Early metabolic engineering experiments showed that accumulation of reactive intermediates can limit flux in engineered ... In 1990s, a new technique called metabolic engineering emerged. This technique analyzes the metabolic pathway of a ... It then uses genetic engineering to relieve these constraints. Some examples of successful metabolic engineering are the ... Metabolic Engineering: Principles and Methodologies ". San Diego: Academic Press Dellomonaco, Clementina.(2011). Engineered ...
Metabolic Engineering is a peer-reviewed scientific journal covering research on production of fuels and chemicals using ... The journal specialises in quantitative analyses of metabolic pathways and their relationship to cell physiology in industrial ...
"A guide to metabolic flux analysis in metabolic engineering: Methods, tools and applications". Metabolic Engineering. Tools and ... "A guide to metabolic flux analysis in metabolic engineering: Methods, tools and applications". Metabolic Engineering. Tools and ... and guiding the identification of bottleneck enzymes in metabolic networks for metabolic engineering efforts. Metabolic flux ... Isotopic labeling Flux balance analysis Fluxomics Metabolic network modelling Metabolomics Metabolic engineering Wiechert W ( ...
From a metabolic engineering or drug-targeting perspective, preference should be given to targeting the earlier steps in a ... Metabolic control analysis (MCA) is a mathematical framework for describing metabolic, signaling, and genetic pathways. MCA ... This is often of importance to metabolic engineers who are interested in increasing rates of production. At steady state the ... MCA has sometimes also been referred to as Metabolic Control Theory, but this terminology was rather strongly opposed by Henrik ...
Metabolic Engineering. 57: 228-238. doi:10.1016/j.ymben.2019.12.004. PMID 31843486. Orsi E, Folch PL, Monje-Lopez V, Fernhout ... "Efficient Cas9-based genome editing of Rhodobacter sphaeroides for metabolic engineering". Microbial Cell Factories. 18 (1): ... A genome-scale metabolic model exists for this microorganism, which can be used for predicting the effect of gene manipulations ... Synthetic biology-driven engineering of the metabolism of R. sphaeroides, in combination to the functional replacement the MEP ...
November 2017). "A biosynthetic route for polysialylating proteins in Escherichia coli". Metabolic Engineering. 44: 293-301. ... Naegeli A, Aebi M (2015). "Current Approaches to Engineering N-Linked Protein Glycosylation in Bacteria". Glyco-Engineering. ... May 2017). "Production of homogeneous glycoprotein with multisite modifications by an engineered N-glycosyltransferase mutant ...
Metabolic Engineering. 20: 9-19. doi:10.1016/j.ymben.2013.07.004. ISSN 1096-7176. PMID 23876414. Belostotsky, Ruth; Pitt, James ... "Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli ...
Metabolic Engineering. 45: 75-85. doi:10.1016/j.ymben.2017.11.016. ISSN 1096-7176. OSTI 1411402. PMID 29203223. (Articles with ... production by genetically engineered Bacillus methanolicus strains". Industrial Crops and Products. 106: 12-20. doi:10.1016/j. ...
"Metabolic engineering of Clostridium autoethanogenum for selective alcohol production". Metabolic Engineering. 40: 104-114. doi ... Ethanol is a byproduct of the metabolic process of yeast. As such, ethanol will be present in any yeast habitat. Ethanol can ... "Flame Temperature Analysis and NOx Emissions for Different Fuels". Mississippi State Department of Chemical Engineering. Lide ... Fire Science and Engineering. 29 (2): 39-43. doi:10.7731/KIFSE.2015.29.2.039. Page 4, Table 3 "Flash points of ethanol-based ...
Merck Award for Metabolic Engineering, USA (2004) Amgen Biochemical Engineering Award, USA (2011) Nature Award for Mentoring, ... His textbook on metabolic engineering has been translated into Chinese and Japanese.[citation needed] In 2019, Nielsen was ... Through metabolic engineering, Nielsen has developed and improved a number of biotechnological processes, such as improving ... Nielsen is the most cited researcher in the field of metabolic engineering, and he is the founding president of the ...
Metabolic Engineering. 69: 15-25. doi:10.1016/j.ymben.2021.10.010. PMID 34715353. S2CID 240229184. Dimpfel W, Schombert L, ...
