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*  Epigenomics
DNA methylation patterns vary greatly between species and even within the same organism. The usage of methylation among animals ... Consistent with a role of DNA methylation in gene repression, regions that were associated with high levels of DNA methylation ... The first epigenetic modification to be characterized in depth was DNA methylation. As its name implies, DNA methylation is the ... The earliest methylation detection assays used methylation modification sensitive restriction endonucleases. Genomic DNA was ...
*  Reprogramming
A wave of methylation then takes place during the implantation stage of the embryo, with CpG islands protected from methylation ... DNA Methylation patterns are largely erased and then re-established between generations in mammals. Almost all of the ... In vitro manipulation of pre-implantation embryos has been shown to disrupt methylation patterns at imprinted loci and plays a ... Mann MR, Chung YG, Nolen LD, Verona RI, Latham KE, Bartolomei MS (September 2003). "Disruption of imprinted gene methylation ...
*  Bayesian tool for methylation analysis
CpG versus non-CpG methylation. Gene 289, 41-8 (2002) Vanyushin, B.F. DNA methylation in plants. Current Topics in Microbiology ... CpG methylation state is generally highly correlated over hundreds of bases, so CpGs grouped together in 50- or 100-bp windows ... Sample methylation states from the Batman model: You'll often have multiple arrays from the same experiment, and these should ... Summarize methylation states to generate the final calls: The "sample" files generated by Batman contain a large set of ...
*  CpG island hypermethylation
Methylation of a gene prevents expression of a gene in a particular way. The reason for methylation to be almost exclusive to ... For example, high methylation is a marker for poor prognosis in lung cancer. CpG island hypermethylation shows much promise for ... DNA methylation acts as an alternative to genetic mutation. According to the Knudsen hypothesis, cancer is a result of multiple ... The introduction of methylation-specific PCR and sodium bisulfite modification added tools to the belt of cancer epigenetics ...
*  Reduced representation bisulfite sequencing
Aberrant methylation in cancer. American Journal of Human Genetics. 60:751-754. Smith, Z.D., Gu, H., Bock, C., Gnike, A., & ... It is integral for the enzymes to not be influenced by the methylation status of the CpGs (sites within the genome where a ... Aberrant methylation has been observed in cancer. In cancer, hypermethylation as well as hypomethylation has been seen in ... Due to the high cost and depth of sequencing needed to analyze methylation status in the entire genome, Meissner et al. ...
*  Bisulfite sequencing
Gonzalgo ML, Jones PA (June 1997). "Rapid quantitation of methylation differences at specific sites using methylation-sensitive ... performed under non-methylation-specific conditions (Figure 3). Microarray-based methods use PCR based on non-methylation- ... is the use of bisulfite treatment of DNA to determine its pattern of methylation. DNA methylation was the first discovered ... The degree of methylation, as represented by the C-to-T content in the amplicon, determines the rapidity of melting and ...
*  Methylation
... contributing to epigenetic inheritance can occur through either DNA methylation or protein methylation. Similarly, ... RNA methylation is thought to have existed before DNA methylation in the early forms of life evolving on earth. N6- ... In biological systems, methylation is catalyzed by enzymes; such methylation can be involved in modification of heavy metals, ... The Purdie methylation is a specific for the methylation at oxygen of carbohydrates using iodomethane and silver oxide. ...
*  DNA methylation
... maintenance methylation and de novo methylation. Maintenance methylation activity is necessary to preserve DNA methylation ... Gene-body methylation appears closely tied to H3K36 methylation. In yeast and mammals, H3K36 methylation is highly enriched in ... relying on DNA methylation MethBase DNA Methylation database hosted on the UCSC Genome Browser MethDB DNA Methylation database ... 4197 SMART Specific Methylation Analysis and Report Tool Human Methylation Mark Atlas DiseaseMeth Human disease methylation ...
*  Histone methylation
Different degrees of residue methylation can confer different functions, as exemplified in the methylation of the commonly ... Examples include methylation of lysine 4 of histone 3 (H3K4), and arginine (R) residues on H3 and H4. Addition of methyl groups ... Histone methylation is key in distinguishing the integrity of the genome and the genes that are expressed by cells, thus giving ... Histone methylation is a process by which methyl groups are transferred to amino acids of histone proteins that make up ...
*  Protein methylation
Unlike CAAX motif methylation, no C-terminal processing is required to facilitate methylation. This C-terminal methylation ... Methylation at lysine 4 and lysine 9 are mutually exclusive and the consequences of site-specific methylation are diametrically ... Protein methylation is one type of post-translational modification. Methylation occurring on nitrogen atoms in N-terminals ... Methylation at lysine 4 correlates with an active state of transcription. Methylation at lysine 9 is associated with ...
*  2'-O-methylation
... is a common nucleoside modification of RNA, where a methyl group is added to the 2' hydroxyl of the ribose ... Having the chemical properties intermediate between RNA and DNA, 2'-O-methylation is presumed to have one of the reactive group ... Currently, about 1210 2'-O-methylations (2'-O-Me) have been identified in mammals and yeast and deposited in RMBase (RNA ... 2015). "Profiling of Ribose Methylations in RNA by High-Throughput Sequencing". Angew. Chem. Int. Ed. 54 (2): 451-455. doi: ...
