MMP8
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... 1997). "Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview". J. Neuroimmunol. 72 (2): 155-61 ... Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving ... A distinct gene product with homology to other matrix metalloproteinases". J. Biol. Chem. 265 (20): 11421-4. doi:10.1016/S0021- ...
MMP9
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... Lee JM, Yin K, Hsin I, Chen S, Fryer JD, Holtzman DM, Hsu CY, Xu J (March 2005). "Matrix metalloproteinase-9 in cerebral- ... Li M, Yang G, Xie B, Babu K, Huang C (February 2014). "Changes in matrix metalloproteinase-9 levels during progression of ... Ramos-DeSimone N, Hahn-Dantona E, Sipley J, Nagase H, French DL, Quigley JP (May 1999). "Activation of matrix metalloproteinase ...
MMP7
... matrix metalloproteinase pump 1, PUMP-1 proteinase, PUMP, metalloproteinase pump-1, putative metalloproteinase, MMP). Human MMP ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... Matrilysin also known as matrix metalloproteinase-7 (MMP-7), pump-1 protease (PUMP-1), or uterine metalloproteinase is an ... Woessner JF, Taplin CJ (November 1988). "Purification and properties of a small latent matrix metalloproteinase of the rat ...
Matrix metalloproteinase
MBInfo - Matrix metalloproteinases (MMPs) facilitate extracellular matrix disassembly The Matrix Metalloproteinase Protein ... Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium- ... "Cysteine array matrix metalloproteinase (CA-MMP)/MMP-23 is a type II transmembrane matrix metalloproteinase regulated by a ... a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase ...
MMP17
Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 (MT-MMP 4) is an enzyme that in ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... 2004). "Expression of membrane type-4 matrix metalloproteinase (metalloproteinase-17) by human eosinophils". Int. J. Biochem. ... Puente XS, Pendas AM, Llano E, Lopez-Otin C (Feb 1999). "Localization of the human membrane type 4-matrix metalloproteinase ...
Proteases in angiogenesis
Numerous proteases including matrix metalloproteinases (MMPs), a disintegrin and metalloproteinase domain (ADAM), a disintegrin ... and by endogenous inhibitors known as tissue inhibitors of metalloproteinases (TIMPs). The role of matrix metalloproteinases ... Matrix metalloproteinases (MMPs) are a large multigene family of zinc-dependent endopeptidases. The collective MMP family is ... Matrix metalloproteinases contain five conserved domains/sequence motifs: Signal peptide sequence, which directs the enzyme ...
Ferula persica
It contains a number of matrix metalloproteinase inhibitors. "Ferula persica Willd". Plants of the World Online. Royal Botanic ... Shahverdi, A.R.; Saadat, F.; Khorramizadeh, M.R.; Iranshahi, M.; Khoshayand, M.R. (2006). "Two matrix metalloproteinases ... 13 (9-10): 712-717. doi:10.1016/j.phymed.2006.01.003. PMID 16487689. v t e (Articles with short description, Short description ... Retrieved 9 January 2022. "Ferula persica Persian asafoetida". The Royal Horticultural Society. 2022. Retrieved 9 January 2022 ...
Metalloprotease inhibitor
Hua, H.; Li, M.; Luo, T; Yin, Y.; Jiang, Y (2011). "Matrix Metalloproteinases in Tumorigenesis: an Evolving Paradigm". Cellular ... Metalloprotease inhibitors are cellular inhibitors of the Matrix metalloproteinases (MMPs). MMPs belong to a family of zinc- ... Brown, P. D. (1997). "Matrix metalloproteinase inhibitors in the treatment of cancer". Medical Oncology. 14 (1): 1-10. doi: ... Matrix metalloproteinase MMP inhibitors Collagen Cancer Periodontitis Arthritis Rheumatoid arthritis Osteoarthritis ...
Alveolar macrophage
Ohbayashi H, Shimokata K (April 2005). "Matrix metalloproteinase-9 and airway remodeling in asthma". Current Drug Targets. ... so activated lymphocytes secrete IFNγ to stimulate the production of matrix metalloproteinase MMP-9 by macrophages. AMs have ... The latent complex is covalently linked to the extracellular matrix by binding to latent TGF-β-binding proteins. TGF-β is ... IL-4 and IL-10 have both been shown to reduce the production of metalloproteinases (endopeptidases which break down collagen ...
