Coussens, L; Fingleton, B; Matrisian, LM (2002). "Matrix metalloproteinase inhibitors and cancer: trials and tribulations". ... and by endogenous inhibitors known as tissue inhibitors of metalloproteases (TIMPs). The role of matrix metalloproteases and ... 2001). "The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis". Cell. ... Nagase, H; Woessner Jr, JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 (31): 21491-21494. doi:10.1074/jbc.274.31. ...
... is a matrix metalloproteinase inhibitor (MMPI). Excision of malignant tumors comprises first line treatment for ... Batimastat Marimastat Coussens, L. M. (2002). "Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations". ... A series of proteolytic enzymes present in tumor cells, known as matrix metalloproteinases, help establish growth of these ... Consequently, considerable research has been devoted to matrix metalloproteinases as a target for anticancer drugs. Clinical ...
It acts as a matrix metalloproteinase inhibitor (MMPI) by mimicking natural MMPI peptides. Batimastat was the first MMPI that ... Rothenberg, M. L.; Nelson, A. R.; Hande, K. R. (1999). "New Drugs on the Horizon: Matrix Metalloproteinase Inhibitors". Stem ... Batimastat (INN/USAN, codenamed BB-94) is an anticancer drug that belongs to the family of drugs called angiogenesis inhibitors ...
Matrisian LM (Apr 1990). "Metalloproteinases and their inhibitors in matrix remodeling". Trends in Genetics. 6 (4): 121-5. doi: ... Matrisian LM (Apr 1990). "Metalloproteinases and their inhibitors in matrix remodeling". Trends in Genetics. 6 (4): 121-5. doi: ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix proteins and during ... The mechanism for MMP-3 is a variation on a larger theme seen in all matrix metalloproteinases. In the active site, a water ...
"Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors". Journal of ... 2007), are using C-terminally truncated SRTX-b to act as a matrix metalloproteinase inhibitor. The removal of the C-terminal ... eliminates its toxic vasopressive activity and also the matrix metalloproteinase inhibitor activity, however with further amino ... the matrix metalloproteinase inhibitory activity is regained and enhanced. This modified sarafotoxin is useful for treating ...
"The Gelatinases and Their Inhibitors: The Structure-Activity Relationships". Matrix Metalloproteinase Inhibitors: Specificity ... "The Gelatinases and Their Inhibitors: The Structure-Activity Relationships". Matrix Metalloproteinase Inhibitors: Specificity ... "Matrix Metalloproteinases in Ischemia - Reperfusion Injury in Brain: Anti-oxidants as Rescuer". Role of Proteases in Cellular ... "Matrix Metalloproteinases in Ischemia - Reperfusion Injury in Brain: Anti-oxidants as Rescuer". Role of Proteases in Cellular ...
1998). "Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male ... It acted as a broad-spectrum matrix metalloproteinase inhibitor. Marimastat performed poorly in clinical trials, and ...
... a new inhibitor of matrix metalloproteinase-14 activity". FEBS Letters. 588 (23): 4319-24. doi:10.1016/j.febslet.2014.09.040. ... As lumican can directly bind to and inhibit matrix metalloproteinase-14 (MMP14), lumican may limit tumor progression by ... "Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell ... Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the LUM gene on chromosome 12. ...
... is a C-glycosidic depside matrix metalloproteinase inhibitor. Evariquinone, isoemericellin, and stromemycin from a ...
Maskos K, Bode W (November 2003). "Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases". ... Okada Y, Hashimoto G (2001). "[Degradation of extracellular matrix by matrix metalloproteinases and joint destruction]". ... Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme that in ... A specific region (183)RWTNNFREY(191) as been identified as a critical segment of matrix metalloproteinase 1 for the expression ...
... (code name AG-3340) is a matrix metalloproteinase (MMP) inhibitor with specific selectivity for MMPs 2, 3, 9, 13, ... "Phase III study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer" (PDF). Journal of Clinical ... a matrix metalloprotease inhibitor" (PDF). Clinical Cancer Research. 10 (3): 909-15. doi:10.1158/1078-0432.CCR-0981-3. PMID ... the inhibition of these MMPs is able to block tumour metastasis by preventing MMP degradation of the extracellular matrix ...
"Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and ... At subantimicrobial doses, doxycycline is an inhibitor of matrix metalloproteases, and has been used in various experimental ...
"Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and ... People with recalcitrant recurrent corneal erosions often show increased levels of matrix metalloproteinase (MMP) enzymes. ...
