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*  CpG island hypermethylation
Hypermethylation is linked to methyl-binding proteins, DNA methyltransferases and histone deacetylase, but the degree to which ... The majority of CpG pairs in mammals are chemically modified by the covalent attachment of a methyl group to the C5 position of ... called CpG island methylator prototype, or CIMP. Higher levels of CpG island hypermethylation are found in CIMP. The frequent ... A CpG island is a Cytosine and Guanine linked by a phosphate in a repeated sequence. These are genetic hotspots as they are ...
*  Methyl-CpG-binding domain protein 2
... is a protein that in humans is encoded by the MBD2 gene. DNA methylation is the major ... "Entrez Gene: MBD2 methyl-CpG binding domain protein 2". Brackertz M, Boeke J, Zhang R, Renkawitz R (October 2002). "Two highly ... Methyl-CpG-binding domain protein 2 has been shown to interact with: GATAD2B, HDAC1, Histone deacetylase 2, MBD3 MIZF, and ... Bakker J, Lin X, Nelson WG (2002). "Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class ...
*  MIZF
... interacts with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) ... MIZF has been shown to interact with Methyl-CpG-binding domain protein 2 and DHX9. GRCm38: Ensembl release 89: ... "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding ... of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein ...
*  MECP2
... (methyl CpG binding protein 2 (Rett syndrome)) is a gene that encodes the protein MECP2. MECP2 appears to be essential ... "Entrez Gene: MECP2 methyl CpG binding protein 2 (Rett syndrome)". Cohen S, Zhou Z, Greenberg ME (May 2008). "Medicine. ... MECP2 is part of a family of methyl-CpG-binding domain proteins (MBD), but possesses its own unique differences which help set ... Van den Veyver IB, Zoghbi HY (2001). "Mutations in the gene encoding methyl-CpG-binding protein 2 cause Rett syndrome". Brain ...
*  Chromomere
Methyl-CpG-binding protein 2 (MeCP2) is a protein that binds to methylated DNA. MeCP2 has been found to associate most strongly ... Morgan, Garry (December 2012). "Association of modified cytosines and the methylated DNA-binding protein MeCP2 with distinctive ... The protein XCAP-D2 is also present at high concentrations within the chromomere, and acts as a condensin component. High ... MeCP2 binding patterns to chromomere domains are proportional to the density of chromomeric DNA found on a chromosome. The ...
*  SIN3A
Methyl-CpG-binding domain protein 2, Nuclear receptor co-repressor 2, OGT, PHF12, Promyelocytic leukemia protein, RBBP4, RBBP7 ... "Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2". Nucleic Acids Research. 28 (10): ... "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A". The Journal of ... Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene. The protein encoded by this ...
*  Rett syndrome
Chen, Richard Z.; Akbarian, Schahram; Tudor, Matthew; Jaenisch, Rudolf (2001). "Deficiency of methyl-CpG binding protein-2 in ... encoding methyl-CpG-binding protein 2". Nature Genetics. 23 (2): 185-8. doi:10.1038/13810. PMID 10508514. Jeffrey l. Neul, JL; ... encoding methyl-CpG-binding protein 2". Nature Genetics. 23 (2): 185-8. doi:10.1038/13810. PMID 10508514. Reference, Genetics ... "Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex". Nature. 393 (6683 ...
*  Epigenetics of autism
Rett syndrome is caused by a mutation in the gene that encodes methyl-CpG-binding protein (MECP2), one of the key epigenetic ... encoding methyl-CpG-binding protein 2". Nature Genetics. 23 (2): 185-188. doi:10.1038/13810. PMID 10508514. Klose, R.J. & Bird ... chromatin immunoprecipitation and bisulfite sequencing have demonstrated that MeCP2 binds to methylated CpG sites within GABRB3 ... MeCP2 binds methylated cytosine residues in DNA and interacts with complexes that remodel chromatin into repressive structures ...
*  Locus coeruleus
... encoding methyl-CpG-binding protein 2". Nat Genet. 23 (2): 185-8. doi:10.1038/13810. CS1 maint: Multiple names: authors list ( ... Using immunoquantification techniques, a decrease of TH protein staining level, number of locus coeruleus TH-expressing neurons ... or an excess of NE may decrease working memory by binding to the lower-affinity α1 receptors. Psychiatric research has ... "Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice". J Neurosci. 26 (5 ...