Tumor-associated macrophage
In addition to producing VEGF-A, TAMs have been shown to modulate VEGF-A concentration through matrix metalloproteinase (MMP)-9 ... October 2000). "Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis". Nature Cell Biology. 2 (10): ... 66 (1): 1-9. doi:10.1016/j.critrevonc.2007.07.004. PMID 17913510. De la Cruz-Merino L, Barco-Sanchez A, Henao Carrasco F, et al ...
Thrombospondin-2
"Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal ... "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal ... It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the ... 17 (1): 225-9. doi:10.1006/geno.1993.1308. PMID 8406456. Adolph KW, Liska DJ, Bornstein P (Jul 1997). "Analysis of the promoter ...
MMP2
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal ... "Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2 ... "Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia ... "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". J. Biol. ...
Biomarker (medicine)
Loukopoulos P, Mungall BA, Straw RC, Thornton JR, Robinson WF (July 2003). "Matrix metalloproteinase-2 and -9 involvement in ... 9 (3): 140-3. doi:10.1016/j.autrev.2009.04.006. hdl:2437/89144. PMID 19427413. Mathsson L, Mullazehi M, Wick MC, et al. ( ... the difference between high and low energy states is approximately 9 molecules per 2 million. Improvements to increase MR ...
Fusion mechanism
This can then trigger expression of matrix metalloproteinase 9 (MMP9). MMP9 can degrade proteins in the extracellular matrix, ... For example, a cell might free itself from the extracellular matrix in order to allow the cell more motility to facilitate ...
Lercanidipine
"Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension". Journal of Cardiovascular ... 57, ISBN 978-3-946057-10-9, S. 171. Chen K, Zhang J, Liu S, Zhang D, Teng Y, Wei C, et al. (June 2012). "Simultaneous ...
Minocycline
The activity of matrix metalloproteinase-9 was decreased by treatment. Clinical and MRI outcomes in this study were supported ... 9 (11): 1407-1411. PMID 21061764. Hubbell CG, Hobbs ER, Rist T, White JW (December 1982). "Efficacy of minocycline compared ...
Snehasikta Swarnakar
"Matrix Metalloproteinases in Ischemia - Reperfusion Injury in Brain: Anti-oxidants as Rescuer". Role of Proteases in Cellular ... "Matrix Metalloproteinases in Ischemia - Reperfusion Injury in Brain: Anti-oxidants as Rescuer". Role of Proteases in Cellular ... Matrix Metalloproteinase Inhibitors: Specificity of Binding and Structure-Activity Relationships. Springer Science & Business ... Matrix Metalloproteinase Inhibitors: Specificity of Binding and Structure-Activity Relationships. Springer Science & Business ...
TFCP2
LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). Along with its main oncogene ... enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological ... 74 (15): 6790-9. doi:10.1128/JVI.74.15.6790-6799.2000. PMC 112196. PMID 10888618. Zhou W, Clouston DR, Wang X, Cerruti L, ... 30 (2): 398-9. PMID 8586452. Romerio F, Gabriel MN, Margolis DM (Dec 1997). "Repression of human immunodeficiency virus type 1 ...
Desmoplasia
In tumors, cancer cells secrete matrix degrading enzymes, such as matrix metalloproteinases (MMPs) that, once cleaved and ... Foda, Hussein D; Zucker, Stanley (2001). "Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis". Drug ... Stroma contains extracellular matrix components such as proteoglycans and glycosaminoglycans which are highly negatively ... In contrast, the stromal cells provide the structure of the organ and secrete extracellular matrix as supportive, connective ...
Pathophysiology of multiple sclerosis
February 2006). "Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with ... A special role is played by Matrix metalloproteinases. These increase BBB T-cell permeability, specially in the case of MMP-9 ... Gray E, Thomas TL, Betmouni S, Scolding N, Love S (September 2008). "Elevated matrix metalloproteinase-9 and degradation of ... promoting inflammatory activity as well continued activation of proteins such as matrix metalloproteinases, which have ...
TNFSF12
"TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages". Circulation Journal. 68 (4): 396-9 ... 9 (1-3): 2273-84. doi:10.2741/1395. PMID 15353286. Lynch CN, Wang YC, Lund JK, Chen YW, Leal JA, Wiley SR (March 1999). "TWEAK ... 274 (13): 8455-9. doi:10.1074/jbc.274.13.8455. PMID 10085077. Kaplan MJ, Ray D, Mo RR, Yung RL, Richardson BC (March 2000). " ... 169 (10): 6020-9. doi:10.4049/jimmunol.169.10.6020. PMID 12421989. Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, Okumura ...
RAC1
Jul 11, 2012). "Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression". Science Translational ... "Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression". Science Translational Medicine. 4 (142 ... 16 (9): 4869-78. doi:10.1128/mcb.16.9.4869. PMC 231489. PMID 8756646. Jefferies C, Bowie A, Brady G, Cooke EL, Li X, O'Neill LA ... 16 (10): 522-9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823. Parri M, Chiarugi P (2010). "Rac and Rho GTPases in cancer cell ...
Chlorotoxin
Deshane J, Garner CC, Sontheimer H (February 2003). "Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2 ... 58 (21): 4871-9. PMID 9809993. Lyons SA, O'Neal J, Sontheimer H (August 2002). "Chlorotoxin, a scorpion-derived peptide, ... 264 (2 Pt 1): C361-9. doi:10.1152/ajpcell.1993.264.2.C361. PMID 8383429. Lippens G, Najib J, Wodak SJ, Tartar A (January 1995 ...
Interstitial collagenase
Maskos K, Bode W (November 2003). "Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases". ... Okada Y, Hashimoto G (2001). "[Degradation of extracellular matrix by matrix metalloproteinases and joint destruction]". ... Seiki M (2003). "Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion". Cancer Lett. 194 (1): 1-11. doi: ... A specific region (183)RWTNNFREY(191) has been identified as a critical segment of matrix metalloproteinase 1 for the ...
Tuberculosis in relation to HIV
It is also seen that HIV co-infection with tuberculosis also reduces concentration of immunopathogenic matrix metalloproteinase ... "Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases". American Journal of Respiratory and ... 163 (1): 32-9. doi:10.7326/M14-2979. PMID 26148280. S2CID 207538325. Ramaseri Sunder, S.; Hanumanth, S. R.; Nagaraju, R. T.; ... 185 (9): 989-997. doi:10.1164/rccm.201110-1769OC. PMC 3359940. PMID 22345579. (CS1 errors: missing periodical, Webarchive ...
Ilomastat
Fini ME, Cui TY, Mouldovan A, Grobelny D, Galardy RE, Fisher SJ (1991). "An inhibitor of the matrix metalloproteinase ... Ilomastat (INN), (codenamed GM6001, proprietary name Galardin®) is a broad-spectrum matrix metalloproteinase inhibitor. This ... Santiskulvong C, Rozengurt E (November 2003). "Galardin (GM 6001), a broad-spectrum matrix metalloproteinase inhibitor, blocks ... "Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases". Invest. Ophthalmol. Vis. ...
Lumican
As lumican can directly bind to and inhibit matrix metalloproteinase-14 (MMP14), lumican may limit tumor progression by ... a new inhibitor of matrix metalloproteinase-14 activity". FEBS Letters. 588 (23): 4319-24. doi:10.1016/j.febslet.2014.09.040. ... "Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell ... Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the LUM gene on chromosome 12. ...
Oleanolic acid
... is also used as standard for comparison of hyaluronidase, elastase and matrix-metalloproteinase-1 inhibition of ... Nema NK, Maity N, Sarkar BK, Mukherjee PK (September 2013). "Matrix metalloproteinase, hyaluronidase and elastase inhibitory ... elastase and matrix-metalloproteinase-1 inhibitor". Indian Journal of Pharmacology. 44 (5): 584-587. doi:10.4103/0253- ... 51 (9): 1182-1187. doi:10.3109/13880209.2013.782505. PMID 23763301. S2CID 24453413. (Articles with short description, Short ...
MMP25
... activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 ... Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene. Proteins of the matrix metalloproteinase ... "Entrez Gene: MMP25 matrix metallopeptidase 25". Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 ( ... Pei D (Feb 2000). "Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage ...
Hyaluronan synthase
"Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity". Surgery. 145 (3): 322 ... When mammalian cells are stimulated by changes in their immediate environment (cytokines, extracellular matrix proximities), ... Matrix Biology. 111: 53-75. doi:10.1016/j.matbio.2022.06.001. PMC 9676077. PMID 35671866. Spicer, Andrew P.; Olson, Jeffrey S ... Matrix Biology. 80: 85-103. doi:10.1016/j.matbio.2018.10.004. PMID 30394292. S2CID 53217005. Bharadwaj AG, Kovar JL, Loughman E ...