Loading...
*  Dihydrofolate reductase
Methotrexate, a competitive inhibitor of DHFR, is one such anticancer drug that inhibits DHFR. Other drugs include trimethoprim ... A regimen of fluorouracil, doxorubicin, and methotrexate was shown to prolong survival in patients with advanced gastric cancer ... I. General features and binding of methotrexate". The Journal of Biological Chemistry. 257 (22): 13650-62. PMID 6815178. " ... Trimethoprim, an antibiotic, inhibits bacterial DHFR while methotrexate, a chemotherapy agent, inhibits mammalian DHFR. However ...
*  Disease-modifying antirheumatic drug
Nandi P, Kingsley GH, Scott DL (May 2008). "Disease-modifying antirheumatic drugs other than methotrexate in rheumatoid ... February 2007). "Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients ... A common triple therapy for rheumatoid arthritis is methotrexate, sulfasalazine, and hydroxychloroquine. When treatment with ... such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts) tsDMARDs are drugs that were developed to ...
*  Antifolate
Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency. Both high- ... Because methotrexate is a competitive inhibitor of DHF reductase, increased concentrations of DHF reductase can overcome the ... Anyone taking low-dose methotrexate for the health problems listed above should consult with a physician about the need for a ... Folic acid Methotrexate Pemetrexed Raltitrexed Pralatrexate The name antifolate usually refers to drugs whose folate antagonism ...
*  Methotrexate
... article on Methotrexate Chembank entry on methotrexate Methotrexate-general article from NIH Methotrexate Injection MedlinePlus ... Methotrexate with dilatation and curettage is used to treat molar pregnancy. Methotrexate can be given by mouth or by injection ... Bertino JR (2000). "Methotrexate: historical aspects". In Cronstein BN, Bertino JR. Methotrexate. Basel: Birkhäuser. ISBN 978-3 ... Probenecid inhibits methotrexate excretion, which increases the risk of methotrexate toxicity. Likewise, retinoids and ...
*  Methotrexate-induced papular eruption
... appears in patients being treated with methotrexate, such as those with rheumatic disease ... January 2008). "Methotrexate-induced papular eruption following treatment of psoriasis". Ann Pharmacother. 42 (1): 138-41. doi: ...
*  Omeprazole
Proton-pump inhibitors like omeprazole have been found to increase the plasma concentrations of methotrexate. Omeprazole is a ... 6 January 2014). "Methotrexate". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 12 April 2014. " ...
*  Thymidine kinase
"Methotrexate". PubChem. "Aminopterin". PubChem. [ ] Köhler G, Milstein C (1975). "Continuous cultures of fused cells secreting ... After fusion, the cells are grown in a medium with methotrexate or aminopterin that inhibit the enzyme dihydrofolate reductase ...
*  Physiologically based pharmacokinetic modelling
Bischoff, K.B.; Dedrick, R.L.; Zaharko, D.S.; Longstreth, J.A. (1971). "Methotrexate pharmacokinetics". Journal of ...
*  Helen King (oncologist)
Jacobs, Peter; Stuart Rutherford, G.; King, Helen S.; Vincent, Mark (1991). "Methotrexate encephalopathy". European Journal of ...
*  Belimumab
Annual prices of generic prescription drugs are prednisone, $140; hydroxychloroquine, $132; oral methotrexate, $432; ...
*  Chemotherapy
The anti-folates include methotrexate and pemetrexed. Methotrexate inhibits dihydrofolate reductase (DHFR), an enzyme that ... Although methotrexate is used to treat both multiple sclerosis and ankylosing spondylitis, its efficacy in these diseases is ... Methotrexate is used in the treatment of rheumatoid arthritis (RA), psoriasis, ankylosing spondylitis and multiple sclerosis. ... "ARK™ Methotrexate Assay". Ark Diagnostics. "Customizing Chemotherapy for Better Cancer Care". My Care Diagnostics. "A Brief ...