Metabolic Engineering. 65: 156-166. doi:10.1016/j.ymben.2020.11.001. ISSN 1096-7176. PMID 33161142. S2CID 226286865. v t e ( ... "Engineering Yarrowia lipolytica for the selective and high-level production of isocitric acid through manipulation of ...
PCC6803 enhances biomass production". Metabolic Engineering. 29: 76-85. doi:10.1016/j.ymben.2015.03.002. PMID 25769289. Durão P ... PCC6803 by engineering a promoter with multiple operons, thus facilitating DNA looping. Their attempt was too effective, as it ... Progress in engineering Synechocystis sp. PCC6803 is currently hampered by promoter issues. As noted above in RNA Polymerase ... PCC6803 is considered a model organism, yet there exist few synthetic parts that can be used for genetic engineering. As ...
Metabolic Engineering. 6 (4): 277-84. doi:10.1016/j.ymben.2004.03.001. PMID 15491857. Vanderbilt Medical Center. "Granner Lab, ... Phosphoenolpyruvate carboxykinase (EC 4.1.1.32, PEPCK) is an enzyme in the lyase family used in the metabolic pathway of ... In animals, this is a rate-controlling step of gluconeogenesis, the process by which cells synthesize glucose from metabolic ... see metabolic supermice. PEPCK (EC 4.1.1.49) is one of three decarboxylation enzymes used in the inorganic carbon concentrating ...
Metabolic Engineering. 12 (4): 332-40. doi:10.1016/j.ymben.2010.04.001. PMC 2949272. PMID 20399282. Boradia VM, Raje M, Raje CI ... A high fraction of enzymes involved in glycolysis, an ancient universal metabolic pathway, exhibit moonlighting behavior. ... hampering the study of inherited metabolic disorders. The complex phenotypes of several disorders are suspected to be caused by ... may be used to determine if a protein has high expression levels that do not correlate to the enzyme's measured metabolic ...
Metabolic Engineering. 6 (4): 300-312. doi:10.1016/j.ymben.2004.03.003. PMID 15491860. Atlas, Ronald M. (2010). Handbook of ... Reeves, Andrew R.; Cernota, William H.; Brikun, Igor A.; Wesley, Roy K.; Mark Weber, J. (October 2004). "Engineering precursor ...
"Engineering the bacterial shapes for enhanced inclusion bodied accumulation". Metabolic Engineering. 29: 227-237. doi:10.1016/j ...
"Metabolic engineering of cyanobacteria for 1-butanol production from carbon dioxide". Metabolic Engineering. 13 (4): 353-363. ... Microbiological and enzymatic engineering have the potential of improving enzyme efficiency and robustness, as well as ... Engineering light-activated metalloproteins to split water at Australia National University Daniel Nocera describes new process ... Advances in Chemical Engineering. Vol. 36. pp. 111-143. doi:10.1016/S0065-2377(09)00404-9. ISBN 9780123747631. Andreiadis, ...
Metabolic Engineering. 35: 9-20. doi:10.1016/j.ymben.2016.01.003. PMID 26827988. Leber, Christopher; Da Silva, Nancy A. (2014- ... Applications in Ecological Engineering. Academic Press. ISBN 978-0-444-53448-4. "Peak Soil: Why cellulosic ethanol, biofuels ... 02-01). "Engineering of Saccharomyces cerevisiae for the synthesis of short chain fatty acids". Biotechnology and ...
Metabolic Engineering. 18: 69-77. doi:10.1016/j.ymben.2013.04.004. PMID 23644174. Durren RL, McIntosh CA (November 1999). " ...
"Metabolic engineering of cyanobacteria for 1-butanol production from carbon dioxide". Metabolic Engineering. 13 (4): 353-363. ... Using genetic engineering and synthetic biology techniques, parts of or whole biofuel-producing metabolic pathways can be ...
"Metabolic engineering of omega-3 long-chain polyunsaturated fatty acids in plants using an acyl-CoA Δ6-desaturase with ω3- ... Metabolic Engineering. 12 (3): 233-240. doi:10.1016/j.ymben.2009.12.001. PMID 20004733. Genes from tiny algae shed light on big ... However, the expression levels of genes and proteins can still vary within the same metabolic pathway. It has also been ...
