... , or methaemoglobinaemia, is a condition of elevated methemoglobin in the blood. Symptoms may include headache ... Methemoglobinemia may be acquired. Classical drug causes of methemoglobinaemia include various antibiotics (trimethoprim, ... Methemoglobinemia can be due to certain medications, chemicals, or food or it can be inherited. Substances involved may include ... Methemoglobinemia is relatively uncommon, with most cases being acquired rather than genetic. Signs and symptoms of ...

... methemoglobinemia; increased blood pressure and heart rate; proteinuria, hematuria (blood in the urine), bladder injury; in ...

... is a congenital subtype of methemoglobinemia. For other congenital subtypes of methemoglobinemia, ... Cyanotic patients with methemoglobinemia display brownish blood while purple deoxyhemoglobin becomes bright red oxyhemoglobin ... They are prone to develop symptomatic methemoglobinemia given further exposure to oxidants. "Hemoglobin M disease (Concept Id: ... 1-44, ISBN 978-0-12-383834-6, retrieved 2022-03-28 Rehman, Habib Ur (2001). "Methemoglobinemia". Western Journal of Medicine. ...

Dela Cruz, Maricel; Glick, Joshua; Merker, Seth H.; Vearrier, David (11 May 2018). "Survival after severe methemoglobinemia ... Wilkerson, Richard G.; Nappe, Thomas M. (2019-05-05). "Methemoglobinemia". NCBI Bookshelf. PMID 30726002. Retrieved 2019-05-10 ... and essentially any pathology that impairs the ability to deliver oxygen may worsen the symptoms of methemoglobinemia. ... Blue baby syndrome Carboxyhemoglobin Methemoglobinemia Bando, S.; Takano, T.; Yubisui, T.; Shirabe, K.; Takeshita, M.; Nakagawa ...

Methemoglobinemia is a blood disorder that can potentially result in various levels of cyanosis. High levels of methylene blue ... Allergic-like reactions and methemoglobinemia have been documented after the use of methylene blue dye in chromopertubation. ... Rehman, Habib Ur (2001). "Methemoglobinemia". Western Journal of Medicine. 175 (3): 193-196. doi:10.1136/ewjm.175.3.193. ISSN ...

"Congenital methemoglobinemia with cytochrome b5 deficiency". N. Engl. J. Med. 315 (14): 893-4. October 1986. doi:10.1056/ ... Online Mendelian Inheritance in Man (OMIM): 250790 - Methemoglobinemia due to deficiency of cytochrome b5 v t e (Articles with ... 498-. ISBN 978-1-4557-5973-6. Mansouri A, Lurie AA (January 1993). "Concise review: methemoglobinemia". Am. J. Hematol. 42 (1 ... so cytochrome b5 deficiency can also result in elevated methemoglobin levels and/or methemoglobinemia, similarly to deficiency ...

"Flutamide induced methemoglobinemia". The Journal of Urology. 157 (4): 1363. doi:10.1016/s0022-5347(01)64982-6. PMID 9120948. ...

... has been associated with several case reports of methemoglobinemia. Bicalutamide does not appear to share this risk ... Khan AM, Singh NT, Bilgrami S (April 1997). "Flutamide induced methemoglobinemia". The Journal of Urology. 157 (4): 1363. doi: ...

Large prilocaine doses can cause methemoglobinemia due to oxidation of hemoglobin by o-toluidine. o-Toluidine is absorbed ... Medetalibeyoğlu A.; Koç E.S.; Beyaz O.; Edizer A. (2020). "Prilocaine-Induced Methemoglobinemia". Case Rep. Acute Med. 3 (2): ... Ryota Higuchi; Tatsuki Fukami; Miki Nakajima; Tsuyoshi Yokoi (2013). "Prilocaine- and Lidocaine-Induced Methemoglobinemia Is ... Nitrosotoluene converts hemoglobin to methemoglobin, resulting in methemoglobinemia.[ISBN missing] Evidence suggests that this ...

