... members of the matrix metalloproteinase family that cleave extracellular matrix constituents. These zinc endopeptidases, which ... Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some ... matrix metalloproteinases: MMP1, MMP2, MMP3, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP19, MMP20, ... "Structure and evolutionary aspects of matrix metalloproteinases: a brief overview". Mol. Cell. Biochem. 253 (1-2): 31-40. doi: ...
"The role of inflammation and matrix metalloproteinases in equine endometriosis". Journal of Veterinary Science. 13 (2): 171-177 ... 30 (2): 61-65. doi:10.1111/j.1439-0531.1995.tb00606.x. What is Endometriosis? It's causes, diagnosis, treatment Aresu, Luca; ... 25 (2): 45-52. doi:10.1294/jes.25.45. PMC 4090358. PMID 25013358. Sprayberry, Kim A (2009). "Chapter 20: Fetal monitoring in ...
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... Köhrmann A, Kammerer U, Kapp M, Dietl J, Anacker J (2009). "Expression of matrix metalloproteinases (MMPs) in primary human ... Hegedüs L, Cho H, Xie X, Eliceiri GL (2008). "Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote ... Yang M, Kurkinen M (1998). "Cloning and characterization of a novel matrix metalloproteinase (MMP), CMMP, from chicken embryo ...
Second, there is an increase in the secretion of matrix metalloproteinases that also act to digest components of the ... Nagase, Hideaki; Woessner, J. Frederick (1999). "Matrix Metalloproteinases". Journal of Biological Chemistry. 274 (31): 21491- ... These proteins have defined interactions that allow the formation of matrix proteins to help fortify the uterine cervix. Toward ... Winkler M, Rath W (1999). "Changes in the cervical extracellular matrix during pregnancy and parturition". Journal of Perinatal ...
Guo H, Li R, Zucker S, Toole BP (February 2000). "EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds ... Major TC, Liang L, Lu X, Rosebury W, Bocan TM (July 2002). "Extracellular matrix metalloproteinase inducer (EMMPRIN) is induced ... Basigin (BSG) also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) ... an extracellular matrix metalloproteinase inducer". The Journal of Investigative Dermatology. 106 (6): 1260-1265. doi:10.1111/ ...
"Matrix metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation". Gastroenterology. 132 ... 2009 Jan 2;284(1):134-40. van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton ... 346 (2): 215-223. doi:10.1016/j.ydbio.2010.07.026. PMC 2945455. PMID 20691176. Shroyer, N. F.; Helmrath, M. A.; Wang, V. Y. -C ... 16 (2): 619-625. doi:10.1128/mcb.16.2.619. PMC 231041. PMID 8552090. Andreu, P.; Peignon, G. G.; Slomianny, C.; Taketo, M. M.; ...
Gene map locus 19p13.2 BSG: Basigin (Ok blood group)/Extracellular matrix metalloproteinase inducer/CD147. Gene map locus ... Cartilage oligomeric matrix protein. Gene map locus 19p13.1 NOTCH3: Notch homolog 3 (Drosophila): Gene map locus 19p13.1-p13.2 ... It is considered the most gene-rich chromosome containing roughly 1,500 genes, despite accounting for only 2 percent of the ... Gene map locus 19q13.2 FCGBP: Fc fragment of IgG binding protein SARS2: seryl-tRNA synthetase 2, mitochondrial. Gene map locus ...
"Cleavage of human corneal type VI collagen alpha 3 chain by matrix metalloproteinase-2". Cornea. 15 (5): 490-6. doi:10.1097/ ... The alpha 3 type VI chain has been shown to bind extracellular matrix proteins, an interaction that explains the importance of ... Expression of an alpha3(VI) chain lacking N-terminal modules N10-N7 restores collagen VI assembly, secretion, and matrix ... chain is critical for extracellular microfibril formation and is present in the extracellular matrix of cultured cells". The ...
February 2006). "Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with ... A special role is played by Matrix metalloproteinases. These increase BBB T-cell permeability, specially in the case of MMP-9 ... Gray E, Thomas TL, Betmouni S, Scolding N, Love S (September 2008). "Elevated matrix metalloproteinase-9 and degradation of ... promoting inflammatory activity as well continued activation of proteins such as matrix metalloproteinases, which have ...
"Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases". J. Biol. ... 226 (2): 285-95. doi:10.1016/S0378-1119(98)00553-8. PMID 9931503. Furuse M, Sasaki H, Tsukita S (1999). "Manner of interaction ... 15 (2): 339-359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015. v t e (Articles with short description, Short ... 2 (2): 93-8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159. Tsukita S, Furuse M, Itoh M (2001). " ...
