Membrane glycoproteins
... , Glycoproteins, All stub articles, Membrane protein stubs). ... Fibronectin Laminin Osteonectin Glycocalyx Media related to Membrane glycoproteins at Wikimedia Commons Membrane+glycoproteins ... Membrane glycoproteins are membrane proteins which play important roles in cell recognition. Examples include: ...
Platelet membrane glycoprotein
Platelet membrane glycoproteins Platelet+membrane+glycoproteins at the U.S. National Library of Medicine Medical Subject ... platelet membrane glycoproteins interact with the extracellular matrix. Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV ... Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis ... The deficiency in glycoprotein Ib-IX-V complex synthesis leads to Bernard-Soulier syndrome. Glycoprotein VI is one of the ...
Lysosome-associated membrane glycoprotein
Lysosome-associated membrane glycoproteins (LAMPs) are integral membrane proteins, specific to lysosomes, and whose exact ... Fukuda Minoru (November 1991). "Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking". J. ... Holness CL, da Silva RP, Fawcett J, Gordon S, Simmons DL (1993). "Macrosialin, a mouse macrophage-restricted glycoprotein, is a ... CD69 (also called gp110 or macrosialin) is a heavily glycosylated integral membrane protein whose structure consists of a mucin ...
SCARB2
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and ... Lewis V, Green SA, Marsh M, Vihko P, Helenius A, Mellman I (Jun 1985). "Glycoproteins of the lysosomal membrane". The Journal ... Ogata S, Fukuda M (Feb 1994). "Lysosomal targeting of Limp II membrane glycoprotein requires a novel Leu-Ile motif at a ... Akasaki K, Michihara A, Fukuzawa M, Kinoshita H, Tsuji H (Sep 1994). "Cycling of an 85-kDa lysosomal membrane glycoprotein ...
SDS-PAGE
Buxbaum, Engelbert (2003). "Cationic electrophoresis and electrotransfer of membrane glycoproteins". Analytical Biochemistry. ... For separation of membrane proteins, BAC-PAGE or CTAB-PAGE may be used as an alternative to SDS-PAGE. For electrophoretic ... Membrane proteins, because of their transmembrane domain, are often composed of the more hydrophobic amino acids, have lower ... Glycoproteins have differential levels of glycosylations and adsorb SDS more unevenly at the glycosylations, resulting in ...
LAMP1
Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins. The LAMP ... Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster ... and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of ... Although the LAMP1 glycoproteins primarily reside across lysosomal membranes, in certain cases they can be expressed across the ...
Eastern blot
2002). "Cationic electrophoresis and electrotransfer of membrane glycoproteins". Analytical Biochemistry. 314 (1): 70-76. doi: ... The oxidized protein is then treated with a complex mixture, generating a new conjugate on the membrane. The membrane is then ... 2009) Eastern blot has been used to describe a blot of proteins on nitrocellulose membrane where the probe is an aptamer rather ... 2005) Eastern blot has been used to describe a blot of proteins on polyvinylidene fluoride membrane where the probe is an ...
Adenovirus genome
CR1 beta membrane glycoprotein modulates the host immune response. Membrane glycoprotein E3 gp19K inhibits the insertion of ... "PHA3620: CR1 beta membrane glycoprotein". NCBI. Retrieved 2013-01-17. "PHA3615: E3 gp19K protein". NCBI. Retrieved 2013-01-17 ... Membrane protein E3 RID-alpha and membrane protein E3 RID-beta performs a variety of molecular functions that contribute to ... class I MHC proteins in the host-cell membrane, thereby preventing T-cell lymphocytes from recognizing that the host cell has ...
Coronavirus spike protein
The S2 region of spike glycoprotein is responsible for membrane fusion between the viral envelope and the host cell, enabling ... The location of membrane fusion-at the plasma membrane or in endosomes-may vary based on the availability of these triggers for ... Ujike, Makoto; Taguchi, Fumihiro (3 April 2015). "Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions". ... In addition to fusion of viral and host cell membranes, some coronavirus spike proteins can initiate membrane fusion between ...