... induces methemoglobinemia. Gonçalves, F. A.; Hamano, K.; Sengers, J. V. (1989). "Density and viscosity of tetralin and ...

TRPV4 Methemoglobinemia, type I; 250800; CYB5R3 Methemoglobinemia, type II; 250800; CYB5R3 Methemoglobinemia, type IV; 250790; ...

Overdoses may generate methemoglobinemia. Nitroglycerin is available in tablets, ointment, solution for intravenous use, ... Kaplan, K. J.; Taber, M.; Teagarden, J. R.; Parker, M.; Davison, R. (1985). "Association of methemoglobinemia and intravenous ...

Methemoglobinemia responds well to treatment, its prognosis is associated with the level of methemoglobinemia and the degree of ... Methemoglobinemia is considered to be rare, with acquired methemoglobinemia encountered more than the congenital form. In the ... Methemoglobinemia, which is a disease defined by high levels of methemoglobin in the blood. Increased levels of methemoglobin ... Additionally an arterial blood gas is useful, for example in the case of methemoglobinemia the PO2 can be expected to be normal ...

Exposure may result in methemoglobinemia. Methyl nitrite is an oxidizing agent and a heat-sensitive explosive; its sensitivity ...

"Methemoglobinemia by cerium nitrate poisoning". Burns. 32 (8): 1060-1061. doi:10.1016/j.burns.2006.04.005. PMID 17027160. Pol, ... although large doses can lead to cerium poisoning and methemoglobinemia. The early lanthanides act as essential cofactors for ...

Bodansky, O. (1951). "Methemoglobinemia And Methemoglobin-Producing Compounds". Pharmacological Reviews. 3 (2): 144-191. ISSN ... He studied the biochemistry of oxyhemoglobin providing insight into the disease methemoglobinemia, helped to explain the ... and this difference in oxidation state is the cause of methemoglobinemia, a medical condition which causes tissue hypoxia. ...

In 2021, the novel Blue-Skinned Gods by S. J. Sindu references a family from Kentucky with methemoglobinemia but does not use ... Cawein, M.; Behlen, Charles H.; Lappat, E. J.; Cohn, J. E. (1964). "Hereditary Diaphorase Deficiency and Methemoglobinemia". ... They are known for having a genetic trait that led to the blood disorder methemoglobinemia, causing the skin to appear blue. ... were both carriers of the recessive methemoglobinemia (met-H) gene. As a result, four of their seven children exhibited blue ...

Anesthesiology 2002;96:1504-13 "Methemoglobinemia". The Lecturio Medical Concept Library. Retrieved 11 August 2021. Kerins et ... it requires intubation and cannot be used for long periods of time due to methemoglobinemia. Prostaglandin PGE1 (Alprostadil) ...

Overdoses may generate methemoglobinemia. "Nitroglycerin". The American Society of Health-System Pharmacists. Archived from the ... "Association of methemoglobinemia and intravenous nitroglycerin administration". The American Journal of Cardiology. 55 (1): 181 ...

The patient developed methemoglobinemia following ingestion. Methemoglobinemia (also known as blue baby syndrome) is a ... Methemoglobinemia can be fatal if left untreated, however when the cause is exposure to a chemical agent (not genetic) a ... Rehman, Habib Ur (September 2001). "Methemoglobinemia". The Western Journal of Medicine. 175 (3): 193-196. doi:10.1136/ewjm. ... Ludlow, John T.; Wilkerson, Richard G.; Nappe, Thomas M. (2023), "Methemoglobinemia", StatPearls, Treasure Island (FL): ...

Other serious side effects include methemoglobinemia. It is not generally recommended during pregnancy due to concerns of side ... Serious Ileus Reduced platelet aggregation Haemorrhage Increased intracranial pressure Metabolic acidosis Methaemoglobinaemia ...

