"Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen ... Melanoma-associated antigen 11 is a protein that in humans is encoded by the MAGEA11 gene. It is also involved in the androgen ... "Entrez Gene: MAGEA11 melanoma antigen family A, 11". Lui QS, Su S, Blackwelder AJ, Minges JT, Wilson EM (2011). " ... Askew EB, Bai S, Hnat AT, Minges JT, Wilson EM (2009). "Melanoma antigen gene protein-A11 (MAGE-11) F-box links the androgen ...
Melanoma-associated antigen H1 is a protein that in humans is encoded by the MAGEH1 gene. This gene is thought to be involved ... "Identification of a new MAGE gene with tumor-specific expression by representational difference analysis". Cancer Res. 58 (4): ... "Entrez Gene: MAGEH1 melanoma antigen family H, 1". Zhu F, Yan W, Zhao ZL, et al. (2001). "Improved PCR-based subtractive ...
Melanoma-associated antigen 9 is a protein that in humans is encoded by the MAGEA9 gene. This gene is a member of the MAGEA ... 2005). "Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell ... Rogner UC, Wilke K, Steck E, Korn B, Poustka A (Mar 1996). "The melanoma antigen gene (MAGE) family is clustered in the ... "Entrez Gene: MAGEA9 melanoma antigen family A, 9". Oehlrich N, Devitt G, Linnebacher M, et al. ( ...
"Entrez Gene: MAGEC2 melanoma antigen family C, 2". Lucas S, De Plaen E, Boon T (2000). "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3 ... 2007). "A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44". Cancer Immunol. ... Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene. This gene is related to members of ... 2001). "MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma". Cancer Res. ...
Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Maile, R.; et al. (2001 ... MHC tetramers are used to identify and label specific T-cells by epitope specific binding, allowing the antigen specific immune ... MHC pentamers have been used in the detection of antigen-specific CD8+ T cells in flow cytometry, and are cited in over 750 ... MHC multimers allow for ex vivo selection and proliferation of T-cells specific to viral or tumor-related antigens, which can ...
... indicates that OA1 peptide is processed and presented on the surface of melanoma cells to be recognized by antigen-specific T ... have characterized OA1 immunologically as a melanoma/melanocyte differentiation antigen. Flow cytometry data suggests that OA1- ... Studies showed that L-DOPA is the specific ligand for the OA1 receptor. L-DOPA is a by-product of melanin biosynthetic pathway ... Moreover, recognition of OA1 by T cells induces cytokine production by the OA1-specific T cells. This means that OA1 is a ...
Wang MX, Earley JJ, Shields JA, Donoso LA (March 1992). "An ocular melanoma-associated antigen. Molecular characterization". ... Berditchevski F, Bazzoni G, Hemler ME (July 1995). "Specific association of CD63 with the VLA-3 and VLA-6 integrins". The ... "Transcriptional enhancement of the human gene encoding for a melanoma-associated antigen (ME491) in association with malignant ... "Isolation and amino terminal sequencing of a novel melanoma-associated antigen". Archives of Biochemistry and Biophysics. 242 ( ...
The gp100 protein is a melanoma antigen i.e. a tumor-associated antigen. Short fragments of it have been used to develop the ... In the mouse model, an HR-gp100-based vaccine triggered antigen-specific T cell responses, as shown by proliferation assays, ... The gp100 protein contains differentiation antigens.[2], and has been widely studied to be used as a target for melanoma ... 1994). "Cloning and expression of the gene for the melanoma-associated ME20 antigen". DNA Cell Biol. 13 (2): 87-95. doi:10.1089 ...
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific ... "Entrez Gene: MAGED1 melanoma antigen family D, 1". Grau C, Starkovich M, Azamian MS, Xia F, Cheung SW, Evans P, Henderson A, ... Zhang CG, Xing GC, Wei HD, Yu YT, He FC (2001). "[A new melanoma antigen-encoding gene subfamily in human chromosome X]". Yi ... Melanoma-associated antigen D1 is a protein that in humans is encoded by the MAGED1 gene. ...