*  Illumina Methylation Assay
MethDB DNA Methylation Database Epigenetics Methylation Station Nature Reviews:DNA methylation Collection in Nature Reviews DNA ... Methylation Analysis Protocols Illumina, Infinium Methylation OMICtools: an educational directory for DNA methylation array ... Analysis of methylation data The scanned microarray images of methylation data are further analyzed by the system, which ... Scatter plots are used to correlate the methylation data; bar plots to visualize relative levels of methylation at each site ...
*  Methylation induced premeiotically
In molecular biology, methylation induced premeiotically (MIP) is a process by which cytosines within repeated DNA sequences ... "A Gene Essential for De Novo Methylation and Development in Ascobolus Reveals a Novel Type of Eukaryotic DNA Methyltransferase ...
*  DNA methylation in cancer
"Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired ... CpG island methylation is generally stably inherited from one cell division to the next through the DNA methylation maintenance ... DNA methylation in cancer plays a variety of roles, helping to change the healthy regulation of gene expression to a disease ... Lee KH, Lee JS, Nam JH, Choi C, Lee MC, Park CS, Juhng SW, Lee JH (2011). "Promoter methylation status of hMLH1, hMSH2, and ...
*  RNA-directed DNA methylation
... (RdDM) is an epigenetic process first discovered in plants (Wassenegger et al, 1994, Cell, Vol 76 ... Bender, Judith (2012). "RNA-Directed DNA Methylation: Getting a Grip on Mechanism". Current Biology. 22 (10): R400-1. doi: ... Wassenegger, Michael; Heimes, Sabine; Riedel, Leonhard; Sänger, Heinz L. (1994). "RNA-directed de novo methylation of genomic ... Law, Julie A.; Jacobsen, Steven E. (2010). "Establishing, maintaining and modifying DNA methylation patterns in plants and ...
*  Methylation specific oligonucleotide microarray
... was developed as a technique to map methylation changes in DNA in cancer. This ... Resources, information and specific protocols for DNA Methylation Analysis Software for DNA Methylation Analysis. ...
*  5-Hydroxymethylcytosine
With the discovery of 5-hydroxymethylcytosine some concerns have been raised regarding DNA methylation studies using the ... Jun 2010) "Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5- ... methylation and differential CTCF binding during stem cell development". Genome Research. 24 (8): 1285-1295. doi:10.1101/gr. ...
*  Neonatal diabetes mellitus
... the mother's genes are affected by DNA methylation (DNA methylation is the process in which methyl groups or CH3- are added to ... "DNA methylation". Wikipedia. 2017-10-18. Das, S.; Lese, C. M.; Song, M.; Jensen, J. L.; Wells, L. A.; Barnoski, B. L.; ... Generally the expression of the mother's alleles of PLAGL1 and HYMAI are blocked or not expressed by DMR methylation and only ...
*  Trimethylarsine
Under wet conditions, the mold Scopulariopsis brevicaulis produces significant amounts of methyl arsines via methylation of ... Index by Molecular Formula Information on Hazardous Chemicals by Class Microbial Methylation of Metalloids: Arsenic, Antimony, ... Frederick Challenger (1955). "Biological methylation". Q. Rev. Chem. Soc. 9 (3): 255-286. doi:10.1039/QR9550900255. Ronald ... Bentley & Thomas G. Chasteen (2002). "Microbial Methylation of Metalloids: Arsenic, Antimony, and Bismuth". Microbiology and ...
*  Scheele's Green
Pentavalent arsenic tends to be reduced to trivalent arsenic and trivalent arsenic tends to proceed via oxidative methylation ... Under wet conditions, the mold Scopulariopsis brevicaulis produced significant amounts of methyl arsines via methylation of ... Ronald Bentley & Thomas G. Chasteen (2002). "Microbial Methylation of Metalloids: Arsenic, Antimony, and Bismuth". Microbiology ... "Biological methylation". Q. Rev. Chem. Soc. 9 (3): 255-286. doi:10.1039/QR9550900255. ...
*  H3K27
... me3, a methylation.. ...
*  Nessa Carey
... consequences of aberrant DNA methylation in complex chronic diseases, existing modulators of DNA methylation used in the clinic ... CHAPTER 4. Targeting DNA Methylation. Epigenetics for Drug Discovery. pp. 68-95. doi:10.1039/9781782628484-00068. Chung, Chun- ... "on the biochemical mechanisms controlling DNA methylation, ...
*  Monocerin
O-methylation occurs. O-methylation Cyclic-ether formation Monocerin produced by Exserohilum turcicum causes Northern Corn Leaf ...
*  Methylmagnesium chloride
Methylation Sakai, Shogo; Jordan, K. D. (1982). "Ab initio study of the structure and vibrational frequencies of the Grignard ...
*  Nucleosome
Common modifications include acetylation, methylation, or ubiquitination of lysine; methylation of arginine; and ... Allfrey VG, Faulkner R, Mirsky AE (May 1964). "acetylation and methylation of histones and their possible role in the ...