*  Amoxicillin
Cancer treatment (methotrexate). Uricosuric drugs. Typhoid vaccine probenecid reduces renal excretion and increases the blood ...
*  Hyperosmia
Methotrexate, administered in the treatment of psoriasis, has been known to cause hyperosmia, and may be more likely to do so ... Zargari, O (2006-12-10). "Methotrexate, hyperosmia, and migraine". Dermatology Online Journal. 12 (7): 28. PMID 17459314. ...
*  Rheumatology
"Methotrexate for Rheumatoid Arthritis". Arthritis.about.com. Retrieved 2013-06-24. Edwards J; Szczepanski L; Szechinski J; ... and the soluble TNF receptor etanercept and Methotrexate for moderate to severe Rheumatoid arthritis. Biologic agent Rituximab ...
*  Lymphomatoid papulosis
It has been described as "clinically benign but histologically malignant." It may respond to methotrexate. It can evolve into ...
*  History of cancer chemotherapy
Joseph Burchenal, at Memorial Sloan-Kettering Cancer Center in New York, with Farber's help, started his own methotrexate study ... Li, MC; Hertz, R; Spencer, DB (1956). "Effect of methotrexate upon choriocarcinoma". Proc Soc Exp Biol Med. 93 (2): 361-366. ... Wright, JC; Gumport, SL; Golomb, FM (1960). "Remissions produced with the use of methotrexate in patients with my- cosis ... These analogues - first aminopterin and then amethopterin (now methotrexate) were antagonistic to folic acid, and blocked the ...
*  Adenosine
Methotrexate's anti-inflammatory effect may be due to its stimulation of adenosine release. In general, adenosine has an ... Cronstein B (2010). "How does methotrexate suppress inflammation?". Clin Exp Rheumatol. 28 (5 Suppl 61): S21-3. PMID 21044428. ...
*  Toxic leukoencephalopathy
In contrast to intravenous methotrexate for cancer patients, leukoencephalopathy induced by orally taken methotrexate may be ... Methotrexate-related leukoencephalopathy prevalence has been reported to decline with time and dosage. Other chemotherapeutic ... High doses of intravenous methotrexate, a necessary component of chemotherapy for acute lymphoblastic leukemia, is known to ... Besides its role in chemotherapy, methotrexate is also used as an orally administered treatment for rheumatoid arthritis. ...
*  Fenoprofen
Methotrexate: May increase methotrexate levels. Phenobarbital: May decrease fenoprofen t ½ . Dosage adjustments of fenoprofen ...
*  Big Baby (House)
The methotrexate is not working. House therefore has his team double the dose and add prednisone, as well as fake the radiation ... House orders the team to start Sarah on methotrexate for the ITP and also wants to give her total body irradiation. Cameron has ...
*  Management of ulcerative colitis
Methotrexate is another immunosuppressive drug. It works by inhibiting folic acid, which is necessary for DNA replication and, ... Methotrexate, which inhibits folic acid. Mercaptopurine is a cytostatic drug that is an antimetabolite. The mercaptopurine ... This may, however, be counter-productive for patients who are also taking methotrexate, which is a folic acid inhibitor. Folic ...
*  Learning problems in childhood cancer
... high-dose methotrexate or cytarabine; or intrathecal chemotherapy). As the mortality rates of childhood cancers have plummeted ...
*  Pharmaceutical Benefits Scheme
Examples include methotrexate, prednisone and amoxycillin. Certain medications listed on the PBS are available only for ...
*  Folinic acid
While not specifically an antidote for methotrexate, folinic acid may also be useful in the treatment of acute methotrexate ... Different dosing protocols are used, but folinic acid should be redosed until the methotrexate level is less than 5 x 10−8 M. ... No apparent effect is seen on pre-existing methotrexate-induced nephrotoxicity. Folinic acid can be taken as a pill (orally) or ... Folinic acid is given following methotrexate as part of a total chemotherapeutic plan, where it may protect against bone marrow ...