Membrane fusion protein
Interbilayer forces in membrane fusion Viral membrane fusion proteins Classification of viral fusion proteins in TCDB database ... not to be confused with chimeric or fusion proteins) are proteins that cause fusion of biological membranes. Membrane fusion is ... Domain 1 contains the catalytic site for membrane fusion. Class IV fusion proteins, better known as fusion-associated small ... which encode products involved in driving membrane fusion. While adult somatic cells do not typically undergo membrane fusion ...
Interbilayer forces in membrane fusion
Random fusion can result in severe problems to the normal functioning of the human body. Fusion of biological membranes is ... Membrane fusion is a key biophysical process that is essential for the functioning of life itself. It is defined as the event ... In living beings, cells are made of an outer coat made of lipid bilayers; which then cause fusion to take place in events such ... biological phenomena including folding and stabilization of macromolecules such as proteins and fusion of cell membranes. The ...
Spike protein
Harrison, Stephen C. (May 2015). "Viral membrane fusion". Virology. 479-480: 498-507. doi:10.1016/j.virol.2015.03.043. PMC ... 33 Many spike proteins are membrane fusion proteins. Being exposed on the surface of the virion, spike proteins can be antigens ... Spike proteins are membrane proteins with typically large external ectodomains, a single transmembrane domain that anchors the ... S is a class I fusion protein and is responsible for mediating viral entry as the first step in viral infection. It is highly ...
Debi Prasad Sarkar
Membrane Fusion Technique. Gulf Professional Publishing. July 1993. pp. 42-. ISBN 978-0-12-182122-7. Robert Blumenthal; Debi P ... "Dilation of the influenza hemagglutinin fusion pore revealed by the kinetics of individual cell-cell fusion events". Journal of ... "Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes". Mol. Biol. Cell. 28 (26): ... "Initial stages of influenza hemagglutinin-induced cell fusion monitored simultaneously by two fluorescent events: cytoplasmic ...
IFITM1
Furthermore, IFITM proteins reduced membrane fluidity and affected membrane curvature to restrict viral membrane fusion with ... IFITM proteins inhibit viral membrane and cellular endosomal or lysosomal vesicle membrane fusion by modifying their lipid ... which in turn blocks viral membrane and vesicle membrane fusion. GRCh38: Ensembl release 89: ENSG00000185885 - Ensembl, May ... Harrison, Stephen C (July 2008). "Viral membrane fusion". Nat Struct Mol Biol. 15 (7): 690-8. doi:10.1038/nsmb.1456. PMC ...
Soluble NSF attachment protein
Morgan A, Burgoyne RD (November 2004). "Membrane traffic: controlling membrane fusion by modifying NSF". Current Biology. 14 ( ... as well as in the disassembly following a vesicle fusion event. Following membrane fusion, the tethering SNARE proteins complex ... The existence of these ATP primed vesicles for fusion at the pre-synaptic membrane is facilitated by the interactions of SNAP ... The suspected mechanism may involve priming of the SNARE-SNAP-NSF complex to increase vesicle fusion at the membranes, however ...
Liposome
Cevc, G; Richardsen, H (1993). "Lipid vesicles and membrane fusion". Advanced Drug Delivery Reviews. 38 (3): 207-232. doi: ... protons can pass through some membranes), the drug will also be neutralized, allowing it to freely pass through a membrane. ... To deliver the molecules to a site of action, the lipid bilayer can fuse with other bilayers such as the cell membrane, thus ... By preparing liposomes in a solution of DNA or drugs (which would normally be unable to diffuse through the membrane) they can ...
Monkeypox virus
Moss B (December 2016). "Membrane fusion during poxvirus entry". Seminars in Cell & Developmental Biology. 60: 89-96. doi: ... Protein synthesis allows for the ER membrane of the factory to dismantle, while small two lipid bilayer membranes will appear ... The monkeypox virus, like other poxviruses, is oval shaped, with a lipoprotein outer membrane. The outer membrane protects the ... Virus entry into the host cell plasma membrane is dependent on a neutral pH, otherwise entry occurs via a low-pH dependent ...
Aquaparamyxovirus
Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm. Sequential transcription, viral mRNAs are ... The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane host ...
