Are MHC antigens involved?". Clinical and Experimental Metastasis. 5 (4): 277-287. doi:10.1007/bf00120723. PMID 3117468. S2CID ... B16 melanoma is a murine tumor cell line used for research as a model for human skin cancers. B16 cells are useful models for ... Those are just a few examples, but the undergirding idea is that the B16 melanoma model is a powerful research tool, and a ... Today, B16 melanoma remains indispensable for metastasis studies. Current research projects focus on the cells' immunological ...
The journal covers both experimental and clinical research on melanoma. According to the Journal Citation Reports, the journal ... Melanoma Research is a bimonthly peer-reviewed medical journal published by Lippincott Williams & Wilkins and the editor-in- ... "Melanoma Research". 2020 Journal Citation Reports. Web of Science (Science ed.). Clarivate. 2021. Official website v t e ( ...
In melanoma and certain other cancers, the numbers of mutations and neoantigens correlate with patient response. Increased PD ... Tomillero A, Moral MA (October 2008). "Gateways to clinical trials". Methods and Findings in Experimental and Clinical ... Ipilimumab was approved by the US Food and Drug Administration (FDA) in March 2011, for the treatment of melanoma, a type of ... Drugs.com: Yervoy "FDA approves Yervoy to reduce the risk of melanoma returning after surgery" (Press release). U.S. Food and ...
Norton, Amy (2 April 2015). "Experimental Melanoma Vaccine Shows Early Promise". HealthDay. Retrieved 14 September 2015. "Urine ... 2015 - Melanoma vaccine and urine test for kidney cancer In a proof of concept study, a research team led by Beatriz Carreno, ... Further study needs to be done to see if the customized vaccines can prevent recurrence in patients with advanced melanoma. A ... Ph.D., shows that personalized medicine can "wake up" the immune systems of melanoma patients. ...
As of mid-2006, dacarbazine is commonly used as a single agent in the treatment of metastatic melanoma, and as part of the ABVD ... Journal of Experimental & Clinical Cancer Research. 19 (1): 21-34. PMID 10840932. Bhatia S, Tykodi SS, Thompson JA (May 2009 ... Serrone L, Zeuli M, Sega FM, Cognetti F (March 2000). "Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year ... is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma. For Hodgkin's lymphoma it is often used ...
"Rac1 activity regulates proliferation of aggressive metastatic melanoma". Experimental Cell Research. 313 (18): 3832-9. doi: ... "A landscape of driver mutations in melanoma". Cell. 150 (2): 251-63. doi:10.1016/j.cell.2012.06.024. PMC 3600117. PMID 22817889 ... "Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma". Nature Genetics. 44 (9): 1006-14. doi:10.1038/ng. ... muscle stretching Activating mutations in Rac1 have been recently discovered in large-scale genomic studies involving melanoma ...
"Experimental Drug May Work in Many Cancers , Discuss Cancer". Archived from the original on 2011-07-10. Banasik M, Stedeford T ... Veliparib for metastatic melanoma. CEP 9722 for non-small-cell lung cancer (NSCLC) E7016 (developed by Eisai): underwent phase ... Experimental: 3-Aminobenzamide, a prototypical PARP inhibitor. PARP1 Parthanatos - PARP-1 dependent cell death Blankenhorn D ( ... PARP inhibitors such as olaparib, under experimental conditions, appear to be beneficial in limiting atrial fibrillation and ...
Also, CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 ... The Journal of Experimental Medicine. 171 (5): 1797-1802. doi:10.1084/jem.171.5.1797. PMC 2187876. PMID 2185333. Schumacher C, ... Richmond A, Thomas HG (February 1988). "Melanoma growth stimulatory activity: isolation from human melanoma tumors and ... Dhawan P, Richmond A (July 2002). "Role of CXCL1 in tumorigenesis of melanoma". Journal of Leukocyte Biology. 72 (1): 9-18. doi ...