Evidence shows that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness of ameloblastoma, however, ... "Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro". BMC Cancer. 8 (182): 182 ... fibro-odontoma Bone grafting Epithelial cell rests of Malassez List of cutaneous conditions Matrix Metalloproteinase-2 Tooth ... 3.0.CO;2-V. PMID 6420036. Miyamoto CT, Brady LW, Markoe A, Salinger D (June 1991). "Ameloblastoma of the jaw. Treatment with ...
"Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases". J. Biol. ... 15 (2): 339-359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015. v t e (Articles with short description, Short ... 2 (2): 93-8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands ... 2 (4): 285-93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601. Tsukita S, Furuse M (2002). "Claudin-based barrier in ...
Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase -1 during protection ... "Role of melatonin in regulating matrix metalloproteinase-9 via tissue inhibitors of metalloproteinase-1 during protection ... "Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway". Journal of ... 49 (2): 156-168. doi:10.1111/j.1600-079X.2010.00780.x. ISSN 1600-079X. PMID 20609072. S2CID 11317152. (Orphaned articles from ...
Snoek-van Beurden PA, Von den Hoff JW (2005). "Zymographic techniques for the analysis of matrix metalloproteinases and their ... 92 (2): 305-312. doi:10.1017/S0031182000064076. PMID 3520446. S2CID 42414630. Vandooren J, Geurts N, Martens E, Van den Steen ... the presence of 2-mercaptoethanol or DTT), and to an extent, heating. Indeed, the separations following heating to 50 °C tend ...
In tumors, cancer cells secrete matrix degrading enzymes, such as matrix metalloproteinases (MMPs) that, once cleaved and ... Foda, Hussein D; Zucker, Stanley (2001). "Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis". Drug ... Stroma contains extracellular matrix components such as proteoglycans and glycosaminoglycans which are highly negatively ... In contrast, the stromal cells provide the structure of the organ and secrete extracellular matrix as supportive, connective ...
See the articles matrix metalloproteinase inhibitor (-mastat) and proteasome inhibitor (-zomib). Protease inhibitors were the ... It is a combination of nirmatrelvir, a protease inhibitor targeted to SARS-CoV-2's 3C-like protease, and ritonavir to inhibit ... Tanomastat is one of the matrix metalloproteinase inhibitors that can be used to treat cancer. Batimastat was also well known ... Within 2 years, annual deaths from AIDS in the United States fell from over 50,000 to approximately 18,000 Prior to this the ...
... matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J ... matrix metalloproteinase-1) interaction". J. Biol. Chem. 276 (31): 29375-81. doi:10.1074/jbc.M102217200. PMID 11359774. Dumin ... Matrix Biol. 16 (4): 143-51. doi:10.1016/S0945-053X(97)90002-0. PMID 9402003. Dickeson SK, Santoro SA (1998). "Ligand ... Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene. The ...
... along with the upregulation of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9). Wound healing by β-NEP results in migration ... doi:10.1016/0006-291X(81)91243-2. PMID 7247945. Yang, Dong Joo; Moh, Sang Hyun; Choi, Yun-Hee; Kim, Ki Woo (2020-10-12). "β- ... and extracellular signal-regulated kinases 1 and 2 (ERK 1 and ERK 2); ...
"Type VIII collagen stimulates smooth muscle cell migration and matrix metalloproteinase synthesis after arterial injury". Am. J ... Kvansakul M, Bogin O, Hohenester E, Yayon A (2004). "Crystal structure of the collagen alpha1(VIII) NC1 trimer". Matrix Biol. ... Leung EW, Rife L, Smith RE, Kay EP (2000). "Extracellular matrix components in retrocorneal fibrous membrane in comparison to ... 22 (2): 145-52. doi:10.1016/S0945-053X(02)00119-1. PMID 12782141. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status ...
Matrix metalloproteinase-24 is an enzyme that in humans is encoded by the MMP24 gene. Proteins of the matrix metalloproteinase ... "Entrez Gene: MMP24 matrix metallopeptidase 24 (membrane-inserted)". Nagase H, Woessner JF (1999). "Matrix metalloproteinases". ... Wang P, Wang X, Pei D (2004). "Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5- ... 2003). "mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their ...