Middelburg virus
Cholesterol is also necessary for the Alphavirus to undergo fusion. This fusion of the endosomal membrane to the viral envelope ... The E1 gene is a membrane fusion protein that is important in viral entry and release. Together, E1 and E2 are the ... After being taken in through endocytosis, a low pH triggers a membrane fusion, which delivers the viral RNA genomes into the ... Kielian, Margaret; Chanel-Vos, Chantal; Liao, Maofu (2010-03-26). "Alphavirus Entry and Membrane Fusion". Viruses. 2 (4): 796- ...
Ghanaian bat henipavirus
Receptor binding and membrane fusion. Attachment glycoprotein G is a tetrameric transmembrane domain protein that has a short ... All domains of the fusion protein are conserved by NiV, HeV, and GhV as the protein contains a fusion cleavage sequence, fusion ... The Fusion protein F is synthesized as an inactive precursor F0 form before being cleaved by cellular proteases into the active ... While HeV and NiV have strong fusion activity with a variety of host cells, GhV is restricted to a limited host range and only ...
Folding@home
... has also been used to study membrane fusion, an essential event for viral infection and a wide range of biological ... The development of models to predict the mechanisms of membrane fusion will assist in the scientific understanding of how to ... This fusion involves conformational changes of viral fusion proteins and protein docking, but the exact molecular mechanisms ... "Model systems for membrane fusion". Chemical Society Reviews (review). 40 (3): 1572-1585. doi:10.1039/c0cs00115e. PMID 21152599 ...
Membrane vesicle trafficking
Exosomes are released eventually due to fusion of this endosome with plasma membrane of cell. Hijacking of exosomal machinery ... This forces the vesicle membrane against the membrane of the target complex (or the outer membrane of the cell) and causes the ... Papahadjopoulos D, Nir S, Düzgünes N (April 1990). "Molecular mechanisms of calcium-induced membrane fusion". Journal of ... It takes place in the form of Golgi membrane-bound micro-sized vesicles, termed membrane vesicles (MVs). In this process, the ...
Boris Zemelman
... minimal machinery for membrane fusion". Cell. 92 (6): 759-72. doi:10.1016/s0092-8674(00)81404-x. PMID 9529252. Zemelman, BV; ... began working in the laboratory of James Rothman on SNARE proteins and their influence on the intracellular membrane fusion. ...
Synaptobrevin
... minimal machinery for membrane fusion". Cell. 92 (6): 759-72. doi:10.1016/S0092-8674(00)81404-X. PMID 9529252. S2CID 5637048. ... SNARE proteins are the key components of the molecular machinery that drives fusion of membranes in exocytosis. Their function ... Bock JB, Scheller RH (October 1999). "SNARE proteins mediate lipid bilayer fusion". Proc. Natl. Acad. Sci. U.S.A. 96 (22): ... "The Mechanisms of Vesicle Budding and Fusion." Cell, Vol. 116, 153-166, January 23, 2004, Synaptobrevin at the U.S. National ...
BICD2
GTPases Regulating Membrane Targeting and Fusion. pp. 607-18. doi:10.1016/S0076-6879(05)03053-3. ISBN 9780121828080. PMID ... 2003). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. 12 (20): 1792-5. doi: ...
Hülle cell
Consequently, to this fusion so called lomasome-like accumulations are visible. These lomasome-like structures are membrane- ... At the basal septum vesicle fusion is observable. ...
STX1A
Wilson DW, Whiteheart SW, Wiedmann M, Brunner M, Rothman JE (May 1992). "A multisubunit particle implicated in membrane fusion ... Hanson PI, Otto H, Barton N, Jahn R (July 1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a ... Hanson PI, Otto H, Barton N, Jahn R (July 1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a ... Hao JC, Salem N, Peng XR, Kelly RB, Bennett MK (March 1997). "Effect of mutations in vesicle-associated membrane protein (VAMP ...
NAPA (gene)
... to the site of membrane fusion, thereby forming the 20S fusion complex. Alpha- and gamma-SNAP are found in a wide range of ... The 'SNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes. According ... Clary DO, Griff IC, Rothman JE (1990). "SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in ... Wilson DW, Whiteheart SW, Wiedmann M, Brunner M, Rothman JE (1992). "A multisubunit particle implicated in membrane fusion". J ...