"The small leucine-rich proteoglycan lumican inhibits melanoma progression". Experimental Cell Research. 296 (2): 294-306. doi: ... Advances in Experimental Medicine and Biology. Vol. 802. pp. 201-30. doi:10.1007/978-94-007-7893-1_13. ISBN 978-94-007-7892-4. ... Kao WW, Funderburgh JL, Xia Y, Liu CY, Conrad GW (Jan 2006). "Focus on molecules: lumican". Experimental Eye Research. 82 (1): ... Jacobson E, Dart AJ, Mondori T, Horadogoda N, Jeffcott LB, Little CB, Smith MM (2015). "Focal experimental injury leads to ...
September 2022). "Wild-type IDH1 inhibition enhances chemotherapy response in melanoma". Journal of Experimental & Clinical ... Ivosidenib (AG-120) has exhibited potent anti-wtIDH1 properties in melanoma under low magnesium and nutrient levels, reflective ...
It may resemble a malignant melanoma.[page needed] It may be caused by poor hygiene,: 121 and may form in retracted navels in ... Ichiki, Y.; Kitajima, Y. (April 17, 2009). "Omphalith". Clinical and Experimental Dermatology. 34 (3): 420-421. doi:10.1111/j. ...
"SOX9 is a dose-dependent metastatic fate determinant in melanoma". Journal of Experimental & Clinical Cancer Research. 38 (1): ...
January 2020). "DNA hypermethylation is associated with invasive phenotype of malignant melanoma". Experimental Dermatology. 29 ... decreased expression has been demonstrated as one of the contributors to the invasive capacity of cancer cells in melanoma. The ...
... "miR-137 inhibits proliferation of melanoma cells by targeting PAK2". Experimental Dermatology. 24 (12): 947-52. doi:10.1111/exd ... The levels of PAK2 activation in experimental systems are inhibited by synthetic PAK-inhibitors and miRs. For example, FRAX1036 ... T93 and T286 contributes to the growth of growth factor-stimulated melanoma cells, Caspase-7 phosphorylation at S30, T173 and ...
"Experimental Drug Improves Survival in Advanced Melanoma - National Cancer Institute". www.cancer.gov. Archived from the ... This phase I trial using PSA-TRICOM with Ipilimumab (Ipi) showed promise for Overall Survival (OS). Ipi is used in melanoma ... Immune Correlates Associated with Clinical Benefit in Patients with Resected High-Risk Stage IIIc/IV Melanoma". Clinical Cancer ...
Núñez NP, Carter PA, Meadows GG (May 2002). "Alcohol consumption promotes body weight loss in melanoma-bearing mice". ... Alcoholism: Clinical and Experimental Research. 26 (5): 617-26. doi:10.1111/j.1530-0277.2002.tb02583.x. PMID 12045469. Pöschl, ... Any alcohol intake is associated with the development of malignant melanoma. "Statistically significant increases in risk also ... 1 June 2004). "Diet and melanoma in a case-control study". Cancer Epidemiology, Biomarkers & Prevention. 13 (6): 1042-51. doi: ...
The Journal of Experimental Zoology. 292 (5): 430-4. doi:10.1002/jez.10067. PMID 11857477. Kapadia SB, Barth H, Baumert T, ... Melanoma Research. 21 (6): 665-76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373. Duggan AE, Marie RS, ...
Two kinds of experimental treatments developed at the National Cancer Institute (NCI), have been used in metastatic melanoma ... Mucosal melanoma; When melanoma occurs on mucous membranes. Desmoplastic melanoma Melanoma with small nevus-like cells Melanoma ... with features of a Spitz nevus Uveal melanoma Vaginal melanoma Polypoid melanoma, a subclass of nodular melanoma. A melanoma in ... ocular melanoma and melanoma of soft parts, or mucosal melanoma (e.g., rectal melanoma), although these tend to metastasize ...
"Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling". Journal of Experimental & Clinical ... It can target miR-301b/LRIG1 signaling pathways, resulting in the inhibition of melanoma growth in vitro. Nerya, Ohad; Vaya, ...
Salem is currently the leader of the Experimental Therapeutics (ET) program at the Holden Comprehensive Cancer Center and co- ... "Pharmacy researcher to use American Cancer Society grant for melanoma research". Archived from the original on 2015-02-18. ... Experimental Therapeutics Program :: Cancer Research "Nanotoxicology Research Core - the Environmental Health Sciences Research ...
