Metyrapone
... can be used in the diagnosis of adrenal insufficiency. Metyrapone 30 mg/kg, maximum dose 3,000 mg, is administered ... Analogues of metyrapone include aminoglutethimide, amphenone B, and mitotane. Metyrapone has been found in early human trials ... Pituitary macroadenomas do not always respond to metyrapone. Metyrapone is used for the medical control of hypercortisolism in ... Metyrapone, sold under the brand name Metopirone, is a medication which is used in the diagnosis of adrenal insufficiency and ...
Hypopituitarism
Stimulation testing with metyrapone is an alternative. Some suggest that an ACTH stimulation test is sufficient as first-line ...
McCune-Albright syndrome
Metyrapone may also be used for treatment. McCune-Albright syndrome is estimated to occur at a frequency between 1 person in ...
Adrenalism
Ketoconazole and metyrapone fall under this drug category. Besides mediating the function of adrenal glands, medications may ...
Mitotane
Analogues of mitotane include aminoglutethimide, amphenone B, and metyrapone. Mitotane was introduced in 1960 for the treatment ...
Steroid 11β-hydroxylase
The CYP11B1 gene is reversibly inhibited by etomidate and metyrapone. 11β-hydroxylase is a steroidogenic enzyme, i.e. the ...
Astex Pharmaceuticals
"Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone". Science. 305 (5684): 683-6. Bibcode: ...
Neurosteroidogenesis inhibitor
Metyrapone, a reversible inhibitor of the enzyme steroid 11β-hydroxylase, may increase inhibitory neurosteroid levels. ... Schmoutz CD, Guerin GF, Goeders NE (2014). "Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine ...
Critical illness-related corticosteroid insufficiency
Both a metyrapone-induced decrease in cortisol and hypoglycemia are potentially harmful to intensive care patients. The exact ... Other stimulation tests for adrenal insufficiency which are used in non-critical patients, such as the test using metyrapone or ... such as metyrapone. Several blood test abnormalities can suggest corticosteroid insufficiency, such as hypoglycemia, ... ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells". J ...
Grant Liddle
Liddle developed the dexamethasone suppression test for assessing adrenal function and the metyrapone test for pituitary ...
Antiglucocorticoid
They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ...
Corticorelin
ACTH stimulation test Dexamethasone suppression test Metyrapone Pituitary-adrenal axis Tetracosactide Andoh K, Kimura T, Saeki ...
Aminoglutethimide
... metyrapone, and mitotane. AG was introduced for medical use, as an anticonvulsant, in 1960. In 1963, it was reported that AG ...
11-Deoxycortisol
"Combined stimulation of adrenocorticotropin and compound-S by single dose metyrapone test as an outpatient procedure to assess ...
Steroidogenesis inhibitor
Aldosterone synthase (CYP11B2) inhibitors such as metyrapone, mitotane, and osilodrostat prevent the production of the potent ... 11β-Hydroxylase (CYP11B1) inhibitors such as amphenone B, etomidate, ketoconazole, metyrapone, mitotane, and osilodrostat ...
Cushing's syndrome
... metyrapone) but they are of limited efficacy.[citation needed] Mifepristone is a powerful glucocorticoid type II receptor ...
Glucocorticoid
... receptor Immunosuppressive drug Membrane glucocorticoid receptor Metyrapone blocks glucocorticoid secretion ...
Anticorticotropin
... metyrapone, mitotane, and aminoglutethimide, have corticotropic or procorticotropic effects. Anticorticotropins are analogous ...
List of MeSH codes (D03)
... metyrapone MeSH D03.383.725.495 - naphthylvinylpyridine MeSH D03.383.725.506 - nevirapine MeSH D03.383.725.518 - nicotine MeSH ...
ACTH stimulation test
... another test used to identify sub-types of adrenal insufficiency Metyrapone, a drug used in the diagnosis of adrenal ...
List of drugs: Met
Metyrapone (INN) Metyridine (INN) (Articles with short description, Short description is different from Wikidata, Lists of ...
Noise-induced hearing loss
... metyrapone (a glucocorticoid receptor antagonist). Treatment options that offer "cures" for NIHL are under research and ...
Amphenone B
One of the most potent of these was metyrapone (2-methyl-1,2-di(pyridin-3-yl)propan-1-one), a selective inhibitor of 11β- ...
Jeffrey Mogil
... and that reduction of stress via metyrapone treatment or a shared social experience (playing the videogame Rock Band together) ...
Adrenal insufficiency
... metyrapone, rifampicin Vascular: e.g. hemorrhage from sepsis, adrenal vein thrombosis, hypercoagulable states such as heparin- ...
ATC code V04
Vitamin A concentrates V04CC01 Sorbitol V04CC02 Magnesium sulfate V04CC03 Sincalide V04CC04 Ceruletide V04CD01 Metyrapone ...