Entry inhibitor
VIR-576 is a synthesized peptide which binds to gp41, preventing fusion of the virus with a cell membrane. ITX5061 for ... Xiao, Tianshu; Cai, Yongfei; Chen, Bing (2021). "HIV-1 entry and membrane fusion inhibitors". Viruses. 13 (5): 735. doi:10.3390 ... Fusion Inhibitor Resource Center HIV+Fusion+Inhibitors at the U.S. National Library of Medicine Medical Subject Headings (MeSH ... which approximates the membrane of HIV and the T cell and promotes their fusion The entry of the viral core into the cell Entry ...
Umifenovir
Fusion between the viral envelope (surrounding the viral capsid) and the cell membrane of the target cell is inhibited. This ... Umifenovir inhibits membrane fusion of influenza virus. Umifenovir prevents contact between the virus and target host cells. ... Boriskin YS, Leneva IA, Pécheur EI, Polyak SJ (2008). "Arbidol: a broad-spectrum antiviral compound that blocks viral fusion". ... Kadam RU, Wilson IA (January 2017). "Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol". ...
SEC22B
"Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". The EMBO Journal. 23 (16): 3216-26. doi:10.1038/ ... "Topological restriction of SNARE-dependent membrane fusion". Nature. 407 (6801): 194-8. Bibcode:2000Natur.407..194P. doi: ... membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The ... "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". The EMBO Journal. 23 (6): 1267-78. ...
Prostasomes
Arienti G, Carlini E, Palmerini CA (January 1997). "Fusion of human sperm to prostasomes at acidic pH". The Journal of Membrane ... Carlini E, Palmerini CA, Cosmi EV, Arienti G (July 1997). "Fusion of sperm with prostasomes: effects on membrane fluidity". ... Fusion of prostasomes with the sperm plasma membrane is required for regulation of different aspects of sperm function, such as ... They possess an unusual lipid composition and a tight and highly ordered structure of their lipid bilayer membrane, resembling ...
Membrane curvature
Martens S, McMahon HT (July 2008). "Mechanisms of membrane fusion: disparate players and common principles". Nature Reviews. ... Membrane curvature is the geometrical measure or characterization of the curvature of membranes. The membranes can be naturally ... Not only does the protein effect membrane curvature, but membrane curvature can affect membrane proteins as well. Conically ... So, to describe membrane shape, it is not sufficient to determine the membrane curling that is seen in a single cross-section ...
Influenza D virus
These glycoproteins allow for attachment and fusion of viral and cellular membranes. Fusion of these membranes allows the viral ... Weissenhorn W, Dessen A, Calder LJ, Harrison SC, Skehel JJ, Wiley DC (1999). "Structural basis for membrane fusion by enveloped ... These viruses also contain proteins on the surface of the cell membrane called glycoproteins. Type A and B have two ... effect of influenza virus glycoproteins on the membrane association of M1 protein". J. Virol. 74 (18): 8709-19. doi:10.1128/jvi ...
STX7
... vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in ... "SNAREs contribute to the specificity of membrane fusion". Neuron. 26 (2): 457-64. doi:10.1016/S0896-6273(00)81177-0. PMID ... Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late ... Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late ...
STX8
... vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in ... "SNAREs contribute to the specificity of membrane fusion". Neuron. 26 (2): 457-64. doi:10.1016/S0896-6273(00)81177-0. PMID ... These function as the machinery for the homotypic fusion of late endosomes. Model organisms have been used in the study of STX8 ... Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (Dec 2000). "A SNARE complex mediating fusion of late ...
SNAP23
It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important ... Mollinedo F, Lazo PA (Feb 1997). "Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human ... form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are ... a component of the membrane fusion machinery". Molecular Biology of the Cell. 11 (10): 3485-94. doi:10.1091/mbc.11.10.3485. PMC ...
SNAP29
... encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. ... Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH (2000). "SNAREs contribute to the specificity of membrane fusion". ... While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple ... This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other ...
NAPB
1992). "A multisubunit particle implicated in membrane fusion". J. Cell Biol. 117 (3): 531-8. doi:10.1083/jcb.117.3.531. PMC ... Prekeris R, Klumperman J, Chen YA, Scheller RH (1998). "Syntaxin 13 mediates cycling of plasma membrane proteins via ...