LAMP3
Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene. It is one ... Zhou Z, Xue Q, Wan Y, Yang Y, Wang J, Hung T (2011). "Lysosome-associated membrane glycoprotein 3 is involved in influenza A ... LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along ... 1998). "A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC ...
Coronavirus membrane protein
Ujike M, Taguchi F (April 2015). "Incorporation of spike and membrane glycoproteins into coronavirus virions". Viruses. 7 (4): ... Its membrane topology orients the C-terminus toward the cytosolic face of the membrane and thus into the interior of the virion ... The membrane (M) protein (previously called E1, sometimes also matrix protein) is an integral membrane protein that is the most ... "Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein". Virology Journal. 6 (1): 79. doi ...
Laminin
... a glycoprotein from basement membranes". The Journal of Biological Chemistry. 254 (19): 9933-7. doi:10.1016/S0021-9258(19)83607 ... The proteins also bind to cell membranes through integrins and other plasma membrane molecules, such as the dystroglycan ... macro-plaques or mini-basement membranes in human term fetal membranes?". Philosophical Transactions of the Royal Society of ... Basement membrane assembly is a cooperative process in which laminins polymerise through their N-terminal domain (LN or domain ...
Protein (nutrient)
Proteins are also used in membranes, such as glycoproteins. When broken down into amino acids, they are used as precursors to ...
Viral neuraminidase
Influenza virus membranes contain two glycoproteins: hemagglutinin and neuraminidase. While the hemagglutinin on the surface of ... Sialic acids are found on various glycoproteins at the host cell surface. The virus then moves from sialic acid group to sialic ... After the virus has entered the cell and has replicated, new viral particles bud from the host cell membrane. The hemagglutinin ... Neuraminidases cleave the terminal sialic acid residues from carbohydrate chains in glycoproteins. Sialic acid is a negatively ...
Hemagglutinin (influenza)
HA is a homotrimeric integral membrane glycoprotein. It is shaped like a cylinder, and is approximately 13.5 nanometres long. ... The host cell membrane then engulfs the virus, a process known as endocytosis, and pinches off to form a new membrane-bound ... Wilson IA, Skehel JJ, Wiley DC (January 1981). "Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A ... The C-terminus of HA2, also known as the transmembrane domain, spans the viral membrane and anchors protein to the membrane. ...
Glutamate carboxypeptidase II
GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N- ... It was found that PSMA was the same as the membrane protein in the small intestine responsible for removal of gamma-linked ... The FOLH1 gene has multiple potential start sites and splice forms, giving rise to differences in membrane protein structure, ... GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. ...
Endoplasmic reticulum
Secretory proteins, mostly glycoproteins, are moved across the endoplasmic reticulum membrane. Proteins that are transported by ... Integral membrane proteins that stay embedded in the membrane as vesicles exit and bind to new membranes. Rab proteins are key ... The membranes of the ER are continuous with the outer nuclear membrane. The endoplasmic reticulum is not found in red blood ... The membrane of the rough endoplasmic reticulum is in the form of large double-membrane sheets that are located near, and ...
LAMP2
... which also house lysosomal membrane glycoproteins. LAMP1 and LAMP2 make up about 50% of lysosomal membrane glycoproteins. (See ... The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with ... Mattei MG, Matterson J, Chen JW, Williams MA, Fukuda M (May 1990). "Two human lysosomal membrane glycoproteins, h-lamp-1 and h- ... "LAMP2 - Lysosome-associated membrane glycoprotein 2 precursor - Homo sapiens (Human) - LAMP2 gene & protein". www.uniprot.org. ...
H19 (gene)
... a cell membrane efflux pump commonly found in multidrug resistant cells; instead, they overexpress a 95kD membrane glycoprotein ... Ross DD, Gao Y, Yang W, Leszyk J, Shively J, Doyle LA (December 1997). "The 95-kilodalton membrane glycoprotein overexpressed ... gene overexpression in atypical multidrug-resistant cells associated with expression of a 95-kilodalton membrane glycoprotein ... Drug-resistant MCF-AdrVp cells do not overexpress P-glycoprotein, ...