*  Neurodevelopmental disorder
... encoding methyl-CpG-binding protein 2". Nat. Genet. 23 (2): 185-8. doi:10.1038/13810. PMID 10508514. Merla G, Howald C, ... Type 2 diabetes may be preceded in its onset by impaired cognitive functioning. A non-diabetic fetus can also be subjected to ... 3.0.CO;2-K. PMID 9066890. "Folic Acid - March of Dimes". "Folate (Folacin, Folic Acid)". "Folic scid: topic home". Centers for ... 63 (1-2): 1-9. doi:10.1054/plef.2000.0184. PMID 10970706. Nordham, Elizabeth A; Anderson, PJ; Jacobs, R; Hughes, M; Warne, GL; ...
*  Causes of autism
... encoding methyl-CpG-binding protein 2". Nature Genetics. 23 (2): 185-188. doi:10.1038/13810. PMID 10508514. Sebat, J. (23 July ... A further 12% of cases are predicted to be caused by protein altering missense mutations that change an amino acid but do not ... of the genome that codes for proteins (the "exome"). These studies found that de novo gene inactivating mutations were observed ... "Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations". Nature. 485 (7397): 246-250. doi: ...
*  1999 in science
... encoding methyl-CpG-binding protein 2" (PDF). Nature Genetics. 23 (2): 185-8. doi:10.1038/13810. PMID 10508514. Retrieved 2015- ...
*  Michele Zappella
"Mutation analysis of the methyl-CpG-binding protein 2 gene (MECP2) in Rett patients with preserved speech". Brain & development ... 14 (2): 98-101. doi:10.1016/S0387-7604(12)80094-5. PMID 1621933. Skjeldal, OH; Von Tetzchner, S; Jacobsen, K; Smith, L; Heiberg ... ISBN 2-228-33510-X. Zappella, Michele. Il Bambino nella Luna, Milano: Feltrinelli, 1979. ISBN 978-88-07-81108-1. Zappella, ... 26 (2): 87. doi:10.1055/s-2007-979732. PMID 7566462. Sørensen, E; Viken, B (1995). "Rett syndrome a developmental disorder. ...
*  MBD3
Methyl-CpG-binding domain protein 3 is a protein that in humans is encoded by the MBD3 gene. DNA methylation is the major ... "Entrez Gene: MBD3 methyl-CpG binding domain protein 3". Sakai H, Urano T, Ookata K, Kim MH, Hirai Y, Saito M, Nojima Y, ... Jiang CL, Jin SG, Pfeifer GP (2004). "MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 ( ... and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, ...
*  CDKL5
Li MR, Pan H, Bao XH, Zhu XW, Cao GN, Zhang YZ, Wu XR (February 2009). "[Methyl-CpG-binding protein 2 gene and CDKL5 gene ... The CDKL5 protein acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of ... Some CDKL5 mutations change a single protein building block (amino acid) in a region of the CDKL5 protein that is critical for ... Researchers are currently working to determine which proteins are targeted by the CDKL5 protein. CDKL5 Deficiency had been ...
*  X-linked intellectual disability
MECP2: methyl CpG binding protein 2 is a transcription regulator, which represses transcription from methylated gene promoters ... FTSJ1: Transfert RNA methyltransferase 1 is a member of the S-adenosylmethionine-binding protein family. This nucleolar protein ... The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. PHF8: PHD ... GDI1: RabGDI alpha makes a complex with geranylgeranylated small GTP-binding proteins of the Rab family and keeps them in the ...
*  DNA methylation
... methylated DNA may be bound by proteins known as methyl-CpG-binding domain proteins (MBDs). MBD proteins then recruit ... MethylCpG Binding Proteins (MBPs) and fusion proteins containing just the Methyl Binding Domain (MBD) are used to separate ... In particular, loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain ... and CpG-rich sequences termed CpG islands that are generally unmethylated and therefore retained the expected CpG content. CpG ...