... "mRNA expression of tumor-associated antigens in melanoma tissues and cell lines". Experimental Dermatology. 11 (4): 292-301. ... Experimental and Clinical Endocrinology & Diabetes. 112 (3): 135-41. doi:10.1055/s-2004-817822. PMID 15052533. Uesaka T, ...
... (preferentially expressed antigen of melanoma) is a protein that in humans is encoded by the PRAME gene. Five ... Experimental and Clinical Immunogenetics. 15 (1): 19-32. doi:10.1159/000019050. PMID 9619397. S2CID 25993773. Matsushita M, ... This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T ... "Entrez Gene: PRAME preferentially expressed antigen in melanoma". Al-Khadairi G, Decock J (July 2019). "Cancer Testis Antigens ...
They are key to an experimental autologous cell therapy (Contego) for metastatic melanoma. Autologous TIL therapy for ... 2007). "Protective effect of a brisk tumor infiltrating lymphocyte infiltrate in melanoma: An EORTC melanoma group study". ... They are an important prognostic factor in melanoma and higher levels being associated with a better outcome. TILs are also ... TILs can not only recognize over-expressed self/melanocyte differentiation antigens, such as Melan-A/MART-1 (melanoma-specific ...
Lu F, Dai DL, Martinka M, Ho V, Li G (Jul 2006). "Nuclear ING2 expression is reduced in human cutaneous melanomas". British ... Experimental Cell Research. 304 (2): 531-43. doi:10.1016/j.yexcr.2004.11.023. PMID 15748897. Barrios-Rodiles M, Brown KR, ... Chin MY, Ng KC, Li G (Apr 2005). "The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells". ...
Following an experimental treatment at the John Wayne Cancer Institute in Santa Monica pioneered by oncologist Donald Morton, ... In 1990, Argerich was diagnosed with malignant melanoma. After treatment, the cancer went into remission, but it recurred in ...
Randazzo BP, Bhat MG, Kesari S, Fraser NW, Brown SM (June 1997). "Treatment of experimental subcutaneous human melanoma with a ... Both in the laboratory and in the clinic it is useful to have a simple means of identifying cells infected by the experimental ... In October 2015, the US FDA approved T-VEC, with the brand name Imlygic, for the treatment of melanoma in patients with ... Other safety trials have used HSV1716 to treat patients with melanoma and squamous-cell carcinoma of head and neck. Since then ...
Adoptive transfer of TILs can increase the survival of melanoma patients when it is used as an adjuvant therapy, i.e. after a ... The Journal of Experimental Medicine. 173: 1373-1384. van der Bruggen P., Traversari C., Chomez P., Lurquin C., De Plaen E., ... A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma ". Science. 254(5038): 1643-1647. van der ... The response of autologous T cells to a human melanoma is dominated by mutated neoantigens ". Proceedings of the National ...
"HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features". Journal of Experimental & ... HERV-K is receptive to microenvironmental modifications and melanoma cells are closely correlated with epigenetic and ...
... in melanoma progression and chemoresistance". Experimental Dermatology. 14 (11): 811-8. doi:10.1111/j.1600-0625.2005.00360.x. ...
Mechanisms and Experimental Therapy. review. Advances in Experimental Medicine and Biology. Vol. 801. New York: Springer. pp. ... Pigment Cell & Melanoma Research. 21 (6): 665-76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373. Strauss ... Advances in Experimental Medicine and Biology. Vol. 723. pp. 603-10. doi:10.1007/978-1-4614-0631-0_77. ISBN 978-1-4614-0630-3. ...
p75NTR has been implicated as a marker for cancer stem cells in melanoma and other cancers. Melanoma cells transplanted into an ... International Journal of Clinical and Experimental Pathology. 7 (12): 8947-8951. PMC 4313973. PMID 25674270. Zubrilov I, Sagi- ... 2014). "Increased expression of melanoma stem cell marker CD271 in metastatic melanoma to the brain". ... July 2010). "Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271". Nature. 466 (7302): 133- ...