2000). "Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines". Cancer Res. 60 (6 ... Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788-95 ... 2006). "Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular ... codes for the human tumor antigen HOM-MEL-40". Cancer Res. 56 (20): 4766-72. PMID 8840996. "Entrez Gene: SSX2 synovial sarcoma ...
... and stands for Human Melanoma Black. It is used in anatomic pathology as a marker for such tumors. The specific antigen ... spindle cell melanomas and desmoplastic melanomas. HMB-45 is nonreactive with almost all non-melanoma human malignancies, with ... The antibody was generated to an extract of melanoma. In a study to determine diagnostic usefulness of specific antibodies used ... HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, ...
"TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients". J Clin Invest. 125 (5): 2046-2058. doi:10.1172 ... TIGIT and PD-1 has been shown to be over-expressed on tumor antigen-specific (TA-specific) CD8+ T cells and CD8+ tumor ... Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of TA-specific CD8+ T ... A large fraction of HIV-specific CD8+ T cells simultaneously express both TIGIT and another negative checkpoint receptor, ...
... the preferentially expressed antigen of melanoma (PRAME) gene family is expanded. It is actively expressed in cancers, but ... One method of this is to introduce public education programs as well as restrict visitors to specific viewing platforms, with ... doi:10.1016/0047-2484(74)90023-2. Harris, R. A.; Rogers, J.; Milosavljevic, A. (2007). "Human-specific changes of genome ... The macaque-human relationships is complex and culturally specific, ranging from relatively peaceful coexistence to extreme ...
1997). "Analysis of MAGE-3-specific cytolytic T lymphocytes in human leukocyte antigen-A2 melanoma patients". Cancer Res. 57 (4 ... 2004). "Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with ... 2001). "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959-63. PMID ... Melanoma-associated antigen 3 (MAGE-A3) is a protein that in humans is encoded by the MAGEA3 gene. This gene is a member of the ...
"Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes". J ... 1998). "The use of melanosomal proteins in the immunotherapy of melanoma". J. Immunother. 21 (4): 237-46. doi:10.1097/00002371- ...
2004). "Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with ... "Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E)". Takahashi K, Shichijo S, Noguchi M, et ... 2001). "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959-63. PMID ... Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene. This gene is a member of the MAGEA ...
"Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 ... "What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma?". The Oncologist ... Tumor antigens can either be improperly expressed normal proteins or abnormal proteins with tumor-specific expression. Somatic ... These antigens are recognized by dendritic cells that present the antigens to cytotoxic T lymphocytes (CTLs) in the lymph nodes ...
... cancer-testis antigens and vascular or stromal specific antigens. Tissue differentiation antigens are those that are specific ... Normally tyrosinase is produced in minute quantities but its levels are very much elevated in melanoma cells. Oncofetal ... and some viral antigens are also cancer antigens. Cancer-testis antigens are antigens expressed primarily in the germ cells of ... Tumor-Specific Antigens (TSA), which are present only on tumor cells and not on any other cell and Tumor-Associated Antigens ( ...
"Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma ... March 2017). "Tumor antigen-specific CD8+ T cells are negatively regulated by PD-1 and Tim-3 in human gastric cancer". Cellular ... January 2002). "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease ... HAVCR2 has also been shown as a CD4+ Th1-specific cell surface protein that regulates macrophage activation, regulates the ...
... melanoma-specific), gp100, tyrosinase, and survivin, but TILs can also recognize other unknown antigens specific to the tumor ... Autologous TIL therapy for metastatic melanoma has broad T cell recognition of both defined and undefined tumor antigens ... 2007). "Protective effect of a brisk tumor infiltrating lymphocyte infiltrate in melanoma: An EORTC melanoma group study". ... Detection of gene expression specific for different kind of immune cell populations can then be used to determine the degree of ...
There is limited information about canine tumor antigens, which is the reason for the lack of tumor-specific vaccines and ... There is one canine tumor vaccine approved by the USDA, for preventing canine melanoma. The Oncept vaccine activates T-cell ... Selection for specific phenotypes in dog breeding causes long-range linkage disequilibrium in their DNA. Certain areas of ... It is important for the owner to be familiar with the diseases to which their specific breed of dog might have a breed ...
One such antigen was MAGE-A1. The coexistence of a progressing melanoma with melanoma-specific T cells implicitly does not ... The discovery of melanoma-specific T cells in patients led to the strategy of adoptively transferring large numbers of in vitro ... immunogenic cancer cells was provided by Boon's 1991 studies of antigens that elicit specific CD8+ T cell responses in melanoma ... However, only in melanoma has autologous TIL transplant succeeded as a treatment. Cancer cells induce apoptosis of activated T ...
B cells can recognize soluble antigen for which their B cell receptor is specific. They can then process the antigen and ... "Phase 1 Study of IMP321 Adjuvant to Anti-PD-1 Therapy in Unresectable or Metastatic Melanoma" at ClinicalTrials.gov Clinical ... Dendritic cells, presenting tumor-specific antigen to T cells, are key to this process. Cancer therapies have included treating ... An antigen-presenting cell (APC) or accessory cell is a cell that displays antigen bound by major histocompatibility complex ( ...
These data clearly demonstrated vaccine-specific immune responses with a broad specter of T cell response against antigens ... 2006). "Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA". Cancer Gene Therapy ... At the end of the 1980s the three-dimensional structure of human leukocyte antigen (HLA) molecule was defined in parallel to ... The five patients carried the corresponding Ras mutation and Ras-specific T cell responses were induced in two of the patients ...
For example, it was recently shown that CD4+ T cells primarily produce TNF after recognition of tumor-antigens in melanoma. TNF ... Of note, results from recent reports suggest that direct recognition of tumors from tumor-antigen specific CD4+ T cells might ... Aberrant expression of MHC Class II in melanoma attracts inflammatory tumor specific CD4+ T cells which dampen CD8+ T cell ... Knutson, K. L.; Disis, M. L. (2005-08-01). "Tumor antigen-specific T helper cells in cancer immunity and immunotherapy". Cancer ...
The same name is also used to refer to the gene which codes for the antigen. The MART-1/melan-A antigen is specific for the ... "Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific ... Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the ... at the National Cancer Institute coined the term MART-1, which stands for "melanoma antigen recognized by T-cells." Coulie et ...
... that are selective for melanoma and breast tumor cells. The Janda laboratory has also identified a scFv specific for the ... Carbohydrate Antigen". Journal of the American Chemical Society. 124 (42): 12439-12446. doi:10.1021/ja020737j. PMID 12381184. ... "Phage-Display Selection of a Human Single-Chain Fv Antibody Highly Specific for Melanoma and Breast Cancer Cells Using a ... "A Human Single-Chain Antibody Specific for Integrin α3β1 Capable of Cell Internalization and Delivery of Antitumor Agents". ...
... canine melanoma, canine and feline fibrosarcoma, and several other forms of cancer. Song S, Zhou F, Nordquist RE, Carubelli R, ... Autologous patient-specific tumor antigen response (apSTAR) technology is a new cancer treatment procedure being developed by ... it does not depend upon cross reactivity in the expression of tumor-specific antigen between hosts (as is required in ... but also due to increases in antigen accessibility caused by the destruction of the tumor. Both elements of this protocol are ...
The Prophage series of patient-specific cancer vaccine candidates can also enhance the immune system's response to tumors. ... The company's QS-21 Stimulon® adjuvant platform strengthens and broadens immune responses to antigens on cancers or foreign ... melanoma, and malaria. In October 2013, GlaxoSmithKline and Agenus announced positive data from an 18-month follow-up of GSK's ... The company is developing checkpoint modulators (CPMs), patient-specific anti-cancer vaccines, and adjuvants desugned for use ...
A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells". Science. 348 (6236): 803 ... "Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens". Nature. 515 (7528): 577-581. Bibcode: ... Tumor-specific mutations in protein-coding genes are then identified by comparison of sequences from tumor and normal DNA. ... A total of 13 patients with melanoma received the RNA vaccine, eight of which had no tumor development during the follow-up. ...