*  Epigenetics of depression
... and Methyl CpG Binding Protein 2 (MeCP2) recruitment to the GDNF promoter. Increased HDAC activity results in a reduction of ... Methylated DNA for example is known to attract methyl CpG brining proteins, which aid in the formation of repressor complexes ... Methylation of CpG islands in the promoter region of GR leads to a decrease in the ability of NGFI-A to bind to the GR promoter ... It has also been experimentally shown that methylation of CpG sites in the enhancer region bound by NGFI-A is detrimental to ...
*  MECP2 duplication syndrome
The cause of M2DS is a duplication of the MECP2 or Methyl CpG binding protein 2 gene located on the X chromosome (Xq28). The ... It is an X-linked genetic disorder caused by the overexpression of MeCP2 protein. Symptoms of M2DS include infantile hypotonia ... Increased levels of MECP2 protein results in abnormal neural function and impaired immune system. Mutations in the MECP2 gene ... Mice treated with an experimental ASO administered through the central nervous system had a reduction of MECP2 protein to ...
*  Mir-184
Its expression is repressed by the binding of methyl-CpG binding protein 2 (MeCP2) to its promoter, but is upregulated by the ... showed that Methyl-CpG binding protein 1 (MBD1) regulates the expression of several miRNAs in adult neural stem/progenitor ... Weitzel RP, Lesniewski ML, Greco NJ, Laughlin MJ (October 2010). "Reduced methyl-CpG protein binding contributing to miR-184 ... MicroRNAs can bind to the three prime untranslated region (3'UTR) of the target messenger RNA (mRNA). Binding of the miRNA can ...
*  GATAD2B
... has been shown to interact with Methyl-CpG-binding domain protein 2, MBD3, RBBP7 and RBBP4. ENSG00000261992 GRCh38: ... Brackertz M, Boeke J, Zhang R, Renkawitz R (2002). "Two highly related p66 proteins comprise a new family of potent ... Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene. ... 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. ...
*  Trefoil factor 1
"A Role for Methyl-CpG Binding Domain Protein 2 in the Modulation of the Estrogen Response of pS2/TFF1 Gene". PLoS ONE. 5 (3): ... Trefoil factor 1 is a protein that in humans is encoded by the TFF1 gene (also called pS2 gene). Members of the trefoil family ... Rio MC, Lepage P, Diemunsch P, Roitsch C, Chambon P (1989). "[Primary structure of human protein pS2]". C. R. Acad. Sci. III, ... They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect ...
*  MBD
Board of Directors Metabolic bone disease Methyl-CpG-binding domain protein 2 a protein which bind the DNA on its methyl-CpG ...
*  Histone deacetylase 2
Methyl-CpG-binding domain protein 2, PHF21A, PPP1R8, RBBP4, RCOR1, RELA, Retinoblastoma protein, SAP30, SIN3A, SMARCA5, SNW1, ... Yang WM, Yao YL, Seto E. "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription ... This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a ... HDAC2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) FactorBook HDAC2 Molecular and ...
*  HDAC1
Homeobox protein TGIF1, Host cell factor C1, IFRD1, IKZF1, ING1, MBD3, MIER1, MLL, MTA1, MTA2, Mad1, Mdm2, Methyl-CpG-binding ... "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) ... the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein". Proceedings of the National ... Retinoblastoma protein, Retinoblastoma-like protein 1, Retinoblastoma-like protein 2, SAP30, SATB1, SIN3A, SIN3B, SPEN, SUDS3, ...
*  Index of biochemistry articles
... ribosomal protein - ribosomal protein S6 kinase - ribosome - RNA - RNA virus - RNA-binding protein - RNA-directed DNA ... myelin basic protein - myeloma protein - myosin - N-formylmethionine - N-formylmethionine leucyl-phenylalanine - N-methyl-D- ... CpG island - cristae - cryptobiology - Crystal structure - Crystallography - cuticula - CXCR4 receptor - cyclic AMP receptor - ... protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein folding - protein isoform - ...
*  OASL
... oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1". Eur. J. ... "Selective inhibition of the dnase activity of the recBC enzyme by the DNA binding protein from Escherichia coli". J. Biol. Chem ... oligoadenylate synthase is a protein family of structurally similar proteins, including OAS1, OAS2, and OAS3. OASL, like the ... 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid ...