Adverse Gestational Outcome in Female C57BL/6 Mice". Frontiers in Nutrition. 3 (1): 1-10. doi:10.3389/fnut. ... NCLAS also came into the limelight due to the WNIN/Ob obese rat strain which is the heaviest inbred rat model available. It has ... "Mice to reveal key to human obesity". The Times of India. Archived from the original on 16 June 2013. "Australia-India food ...
The idea of inbreeding to achieve this goal of a 'pure strain' in mice was one that may have created a negative response to the ... C57BL/6 (lab mice), etc. These organisms have led to many advances in the past century. Some of the first work with what would ... Making Mice, pp. 30-35 Rader, Making Mice Rader, Making Mice, pp. 190-195 Rader, Making Mice, p. 252 Allen, Garland E. Thomas ... He would continue his work with these mice and used his research to demonstrate that inbreeding is an effective way of ...
Smith HJ (December 1966). "Antigenicity of carcinogen-induced and spontaneous tumours in inbred mice". British Journal of ... NK1.1 or NK1.2 in C57BL/6 mice. The NKp46 cell surface marker constitutes, at the moment, another NK cell marker of preference ... in the mouse, and by Hugh Pross and doctoral student Mikael Jondal in the human. The mouse and human work was carried out under ... In both mice and humans, NKs can be seen to play a role in tumor immunosurveillance by directly inducing the death of tumor ...
Pacific Pocket Mouse Family Muridae Mastomys coucha, Southern multimammate mouse (2019) Mus musculus Strain: C57BL/6J, mouse ( ... August 2022). "A Chromosome-Length Reference Genome for the Endangered Pacific Pocket Mouse Reveals Recent Inbreeding in a ... December 2002). "Initial sequencing and comparative analysis of the mouse genome". Nature. 420 (6915): 520-62. Bibcode: ... Java mouse-deer (2019) Order Rodentia Family Caviidae Hydrochoerus hydrochaeris, capybara (2018) Family Cricetidae Microtus ...