... members of the matrix metalloproteinase family that cleave extracellular matrix constituents. These zinc endopeptidases, which ... The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). Hemopexin (EC 3.2.1.35) is a serum ... Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). ... matrix metalloproteinases: MMP1, MMP2, MMP3, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP19, MMP20, ...
"The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer". Folia ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... Lee JM, Yin K, Hsin I, Chen S, Fryer JD, Holtzman DM, Hsu CY, Xu J (March 2005). "Matrix metalloproteinase-9 in cerebral- ... Li M, Yang G, Xie B, Babu K, Huang C (February 2014). "Changes in matrix metalloproteinase-9 levels during progression of ...
Matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) in mature human odontoblasts and pulp tissue. ... Dentin is a bone-like matrix that is porous and yellow-hued material. It is made up of 70% inorganic materials (mainly ... Cells and Extracellular Matrices of Dentin and Pulp: A Biological Basis For Repair and Tissue Engineering, M. Goldberg and A.J ...
... (INN), also known as galardin or GM6001 is a broad-spectrum matrix metalloproteinase inhibitor. Ilomastat is a member ... Santiskulvong C, Rozengurt E (November 2003). "Galardin (GM 6001), a broad-spectrum matrix metalloproteinase inhibitor, blocks ... "Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases". Invest. Ophthalmol. Vis. ... Kocer SS, Walker SG, Zerler B, Golub LM, Simon SR (November 2005). "Metalloproteinase inhibitors, nonantimicrobial chemically ...
Matrix metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene. Proteins of the matrix metalloproteinase ... "Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1- ... Matrix metalloproteinase ARK5 GRCh38: Ensembl release 89: ENSG00000157227 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 (31): 21491-4. doi:10.1074/jbc.274.31.21491. PMID ...
Ryan, M. E.; Usman, A.; Ramamurthy, N. S.; Golub, L. M.; Greenwald, R. A. (2001). "Excessive matrix metalloproteinase activity ... Tetracycline antibiotics are protein synthesis inhibitors, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome ... Tetracyclines also have been found to inhibit matrix metalloproteinases. This mechanism does not add to their antibiotic ...
"Potential role of matrix metalloproteinase-2,-9 and tissue inhibitors of metalloproteinase-1,-2 in exudative pleural effusions ... matrix metalloproteinases and tumour markers such as carcinoembryonic antigen. Pleural fluid mesothelin has a sensitivity of 71 ...
"Rapid inactivation of alpha-1-proteinase inhibitor by neutrophil specific leukolysin/membrane-type matrix metalloproteinase 6 ... activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 ... Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene. Proteins of the matrix metalloproteinase ... "Entrez Gene: MMP25 matrix metallopeptidase 25". Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 ( ...
"Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor ... "Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2 ... The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMP), a group of peptidases ... Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene ...
Matrix metalloproteinases One of the newest theories for the molecular basis of laminitis involves matrix metalloproteinases ( ... To prevent tissue damage, they are regulated by tissue inhibitors of metalloproteinases (TIMPs). In cases of laminitis, an ... MMPs). Metalloproteinases are enzymes that can degrade collagen, growth factors, and cytokines to remodel the extracellular ... so that they may cleave substances within the extracellular matrix and therefore break down the basement membrane. Since the ...
Matrix metalloproteinases are inhibited by tissue inhibitors of matrix metalloproteinases (TIMPs) which are found at lower ... Breakdown of collagen: collagen is broken down by enzymes called matrix metalloproteinases (MMPs), which are found at higher ...
Docherty, A.J.P.; Murphy, G. (1990). "The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and ... 1986). "A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. ... Emonard, H.; Grimaud, J.A. (1990). "Matrix metalloproteinase. A review". Cell. Mol. Biol. 36: 131-153. PMID 2165861. ... Stromelysin 1 (EC 3.4.24.17, matrix metalloproteinase 3, proteoglycanase, collagenase activating protein, procollagenase ...
The involvement of AP-1 in the aforementioned inflammatory cascade activates matrix metalloproteinases, which contribute to ... the high risk of birth defects with 5α-reductase inhibitors limits their use in women.[1][138] However, 5α-reductase inhibitors ... Azzouni F, Zeitouni N, Mohler J (February 2013). "Role of 5α-reductase inhibitors in androgen-stimulated skin disorders". ... and inhibitors of the stearoyl-CoA desaturase-1 enzyme are also a focus of research efforts.[10][91] Particles that release ...