Metabolic Engineering. 43 (Pt B): 198-207. doi:10.1016/j.ymben.2016.11.004. PMC 5429990. PMID 27856334. Wan-angkan, P.; et al ... Jiang L, Boufersaoui A, Yang C, Ko B, Rakheja D, Guevara G, Hu Z, DeBerardinis RJ (September 2017). "Quantitative metabolic ... Patients with D-2/L-2-hydroxyglutaric aciduria display neonatal onset metabolic encephalopathy, infantile epilepsy, global ... Inborn Metabolic Diseases. Germany: Springer. p. 344. ISBN 978-3-662-49771-5. Cohen I, Staretz-Chacham O, Wormser O, Perez Y, ...
Trantas E, Panopoulos N, Ververidis F (November 2009). "Metabolic engineering of the complete pathway leading to heterologous ... Metabolic Engineering. 11 (6): 355-66. doi:10.1016/j.ymben.2009.07.004. PMID 19631278. Ververidis F, Trantas E, Douglas C, ... Several recent research articles have demonstrated the efficient production of flavonoid molecules from genetically engineered ... which can be transferred to engineered microorganisms within Synthetic Microbial Consortia to promote flavonoid assembly ...
Metabolic Engineering. 8 (6): 532-42. doi:10.1016/j.ymben.2006.06.004. PMID 16891140. Ansell R, Granath K, Hohmann S, Thevelein ... The NAD+/NADH coenzyme couple act as an electron reservoir for metabolic redox reactions, carrying electrons from one reaction ... Simultaneously, NADH is oxidized to NAD+ in the following reaction: As a result, NAD+ is regenerated for further metabolic ... Geertman JM, van Maris AJ, van Dijken JP, Pronk JT (Nov 2006). "Physiological and genetic engineering of cytosolic redox ...
"Computational tools for metabolic engineering". Metabolic Engineering. 14 (3): 270-80. doi:10.1016/j.ymben.2012.03.001. PMC ... dedicated to metabolic networks) Scope selection Copeland, WB; Bartley, BA; Chandran, D; Galdzicki, M; Kim, KH; Sleight, SC; ... Input Import and export metabolic network using the SBML format Time-series data from CSV file Import data from CSV file Load ... Animation of time-series data Visualization of time-series in the context of the metabolic network Data analysis views ( ...
Milne, N.; Thomsen, P.; Knudsen, N.; Rubaszka, P.; Kristensen, M.; Borodina, I. (2020). "Metabolic engineering of Saccharomyces ... Metabolic Engineering. 60: 25-36. doi:10.1016/j.ymben.2019.12.007. PMC 7232020. PMID 32224264. Wong, Garrett; Lim, Li Rong; Tan ... Satyanarayana M (October 7, 2019). "Modified E. coli pump out psilocybin". Chemical & Engineering News. 97 (39): 11. doi: ...
Metabolic Engineering. 44: 236-245. doi:10.1016/j.ymben.2017.10.009. PMID 29061492. Rahman, Asif; Linton, Elisabeth; Hatch, ... For synthetic biology, consortia take the ability to engineer novel cell behaviors to a population level. Consortia are more ... One of the more salient applications of engineering behaviors and interactions between microbes in a community is the ability ... Microbial consortium Hays, Stephanie G.; Ducat, Daniel C. (14 February 2014). "Engineering cyanobacteria as photosynthetic ...
Metabolic engineering for the production of high quantities of succinic acid should be optimized. "Genus: Basfia". lpsn.dsmz.de ... Metabolic Engineering. 7 (3): 229-239. doi:10.1016/j.ymben.2005.03.001. ISSN 1096-7176. PMID 15885621. (CS1 errors: missing ... "Novel pathway engineering design of the anaerobic central metabolic pathway in Escherichia coli to increase succinate yield and ... All known strains anaerobically produce significant amounts of succinic acid, acetic acid, and formic acid as metabolic ...
Metabolic Engineering. 44: 22-29. doi:10.1016/j.ymben.2017.09.001. PMID 28890188. S2CID 23405962. Yu S, Qin W, Zhuang G, Zhang ... The resulting engineered protein could exist in two different oxidation states (reduced dithiol or oxidized disulfide), each ... The reduction-oxidation sensitive green fluorescent protein (roGFP) is a green fluorescent protein engineered to be sensitive ... Synapto-pHluorin Cannon MB, Remington SJ (January 2006). "Re-engineering redox-sensitive green fluorescent protein for improved ...