"Entrez Gene: MMP21 matrix metallopeptidase 21". Brinckerhoff CE, Matrisian LM (2002). "Matrix metalloproteinases: a tail of a ... Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene. This gene encodes a member of ... 2004). "The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer". Anticancer Res. 24 (1): 199- ... 2003). "Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer". Gene ...
Hughes PM, Wells GM, Perry VH, Brown MC, Miller KM (2002). "Comparison of matrix metalloproteinase expression during wallerian ... 12 (2): 175-87, vii. doi:10.1016/S1052-5149(02)00009-6. PMID 12391630. Smith D. and Greenwald B. 2003.Management and staging of ... 13 (2): 199-214. doi:10.1197/j.aem.2005.07.031. PMID 16436787. Gennarelli TA (1993). "Mechanisms of brain injury". The Journal ... 11 (2): 173-86. doi:10.1089/neu.1994.11.173. PMID 7523685. Povlishock JT, Christman CW (August 1995). "The pathobiology of ...
One study found that Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting ... "Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis". ... 286 (1-2): 99-103. doi:10.1016/j.jns.2009.05.028. PMC 2760629. PMID 19539954. Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K ... 234 (1-2): 87-91. doi:10.1016/j.jns.2005.03.042. PMID 15935383. S2CID 38949982. Oztaş B, Kiliç S, Dural E, Ispir T (November ...
"Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I ... 3.0.CO;2-G. PMC 3501957. PMID 10967549. Iida J, Pei D, Kang T, Simpson MA, Herlyn M, Furcht LT, McCarthy JB (June 2001). " ... 114 (2): 359-71. doi:10.1083/jcb.114.2.359. PMC 2289079. PMID 1906475. de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, ... 122 (2): 433-42. doi:10.1046/j.0022-202X.2004.22207.x. PMID 15009727. Fukushi J, Makagiansar IT, Stallcup WB (August 2004). " ...
... matrix metalloproteinase 10, transin 2, proteoglycanase 2) is an enzyme. This enzyme catalyses the following chemical reaction ... "Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases". Biochemistry. 28 (12): 5195-203. ... Stromelysin+2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.24). ...
Cells can only migrate over living tissue, so they must excrete collagenases and proteases like matrix metalloproteinases (MMPs ... Mirastschijski U, Haaksma CJ, Tomasek JJ, Agren MS (October 2004). "Matrix metalloproteinase inhibitor GM 6001 attenuates ... and matrix contraction (between day 4 and day 14) Endothelial cells and angiogenesis (begins on day 4) Dermal matrix: elements ... "Modeling dermal granulation tissue with the linear fibroblast-populated collagen matrix: a comparison with the round matrix ...
"ROCK inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular ... 55 (2): 89-95. doi:10.3109/03008207.2013.852544. PMID 24111521. S2CID 41211282. Qi Y, Liang X, Dai F, Guan H, Sun J, Yao W ( ... 354 (2): 299-310. doi:10.1016/j.canlet.2014.08.032. PMC 4182185. PMID 25172415. Phrommintikul A, Tran L, Kompa A, Wang B, ... doi:10.1038/s41592-021-01126-2. PMC 8314867. PMID 33941937. Kale VP, Hengst JA, Desai DH, Dick TE, Choe KN, Colledge AL, et al ...
Nguyen Q, Murphy G, Hughes CE, Mort JS, Roughley PJ (October 1993). "Matrix metalloproteinases cleave at two distinct sites on ... Matrix. 11 (5): 339-46. doi:10.1016/s0934-8832(11)80205-2. PMID 1725805. Rhodes C, Savagner P, Line S, Sasaki M, Chirigos M, ... 57 (2): 219-26. doi:10.1006/geno.1999.5766. PMID 10198161. Hirakawa S, Oohashi T, Su WD, Yoshioka H, Murakami T, Arata J, ... 175 (2): 505-15. CiteSeerX 10.1.1.321.4397. doi:10.1677/joe.0.1750505. PMID 12429048. S2CID 1722539. Spicer AP, Joo A, Bowling ...
"Expression of matrix metalloproteinase-26 and tissue inhibitor of matrix metalloproteinase-3 and -4 in endometrium throughout ... Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal ... "Entrez Gene: MMP26 matrix metallopeptidase 26". Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 ( ... 2001). "Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of ...
March 2007). "Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine ... cysteine proteases and matrix metalloproteinases, increased) and their inhibitors (such as cystatin C, decreased). A few ... The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, ... 42 (2): 93-7. doi:10.5414/cpp42093. PMID 15180169. Demirtaş S, Akan O, Can M, Elmali E, Akan H (February 2006). "Cystatin C can ...