Symptoms of methemoglobinemia usually occur within minutes to hours of applying benzocaine, and can occur upon the first-time ... 2007 Feb 6, updated 2007 Feb 9. From FDA website Shua-Haim JR, Gross JS (May 1995). "Methemoglobinemia toxicity from topical ... "Benzocaine Topical Products: Sprays, Gels and Liquids - Risk of Methemoglobinemia". Drugs.com. Retrieved March 20, 2014. "FDA ... benzocaine products applied to the mouth or mucous membranes has been found to be a cause of methemoglobinemia, a disorder in ...

Its use has been associated with fatal methemoglobinemia. Methemoglobinemia is the primary toxic effect of ethyl nitrite. Due ... Titov, V Yu; Petrenko, Yu M (2005). "Proposed mechanism of nitrite-induced methemoglobinemia". Biochemistry (Mosc). 70 (4): 473 ... resulting in methemoglobinemia, which may or may not be severe, or even fatal. "NFPA 704 Ratings for Common Chemicals". Semon, ...

Its primary toxicity mechanism is methemoglobinemia. It may cause permanent nerve damage. For occupational exposures, the ...

Mutations in the CYB5R3 gene cause methemoglobinemia types I and II. This is a rare autosomal recessive disease due to a ... Hudspeth MP, Joseph S, Holden KR (Jan 2010). "A novel mutation in type II methemoglobinemia". Journal of Child Neurology. 25 (1 ... Type I recessive congenital methemoglobinemia (RCM) is characterized by a deficiency of the soluble isoform and manifests as ... Mutations in this gene cause methemoglobinemias. Cytochrome b5 reductase is involved in the transfer of reducing equivalents ...

Isobutyl nitrite is known to cause methemoglobinemia. Severe methemoglobinemia may be treated with methylene blue. Early in the ... Dixon DS, Reisch RF, Santinga PH (July 1981). "Fatal methemoglobinemia resulting from ingestion of isobutyl nitrite, a "room ... Modarai, B; Kapadia, YK; Kerins, M; Terris, J (May 2002). "Methylene blue: a treatment for severe methaemoglobinaemia secondary ... Pruijm MT, de Meijer PH (December 2002). "[Methemoglobinemia due to ingestion of isobutyl nitrite ('poppers')]". Nederlands ...

Methemoglobinemia may also occur in some cases. This is where higher than normal levels of methemoglobin-a form of hemoglobin ... Hemolysis may require a blood transfusion to replace the lost red blood cells, while methemoglobinemia is treated with ... MMH also causes oxidative stress leading to methemoglobinemia. Additionally during the metabolism of MMH, N-methyl-N- ...

Methemoglobinemia may also occur in some cases. This is where higher than normal levels of methemoglobin, which is a form of ... Hemolysis may require a blood transfusion to replace the lost red blood cells, while methemoglobinemia is treated with ... MMH also causes oxidative stress leading to methemoglobinemia. Inhibition of diamine oxidase (histaminase) elevates histamine ...

Isobutyl nitrite is known to cause methemoglobinemia. Severe methemoglobinemia may be treated with methylene blue. Another use ... As a medication, it is mainly used to treat methemoglobinemia by chemically reducing the ferric iron in hemoglobin to ferrous ... While use during pregnancy may harm the baby, not using it in methemoglobinemia is likely more dangerous. Methylene blue was ... Methylene blue is employed as a medication for the treatment of methemoglobinemia, which can arise from ingestion of certain ...

Methemoglobinemia occurs in about 15 % of patients treated with long-term dapsone at standard doses (100 mg/day). Only special ... It may lead to hemolytic anemia and methemoglobinemia. The side-effect is more common and severe in those with glucose-6- ... Other side effects include liver inflammation, methemoglobinemia, and a number of types of skin rashes. While the safety of use ... Dapsone metabolites produced by the cytochrome P450 2C19 isozyme are associated with the methemoglobinemia side effect of the ...