GP2 (gene)
Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene. GRCh38: ... "Entrez Gene: GP2 glycoprotein 2 (zymogen granule membrane)". Jacob M, Lainé J, LeBel D (1993). "Specific interactions of ... Fukuoka S, Freedman SD, Scheele GA (1991). "A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein ... Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes". J. Biol. ...
Ligand-targeted liposome
Proteins can target the transferrin receptor membrane glycoprotein. Sugars and vitamins are recognized by cellular transport ... Adsorption and membrane fusion are non-covalent methods for the attachment of monoclonal antibodies. Chemical linkages such as ... Surface-coupled ligands offer a greater degree of freedom to move on the liposome membrane for optimal interactions. Ligands ... Determinants can include histones, basement membrane fibrinogen, selectins, adhesion molecules, or other ligand targets. For ...
POM121
"Entrez Gene: POM121 POM121 membrane glycoprotein (homo sapiens)". Kihlmark M, Imreh G, Hallberg E (October 2001). "Sequential ... Hallberg E, Wozniak RW, Blobel G (Aug 1993). "An integral membrane protein of the pore membrane domain of the nuclear envelope ... Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene. Alternatively spliced ... The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and ...
LYVE1
... is a type I integral membrane glycoprotein. It acts as a receptor and binds to both soluble and immobilized hyaluronan. ... February 1999). "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan". The Journal of ... February 1999). "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan". The Journal of ... 2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane ...
Cardiac muscle
Cardiomyocytes are linked to the basement membrane via specialised glycoproteins called integrins. Humans are born with a set ... This is the direct result of a membrane which allows sodium ions to slowly enter the cell until the threshold is reached for ... They are continuous with the cell membrane, are composed of the same phospholipid bilayer, and are open at the cell surface to ... Cardiomyocytes contain T-tubules, pouches of cell membrane that run from the cell surface to the cell's interior which help to ...
Juxtacrine signalling
An extracellular matrix glycoprotein and a membrane protein interact. Additionally, in unicellular organisms such as bacteria, ... In this type of signaling, specific membrane-bound ligands bind to a cell's membrane. A cell with the appropriate cell surface ... A membrane-bound ligand (protein, oligosaccharide, lipid) and a membrane protein of two adjacent cells interact. A ... Eph ligands can only activate receptors when bound to a membrane. This is because a high density of the Eph ligand is necessary ...
PSCA (gene)
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in ... The proteins translated from the gene, is then glycosylated in the ER, and transported to the cell membrane where it is ...
Cell signaling
An extracellular matrix glycoprotein and a membrane protein interact. Additionally, in unicellular organisms such as bacteria, ... There are three types: A membrane ligand (protein, oligosaccharide, lipid) and a membrane protein of two adjacent cells ... Scaffold protein Biosemiotics Molecular cellular cognition Crosstalk (biology) Bacterial outer membrane vesicles Membrane ... membrane-bound secretory vesicles are carried to the cell membrane, where they dock and fuse at porosomes and their contents (i ...
Protein purification
Many membrane proteins are glycoproteins and can be purified by lectin affinity chromatography. Detergent-solubilized proteins ... Purification of integral membrane proteins requires disruption of the cell membrane in order to isolate any one particular ... A detergent such as sodium dodecyl sulfate (SDS) can be used to dissolve cell membranes and keep membrane proteins in solution ... Ultrafiltration concentrates a protein solution using selective permeable membranes. The function of the membrane is to let the ...
Contact inhibition
Weiser, R.J.; Doris Renauer (1985). "Involvement of plasma membrane glycoproteins in the contact-dependent inhibition of growth ... "Contact Inhibition of Growth of Human Diploid Fibroblasts by Immobilized Plasma Membrane Glycoproteins". Journal of Cell ...
Nidogen-1
... is a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other ... Macro-Plaques or Mini-Basement Membranes in Human Term Fetal Membranes?". Phil. Trans. R. Soc. Lond. B. 342 (1300): 121-136. ... Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV ... Yurchenco PD, Schittny JC (1990). "Molecular architecture of basement membranes". FASEB J. 4 (6): 1577-90. doi:10.1096/fasebj. ...
Glycoprotein IX
Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 ... 1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524-7. doi: ... "Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V". Blood. 87 (4): 1385- ... "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von ...